Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANX3_LEIMU

TriTrypDb:

LmxM.12.0450

Length:

1091

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1002	1006	PF00656	0.662
CLV_C14_Caspase3-7	134	138	PF00656	0.742
CLV_C14_Caspase3-7	466	470	PF00656	0.564
CLV_C14_Caspase3-7	896	900	PF00656	0.622
CLV_C14_Caspase3-7	995	999	PF00656	0.734
CLV_NRD_NRD_1	1050	1052	PF00675	0.655
CLV_NRD_NRD_1	1089	1091	PF00675	0.734
CLV_NRD_NRD_1	210	212	PF00675	0.709
CLV_NRD_NRD_1	283	285	PF00675	0.571
CLV_NRD_NRD_1	448	450	PF00675	0.521
CLV_NRD_NRD_1	543	545	PF00675	0.677
CLV_NRD_NRD_1	595	597	PF00675	0.460
CLV_NRD_NRD_1	683	685	PF00675	0.444
CLV_NRD_NRD_1	739	741	PF00675	0.705
CLV_NRD_NRD_1	907	909	PF00675	0.746
CLV_NRD_NRD_1	931	933	PF00675	0.693
CLV_PCSK_FUR_1	1087	1091	PF00082	0.705
CLV_PCSK_FUR_1	593	597	PF00082	0.458
CLV_PCSK_KEX2_1	1050	1052	PF00082	0.655
CLV_PCSK_KEX2_1	1086	1088	PF00082	0.784
CLV_PCSK_KEX2_1	1089	1091	PF00082	0.741
CLV_PCSK_KEX2_1	210	212	PF00082	0.709
CLV_PCSK_KEX2_1	283	285	PF00082	0.571
CLV_PCSK_KEX2_1	448	450	PF00082	0.521
CLV_PCSK_KEX2_1	542	544	PF00082	0.677
CLV_PCSK_KEX2_1	595	597	PF00082	0.460
CLV_PCSK_KEX2_1	683	685	PF00082	0.444
CLV_PCSK_KEX2_1	739	741	PF00082	0.705
CLV_PCSK_KEX2_1	906	908	PF00082	0.748
CLV_PCSK_PC1ET2_1	1086	1088	PF00082	0.784
CLV_PCSK_PC7_1	206	212	PF00082	0.730
CLV_PCSK_PC7_1	279	285	PF00082	0.574
CLV_PCSK_SKI1_1	1028	1032	PF00082	0.669
CLV_PCSK_SKI1_1	1042	1046	PF00082	0.504
CLV_PCSK_SKI1_1	260	264	PF00082	0.453
CLV_PCSK_SKI1_1	568	572	PF00082	0.501
CLV_PCSK_SKI1_1	948	952	PF00082	0.536
CLV_PCSK_SKI1_1	985	989	PF00082	0.694
CLV_Separin_Metazoa	191	195	PF03568	0.418
DEG_APCC_DBOX_1	567	575	PF00400	0.494
DEG_APCC_DBOX_1	578	586	PF00400	0.363
DEG_APCC_DBOX_1	666	674	PF00400	0.601
DEG_SCF_TRCP1_1	1007	1012	PF00400	0.693
DEG_SPOP_SBC_1	221	225	PF00917	0.550
DEG_SPOP_SBC_1	235	239	PF00917	0.656
DEG_SPOP_SBC_1	508	512	PF00917	0.657
DEG_SPOP_SBC_1	80	84	PF00917	0.543
DEG_SPOP_SBC_1	954	958	PF00917	0.543
DOC_ANK_TNKS_1	283	290	PF00023	0.521
DOC_ANK_TNKS_1	525	532	PF00023	0.651
DOC_CKS1_1	563	568	PF01111	0.507
DOC_MAPK_gen_1	113	120	PF00069	0.556
DOC_MAPK_gen_1	359	368	PF00069	0.467
DOC_MAPK_gen_1	665	673	PF00069	0.551
DOC_PP1_RVXF_1	322	328	PF00149	0.486
DOC_PP2B_LxvP_1	424	427	PF13499	0.630
DOC_PP2B_LxvP_1	553	556	PF13499	0.517
DOC_PP4_FxxP_1	425	428	PF00568	0.627
DOC_USP7_MATH_1	100	104	PF00917	0.546
DOC_USP7_MATH_1	1030	1034	PF00917	0.632
DOC_USP7_MATH_1	167	171	PF00917	0.335
DOC_USP7_MATH_1	2	6	PF00917	0.555
DOC_USP7_MATH_1	217	221	PF00917	0.628
DOC_USP7_MATH_1	234	238	PF00917	0.563
DOC_USP7_MATH_1	319	323	PF00917	0.603
DOC_USP7_MATH_1	389	393	PF00917	0.686
DOC_USP7_MATH_1	432	436	PF00917	0.699
DOC_USP7_MATH_1	548	552	PF00917	0.533
DOC_USP7_MATH_1	758	762	PF00917	0.712
DOC_USP7_MATH_1	771	775	PF00917	0.602
DOC_USP7_MATH_1	80	84	PF00917	0.619
DOC_USP7_MATH_1	866	870	PF00917	0.697
DOC_USP7_MATH_1	881	885	PF00917	0.620
DOC_USP7_MATH_1	921	925	PF00917	0.708
DOC_USP7_MATH_1	994	998	PF00917	0.672
DOC_WW_Pin1_4	107	112	PF00397	0.679
DOC_WW_Pin1_4	143	148	PF00397	0.690
DOC_WW_Pin1_4	287	292	PF00397	0.499
DOC_WW_Pin1_4	391	396	PF00397	0.697
DOC_WW_Pin1_4	400	405	PF00397	0.640
DOC_WW_Pin1_4	408	413	PF00397	0.526
DOC_WW_Pin1_4	477	482	PF00397	0.674
DOC_WW_Pin1_4	494	499	PF00397	0.546
DOC_WW_Pin1_4	56	61	PF00397	0.679
DOC_WW_Pin1_4	562	567	PF00397	0.641
DOC_WW_Pin1_4	63	68	PF00397	0.644
DOC_WW_Pin1_4	917	922	PF00397	0.797
DOC_WW_Pin1_4	943	948	PF00397	0.571
LIG_14-3-3_CanoR_1	113	119	PF00244	0.737
LIG_14-3-3_CanoR_1	419	425	PF00244	0.597
LIG_14-3-3_CanoR_1	588	593	PF00244	0.382
LIG_14-3-3_CanoR_1	752	756	PF00244	0.737
LIG_14-3-3_CanoR_1	759	767	PF00244	0.724
LIG_14-3-3_CanoR_1	772	780	PF00244	0.607
LIG_14-3-3_CanoR_1	796	802	PF00244	0.658
LIG_BRCT_BRCA1_1	773	777	PF00533	0.666
LIG_Clathr_ClatBox_1	165	169	PF01394	0.518
LIG_Clathr_ClatBox_1	849	853	PF01394	0.684
LIG_FHA_1	107	113	PF00498	0.687
LIG_FHA_1	115	121	PF00498	0.624
LIG_FHA_1	156	162	PF00498	0.565
LIG_FHA_1	245	251	PF00498	0.594
LIG_FHA_1	370	376	PF00498	0.579
LIG_FHA_1	522	528	PF00498	0.638
LIG_FHA_1	557	563	PF00498	0.669
LIG_FHA_1	56	62	PF00498	0.565
LIG_FHA_1	844	850	PF00498	0.710
LIG_FHA_1	949	955	PF00498	0.727
LIG_FHA_2	129	135	PF00498	0.704
LIG_FHA_2	178	184	PF00498	0.498
LIG_FHA_2	270	276	PF00498	0.461
LIG_FHA_2	376	382	PF00498	0.485
LIG_FHA_2	386	392	PF00498	0.593
LIG_FHA_2	395	401	PF00498	0.653
LIG_FHA_2	474	480	PF00498	0.729
LIG_FHA_2	509	515	PF00498	0.659
LIG_FHA_2	852	858	PF00498	0.704
LIG_FHA_2	887	893	PF00498	0.691
LIG_FXI_DFP_1	251	255	PF00024	0.541
LIG_GBD_Chelix_1	367	375	PF00786	0.562
LIG_LIR_Apic_2	422	428	PF02991	0.632
LIG_LIR_Gen_1	386	395	PF02991	0.682
LIG_LIR_Gen_1	567	575	PF02991	0.444
LIG_LIR_Gen_1	662	671	PF02991	0.528
LIG_LIR_Gen_1	774	785	PF02991	0.457
LIG_LIR_Nem_3	386	390	PF02991	0.671
LIG_LIR_Nem_3	567	572	PF02991	0.532
LIG_LIR_Nem_3	662	666	PF02991	0.515
LIG_NRBOX	780	786	PF00104	0.586
LIG_PCNA_PIPBox_1	41	50	PF02747	0.483
LIG_SH2_CRK	569	573	PF00017	0.502
LIG_SH2_NCK_1	216	220	PF00017	0.607
LIG_SH2_NCK_1	569	573	PF00017	0.502
LIG_SH2_NCK_1	613	617	PF00017	0.565
LIG_SH2_SRC	318	321	PF00017	0.579
LIG_SH2_SRC	613	616	PF00017	0.579
LIG_SH2_SRC	709	712	PF00017	0.582
LIG_SH2_STAP1	37	41	PF00017	0.497
LIG_SH2_STAT3	630	633	PF00017	0.486
LIG_SH2_STAT5	285	288	PF00017	0.576
LIG_SH2_STAT5	47	50	PF00017	0.631
LIG_SH2_STAT5	630	633	PF00017	0.486
LIG_SH2_STAT5	709	712	PF00017	0.582
LIG_SH3_1	57	63	PF00018	0.688
LIG_SH3_3	30	36	PF00018	0.688
LIG_SH3_3	485	491	PF00018	0.687
LIG_SH3_3	57	63	PF00018	0.688
LIG_SH3_3	609	615	PF00018	0.663
LIG_SH3_3	649	655	PF00018	0.547
LIG_SH3_3	750	756	PF00018	0.618
LIG_SH3_3	826	832	PF00018	0.658
LIG_SH3_CIN85_PxpxPR_1	767	772	PF14604	0.680
LIG_Sin3_3	1045	1052	PF02671	0.580
LIG_SUMO_SIM_anti_2	558	565	PF11976	0.631
LIG_SUMO_SIM_par_1	163	170	PF11976	0.529
LIG_TRAF2_1	132	135	PF00917	0.624
LIG_TRAF2_1	180	183	PF00917	0.558
LIG_TRAF2_1	825	828	PF00917	0.718
LIG_TRAF2_1	832	835	PF00917	0.686
LIG_TYR_ITSM	565	572	PF00017	0.470
LIG_UBA3_1	670	675	PF00899	0.615
MOD_CDC14_SPxK_1	110	113	PF00782	0.680
MOD_CDC14_SPxK_1	146	149	PF00782	0.673
MOD_CDK_SPK_2	63	68	PF00069	0.564
MOD_CDK_SPK_2	943	948	PF00069	0.541
MOD_CDK_SPxK_1	107	113	PF00069	0.683
MOD_CDK_SPxK_1	143	149	PF00069	0.690
MOD_CDK_SPxK_1	562	568	PF00069	0.566
MOD_CDK_SPxxK_3	391	398	PF00069	0.698
MOD_CK1_1	1012	1018	PF00069	0.739
MOD_CK1_1	220	226	PF00069	0.685
MOD_CK1_1	237	243	PF00069	0.557
MOD_CK1_1	290	296	PF00069	0.529
MOD_CK1_1	411	417	PF00069	0.695
MOD_CK1_1	468	474	PF00069	0.733
MOD_CK1_1	5	11	PF00069	0.640
MOD_CK1_1	522	528	PF00069	0.659
MOD_CK1_1	534	540	PF00069	0.584
MOD_CK1_1	551	557	PF00069	0.664
MOD_CK1_1	81	87	PF00069	0.637
MOD_CK1_1	884	890	PF00069	0.651
MOD_CK1_1	917	923	PF00069	0.750
MOD_CK1_1	955	961	PF00069	0.659
MOD_CK2_1	128	134	PF00069	0.754
MOD_CK2_1	167	173	PF00069	0.519
MOD_CK2_1	177	183	PF00069	0.438
MOD_CK2_1	269	275	PF00069	0.510
MOD_CK2_1	375	381	PF00069	0.429
MOD_CK2_1	385	391	PF00069	0.469
MOD_CK2_1	473	479	PF00069	0.736
MOD_CK2_1	508	514	PF00069	0.664
MOD_CK2_1	533	539	PF00069	0.593
MOD_CK2_1	56	62	PF00069	0.543
MOD_CK2_1	804	810	PF00069	0.734
MOD_CK2_1	834	840	PF00069	0.763
MOD_CK2_1	851	857	PF00069	0.555
MOD_CK2_1	879	885	PF00069	0.556
MOD_CK2_1	910	916	PF00069	0.751
MOD_CK2_1	943	949	PF00069	0.626
MOD_CK2_1	955	961	PF00069	0.729
MOD_Cter_Amidation	904	907	PF01082	0.748
MOD_GlcNHglycan	1007	1010	PF01048	0.705
MOD_GlcNHglycan	1032	1035	PF01048	0.641
MOD_GlcNHglycan	1045	1048	PF01048	0.517
MOD_GlcNHglycan	130	134	PF01048	0.617
MOD_GlcNHglycan	212	215	PF01048	0.645
MOD_GlcNHglycan	219	222	PF01048	0.589
MOD_GlcNHglycan	239	242	PF01048	0.650
MOD_GlcNHglycan	28	31	PF01048	0.564
MOD_GlcNHglycan	292	295	PF01048	0.512
MOD_GlcNHglycan	413	416	PF01048	0.736
MOD_GlcNHglycan	440	443	PF01048	0.695
MOD_GlcNHglycan	494	497	PF01048	0.687
MOD_GlcNHglycan	527	530	PF01048	0.713
MOD_GlcNHglycan	536	539	PF01048	0.752
MOD_GlcNHglycan	545	548	PF01048	0.764
MOD_GlcNHglycan	606	610	PF01048	0.614
MOD_GlcNHglycan	741	744	PF01048	0.689
MOD_GlcNHglycan	761	764	PF01048	0.672
MOD_GlcNHglycan	773	776	PF01048	0.704
MOD_GlcNHglycan	806	809	PF01048	0.734
MOD_GlcNHglycan	835	839	PF01048	0.667
MOD_GlcNHglycan	881	884	PF01048	0.570
MOD_GlcNHglycan	941	944	PF01048	0.560
MOD_GSK3_1	1	8	PF00069	0.651
MOD_GSK3_1	1001	1008	PF00069	0.740
MOD_GSK3_1	1012	1019	PF00069	0.631
MOD_GSK3_1	1077	1084	PF00069	0.700
MOD_GSK3_1	114	121	PF00069	0.740
MOD_GSK3_1	143	150	PF00069	0.686
MOD_GSK3_1	15	22	PF00069	0.583
MOD_GSK3_1	167	174	PF00069	0.336
MOD_GSK3_1	202	209	PF00069	0.713
MOD_GSK3_1	217	224	PF00069	0.517
MOD_GSK3_1	385	392	PF00069	0.660
MOD_GSK3_1	467	474	PF00069	0.671
MOD_GSK3_1	517	524	PF00069	0.614
MOD_GSK3_1	551	558	PF00069	0.690
MOD_GSK3_1	584	591	PF00069	0.410
MOD_GSK3_1	74	81	PF00069	0.563
MOD_GSK3_1	910	917	PF00069	0.800
MOD_GSK3_1	934	941	PF00069	0.754
MOD_GSK3_1	948	955	PF00069	0.642
MOD_N-GLC_1	20	25	PF02516	0.700
MOD_N-GLC_1	55	60	PF02516	0.530
MOD_NEK2_1	118	123	PF00069	0.732
MOD_NEK2_1	192	197	PF00069	0.554
MOD_NEK2_1	20	25	PF00069	0.610
MOD_NEK2_1	222	227	PF00069	0.509
MOD_NEK2_1	375	380	PF00069	0.473
MOD_NEK2_1	390	395	PF00069	0.670
MOD_NEK2_1	501	506	PF00069	0.687
MOD_NEK2_1	532	537	PF00069	0.675
MOD_NEK2_1	741	746	PF00069	0.713
MOD_NEK2_1	780	785	PF00069	0.581
MOD_NEK2_1	795	800	PF00069	0.512
MOD_NEK2_1	85	90	PF00069	0.558
MOD_NEK2_1	938	943	PF00069	0.575
MOD_NEK2_2	420	425	PF00069	0.642
MOD_PIKK_1	1077	1083	PF00454	0.614
MOD_PIKK_1	118	124	PF00454	0.730
MOD_PIKK_1	155	161	PF00454	0.561
MOD_PIKK_1	226	232	PF00454	0.662
MOD_PIKK_1	244	250	PF00454	0.444
MOD_PIKK_1	751	757	PF00454	0.682
MOD_PIKK_1	8	14	PF00454	0.699
MOD_PIKK_1	886	892	PF00454	0.688
MOD_PIKK_1	976	982	PF00454	0.732
MOD_PKA_1	210	216	PF00069	0.673
MOD_PKA_1	542	548	PF00069	0.674
MOD_PKA_1	683	689	PF00069	0.451
MOD_PKA_1	739	745	PF00069	0.640
MOD_PKA_2	1012	1018	PF00069	0.698
MOD_PKA_2	114	120	PF00069	0.737
MOD_PKA_2	135	141	PF00069	0.721
MOD_PKA_2	210	216	PF00069	0.673
MOD_PKA_2	525	531	PF00069	0.713
MOD_PKA_2	542	548	PF00069	0.721
MOD_PKA_2	594	600	PF00069	0.527
MOD_PKA_2	683	689	PF00069	0.502
MOD_PKA_2	739	745	PF00069	0.700
MOD_PKA_2	751	757	PF00069	0.619
MOD_PKA_2	758	764	PF00069	0.573
MOD_PKA_2	771	777	PF00069	0.519
MOD_PKA_2	795	801	PF00069	0.635
MOD_PKA_2	892	898	PF00069	0.700
MOD_PKB_1	908	916	PF00069	0.750
MOD_Plk_1	385	391	PF00069	0.619
MOD_Plk_1	605	611	PF00069	0.670
MOD_Plk_1	948	954	PF00069	0.723
MOD_Plk_2-3	1001	1007	PF00069	0.690
MOD_Plk_2-3	135	141	PF00069	0.684
MOD_Plk_2-3	269	275	PF00069	0.510
MOD_Plk_2-3	369	375	PF00069	0.524
MOD_Plk_2-3	717	723	PF00069	0.667
MOD_Plk_2-3	853	859	PF00069	0.562
MOD_Plk_2-3	892	898	PF00069	0.562
MOD_Plk_2-3	914	920	PF00069	0.702
MOD_Plk_4	167	173	PF00069	0.522
MOD_Plk_4	420	426	PF00069	0.639
MOD_Plk_4	440	446	PF00069	0.521
MOD_Plk_4	480	486	PF00069	0.819
MOD_Plk_4	548	554	PF00069	0.615
MOD_Plk_4	558	564	PF00069	0.633
MOD_Plk_4	581	587	PF00069	0.306
MOD_Plk_4	780	786	PF00069	0.586
MOD_Plk_4	921	927	PF00069	0.712
MOD_ProDKin_1	107	113	PF00069	0.683
MOD_ProDKin_1	143	149	PF00069	0.690
MOD_ProDKin_1	287	293	PF00069	0.499
MOD_ProDKin_1	391	397	PF00069	0.693
MOD_ProDKin_1	400	406	PF00069	0.639
MOD_ProDKin_1	408	414	PF00069	0.525
MOD_ProDKin_1	477	483	PF00069	0.673
MOD_ProDKin_1	494	500	PF00069	0.546
MOD_ProDKin_1	56	62	PF00069	0.680
MOD_ProDKin_1	562	568	PF00069	0.627
MOD_ProDKin_1	63	69	PF00069	0.644
MOD_ProDKin_1	917	923	PF00069	0.798
MOD_ProDKin_1	943	949	PF00069	0.571
TRG_DiLeu_BaEn_4	163	169	PF01217	0.341
TRG_DiLeu_BaEn_4	721	727	PF01217	0.677
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.512
TRG_ENDOCYTIC_2	569	572	PF00928	0.505
TRG_ENDOCYTIC_2	663	666	PF00928	0.431
TRG_ER_diArg_1	1049	1051	PF00400	0.647
TRG_ER_diArg_1	1087	1090	PF00400	0.703
TRG_ER_diArg_1	112	115	PF00400	0.699
TRG_ER_diArg_1	210	212	PF00400	0.709
TRG_ER_diArg_1	258	261	PF00400	0.377
TRG_ER_diArg_1	283	285	PF00400	0.571
TRG_ER_diArg_1	360	363	PF00400	0.501
TRG_ER_diArg_1	541	544	PF00400	0.769
TRG_ER_diArg_1	592	595	PF00400	0.571
TRG_ER_diArg_1	739	741	PF00400	0.705
TRG_ER_diArg_1	906	908	PF00400	0.748
TRG_NES_CRM1_1	643	657	PF08389	0.489
TRG_NES_CRM1_1	961	973	PF08389	0.728
TRG_NLS_MonoExtC_3	1085	1090	PF00514	0.857
TRG_NLS_MonoExtN_4	1083	1090	PF00514	0.847
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6K8	Leishmania donovani	87%	100%
A4H6W0	Leishmania braziliensis	66%	99%
E9AGD3	Leishmania infantum	87%	100%
Q4QGP7	Leishmania major	85%	100%