Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANW4_LEIMU

TriTrypDb:

LmxM.12.0370

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9ANW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.745
CLV_C14_Caspase3-7	255	259	PF00656	0.680
CLV_NRD_NRD_1	280	282	PF00675	0.484
CLV_NRD_NRD_1	86	88	PF00675	0.695
CLV_PCSK_KEX2_1	280	282	PF00082	0.484
CLV_PCSK_KEX2_1	40	42	PF00082	0.413
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.424
CLV_PCSK_PC7_1	276	282	PF00082	0.600
CLV_PCSK_SKI1_1	242	246	PF00082	0.366
CLV_PCSK_SKI1_1	47	51	PF00082	0.418
DEG_SPOP_SBC_1	163	167	PF00917	0.819
DOC_CYCLIN_RxL_1	239	247	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.411
DOC_MAPK_gen_1	126	135	PF00069	0.703
DOC_MAPK_gen_1	87	95	PF00069	0.382
DOC_PP1_RVXF_1	45	52	PF00149	0.546
DOC_PP1_RVXF_1	89	96	PF00149	0.377
DOC_PP2B_LxvP_1	210	213	PF13499	0.822
DOC_USP7_MATH_1	162	166	PF00917	0.816
DOC_USP7_MATH_1	19	23	PF00917	0.510
DOC_WW_Pin1_4	109	114	PF00397	0.411
DOC_WW_Pin1_4	169	174	PF00397	0.765
DOC_WW_Pin1_4	269	274	PF00397	0.659
LIG_14-3-3_CanoR_1	53	61	PF00244	0.443
LIG_BRCT_BRCA1_1	98	102	PF00533	0.411
LIG_CaM_NSCaTE_8	51	58	PF13499	0.450
LIG_deltaCOP1_diTrp_1	194	199	PF00928	0.722
LIG_FHA_1	125	131	PF00498	0.638
LIG_FHA_1	205	211	PF00498	0.679
LIG_FHA_1	309	315	PF00498	0.703
LIG_FHA_2	230	236	PF00498	0.767
LIG_LIR_Nem_3	141	147	PF02991	0.619
LIG_PCNA_yPIPBox_3	74	88	PF02747	0.471
LIG_PTB_Apo_2	103	110	PF02174	0.450
LIG_SH2_NCK_1	31	35	PF00017	0.587
LIG_SH2_STAP1	44	48	PF00017	0.692
LIG_SH2_STAT3	71	74	PF00017	0.449
LIG_SH3_3	158	164	PF00018	0.679
LIG_SH3_3	167	173	PF00018	0.775
LIG_SH3_3	200	206	PF00018	0.725
LIG_TYR_ITIM	29	34	PF00017	0.585
MOD_CDK_SPxxK_3	269	276	PF00069	0.609
MOD_CK1_1	12	18	PF00069	0.660
MOD_CK1_1	3	9	PF00069	0.687
MOD_CK1_1	56	62	PF00069	0.512
MOD_CK2_1	265	271	PF00069	0.857
MOD_GlcNHglycan	12	15	PF01048	0.435
MOD_GlcNHglycan	166	169	PF01048	0.429
MOD_GlcNHglycan	267	270	PF01048	0.557
MOD_GlcNHglycan	5	8	PF01048	0.590
MOD_GlcNHglycan	55	58	PF01048	0.403
MOD_GlcNHglycan	98	101	PF01048	0.411
MOD_GSK3_1	250	257	PF00069	0.751
MOD_GSK3_1	261	268	PF00069	0.840
MOD_GSK3_1	49	56	PF00069	0.419
MOD_N-GLC_1	3	8	PF02516	0.548
MOD_NEK2_1	124	129	PF00069	0.642
MOD_NEK2_1	244	249	PF00069	0.572
MOD_PIKK_1	204	210	PF00454	0.710
MOD_PIKK_1	215	221	PF00454	0.752
MOD_PIKK_1	244	250	PF00454	0.779
MOD_PKA_2	215	221	PF00069	0.732
MOD_Plk_1	308	314	PF00069	0.699
MOD_Plk_4	56	62	PF00069	0.464
MOD_ProDKin_1	109	115	PF00069	0.411
MOD_ProDKin_1	169	175	PF00069	0.767
MOD_ProDKin_1	269	275	PF00069	0.648
MOD_SUMO_for_1	295	298	PF00179	0.708
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.689
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.465
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.432
TRG_ENDOCYTIC_2	31	34	PF00928	0.584
TRG_ER_diArg_1	279	281	PF00400	0.689
TRG_ER_diArg_1	81	84	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL14	Leptomonas seymouri	38%	95%
A0A3S7WRY6	Leishmania donovani	86%	100%
A4H6V2	Leishmania braziliensis	66%	100%
E9AGC4	Leishmania infantum	86%	100%
Q4QGQ6	Leishmania major	86%	100%