Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANX5_LEIMU

TriTrypDb:

LmxM.12.0470

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.544
CLV_C14_Caspase3-7	251	255	PF00656	0.717
CLV_C14_Caspase3-7	439	443	PF00656	0.499
CLV_C14_Caspase3-7	678	682	PF00656	0.551
CLV_C14_Caspase3-7	89	93	PF00656	0.703
CLV_NRD_NRD_1	111	113	PF00675	0.671
CLV_NRD_NRD_1	143	145	PF00675	0.743
CLV_NRD_NRD_1	157	159	PF00675	0.571
CLV_NRD_NRD_1	215	217	PF00675	0.687
CLV_NRD_NRD_1	400	402	PF00675	0.615
CLV_NRD_NRD_1	417	419	PF00675	0.610
CLV_NRD_NRD_1	498	500	PF00675	0.492
CLV_PCSK_KEX2_1	143	145	PF00082	0.745
CLV_PCSK_KEX2_1	157	159	PF00082	0.569
CLV_PCSK_KEX2_1	215	217	PF00082	0.684
CLV_PCSK_KEX2_1	400	402	PF00082	0.615
CLV_PCSK_KEX2_1	417	419	PF00082	0.610
CLV_PCSK_KEX2_1	498	500	PF00082	0.492
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.695
CLV_PCSK_SKI1_1	387	391	PF00082	0.664
CLV_PCSK_SKI1_1	401	405	PF00082	0.687
CLV_PCSK_SKI1_1	451	455	PF00082	0.559
DEG_COP1_1	165	174	PF00400	0.508
DEG_COP1_1	564	575	PF00400	0.505
DEG_SCF_TRCP1_1	223	228	PF00400	0.679
DEG_SPOP_SBC_1	197	201	PF00917	0.538
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	704	710	PF00134	0.509
DOC_MAPK_gen_1	112	122	PF00069	0.656
DOC_MAPK_HePTP_8	311	323	PF00069	0.599
DOC_MAPK_JIP1_4	457	463	PF00069	0.483
DOC_MAPK_MEF2A_6	314	323	PF00069	0.600
DOC_MAPK_MEF2A_6	571	580	PF00069	0.649
DOC_PP2B_LxvP_1	354	357	PF13499	0.657
DOC_PP2B_LxvP_1	511	514	PF13499	0.458
DOC_PP2B_LxvP_1	570	573	PF13499	0.672
DOC_PP2B_LxvP_1	578	581	PF13499	0.673
DOC_PP2B_LxvP_1	690	693	PF13499	0.525
DOC_PP4_FxxP_1	503	506	PF00568	0.530
DOC_PP4_MxPP_1	510	513	PF00568	0.468
DOC_USP7_MATH_1	11	15	PF00917	0.706
DOC_USP7_MATH_1	139	143	PF00917	0.818
DOC_USP7_MATH_1	153	157	PF00917	0.628
DOC_USP7_MATH_1	197	201	PF00917	0.551
DOC_USP7_MATH_1	209	213	PF00917	0.671
DOC_USP7_MATH_1	270	274	PF00917	0.692
DOC_USP7_MATH_1	276	280	PF00917	0.654
DOC_USP7_MATH_1	359	363	PF00917	0.502
DOC_USP7_MATH_1	443	447	PF00917	0.524
DOC_USP7_MATH_1	484	488	PF00917	0.666
DOC_USP7_MATH_1	530	534	PF00917	0.641
DOC_USP7_MATH_1	550	554	PF00917	0.631
DOC_USP7_MATH_1	613	617	PF00917	0.447
DOC_USP7_MATH_1	709	713	PF00917	0.668
DOC_USP7_MATH_1	72	76	PF00917	0.762
DOC_USP7_MATH_1	86	90	PF00917	0.603
DOC_USP7_UBL2_3	109	113	PF12436	0.667
DOC_WW_Pin1_4	183	188	PF00397	0.549
DOC_WW_Pin1_4	234	239	PF00397	0.736
DOC_WW_Pin1_4	441	446	PF00397	0.597
DOC_WW_Pin1_4	517	522	PF00397	0.550
DOC_WW_Pin1_4	587	592	PF00397	0.501
DOC_WW_Pin1_4	695	700	PF00397	0.721
DOC_WW_Pin1_4	7	12	PF00397	0.646
DOC_WW_Pin1_4	703	708	PF00397	0.584
DOC_WW_Pin1_4	94	99	PF00397	0.758
LIG_14-3-3_CanoR_1	112	122	PF00244	0.629
LIG_14-3-3_CanoR_1	147	153	PF00244	0.763
LIG_14-3-3_CanoR_1	400	408	PF00244	0.613
LIG_14-3-3_CanoR_1	417	424	PF00244	0.768
LIG_14-3-3_CanoR_1	498	504	PF00244	0.490
LIG_14-3-3_CanoR_1	539	545	PF00244	0.669
LIG_14-3-3_CanoR_1	614	622	PF00244	0.511
LIG_14-3-3_CanoR_1	645	651	PF00244	0.671
LIG_14-3-3_CanoR_1	78	82	PF00244	0.668
LIG_AP2alpha_2	54	56	PF02296	0.680
LIG_BIR_III_2	442	446	PF00653	0.489
LIG_BRCT_BRCA1_1	540	544	PF00533	0.628
LIG_CaMK_CASK_1	639	645	PF00069	0.479
LIG_CtBP_PxDLS_1	560	564	PF00389	0.664
LIG_deltaCOP1_diTrp_1	681	685	PF00928	0.524
LIG_DLG_GKlike_1	571	578	PF00625	0.567
LIG_EVH1_1	580	584	PF00568	0.564
LIG_EVH1_2	512	516	PF00568	0.470
LIG_FHA_1	171	177	PF00498	0.744
LIG_FHA_1	183	189	PF00498	0.640
LIG_FHA_1	264	270	PF00498	0.638
LIG_FHA_1	314	320	PF00498	0.650
LIG_FHA_1	388	394	PF00498	0.674
LIG_FHA_1	430	436	PF00498	0.619
LIG_FHA_1	502	508	PF00498	0.512
LIG_FHA_1	524	530	PF00498	0.496
LIG_FHA_1	567	573	PF00498	0.566
LIG_FHA_1	687	693	PF00498	0.711
LIG_FHA_2	133	139	PF00498	0.689
LIG_FHA_2	187	193	PF00498	0.698
LIG_FHA_2	335	341	PF00498	0.565
LIG_FHA_2	57	63	PF00498	0.648
LIG_Integrin_RGD_1	636	638	PF01839	0.582
LIG_LIR_Apic_2	32	38	PF02991	0.556
LIG_LIR_Apic_2	372	376	PF02991	0.502
LIG_LIR_Apic_2	452	458	PF02991	0.584
LIG_LIR_Apic_2	501	506	PF02991	0.488
LIG_LIR_Apic_2	680	686	PF02991	0.624
LIG_LIR_Gen_1	533	542	PF02991	0.636
LIG_LIR_Nem_3	353	358	PF02991	0.575
LIG_LIR_Nem_3	533	537	PF02991	0.637
LIG_LYPXL_S_1	354	358	PF13949	0.576
LIG_LYPXL_yS_3	355	358	PF13949	0.573
LIG_MYND_3	349	353	PF01753	0.663
LIG_NRBOX	121	127	PF00104	0.573
LIG_NRBOX	48	54	PF00104	0.587
LIG_Pex14_2	544	548	PF04695	0.627
LIG_SH2_CRK	373	377	PF00017	0.570
LIG_SH2_CRK	509	513	PF00017	0.514
LIG_SH2_STAP1	288	292	PF00017	0.709
LIG_SH2_STAT5	260	263	PF00017	0.651
LIG_SH2_STAT5	596	599	PF00017	0.658
LIG_SH3_3	166	172	PF00018	0.716
LIG_SH3_3	355	361	PF00018	0.531
LIG_SH3_3	578	584	PF00018	0.607
LIG_SH3_3	691	697	PF00018	0.651
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.617
LIG_SUMO_SIM_par_1	315	320	PF11976	0.653
LIG_SUMO_SIM_par_1	356	362	PF11976	0.502
LIG_SUMO_SIM_par_1	388	396	PF11976	0.671
LIG_SUMO_SIM_par_1	459	465	PF11976	0.486
LIG_TRAF2_1	296	299	PF00917	0.661
LIG_TRAF2_1	607	610	PF00917	0.630
LIG_TRFH_1	509	513	PF08558	0.473
LIG_WW_2	581	584	PF00397	0.563
MOD_CDK_SPK_2	7	12	PF00069	0.606
MOD_CK1_1	129	135	PF00069	0.654
MOD_CK1_1	151	157	PF00069	0.728
MOD_CK1_1	201	207	PF00069	0.716
MOD_CK1_1	221	227	PF00069	0.668
MOD_CK1_1	237	243	PF00069	0.563
MOD_CK1_1	246	252	PF00069	0.643
MOD_CK1_1	264	270	PF00069	0.592
MOD_CK1_1	279	285	PF00069	0.729
MOD_CK1_1	287	293	PF00069	0.621
MOD_CK1_1	313	319	PF00069	0.669
MOD_CK1_1	335	341	PF00069	0.650
MOD_CK1_1	402	408	PF00069	0.679
MOD_CK1_1	444	450	PF00069	0.583
MOD_CK1_1	465	471	PF00069	0.687
MOD_CK1_1	487	493	PF00069	0.653
MOD_CK1_1	501	507	PF00069	0.588
MOD_CK1_1	515	521	PF00069	0.565
MOD_CK1_1	562	568	PF00069	0.581
MOD_CK1_1	590	596	PF00069	0.615
MOD_CK1_1	649	655	PF00069	0.655
MOD_CK1_1	698	704	PF00069	0.735
MOD_CK1_1	712	718	PF00069	0.579
MOD_CK1_1	77	83	PF00069	0.726
MOD_CK2_1	102	108	PF00069	0.612
MOD_CK2_1	113	119	PF00069	0.666
MOD_CK2_1	132	138	PF00069	0.518
MOD_CK2_1	162	168	PF00069	0.815
MOD_CK2_1	188	194	PF00069	0.629
MOD_CK2_1	334	340	PF00069	0.712
MOD_CK2_1	359	365	PF00069	0.647
MOD_GlcNHglycan	104	107	PF01048	0.531
MOD_GlcNHglycan	115	118	PF01048	0.674
MOD_GlcNHglycan	13	16	PF01048	0.689
MOD_GlcNHglycan	223	226	PF01048	0.723
MOD_GlcNHglycan	334	337	PF01048	0.716
MOD_GlcNHglycan	401	404	PF01048	0.536
MOD_GlcNHglycan	438	441	PF01048	0.701
MOD_GlcNHglycan	451	454	PF01048	0.609
MOD_GlcNHglycan	467	470	PF01048	0.671
MOD_GlcNHglycan	484	487	PF01048	0.517
MOD_GlcNHglycan	552	555	PF01048	0.607
MOD_GlcNHglycan	556	559	PF01048	0.652
MOD_GlcNHglycan	68	71	PF01048	0.752
MOD_GlcNHglycan	686	689	PF01048	0.599
MOD_GlcNHglycan	727	730	PF01048	0.630
MOD_GlcNHglycan	74	77	PF01048	0.734
MOD_GlcNHglycan	81	84	PF01048	0.633
MOD_GlcNHglycan	88	91	PF01048	0.596
MOD_GSK3_1	107	114	PF00069	0.701
MOD_GSK3_1	125	132	PF00069	0.498
MOD_GSK3_1	147	154	PF00069	0.738
MOD_GSK3_1	182	189	PF00069	0.742
MOD_GSK3_1	197	204	PF00069	0.614
MOD_GSK3_1	205	212	PF00069	0.669
MOD_GSK3_1	221	228	PF00069	0.598
MOD_GSK3_1	237	244	PF00069	0.604
MOD_GSK3_1	264	271	PF00069	0.688
MOD_GSK3_1	276	283	PF00069	0.677
MOD_GSK3_1	294	301	PF00069	0.595
MOD_GSK3_1	302	309	PF00069	0.695
MOD_GSK3_1	313	320	PF00069	0.513
MOD_GSK3_1	332	339	PF00069	0.610
MOD_GSK3_1	402	409	PF00069	0.682
MOD_GSK3_1	449	456	PF00069	0.572
MOD_GSK3_1	468	475	PF00069	0.554
MOD_GSK3_1	540	547	PF00069	0.663
MOD_GSK3_1	550	557	PF00069	0.664
MOD_GSK3_1	561	568	PF00069	0.632
MOD_GSK3_1	595	602	PF00069	0.587
MOD_GSK3_1	645	652	PF00069	0.659
MOD_GSK3_1	68	75	PF00069	0.722
MOD_GSK3_1	698	705	PF00069	0.713
MOD_GSK3_1	7	14	PF00069	0.756
MOD_GSK3_1	708	715	PF00069	0.590
MOD_LATS_1	245	251	PF00433	0.684
MOD_LATS_1	496	502	PF00433	0.495
MOD_N-GLC_2	232	234	PF02516	0.669
MOD_NEK2_1	125	130	PF00069	0.586
MOD_NEK2_1	2	7	PF00069	0.745
MOD_NEK2_1	202	207	PF00069	0.609
MOD_NEK2_1	241	246	PF00069	0.724
MOD_NEK2_1	256	261	PF00069	0.551
MOD_NEK2_1	31	36	PF00069	0.748
MOD_NEK2_1	317	322	PF00069	0.657
MOD_NEK2_1	410	415	PF00069	0.773
MOD_NEK2_1	435	440	PF00069	0.713
MOD_NEK2_1	449	454	PF00069	0.566
MOD_NEK2_1	482	487	PF00069	0.501
MOD_NEK2_1	576	581	PF00069	0.651
MOD_NEK2_1	68	73	PF00069	0.680
MOD_NEK2_2	566	571	PF00069	0.589
MOD_PIKK_1	29	35	PF00454	0.766
MOD_PIKK_1	416	422	PF00454	0.687
MOD_PKA_1	498	504	PF00069	0.490
MOD_PKA_2	11	17	PF00069	0.607
MOD_PKA_2	111	117	PF00069	0.702
MOD_PKA_2	294	300	PF00069	0.554
MOD_PKA_2	399	405	PF00069	0.594
MOD_PKA_2	416	422	PF00069	0.800
MOD_PKA_2	498	504	PF00069	0.497
MOD_PKA_2	538	544	PF00069	0.671
MOD_PKA_2	613	619	PF00069	0.484
MOD_PKA_2	652	658	PF00069	0.495
MOD_PKA_2	77	83	PF00069	0.666
MOD_Plk_1	107	113	PF00069	0.551
MOD_Plk_1	264	270	PF00069	0.673
MOD_Plk_1	280	286	PF00069	0.567
MOD_Plk_1	387	393	PF00069	0.705
MOD_Plk_1	472	478	PF00069	0.560
MOD_Plk_1	584	590	PF00069	0.597
MOD_Plk_1	669	675	PF00069	0.686
MOD_Plk_2-3	294	300	PF00069	0.513
MOD_Plk_4	170	176	PF00069	0.504
MOD_Plk_4	198	204	PF00069	0.653
MOD_Plk_4	256	262	PF00069	0.663
MOD_Plk_4	264	270	PF00069	0.635
MOD_Plk_4	313	319	PF00069	0.687
MOD_Plk_4	359	365	PF00069	0.499
MOD_Plk_4	512	518	PF00069	0.518
MOD_Plk_4	544	550	PF00069	0.547
MOD_Plk_4	571	577	PF00069	0.765
MOD_Plk_4	712	718	PF00069	0.681
MOD_ProDKin_1	183	189	PF00069	0.552
MOD_ProDKin_1	234	240	PF00069	0.736
MOD_ProDKin_1	441	447	PF00069	0.599
MOD_ProDKin_1	517	523	PF00069	0.549
MOD_ProDKin_1	587	593	PF00069	0.503
MOD_ProDKin_1	695	701	PF00069	0.720
MOD_ProDKin_1	7	13	PF00069	0.642
MOD_ProDKin_1	703	709	PF00069	0.575
MOD_ProDKin_1	94	100	PF00069	0.758
MOD_SUMO_rev_2	381	389	PF00179	0.505
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.501
TRG_ENDOCYTIC_2	355	358	PF00928	0.573
TRG_ENDOCYTIC_2	626	629	PF00928	0.620
TRG_ER_diArg_1	214	216	PF00400	0.565
TRG_ER_diArg_1	498	500	PF00400	0.492
TRG_NLS_MonoExtC_3	142	147	PF00514	0.693
TRG_NLS_MonoExtN_4	109	116	PF00514	0.663
TRG_NLS_MonoExtN_4	143	148	PF00514	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I993	Leishmania donovani	76%	100%
A4H6X0	Leishmania braziliensis	54%	100%
E9AGD5	Leishmania infantum	76%	99%
Q4QGP5	Leishmania major	72%	96%