GST N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, N-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANW3_LEIMU

TriTrypDb:

LmxM.12.0360

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANW3

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.475
CLV_NRD_NRD_1	161	163	PF00675	0.418
CLV_NRD_NRD_1	260	262	PF00675	0.737
CLV_NRD_NRD_1	354	356	PF00675	0.387
CLV_PCSK_KEX2_1	161	163	PF00082	0.489
CLV_PCSK_KEX2_1	260	262	PF00082	0.737
CLV_PCSK_SKI1_1	131	135	PF00082	0.514
CLV_PCSK_SKI1_1	149	153	PF00082	0.476
CLV_PCSK_SKI1_1	16	20	PF00082	0.281
CLV_PCSK_SKI1_1	328	332	PF00082	0.266
CLV_PCSK_SKI1_1	343	347	PF00082	0.308
DEG_APCC_DBOX_1	295	303	PF00400	0.538
DEG_SCF_FBW7_1	271	278	PF00400	0.658
DOC_CYCLIN_RxL_1	228	241	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.475
DOC_MAPK_gen_1	228	238	PF00069	0.543
DOC_MAPK_gen_1	340	350	PF00069	0.508
DOC_MAPK_gen_1	355	362	PF00069	0.322
DOC_MAPK_MEF2A_6	343	350	PF00069	0.471
DOC_MAPK_MEF2A_6	355	362	PF00069	0.340
DOC_MAPK_MEF2A_6	76	84	PF00069	0.530
DOC_MAPK_NFAT4_5	343	351	PF00069	0.500
DOC_MAPK_NFAT4_5	355	363	PF00069	0.465
DOC_MIT_MIM_1	157	167	PF04212	0.364
DOC_PP1_RVXF_1	123	129	PF00149	0.410
DOC_PP1_RVXF_1	231	238	PF00149	0.406
DOC_PP2B_LxvP_1	346	349	PF13499	0.457
DOC_USP7_MATH_1	255	259	PF00917	0.701
DOC_USP7_MATH_1	262	266	PF00917	0.642
DOC_USP7_MATH_1	275	279	PF00917	0.572
DOC_WW_Pin1_4	271	276	PF00397	0.624
DOC_WW_Pin1_4	8	13	PF00397	0.394
LIG_14-3-3_CanoR_1	183	193	PF00244	0.696
LIG_14-3-3_CanoR_1	208	213	PF00244	0.529
LIG_14-3-3_CanoR_1	276	280	PF00244	0.648
LIG_14-3-3_CanoR_1	284	288	PF00244	0.624
LIG_Actin_WH2_2	152	169	PF00022	0.437
LIG_Actin_WH2_2	314	330	PF00022	0.575
LIG_deltaCOP1_diTrp_1	116	121	PF00928	0.328
LIG_eIF4E_1	13	19	PF01652	0.362
LIG_eIF4E_1	341	347	PF01652	0.524
LIG_FHA_1	15	21	PF00498	0.451
LIG_FHA_2	111	117	PF00498	0.407
LIG_FHA_2	185	191	PF00498	0.625
LIG_FHA_2	239	245	PF00498	0.560
LIG_FHA_2	306	312	PF00498	0.451
LIG_GBD_Chelix_1	215	223	PF00786	0.368
LIG_LIR_Gen_1	116	126	PF02991	0.327
LIG_LIR_Nem_3	116	121	PF02991	0.328
LIG_LIR_Nem_3	130	136	PF02991	0.349
LIG_LIR_Nem_3	338	342	PF02991	0.513
LIG_LRP6_Inhibitor_1	358	364	PF00058	0.445
LIG_Rb_LxCxE_1	317	338	PF01857	0.501
LIG_SH2_CRK	23	27	PF00017	0.468
LIG_SH2_CRK	342	346	PF00017	0.540
LIG_SH2_NCK_1	213	217	PF00017	0.574
LIG_SH2_STAP1	129	133	PF00017	0.460
LIG_SH2_STAT3	129	132	PF00017	0.445
LIG_SH2_STAT5	129	132	PF00017	0.464
LIG_SH2_STAT5	13	16	PF00017	0.362
LIG_SH2_STAT5	165	168	PF00017	0.505
LIG_SH2_STAT5	63	66	PF00017	0.281
LIG_SH2_STAT5	73	76	PF00017	0.281
LIG_SH3_3	93	99	PF00018	0.676
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.531
LIG_SUMO_SIM_par_1	80	85	PF11976	0.499
LIG_TRAF2_1	187	190	PF00917	0.577
LIG_UBA3_1	235	240	PF00899	0.545
MOD_CDK_SPK_2	271	276	PF00069	0.624
MOD_CK1_1	184	190	PF00069	0.545
MOD_CK1_1	201	207	PF00069	0.595
MOD_CK1_1	265	271	PF00069	0.640
MOD_CK1_1	282	288	PF00069	0.673
MOD_CK1_1	289	295	PF00069	0.564
MOD_CK2_1	105	111	PF00069	0.380
MOD_CK2_1	184	190	PF00069	0.575
MOD_CK2_1	238	244	PF00069	0.522
MOD_GlcNHglycan	176	179	PF01048	0.539
MOD_GlcNHglycan	271	274	PF01048	0.594
MOD_GlcNHglycan	281	284	PF01048	0.547
MOD_GlcNHglycan	288	291	PF01048	0.448
MOD_GlcNHglycan	84	87	PF01048	0.674
MOD_GSK3_1	105	112	PF00069	0.499
MOD_GSK3_1	174	181	PF00069	0.549
MOD_GSK3_1	204	211	PF00069	0.540
MOD_GSK3_1	256	263	PF00069	0.682
MOD_GSK3_1	265	272	PF00069	0.610
MOD_GSK3_1	275	282	PF00069	0.594
MOD_N-GLC_1	38	43	PF02516	0.319
MOD_NEK2_1	1	6	PF00069	0.370
MOD_NEK2_1	109	114	PF00069	0.497
MOD_NEK2_1	269	274	PF00069	0.710
MOD_NEK2_1	314	319	PF00069	0.489
MOD_NEK2_1	64	69	PF00069	0.281
MOD_NEK2_1	80	85	PF00069	0.494
MOD_PIKK_1	110	116	PF00454	0.419
MOD_PK_1	208	214	PF00069	0.586
MOD_PKA_1	239	245	PF00069	0.589
MOD_PKA_1	260	266	PF00069	0.730
MOD_PKA_2	201	207	PF00069	0.538
MOD_PKA_2	260	266	PF00069	0.664
MOD_PKA_2	275	281	PF00069	0.542
MOD_PKA_2	283	289	PF00069	0.649
MOD_Plk_1	110	116	PF00069	0.476
MOD_Plk_2-3	38	44	PF00069	0.413
MOD_Plk_4	1	7	PF00069	0.350
MOD_Plk_4	105	111	PF00069	0.474
MOD_Plk_4	114	120	PF00069	0.406
MOD_Plk_4	208	214	PF00069	0.563
MOD_Plk_4	275	281	PF00069	0.694
MOD_Plk_4	289	295	PF00069	0.646
MOD_Plk_4	341	347	PF00069	0.500
MOD_ProDKin_1	271	277	PF00069	0.624
MOD_ProDKin_1	8	14	PF00069	0.394
TRG_ENDOCYTIC_2	23	26	PF00928	0.413
TRG_ENDOCYTIC_2	342	345	PF00928	0.474
TRG_ER_diArg_1	161	163	PF00400	0.517
TRG_ER_diArg_1	219	222	PF00400	0.615
TRG_ER_diArg_1	260	262	PF00400	0.737
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY02	Leptomonas seymouri	68%	98%
A0A1X0NNU8	Trypanosomatidae	36%	91%
A0A3R7MZA1	Trypanosoma rangeli	37%	100%
A0A3S7WRV8	Leishmania donovani	94%	99%
A4H6V1	Leishmania braziliensis	83%	100%
C9ZQA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGC3	Leishmania infantum	94%	99%
Q4QGQ7	Leishmania major	93%	100%
V5DE18	Trypanosoma cruzi	39%	100%