NOT2_3_5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 2, putative

Species:

Leishmania mexicana

UniProt:

E9ANW2_LEIMU

TriTrypDb:

LmxM.12.0350

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0030015	CCR4-NOT core complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0140535	intracellular protein-containing complex	2	5
GO:0000932	P-body	5	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANW2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	5
GO:0009889	regulation of biosynthetic process	4	5
GO:0010468	regulation of gene expression	5	5
GO:0010556	regulation of macromolecule biosynthetic process	5	5
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	5
GO:0019222	regulation of metabolic process	3	5
GO:0031323	regulation of cellular metabolic process	4	5
GO:0031326	regulation of cellular biosynthetic process	5	5
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0051171	regulation of nitrogen compound metabolic process	4	5
GO:0051252	regulation of RNA metabolic process	5	5
GO:0060255	regulation of macromolecule metabolic process	4	5
GO:0065007	biological regulation	1	5
GO:0080090	regulation of primary metabolic process	4	5
GO:1903506	regulation of nucleic acid-templated transcription	7	5
GO:2001141	regulation of RNA biosynthetic process	6	5
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.702
CLV_C14_Caspase3-7	477	481	PF00656	0.542
CLV_NRD_NRD_1	68	70	PF00675	0.759
CLV_PCSK_KEX2_1	455	457	PF00082	0.342
CLV_PCSK_KEX2_1	68	70	PF00082	0.759
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.342
CLV_PCSK_SKI1_1	435	439	PF00082	0.381
CLV_PCSK_SKI1_1	483	487	PF00082	0.323
CLV_PCSK_SKI1_1	69	73	PF00082	0.615
DEG_COP1_1	327	335	PF00400	0.791
DEG_SPOP_SBC_1	325	329	PF00917	0.535
DOC_MAPK_gen_1	132	140	PF00069	0.764
DOC_MAPK_JIP1_4	409	415	PF00069	0.632
DOC_MAPK_MEF2A_6	318	326	PF00069	0.778
DOC_PP2B_LxvP_1	138	141	PF13499	0.772
DOC_PP2B_LxvP_1	50	53	PF13499	0.744
DOC_PP4_FxxP_1	25	28	PF00568	0.846
DOC_PP4_FxxP_1	399	402	PF00568	0.524
DOC_USP7_MATH_1	265	269	PF00917	0.782
DOC_USP7_MATH_1	274	278	PF00917	0.761
DOC_USP7_MATH_1	387	391	PF00917	0.712
DOC_USP7_MATH_1	551	555	PF00917	0.851
DOC_USP7_MATH_1	562	566	PF00917	0.751
DOC_USP7_MATH_1	567	571	PF00917	0.682
DOC_USP7_UBL2_3	314	318	PF12436	0.736
DOC_USP7_UBL2_3	407	411	PF12436	0.632
DOC_WW_Pin1_4	249	254	PF00397	0.829
DOC_WW_Pin1_4	326	331	PF00397	0.670
DOC_WW_Pin1_4	563	568	PF00397	0.854
LIG_14-3-3_CanoR_1	109	117	PF00244	0.681
LIG_14-3-3_CanoR_1	409	414	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.868
LIG_eIF4E_1	311	317	PF01652	0.723
LIG_FHA_1	327	333	PF00498	0.808
LIG_FHA_1	337	343	PF00498	0.589
LIG_FHA_1	359	365	PF00498	0.671
LIG_FHA_1	383	389	PF00498	0.703
LIG_FHA_1	486	492	PF00498	0.632
LIG_FHA_2	475	481	PF00498	0.542
LIG_FHA_2	60	66	PF00498	0.701
LIG_LIR_Apic_2	23	28	PF02991	0.850
LIG_LIR_Apic_2	392	397	PF02991	0.711
LIG_LIR_Apic_2	398	402	PF02991	0.427
LIG_LIR_Apic_2	403	408	PF02991	0.504
LIG_LIR_Gen_1	354	364	PF02991	0.677
LIG_LIR_Gen_1	417	426	PF02991	0.632
LIG_LIR_Gen_1	486	494	PF02991	0.632
LIG_LIR_Nem_3	354	360	PF02991	0.681
LIG_LIR_Nem_3	389	394	PF02991	0.572
LIG_LIR_Nem_3	417	421	PF02991	0.632
LIG_LIR_Nem_3	424	430	PF02991	0.550
LIG_LIR_Nem_3	486	492	PF02991	0.632
LIG_LIR_Nem_3	496	500	PF02991	0.516
LIG_MYND_1	242	246	PF01753	0.678
LIG_PCNA_yPIPBox_3	204	215	PF02747	0.749
LIG_SH2_CRK	405	409	PF00017	0.632
LIG_SH2_CRK	431	435	PF00017	0.632
LIG_SH2_PTP2	394	397	PF00017	0.700
LIG_SH2_SRC	331	334	PF00017	0.796
LIG_SH2_STAP1	391	395	PF00017	0.718
LIG_SH2_STAT3	185	188	PF00017	0.719
LIG_SH2_STAT5	331	334	PF00017	0.796
LIG_SH2_STAT5	394	397	PF00017	0.548
LIG_SH2_STAT5	428	431	PF00017	0.632
LIG_SH2_STAT5	489	492	PF00017	0.632
LIG_SH3_3	275	281	PF00018	0.839
LIG_SH3_3	316	322	PF00018	0.592
LIG_SH3_3	327	333	PF00018	0.651
LIG_SH3_3	335	341	PF00018	0.600
LIG_SH3_3	488	494	PF00018	0.632
LIG_SH3_4	407	414	PF00018	0.632
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.699
LIG_TRAF2_1	522	525	PF00917	0.716
LIG_WRC_WIRS_1	415	420	PF05994	0.632
LIG_WW_2	322	325	PF00397	0.792
MOD_CK1_1	154	160	PF00069	0.496
MOD_CK1_1	217	223	PF00069	0.534
MOD_CK1_1	414	420	PF00069	0.632
MOD_CK1_1	543	549	PF00069	0.552
MOD_CK1_1	565	571	PF00069	0.725
MOD_CK2_1	108	114	PF00069	0.715
MOD_CK2_1	331	337	PF00069	0.790
MOD_CK2_1	369	375	PF00069	0.689
MOD_CK2_1	467	473	PF00069	0.520
MOD_CK2_1	59	65	PF00069	0.719
MOD_GlcNHglycan	110	113	PF01048	0.724
MOD_GlcNHglycan	216	219	PF01048	0.533
MOD_GlcNHglycan	237	240	PF01048	0.809
MOD_GlcNHglycan	29	32	PF01048	0.539
MOD_GlcNHglycan	333	336	PF01048	0.794
MOD_GlcNHglycan	342	345	PF01048	0.630
MOD_GlcNHglycan	514	519	PF01048	0.668
MOD_GlcNHglycan	542	545	PF01048	0.726
MOD_GlcNHglycan	546	549	PF01048	0.728
MOD_GlcNHglycan	560	563	PF01048	0.622
MOD_GlcNHglycan	567	570	PF01048	0.848
MOD_GSK3_1	187	194	PF00069	0.723
MOD_GSK3_1	217	224	PF00069	0.686
MOD_GSK3_1	336	343	PF00069	0.697
MOD_GSK3_1	378	385	PF00069	0.701
MOD_GSK3_1	483	490	PF00069	0.632
MOD_GSK3_1	540	547	PF00069	0.546
MOD_GSK3_1	558	565	PF00069	0.705
MOD_N-GLC_1	151	156	PF02516	0.754
MOD_N-GLC_1	164	169	PF02516	0.551
MOD_N-GLC_1	266	271	PF02516	0.839
MOD_N-GLC_1	355	360	PF02516	0.679
MOD_N-GLC_1	557	562	PF02516	0.722
MOD_N-GLC_1	563	568	PF02516	0.696
MOD_NEK2_1	234	239	PF00069	0.807
MOD_NEK2_1	355	360	PF00069	0.679
MOD_NEK2_1	379	384	PF00069	0.696
MOD_NEK2_1	485	490	PF00069	0.504
MOD_NEK2_1	59	64	PF00069	0.714
MOD_NEK2_2	487	492	PF00069	0.632
MOD_PIKK_1	187	193	PF00454	0.723
MOD_PIKK_1	199	205	PF00454	0.497
MOD_PIKK_1	345	351	PF00454	0.727
MOD_PIKK_1	364	370	PF00454	0.372
MOD_PIKK_1	499	505	PF00454	0.632
MOD_PIKK_1	528	534	PF00454	0.746
MOD_PKA_2	108	114	PF00069	0.739
MOD_Plk_1	164	170	PF00069	0.720
MOD_Plk_1	266	272	PF00069	0.680
MOD_Plk_1	355	361	PF00069	0.546
MOD_Plk_1	364	370	PF00069	0.576
MOD_Plk_1	422	428	PF00069	0.632
MOD_Plk_1	514	520	PF00069	0.681
MOD_Plk_2-3	467	473	PF00069	0.632
MOD_Plk_4	20	26	PF00069	0.862
MOD_Plk_4	422	428	PF00069	0.632
MOD_Plk_4	467	473	PF00069	0.632
MOD_Plk_4	487	493	PF00069	0.400
MOD_ProDKin_1	249	255	PF00069	0.829
MOD_ProDKin_1	326	332	PF00069	0.669
MOD_ProDKin_1	563	569	PF00069	0.852
MOD_SUMO_for_1	421	424	PF00179	0.632
MOD_SUMO_rev_2	392	402	PF00179	0.690
TRG_DiLeu_BaEn_1	515	520	PF01217	0.689
TRG_ENDOCYTIC_2	393	396	PF00928	0.712
TRG_ENDOCYTIC_2	489	492	PF00928	0.632
TRG_ER_diArg_1	134	137	PF00400	0.766
TRG_NLS_MonoCore_2	405	410	PF00514	0.632
TRG_NLS_MonoExtC_3	405	410	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.759
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.732
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRX6	Leishmania donovani	94%	100%
E9AGC2	Leishmania infantum	93%	100%
Q4QGQ8	Leishmania major	91%	100%