NAD(P)-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANW6_LEIMU

TriTrypDb:

LmxM.12.0390

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANW6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.683
CLV_C14_Caspase3-7	155	159	PF00656	0.423
CLV_NRD_NRD_1	155	157	PF00675	0.424
CLV_NRD_NRD_1	369	371	PF00675	0.616
CLV_PCSK_KEX2_1	108	110	PF00082	0.503
CLV_PCSK_KEX2_1	350	352	PF00082	0.465
CLV_PCSK_KEX2_1	69	71	PF00082	0.631
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.619
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.465
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.631
CLV_PCSK_SKI1_1	139	143	PF00082	0.424
CLV_PCSK_SKI1_1	163	167	PF00082	0.441
CLV_PCSK_SKI1_1	92	96	PF00082	0.469
DEG_SPOP_SBC_1	241	245	PF00917	0.416
DEG_SPOP_SBC_1	246	250	PF00917	0.484
DOC_ANK_TNKS_1	350	357	PF00023	0.463
DOC_CKS1_1	82	87	PF01111	0.378
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.543
DOC_USP7_MATH_1	107	111	PF00917	0.601
DOC_USP7_MATH_1	114	118	PF00917	0.634
DOC_USP7_MATH_1	228	232	PF00917	0.493
DOC_USP7_MATH_1	246	250	PF00917	0.466
DOC_USP7_MATH_1	261	265	PF00917	0.427
DOC_USP7_MATH_1	323	327	PF00917	0.371
DOC_USP7_UBL2_3	367	371	PF12436	0.607
DOC_WW_Pin1_4	187	192	PF00397	0.537
DOC_WW_Pin1_4	280	285	PF00397	0.586
DOC_WW_Pin1_4	339	344	PF00397	0.532
DOC_WW_Pin1_4	73	78	PF00397	0.653
DOC_WW_Pin1_4	81	86	PF00397	0.526
LIG_14-3-3_CanoR_1	302	310	PF00244	0.619
LIG_14-3-3_CanoR_1	35	44	PF00244	0.436
LIG_14-3-3_CanoR_1	92	97	PF00244	0.461
LIG_14-3-3_CterR_2	397	400	PF00244	0.540
LIG_deltaCOP1_diTrp_1	97	105	PF00928	0.381
LIG_FHA_1	144	150	PF00498	0.224
LIG_FHA_1	175	181	PF00498	0.445
LIG_FHA_1	232	238	PF00498	0.499
LIG_FHA_1	255	261	PF00498	0.524
LIG_FHA_1	8	14	PF00498	0.362
LIG_FHA_2	153	159	PF00498	0.408
LIG_FHA_2	164	170	PF00498	0.356
LIG_FHA_2	82	88	PF00498	0.490
LIG_LIR_Apic_2	182	186	PF02991	0.292
LIG_LIR_Gen_1	146	152	PF02991	0.419
LIG_LIR_Gen_1	169	176	PF02991	0.329
LIG_LIR_Gen_1	304	315	PF02991	0.500
LIG_LIR_Gen_1	42	52	PF02991	0.499
LIG_LIR_Gen_1	95	106	PF02991	0.381
LIG_LIR_Nem_3	135	141	PF02991	0.426
LIG_LIR_Nem_3	169	173	PF02991	0.335
LIG_LIR_Nem_3	248	254	PF02991	0.524
LIG_LIR_Nem_3	304	310	PF02991	0.533
LIG_LIR_Nem_3	42	47	PF02991	0.512
LIG_LIR_Nem_3	95	101	PF02991	0.372
LIG_PCNA_yPIPBox_3	24	37	PF02747	0.501
LIG_PDZ_Class_2	395	400	PF00595	0.526
LIG_Pex14_2	101	105	PF04695	0.379
LIG_SH2_CRK	138	142	PF00017	0.491
LIG_SH2_CRK	170	174	PF00017	0.354
LIG_SH2_CRK	183	187	PF00017	0.463
LIG_SH2_NCK_1	183	187	PF00017	0.463
LIG_SH2_SRC	170	173	PF00017	0.337
LIG_SH2_SRC	382	385	PF00017	0.346
LIG_SH2_STAP1	170	174	PF00017	0.311
LIG_SH2_STAP1	44	48	PF00017	0.504
LIG_SH2_STAT5	172	175	PF00017	0.325
LIG_SH2_STAT5	382	385	PF00017	0.311
LIG_SH3_2	362	367	PF14604	0.399
LIG_SH3_3	359	365	PF00018	0.415
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.523
LIG_SUMO_SIM_par_1	28	34	PF11976	0.353
LIG_UBA3_1	252	258	PF00899	0.267
MOD_CDC14_SPxK_1	190	193	PF00782	0.503
MOD_CDK_SPxK_1	187	193	PF00069	0.471
MOD_CK1_1	110	116	PF00069	0.630
MOD_CK1_1	161	167	PF00069	0.566
MOD_CK1_1	231	237	PF00069	0.490
MOD_CK1_1	242	248	PF00069	0.226
MOD_CK2_1	261	267	PF00069	0.461
MOD_CK2_1	341	347	PF00069	0.680
MOD_CK2_1	39	45	PF00069	0.570
MOD_CK2_1	58	64	PF00069	0.657
MOD_CK2_1	65	71	PF00069	0.638
MOD_CK2_1	81	87	PF00069	0.462
MOD_DYRK1A_RPxSP_1	339	343	PF00069	0.452
MOD_GlcNHglycan	112	115	PF01048	0.602
MOD_GlcNHglycan	116	119	PF01048	0.615
MOD_GlcNHglycan	160	163	PF01048	0.523
MOD_GlcNHglycan	183	186	PF01048	0.346
MOD_GlcNHglycan	231	234	PF01048	0.498
MOD_GlcNHglycan	244	247	PF01048	0.322
MOD_GlcNHglycan	325	328	PF01048	0.410
MOD_GlcNHglycan	343	346	PF01048	0.468
MOD_GSK3_1	110	117	PF00069	0.500
MOD_GSK3_1	240	247	PF00069	0.512
MOD_GSK3_1	323	330	PF00069	0.433
MOD_GSK3_1	339	346	PF00069	0.484
MOD_GSK3_1	73	80	PF00069	0.600
MOD_LATS_1	272	278	PF00433	0.532
MOD_N-GLC_1	37	42	PF02516	0.360
MOD_NEK2_1	152	157	PF00069	0.413
MOD_NEK2_1	181	186	PF00069	0.410
MOD_NEK2_1	310	315	PF00069	0.546
MOD_NEK2_1	36	41	PF00069	0.432
MOD_NEK2_1	48	53	PF00069	0.280
MOD_PIKK_1	99	105	PF00454	0.564
MOD_PKA_1	108	114	PF00069	0.565
MOD_PKA_2	108	114	PF00069	0.636
MOD_PKA_2	121	127	PF00069	0.586
MOD_PKA_2	301	307	PF00069	0.650
MOD_Plk_1	261	267	PF00069	0.433
MOD_Plk_1	37	43	PF00069	0.433
MOD_Plk_1	99	105	PF00069	0.498
MOD_Plk_2-3	262	268	PF00069	0.506
MOD_Plk_4	247	253	PF00069	0.418
MOD_Plk_4	77	83	PF00069	0.402
MOD_ProDKin_1	187	193	PF00069	0.551
MOD_ProDKin_1	280	286	PF00069	0.579
MOD_ProDKin_1	339	345	PF00069	0.533
MOD_ProDKin_1	73	79	PF00069	0.645
MOD_ProDKin_1	81	87	PF00069	0.521
TRG_DiLeu_BaEn_4	99	105	PF01217	0.498
TRG_ENDOCYTIC_2	138	141	PF00928	0.387
TRG_ENDOCYTIC_2	147	150	PF00928	0.333
TRG_ENDOCYTIC_2	170	173	PF00928	0.337
TRG_ENDOCYTIC_2	44	47	PF00928	0.504
TRG_NES_CRM1_1	212	226	PF08389	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D9	Leptomonas seymouri	49%	100%
A0A1X0NR33	Trypanosomatidae	33%	100%
A0A3S7WRX1	Leishmania donovani	85%	96%
A0A422NA30	Trypanosoma rangeli	36%	100%
A4H6V4	Leishmania braziliensis	72%	99%
C9ZUI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGC6	Leishmania infantum	85%	96%
Q4QGQ4	Leishmania major	84%	100%
V5BTJ4	Trypanosoma cruzi	35%	100%