Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANX1_LEIMU

TriTrypDb:

LmxM.12.0430

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.699
CLV_C14_Caspase3-7	387	391	PF00656	0.514
CLV_C14_Caspase3-7	57	61	PF00656	0.554
CLV_NRD_NRD_1	501	503	PF00675	0.624
CLV_NRD_NRD_1	583	585	PF00675	0.840
CLV_NRD_NRD_1	609	611	PF00675	0.527
CLV_PCSK_KEX2_1	501	503	PF00082	0.624
CLV_PCSK_KEX2_1	583	585	PF00082	0.840
CLV_PCSK_KEX2_1	609	611	PF00082	0.527
CLV_PCSK_SKI1_1	174	178	PF00082	0.653
CLV_PCSK_SKI1_1	441	445	PF00082	0.627
CLV_PCSK_SKI1_1	609	613	PF00082	0.449
DEG_APCC_DBOX_1	433	441	PF00400	0.619
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SPOP_SBC_1	211	215	PF00917	0.749
DEG_SPOP_SBC_1	549	553	PF00917	0.643
DOC_CKS1_1	180	185	PF01111	0.790
DOC_CKS1_1	442	447	PF01111	0.618
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.790
DOC_CYCLIN_yCln2_LP_2	417	423	PF00134	0.650
DOC_MAPK_gen_1	330	337	PF00069	0.770
DOC_PP2B_LxvP_1	324	327	PF13499	0.554
DOC_PP2B_LxvP_1	417	420	PF13499	0.561
DOC_PP2B_LxvP_1	566	569	PF13499	0.535
DOC_PP4_FxxP_1	467	470	PF00568	0.609
DOC_PP4_FxxP_1	537	540	PF00568	0.547
DOC_PP4_FxxP_1	631	634	PF00568	0.621
DOC_USP7_MATH_1	18	22	PF00917	0.663
DOC_USP7_MATH_1	192	196	PF00917	0.670
DOC_USP7_MATH_1	212	216	PF00917	0.706
DOC_USP7_MATH_1	247	251	PF00917	0.700
DOC_USP7_MATH_1	258	262	PF00917	0.752
DOC_USP7_MATH_1	278	282	PF00917	0.695
DOC_USP7_MATH_1	286	290	PF00917	0.720
DOC_USP7_MATH_1	312	316	PF00917	0.655
DOC_USP7_MATH_1	378	382	PF00917	0.791
DOC_USP7_MATH_1	549	553	PF00917	0.799
DOC_USP7_MATH_2	447	453	PF00917	0.502
DOC_WW_Pin1_4	179	184	PF00397	0.789
DOC_WW_Pin1_4	261	266	PF00397	0.557
DOC_WW_Pin1_4	282	287	PF00397	0.854
DOC_WW_Pin1_4	427	432	PF00397	0.366
DOC_WW_Pin1_4	441	446	PF00397	0.439
DOC_WW_Pin1_4	466	471	PF00397	0.609
DOC_WW_Pin1_4	538	543	PF00397	0.730
DOC_WW_Pin1_4	589	594	PF00397	0.566
LIG_14-3-3_CanoR_1	174	179	PF00244	0.663
LIG_14-3-3_CanoR_1	223	233	PF00244	0.766
LIG_14-3-3_CanoR_1	259	264	PF00244	0.644
LIG_14-3-3_CanoR_1	345	354	PF00244	0.842
LIG_14-3-3_CanoR_1	492	498	PF00244	0.610
LIG_14-3-3_CanoR_1	501	511	PF00244	0.466
LIG_14-3-3_CanoR_1	513	519	PF00244	0.475
LIG_14-3-3_CanoR_1	564	569	PF00244	0.563
LIG_14-3-3_CanoR_1	609	615	PF00244	0.606
LIG_14-3-3_CanoR_1	637	645	PF00244	0.621
LIG_BIR_III_4	6	10	PF00653	0.555
LIG_BIR_III_4	60	64	PF00653	0.562
LIG_CtBP_PxDLS_1	494	498	PF00389	0.592
LIG_deltaCOP1_diTrp_1	102	109	PF00928	0.661
LIG_deltaCOP1_diTrp_1	418	425	PF00928	0.638
LIG_EVH1_2	408	412	PF00568	0.724
LIG_FHA_1	118	124	PF00498	0.638
LIG_FHA_1	175	181	PF00498	0.679
LIG_FHA_1	225	231	PF00498	0.769
LIG_FHA_1	275	281	PF00498	0.574
LIG_FHA_1	85	91	PF00498	0.789
LIG_FHA_2	252	258	PF00498	0.772
LIG_FHA_2	293	299	PF00498	0.764
LIG_FHA_2	35	41	PF00498	0.790
LIG_FHA_2	473	479	PF00498	0.631
LIG_FHA_2	573	579	PF00498	0.824
LIG_FHA_2	611	617	PF00498	0.592
LIG_LIR_Apic_2	465	470	PF02991	0.612
LIG_LIR_Gen_1	106	117	PF02991	0.609
LIG_LIR_Gen_1	449	459	PF02991	0.588
LIG_LIR_Gen_1	484	495	PF02991	0.622
LIG_LIR_Nem_3	102	107	PF02991	0.677
LIG_LIR_Nem_3	108	112	PF02991	0.504
LIG_LIR_Nem_3	418	424	PF02991	0.637
LIG_LIR_Nem_3	449	454	PF02991	0.587
LIG_LIR_Nem_3	456	461	PF02991	0.485
LIG_LIR_Nem_3	478	482	PF02991	0.662
LIG_LIR_Nem_3	484	490	PF02991	0.523
LIG_LIR_Nem_3	578	582	PF02991	0.829
LIG_PDZ_Class_2	662	667	PF00595	0.656
LIG_SH2_CRK	13	17	PF00017	0.598
LIG_SH2_CRK	442	446	PF00017	0.618
LIG_SH2_CRK	487	491	PF00017	0.618
LIG_SH2_CRK	579	583	PF00017	0.835
LIG_SH2_STAP1	13	17	PF00017	0.598
LIG_SH2_STAP1	164	168	PF00017	0.617
LIG_SH2_STAP1	511	515	PF00017	0.650
LIG_SH2_STAT5	503	506	PF00017	0.599
LIG_SH2_STAT5	656	659	PF00017	0.587
LIG_SH3_3	246	252	PF00018	0.851
LIG_SH3_3	277	283	PF00018	0.843
LIG_SH3_3	403	409	PF00018	0.778
LIG_SH3_3	488	494	PF00018	0.637
LIG_SH3_3	566	572	PF00018	0.628
LIG_SUMO_SIM_par_1	182	187	PF11976	0.618
LIG_SUMO_SIM_par_1	493	499	PF11976	0.602
LIG_SUMO_SIM_par_1	610	616	PF11976	0.598
LIG_SUMO_SIM_par_1	83	92	PF11976	0.627
LIG_TRAF2_1	21	24	PF00917	0.544
LIG_TYR_ITIM	11	16	PF00017	0.578
LIG_WRC_WIRS_1	661	666	PF05994	0.548
MOD_CDK_SPxxK_3	427	434	PF00069	0.548
MOD_CK1_1	206	212	PF00069	0.589
MOD_CK1_1	213	219	PF00069	0.535
MOD_CK1_1	236	242	PF00069	0.642
MOD_CK1_1	250	256	PF00069	0.625
MOD_CK1_1	261	267	PF00069	0.629
MOD_CK1_1	270	276	PF00069	0.540
MOD_CK1_1	285	291	PF00069	0.536
MOD_CK1_1	315	321	PF00069	0.665
MOD_CK1_1	427	433	PF00069	0.627
MOD_CK1_1	567	573	PF00069	0.777
MOD_CK1_1	589	595	PF00069	0.563
MOD_CK1_1	603	609	PF00069	0.712
MOD_CK1_1	81	87	PF00069	0.694
MOD_CK1_1	89	95	PF00069	0.598
MOD_CK2_1	18	24	PF00069	0.619
MOD_CK2_1	292	298	PF00069	0.768
MOD_CK2_1	407	413	PF00069	0.726
MOD_CK2_1	450	456	PF00069	0.583
MOD_CK2_1	472	478	PF00069	0.632
MOD_CK2_1	493	499	PF00069	0.602
MOD_CK2_1	549	555	PF00069	0.836
MOD_CK2_1	572	578	PF00069	0.821
MOD_CK2_1	610	616	PF00069	0.569
MOD_CK2_1	94	100	PF00069	0.685
MOD_GlcNHglycan	124	127	PF01048	0.650
MOD_GlcNHglycan	186	189	PF01048	0.685
MOD_GlcNHglycan	241	244	PF01048	0.849
MOD_GlcNHglycan	245	248	PF01048	0.783
MOD_GlcNHglycan	269	272	PF01048	0.611
MOD_GlcNHglycan	288	291	PF01048	0.746
MOD_GlcNHglycan	310	313	PF01048	0.841
MOD_GlcNHglycan	347	350	PF01048	0.546
MOD_GlcNHglycan	353	357	PF01048	0.548
MOD_GlcNHglycan	379	383	PF01048	0.787
MOD_GlcNHglycan	483	486	PF01048	0.626
MOD_GlcNHglycan	545	548	PF01048	0.808
MOD_GlcNHglycan	566	569	PF01048	0.705
MOD_GlcNHglycan	57	60	PF01048	0.803
MOD_GlcNHglycan	588	591	PF01048	0.734
MOD_GlcNHglycan	602	606	PF01048	0.507
MOD_GlcNHglycan	64	67	PF01048	0.746
MOD_GSK3_1	206	213	PF00069	0.625
MOD_GSK3_1	232	239	PF00069	0.833
MOD_GSK3_1	243	250	PF00069	0.685
MOD_GSK3_1	259	266	PF00069	0.609
MOD_GSK3_1	270	277	PF00069	0.622
MOD_GSK3_1	278	285	PF00069	0.819
MOD_GSK3_1	289	296	PF00069	0.655
MOD_GSK3_1	30	37	PF00069	0.743
MOD_GSK3_1	308	315	PF00069	0.635
MOD_GSK3_1	543	550	PF00069	0.736
MOD_GSK3_1	600	607	PF00069	0.613
MOD_GSK3_1	78	85	PF00069	0.744
MOD_LATS_1	360	366	PF00433	0.763
MOD_NEK2_1	184	189	PF00069	0.686
MOD_NEK2_1	210	215	PF00069	0.636
MOD_NEK2_1	237	242	PF00069	0.777
MOD_NEK2_1	308	313	PF00069	0.743
MOD_NEK2_1	424	429	PF00069	0.630
MOD_NEK2_1	548	553	PF00069	0.829
MOD_NEK2_1	554	559	PF00069	0.738
MOD_NEK2_1	600	605	PF00069	0.751
MOD_NEK2_1	617	622	PF00069	0.315
MOD_NEK2_1	82	87	PF00069	0.509
MOD_NEK2_2	514	519	PF00069	0.595
MOD_PIKK_1	263	269	PF00454	0.656
MOD_PIKK_1	289	295	PF00454	0.562
MOD_PIKK_1	325	331	PF00454	0.650
MOD_PK_1	362	368	PF00069	0.758
MOD_PKA_1	44	50	PF00069	0.820
MOD_PKA_2	258	264	PF00069	0.643
MOD_PKA_2	54	60	PF00069	0.720
MOD_Plk_1	107	113	PF00069	0.602
MOD_Plk_1	206	212	PF00069	0.622
MOD_Plk_1	352	358	PF00069	0.557
MOD_Plk_1	397	403	PF00069	0.686
MOD_Plk_1	449	455	PF00069	0.583
MOD_Plk_1	617	623	PF00069	0.581
MOD_Plk_2-3	100	106	PF00069	0.394
MOD_Plk_2-3	450	456	PF00069	0.583
MOD_Plk_4	206	212	PF00069	0.680
MOD_Plk_4	397	403	PF00069	0.733
MOD_Plk_4	450	456	PF00069	0.583
MOD_Plk_4	472	478	PF00069	0.632
MOD_Plk_4	486	492	PF00069	0.392
MOD_Plk_4	660	666	PF00069	0.544
MOD_ProDKin_1	179	185	PF00069	0.789
MOD_ProDKin_1	261	267	PF00069	0.557
MOD_ProDKin_1	282	288	PF00069	0.855
MOD_ProDKin_1	427	433	PF00069	0.359
MOD_ProDKin_1	441	447	PF00069	0.439
MOD_ProDKin_1	466	472	PF00069	0.615
MOD_ProDKin_1	538	544	PF00069	0.731
MOD_ProDKin_1	589	595	PF00069	0.561
TRG_DiLeu_BaEn_1	456	461	PF01217	0.601
TRG_ENDOCYTIC_2	13	16	PF00928	0.589
TRG_ENDOCYTIC_2	487	490	PF00928	0.627
TRG_ENDOCYTIC_2	579	582	PF00928	0.834
TRG_ER_diArg_1	500	502	PF00400	0.614
TRG_ER_diArg_1	532	535	PF00400	0.819
TRG_ER_diArg_1	582	584	PF00400	0.838
TRG_ER_diArg_1	609	611	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRW8	Leishmania donovani	85%	100%
A4H6V8	Leishmania braziliensis	68%	100%
E9AGD1	Leishmania infantum	85%	100%
Q4QGP9	Leishmania major	82%	100%