Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANX4_LEIMU

TriTrypDb:

LmxM.12.0460

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.695
CLV_C14_Caspase3-7	546	550	PF00656	0.653
CLV_C14_Caspase3-7	706	710	PF00656	0.813
CLV_NRD_NRD_1	106	108	PF00675	0.769
CLV_NRD_NRD_1	185	187	PF00675	0.668
CLV_NRD_NRD_1	252	254	PF00675	0.733
CLV_NRD_NRD_1	366	368	PF00675	0.763
CLV_NRD_NRD_1	374	376	PF00675	0.646
CLV_NRD_NRD_1	596	598	PF00675	0.660
CLV_NRD_NRD_1	671	673	PF00675	0.586
CLV_NRD_NRD_1	684	686	PF00675	0.682
CLV_NRD_NRD_1	718	720	PF00675	0.517
CLV_NRD_NRD_1	738	740	PF00675	0.696
CLV_PCSK_KEX2_1	106	108	PF00082	0.764
CLV_PCSK_KEX2_1	185	187	PF00082	0.668
CLV_PCSK_KEX2_1	252	254	PF00082	0.733
CLV_PCSK_KEX2_1	366	368	PF00082	0.771
CLV_PCSK_KEX2_1	374	376	PF00082	0.638
CLV_PCSK_KEX2_1	596	598	PF00082	0.660
CLV_PCSK_KEX2_1	671	673	PF00082	0.586
CLV_PCSK_KEX2_1	684	686	PF00082	0.682
CLV_PCSK_KEX2_1	738	740	PF00082	0.693
CLV_PCSK_PC7_1	248	254	PF00082	0.726
CLV_PCSK_PC7_1	592	598	PF00082	0.658
CLV_PCSK_SKI1_1	110	114	PF00082	0.765
CLV_PCSK_SKI1_1	34	38	PF00082	0.542
CLV_PCSK_SKI1_1	375	379	PF00082	0.511
CLV_PCSK_SKI1_1	526	530	PF00082	0.764
CLV_PCSK_SKI1_1	60	64	PF00082	0.750
DEG_APCC_KENBOX_2	277	281	PF00400	0.544
DEG_Nend_UBRbox_3	1	3	PF02207	0.749
DEG_SPOP_SBC_1	96	100	PF00917	0.730
DOC_ANK_TNKS_1	595	602	PF00023	0.586
DOC_CDC14_PxL_1	187	195	PF14671	0.719
DOC_CKS1_1	265	270	PF01111	0.708
DOC_CKS1_1	475	480	PF01111	0.757
DOC_CKS1_1	674	679	PF01111	0.568
DOC_CYCLIN_RxL_1	106	115	PF00134	0.731
DOC_CYCLIN_yClb3_PxF_3	259	265	PF00134	0.708
DOC_CYCLIN_yCln2_LP_2	209	212	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.534
DOC_MAPK_gen_1	106	113	PF00069	0.762
DOC_MAPK_gen_1	757	764	PF00069	0.683
DOC_MAPK_JIP1_4	107	113	PF00069	0.715
DOC_PP1_RVXF_1	58	65	PF00149	0.535
DOC_PP2B_LxvP_1	119	122	PF13499	0.652
DOC_PP2B_LxvP_1	198	201	PF13499	0.774
DOC_PP2B_LxvP_1	209	212	PF13499	0.618
DOC_PP2B_LxvP_1	235	238	PF13499	0.530
DOC_PP2B_LxvP_1	528	531	PF13499	0.767
DOC_PP4_FxxP_1	265	268	PF00568	0.797
DOC_USP7_MATH_1	112	116	PF00917	0.766
DOC_USP7_MATH_1	122	126	PF00917	0.657
DOC_USP7_MATH_1	145	149	PF00917	0.669
DOC_USP7_MATH_1	15	19	PF00917	0.559
DOC_USP7_MATH_1	153	157	PF00917	0.709
DOC_USP7_MATH_1	201	205	PF00917	0.772
DOC_USP7_MATH_1	243	247	PF00917	0.561
DOC_USP7_MATH_1	269	273	PF00917	0.673
DOC_USP7_MATH_1	295	299	PF00917	0.536
DOC_USP7_MATH_1	413	417	PF00917	0.583
DOC_USP7_MATH_1	434	438	PF00917	0.565
DOC_USP7_MATH_1	483	487	PF00917	0.683
DOC_USP7_MATH_1	492	496	PF00917	0.690
DOC_USP7_MATH_1	552	556	PF00917	0.503
DOC_USP7_MATH_1	645	649	PF00917	0.527
DOC_USP7_MATH_1	695	699	PF00917	0.663
DOC_USP7_MATH_1	73	77	PF00917	0.745
DOC_USP7_MATH_1	745	749	PF00917	0.755
DOC_USP7_MATH_1	760	764	PF00917	0.682
DOC_USP7_MATH_1	91	95	PF00917	0.552
DOC_WW_Pin1_4	140	145	PF00397	0.860
DOC_WW_Pin1_4	255	260	PF00397	0.670
DOC_WW_Pin1_4	26	31	PF00397	0.719
DOC_WW_Pin1_4	264	269	PF00397	0.575
DOC_WW_Pin1_4	282	287	PF00397	0.557
DOC_WW_Pin1_4	299	304	PF00397	0.584
DOC_WW_Pin1_4	307	312	PF00397	0.589
DOC_WW_Pin1_4	398	403	PF00397	0.778
DOC_WW_Pin1_4	428	433	PF00397	0.747
DOC_WW_Pin1_4	44	49	PF00397	0.578
DOC_WW_Pin1_4	474	479	PF00397	0.827
DOC_WW_Pin1_4	663	668	PF00397	0.549
DOC_WW_Pin1_4	673	678	PF00397	0.555
DOC_WW_Pin1_4	712	717	PF00397	0.765
DOC_WW_Pin1_4	97	102	PF00397	0.733
LIG_14-3-3_CanoR_1	185	191	PF00244	0.757
LIG_14-3-3_CanoR_1	233	238	PF00244	0.745
LIG_14-3-3_CanoR_1	248	256	PF00244	0.569
LIG_14-3-3_CanoR_1	332	340	PF00244	0.773
LIG_14-3-3_CanoR_1	366	372	PF00244	0.762
LIG_14-3-3_CanoR_1	374	378	PF00244	0.639
LIG_14-3-3_CanoR_1	443	451	PF00244	0.799
LIG_14-3-3_CanoR_1	452	458	PF00244	0.668
LIG_14-3-3_CanoR_1	526	531	PF00244	0.702
LIG_14-3-3_CanoR_1	60	65	PF00244	0.748
LIG_14-3-3_CanoR_1	671	677	PF00244	0.735
LIG_14-3-3_CanoR_1	685	691	PF00244	0.586
LIG_14-3-3_CanoR_1	757	763	PF00244	0.751
LIG_14-3-3_CanoR_1	83	89	PF00244	0.536
LIG_BRCT_BRCA1_1	261	265	PF00533	0.614
LIG_BRCT_BRCA1_1	724	728	PF00533	0.684
LIG_BRCT_BRCA1_1	760	764	PF00533	0.679
LIG_BRCT_BRCA1_2	724	730	PF00533	0.683
LIG_deltaCOP1_diTrp_1	538	547	PF00928	0.582
LIG_EVH1_1	210	214	PF00568	0.620
LIG_FHA_1	153	159	PF00498	0.658
LIG_FHA_1	204	210	PF00498	0.697
LIG_FHA_1	23	29	PF00498	0.695
LIG_FHA_1	265	271	PF00498	0.663
LIG_FHA_1	654	660	PF00498	0.768
LIG_FHA_2	687	693	PF00498	0.710
LIG_FHA_2	697	703	PF00498	0.634
LIG_GSK3_LRP6_1	259	264	PF00069	0.604
LIG_LIR_Apic_2	262	268	PF02991	0.623
LIG_LIR_Apic_2	431	436	PF02991	0.744
LIG_LIR_Apic_2	539	545	PF02991	0.709
LIG_LIR_Apic_2	61	67	PF02991	0.534
LIG_LIR_Apic_2	619	624	PF02991	0.679
LIG_MYND_1	101	105	PF01753	0.725
LIG_PCNA_yPIPBox_3	684	697	PF02747	0.542
LIG_Pex14_2	543	547	PF04695	0.480
LIG_SH2_CRK	433	437	PF00017	0.750
LIG_SH2_NCK_1	433	437	PF00017	0.750
LIG_SH2_STAP1	771	775	PF00017	0.672
LIG_SH2_STAT5	371	374	PF00017	0.751
LIG_SH3_2	101	106	PF14604	0.726
LIG_SH3_3	141	147	PF00018	0.734
LIG_SH3_3	208	214	PF00018	0.726
LIG_SH3_3	24	30	PF00018	0.689
LIG_SH3_3	253	259	PF00018	0.771
LIG_SH3_3	265	271	PF00018	0.649
LIG_SH3_3	475	481	PF00018	0.655
LIG_SH3_3	661	667	PF00018	0.645
LIG_SH3_3	710	716	PF00018	0.771
LIG_SH3_3	746	752	PF00018	0.720
LIG_SH3_3	8	14	PF00018	0.618
LIG_SH3_3	83	89	PF00018	0.578
LIG_SH3_3	98	104	PF00018	0.705
LIG_Sin3_3	490	497	PF02671	0.521
LIG_SUMO_SIM_anti_2	709	715	PF11976	0.545
LIG_TRAF2_1	17	20	PF00917	0.539
LIG_TRAF2_1	778	781	PF00917	0.615
LIG_WRC_WIRS_1	378	383	PF05994	0.684
LIG_WRC_WIRS_1	544	549	PF05994	0.581
LIG_WW_3	103	107	PF00397	0.721
MOD_CDK_SPxK_1	474	480	PF00069	0.606
MOD_CDK_SPxxK_3	398	405	PF00069	0.709
MOD_CDK_SPxxK_3	712	719	PF00069	0.663
MOD_CK1_1	138	144	PF00069	0.779
MOD_CK1_1	18	24	PF00069	0.714
MOD_CK1_1	246	252	PF00069	0.804
MOD_CK1_1	255	261	PF00069	0.654
MOD_CK1_1	293	299	PF00069	0.764
MOD_CK1_1	302	308	PF00069	0.638
MOD_CK1_1	309	315	PF00069	0.546
MOD_CK1_1	370	376	PF00069	0.815
MOD_CK1_1	391	397	PF00069	0.592
MOD_CK1_1	455	461	PF00069	0.654
MOD_CK1_1	476	482	PF00069	0.750
MOD_CK1_1	648	654	PF00069	0.748
MOD_CK1_1	698	704	PF00069	0.772
MOD_CK1_1	758	764	PF00069	0.814
MOD_CK1_1	767	773	PF00069	0.600
MOD_CK1_1	87	93	PF00069	0.703
MOD_CK2_1	220	226	PF00069	0.712
MOD_CK2_1	465	471	PF00069	0.530
MOD_CK2_1	606	612	PF00069	0.450
MOD_CK2_1	686	692	PF00069	0.709
MOD_CK2_1	696	702	PF00069	0.692
MOD_CK2_1	712	718	PF00069	0.805
MOD_CK2_1	738	744	PF00069	0.838
MOD_Cter_Amidation	364	367	PF01082	0.535
MOD_GlcNHglycan	114	117	PF01048	0.801
MOD_GlcNHglycan	15	18	PF01048	0.601
MOD_GlcNHglycan	198	201	PF01048	0.784
MOD_GlcNHglycan	20	24	PF01048	0.534
MOD_GlcNHglycan	249	252	PF01048	0.636
MOD_GlcNHglycan	336	339	PF01048	0.749
MOD_GlcNHglycan	392	396	PF01048	0.551
MOD_GlcNHglycan	415	418	PF01048	0.741
MOD_GlcNHglycan	428	431	PF01048	0.593
MOD_GlcNHglycan	445	448	PF01048	0.622
MOD_GlcNHglycan	467	470	PF01048	0.756
MOD_GlcNHglycan	490	493	PF01048	0.747
MOD_GlcNHglycan	518	521	PF01048	0.690
MOD_GlcNHglycan	572	575	PF01048	0.408
MOD_GlcNHglycan	616	621	PF01048	0.681
MOD_GlcNHglycan	635	638	PF01048	0.623
MOD_GlcNHglycan	647	650	PF01048	0.680
MOD_GlcNHglycan	7	10	PF01048	0.752
MOD_GlcNHglycan	723	727	PF01048	0.811
MOD_GlcNHglycan	729	733	PF01048	0.728
MOD_GlcNHglycan	77	80	PF01048	0.673
MOD_GlcNHglycan	89	92	PF01048	0.600
MOD_GSK3_1	1	8	PF00069	0.632
MOD_GSK3_1	15	22	PF00069	0.669
MOD_GSK3_1	233	240	PF00069	0.742
MOD_GSK3_1	243	250	PF00069	0.641
MOD_GSK3_1	255	262	PF00069	0.566
MOD_GSK3_1	270	277	PF00069	0.694
MOD_GSK3_1	284	291	PF00069	0.579
MOD_GSK3_1	295	302	PF00069	0.578
MOD_GSK3_1	305	312	PF00069	0.601
MOD_GSK3_1	334	341	PF00069	0.653
MOD_GSK3_1	346	353	PF00069	0.672
MOD_GSK3_1	366	373	PF00069	0.735
MOD_GSK3_1	377	384	PF00069	0.577
MOD_GSK3_1	387	394	PF00069	0.626
MOD_GSK3_1	428	435	PF00069	0.678
MOD_GSK3_1	461	468	PF00069	0.637
MOD_GSK3_1	488	495	PF00069	0.611
MOD_GSK3_1	526	533	PF00069	0.682
MOD_GSK3_1	54	61	PF00069	0.675
MOD_GSK3_1	644	651	PF00069	0.772
MOD_GSK3_1	760	767	PF00069	0.769
MOD_GSK3_1	87	94	PF00069	0.693
MOD_GSK3_1	95	102	PF00069	0.664
MOD_LATS_1	184	190	PF00433	0.562
MOD_N-GLC_1	282	287	PF02516	0.743
MOD_N-GLC_1	438	443	PF02516	0.579
MOD_N-GLC_1	465	470	PF02516	0.624
MOD_NEK2_1	244	249	PF00069	0.641
MOD_NEK2_1	347	352	PF00069	0.636
MOD_NEK2_1	377	382	PF00069	0.730
MOD_NEK2_1	403	408	PF00069	0.751
MOD_NEK2_1	438	443	PF00069	0.649
MOD_NEK2_1	696	701	PF00069	0.566
MOD_NEK2_1	728	733	PF00069	0.661
MOD_NEK2_1	764	769	PF00069	0.672
MOD_PIKK_1	15	21	PF00454	0.542
MOD_PIKK_1	332	338	PF00454	0.770
MOD_PIKK_1	438	444	PF00454	0.578
MOD_PIKK_1	606	612	PF00454	0.450
MOD_PIKK_1	686	692	PF00454	0.695
MOD_PIKK_1	733	739	PF00454	0.701
MOD_PK_1	233	239	PF00069	0.543
MOD_PK_1	252	258	PF00069	0.692
MOD_PKA_1	252	258	PF00069	0.724
MOD_PKA_1	366	372	PF00069	0.762
MOD_PKA_1	684	690	PF00069	0.700
MOD_PKA_1	738	744	PF00069	0.645
MOD_PKA_2	247	253	PF00069	0.693
MOD_PKA_2	366	372	PF00069	0.762
MOD_PKA_2	373	379	PF00069	0.652
MOD_PKA_2	684	690	PF00069	0.790
MOD_PKA_2	738	744	PF00069	0.792
MOD_PKA_2	758	764	PF00069	0.748
MOD_PKB_1	231	239	PF00069	0.535
MOD_PKB_1	443	451	PF00069	0.676
MOD_Plk_1	153	159	PF00069	0.655
MOD_Plk_1	460	466	PF00069	0.630
MOD_Plk_1	538	544	PF00069	0.650
MOD_Plk_1	616	622	PF00069	0.666
MOD_Plk_1	722	728	PF00069	0.746
MOD_Plk_4	311	317	PF00069	0.584
MOD_Plk_4	367	373	PF00069	0.757
MOD_Plk_4	538	544	PF00069	0.650
MOD_Plk_4	760	766	PF00069	0.670
MOD_ProDKin_1	140	146	PF00069	0.858
MOD_ProDKin_1	255	261	PF00069	0.669
MOD_ProDKin_1	26	32	PF00069	0.722
MOD_ProDKin_1	264	270	PF00069	0.574
MOD_ProDKin_1	282	288	PF00069	0.560
MOD_ProDKin_1	299	305	PF00069	0.584
MOD_ProDKin_1	307	313	PF00069	0.588
MOD_ProDKin_1	398	404	PF00069	0.776
MOD_ProDKin_1	428	434	PF00069	0.747
MOD_ProDKin_1	44	50	PF00069	0.580
MOD_ProDKin_1	474	480	PF00069	0.826
MOD_ProDKin_1	663	669	PF00069	0.549
MOD_ProDKin_1	673	679	PF00069	0.555
MOD_ProDKin_1	712	718	PF00069	0.764
MOD_ProDKin_1	97	103	PF00069	0.732
MOD_SUMO_rev_2	638	648	PF00179	0.608
MOD_SUMO_rev_2	715	722	PF00179	0.510
TRG_DiLeu_BaEn_1	692	697	PF01217	0.557
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.589
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.586
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.697
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.690
TRG_ER_diArg_1	105	107	PF00400	0.768
TRG_ER_diArg_1	185	187	PF00400	0.668
TRG_ER_diArg_1	230	233	PF00400	0.540
TRG_ER_diArg_1	595	597	PF00400	0.643
TRG_ER_diArg_1	670	672	PF00400	0.590
TRG_ER_diArg_1	683	685	PF00400	0.687
TRG_ER_diArg_1	738	740	PF00400	0.693
TRG_ER_diArg_1	756	759	PF00400	0.755

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9B3	Leishmania donovani	78%	100%
A4H707	Leishmania braziliensis	54%	100%
E9AGD4	Leishmania infantum	79%	100%
Q4QGP6	Leishmania major	76%	100%