Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANW0_LEIMU

TriTrypDb:

LmxM.12.0330

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	655	659	PF00656	0.546
CLV_C14_Caspase3-7	866	870	PF00656	0.459
CLV_NRD_NRD_1	15	17	PF00675	0.569
CLV_NRD_NRD_1	19	21	PF00675	0.552
CLV_NRD_NRD_1	319	321	PF00675	0.650
CLV_NRD_NRD_1	379	381	PF00675	0.584
CLV_NRD_NRD_1	41	43	PF00675	0.603
CLV_NRD_NRD_1	416	418	PF00675	0.589
CLV_NRD_NRD_1	448	450	PF00675	0.567
CLV_NRD_NRD_1	5	7	PF00675	0.662
CLV_NRD_NRD_1	524	526	PF00675	0.697
CLV_NRD_NRD_1	528	530	PF00675	0.651
CLV_NRD_NRD_1	900	902	PF00675	0.547
CLV_PCSK_FUR_1	39	43	PF00082	0.553
CLV_PCSK_KEX2_1	15	17	PF00082	0.552
CLV_PCSK_KEX2_1	19	21	PF00082	0.545
CLV_PCSK_KEX2_1	319	321	PF00082	0.650
CLV_PCSK_KEX2_1	379	381	PF00082	0.584
CLV_PCSK_KEX2_1	41	43	PF00082	0.603
CLV_PCSK_KEX2_1	416	418	PF00082	0.571
CLV_PCSK_KEX2_1	448	450	PF00082	0.609
CLV_PCSK_KEX2_1	5	7	PF00082	0.544
CLV_PCSK_KEX2_1	524	526	PF00082	0.805
CLV_PCSK_KEX2_1	528	530	PF00082	0.737
CLV_PCSK_KEX2_1	900	902	PF00082	0.547
CLV_PCSK_PC7_1	15	21	PF00082	0.569
CLV_PCSK_PC7_1	524	530	PF00082	0.668
CLV_PCSK_SKI1_1	309	313	PF00082	0.617
CLV_PCSK_SKI1_1	455	459	PF00082	0.579
CLV_PCSK_SKI1_1	493	497	PF00082	0.549
CLV_PCSK_SKI1_1	727	731	PF00082	0.498
CLV_PCSK_SKI1_1	871	875	PF00082	0.626
CLV_PCSK_SKI1_1	893	897	PF00082	0.562
CLV_Separin_Metazoa	801	805	PF03568	0.489
DEG_APCC_DBOX_1	4	12	PF00400	0.546
DEG_APCC_DBOX_1	492	500	PF00400	0.544
DEG_APCC_DBOX_1	892	900	PF00400	0.551
DEG_SPOP_SBC_1	295	299	PF00917	0.606
DEG_SPOP_SBC_1	339	343	PF00917	0.659
DEG_SPOP_SBC_1	456	460	PF00917	0.517
DOC_CYCLIN_RxL_1	490	501	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	813	819	PF00134	0.641
DOC_MAPK_gen_1	891	899	PF00069	0.552
DOC_MAPK_gen_1	900	908	PF00069	0.465
DOC_MAPK_MEF2A_6	217	225	PF00069	0.512
DOC_MAPK_MEF2A_6	891	899	PF00069	0.552
DOC_PP1_RVXF_1	447	454	PF00149	0.553
DOC_PP1_RVXF_1	869	875	PF00149	0.444
DOC_PP2B_LxvP_1	202	205	PF13499	0.619
DOC_PP2B_LxvP_1	813	816	PF13499	0.615
DOC_PP4_FxxP_1	632	635	PF00568	0.627
DOC_USP7_MATH_1	170	174	PF00917	0.547
DOC_USP7_MATH_1	247	251	PF00917	0.705
DOC_USP7_MATH_1	254	258	PF00917	0.644
DOC_USP7_MATH_1	295	299	PF00917	0.606
DOC_USP7_MATH_1	321	325	PF00917	0.722
DOC_USP7_MATH_1	326	330	PF00917	0.776
DOC_USP7_MATH_1	333	337	PF00917	0.649
DOC_USP7_MATH_1	352	356	PF00917	0.564
DOC_USP7_MATH_1	468	472	PF00917	0.605
DOC_USP7_MATH_1	475	479	PF00917	0.503
DOC_USP7_MATH_1	48	52	PF00917	0.672
DOC_USP7_MATH_1	502	506	PF00917	0.620
DOC_USP7_MATH_1	527	531	PF00917	0.705
DOC_USP7_MATH_1	592	596	PF00917	0.644
DOC_USP7_MATH_1	600	604	PF00917	0.599
DOC_USP7_MATH_1	697	701	PF00917	0.723
DOC_USP7_MATH_1	723	727	PF00917	0.766
DOC_USP7_MATH_1	746	750	PF00917	0.719
DOC_USP7_MATH_1	833	837	PF00917	0.662
DOC_USP7_MATH_1	841	845	PF00917	0.733
DOC_USP7_MATH_1	860	864	PF00917	0.615
DOC_USP7_MATH_2	424	430	PF00917	0.678
DOC_WW_Pin1_4	125	130	PF00397	0.615
DOC_WW_Pin1_4	193	198	PF00397	0.597
DOC_WW_Pin1_4	240	245	PF00397	0.505
DOC_WW_Pin1_4	314	319	PF00397	0.588
DOC_WW_Pin1_4	322	327	PF00397	0.660
DOC_WW_Pin1_4	331	336	PF00397	0.598
DOC_WW_Pin1_4	340	345	PF00397	0.622
DOC_WW_Pin1_4	44	49	PF00397	0.610
DOC_WW_Pin1_4	498	503	PF00397	0.661
DOC_WW_Pin1_4	538	543	PF00397	0.727
DOC_WW_Pin1_4	596	601	PF00397	0.602
DOC_WW_Pin1_4	614	619	PF00397	0.644
DOC_WW_Pin1_4	65	70	PF00397	0.531
DOC_WW_Pin1_4	658	663	PF00397	0.683
DOC_WW_Pin1_4	822	827	PF00397	0.701
DOC_WW_Pin1_4	834	839	PF00397	0.571
DOC_WW_Pin1_4	854	859	PF00397	0.533
LIG_14-3-3_CanoR_1	19	25	PF00244	0.612
LIG_14-3-3_CanoR_1	231	237	PF00244	0.518
LIG_14-3-3_CanoR_1	261	270	PF00244	0.512
LIG_14-3-3_CanoR_1	41	50	PF00244	0.663
LIG_14-3-3_CanoR_1	528	534	PF00244	0.642
LIG_14-3-3_CanoR_1	627	633	PF00244	0.544
LIG_14-3-3_CanoR_1	689	694	PF00244	0.649
LIG_14-3-3_CanoR_1	703	709	PF00244	0.690
LIG_14-3-3_CanoR_1	725	732	PF00244	0.531
LIG_14-3-3_CanoR_1	818	827	PF00244	0.698
LIG_14-3-3_CanoR_1	900	909	PF00244	0.560
LIG_Actin_WH2_2	802	820	PF00022	0.587
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_BRCT_BRCA1_1	100	104	PF00533	0.528
LIG_BRCT_BRCA1_1	67	71	PF00533	0.523
LIG_Clathr_ClatBox_1	395	399	PF01394	0.582
LIG_FHA_1	132	138	PF00498	0.594
LIG_FHA_1	167	173	PF00498	0.581
LIG_FHA_1	175	181	PF00498	0.545
LIG_FHA_1	19	25	PF00498	0.672
LIG_FHA_1	263	269	PF00498	0.633
LIG_FHA_1	368	374	PF00498	0.749
LIG_FHA_1	432	438	PF00498	0.627
LIG_FHA_1	567	573	PF00498	0.553
LIG_FHA_1	577	583	PF00498	0.586
LIG_FHA_1	642	648	PF00498	0.498
LIG_FHA_1	662	668	PF00498	0.637
LIG_FHA_1	70	76	PF00498	0.556
LIG_FHA_1	812	818	PF00498	0.552
LIG_FHA_1	892	898	PF00498	0.585
LIG_FHA_2	149	155	PF00498	0.556
LIG_FHA_2	54	60	PF00498	0.560
LIG_FHA_2	542	548	PF00498	0.628
LIG_FHA_2	653	659	PF00498	0.723
LIG_GBD_Chelix_1	564	572	PF00786	0.538
LIG_LIR_Apic_2	313	318	PF02991	0.650
LIG_LIR_Apic_2	631	635	PF02991	0.608
LIG_LIR_Gen_1	216	226	PF02991	0.516
LIG_LIR_Gen_1	59	69	PF02991	0.448
LIG_LIR_Gen_1	714	724	PF02991	0.654
LIG_LIR_Gen_1	805	815	PF02991	0.562
LIG_LIR_Nem_3	216	222	PF02991	0.629
LIG_LIR_Nem_3	310	315	PF02991	0.621
LIG_LIR_Nem_3	445	450	PF02991	0.782
LIG_LIR_Nem_3	59	65	PF02991	0.462
LIG_LIR_Nem_3	714	720	PF02991	0.652
LIG_LIR_Nem_3	805	810	PF02991	0.537
LIG_LIR_Nem_3	905	911	PF02991	0.595
LIG_NRBOX	491	497	PF00104	0.541
LIG_PCNA_PIPBox_1	91	100	PF02747	0.566
LIG_PTAP_UEV_1	353	358	PF05743	0.531
LIG_SH2_CRK	315	319	PF00017	0.663
LIG_SH2_CRK	447	451	PF00017	0.797
LIG_SH2_CRK	717	721	PF00017	0.652
LIG_SH2_SRC	391	394	PF00017	0.619
LIG_SH2_STAP1	391	395	PF00017	0.621
LIG_SH2_STAP1	693	697	PF00017	0.674
LIG_SH2_STAT5	482	485	PF00017	0.596
LIG_SH2_STAT5	97	100	PF00017	0.559
LIG_SH3_1	320	326	PF00018	0.624
LIG_SH3_3	154	160	PF00018	0.589
LIG_SH3_3	191	197	PF00018	0.768
LIG_SH3_3	231	237	PF00018	0.555
LIG_SH3_3	320	326	PF00018	0.624
LIG_SH3_3	351	357	PF00018	0.537
LIG_SH3_3	448	454	PF00018	0.690
LIG_SH3_3	586	592	PF00018	0.649
LIG_SH3_3	8	14	PF00018	0.615
LIG_SH3_3	908	914	PF00018	0.542
LIG_SUMO_SIM_anti_2	894	900	PF11976	0.547
LIG_SUMO_SIM_par_1	128	134	PF11976	0.616
LIG_SUMO_SIM_par_1	795	801	PF11976	0.498
LIG_TRAF2_1	108	111	PF00917	0.512
LIG_TRAF2_1	424	427	PF00917	0.679
LIG_TRAF2_1	544	547	PF00917	0.610
LIG_WRC_WIRS_1	225	230	PF05994	0.521
MOD_CDC14_SPxK_1	317	320	PF00782	0.575
MOD_CDK_SPK_2	314	319	PF00069	0.552
MOD_CDK_SPxK_1	314	320	PF00069	0.558
MOD_CDK_SPxK_1	614	620	PF00069	0.673
MOD_CDK_SPxxK_3	854	861	PF00069	0.534
MOD_CK1_1	173	179	PF00069	0.559
MOD_CK1_1	18	24	PF00069	0.655
MOD_CK1_1	187	193	PF00069	0.638
MOD_CK1_1	263	269	PF00069	0.463
MOD_CK1_1	296	302	PF00069	0.672
MOD_CK1_1	325	331	PF00069	0.728
MOD_CK1_1	334	340	PF00069	0.638
MOD_CK1_1	343	349	PF00069	0.630
MOD_CK1_1	429	435	PF00069	0.530
MOD_CK1_1	44	50	PF00069	0.653
MOD_CK1_1	469	475	PF00069	0.707
MOD_CK1_1	478	484	PF00069	0.577
MOD_CK1_1	530	536	PF00069	0.704
MOD_CK1_1	537	543	PF00069	0.715
MOD_CK1_1	567	573	PF00069	0.586
MOD_CK1_1	603	609	PF00069	0.672
MOD_CK1_1	692	698	PF00069	0.650
MOD_CK1_1	704	710	PF00069	0.611
MOD_CK1_1	821	827	PF00069	0.701
MOD_CK1_1	849	855	PF00069	0.733
MOD_CK1_1	863	869	PF00069	0.624
MOD_CK2_1	159	165	PF00069	0.489
MOD_CK2_1	224	230	PF00069	0.534
MOD_CK2_1	53	59	PF00069	0.566
MOD_CK2_1	541	547	PF00069	0.668
MOD_CK2_1	841	847	PF00069	0.601
MOD_Cter_Amidation	39	42	PF01082	0.554
MOD_DYRK1A_RPxSP_1	322	326	PF00069	0.580
MOD_GlcNHglycan	1	4	PF01048	0.593
MOD_GlcNHglycan	172	175	PF01048	0.415
MOD_GlcNHglycan	189	192	PF01048	0.498
MOD_GlcNHglycan	271	275	PF01048	0.624
MOD_GlcNHglycan	328	331	PF01048	0.706
MOD_GlcNHglycan	354	357	PF01048	0.614
MOD_GlcNHglycan	464	467	PF01048	0.734
MOD_GlcNHglycan	477	480	PF01048	0.669
MOD_GlcNHglycan	504	507	PF01048	0.675
MOD_GlcNHglycan	51	54	PF01048	0.679
MOD_GlcNHglycan	536	539	PF01048	0.757
MOD_GlcNHglycan	569	572	PF01048	0.581
MOD_GlcNHglycan	614	617	PF01048	0.594
MOD_GlcNHglycan	713	716	PF01048	0.654
MOD_GlcNHglycan	727	730	PF01048	0.599
MOD_GlcNHglycan	736	740	PF01048	0.697
MOD_GlcNHglycan	792	795	PF01048	0.482
MOD_GlcNHglycan	862	865	PF01048	0.603
MOD_GSK3_1	131	138	PF00069	0.493
MOD_GSK3_1	166	173	PF00069	0.555
MOD_GSK3_1	183	190	PF00069	0.600
MOD_GSK3_1	293	300	PF00069	0.664
MOD_GSK3_1	310	317	PF00069	0.568
MOD_GSK3_1	321	328	PF00069	0.681
MOD_GSK3_1	331	338	PF00069	0.688
MOD_GSK3_1	339	346	PF00069	0.554
MOD_GSK3_1	44	51	PF00069	0.737
MOD_GSK3_1	455	462	PF00069	0.625
MOD_GSK3_1	464	471	PF00069	0.665
MOD_GSK3_1	498	505	PF00069	0.675
MOD_GSK3_1	53	60	PF00069	0.612
MOD_GSK3_1	530	537	PF00069	0.790
MOD_GSK3_1	567	574	PF00069	0.666
MOD_GSK3_1	592	599	PF00069	0.766
MOD_GSK3_1	65	72	PF00069	0.565
MOD_GSK3_1	684	691	PF00069	0.675
MOD_GSK3_1	692	699	PF00069	0.634
MOD_GSK3_1	707	714	PF00069	0.651
MOD_GSK3_1	731	738	PF00069	0.680
MOD_GSK3_1	818	825	PF00069	0.698
MOD_NEK2_1	131	136	PF00069	0.538
MOD_NEK2_1	148	153	PF00069	0.430
MOD_NEK2_1	184	189	PF00069	0.705
MOD_NEK2_1	497	502	PF00069	0.550
MOD_NEK2_1	534	539	PF00069	0.680
MOD_NEK2_1	628	633	PF00069	0.560
MOD_NEK2_1	701	706	PF00069	0.683
MOD_NEK2_1	711	716	PF00069	0.588
MOD_NEK2_1	846	851	PF00069	0.702
MOD_NEK2_1	98	103	PF00069	0.523
MOD_NEK2_2	254	259	PF00069	0.596
MOD_NEK2_2	374	379	PF00069	0.625
MOD_PIKK_1	263	269	PF00454	0.563
MOD_PIKK_1	359	365	PF00454	0.595
MOD_PIKK_1	457	463	PF00454	0.593
MOD_PIKK_1	541	547	PF00454	0.668
MOD_PIKK_1	788	794	PF00454	0.636
MOD_PIKK_1	9	15	PF00454	0.574
MOD_PIKK_1	98	104	PF00454	0.559
MOD_PK_1	20	26	PF00069	0.575
MOD_PKA_1	15	21	PF00069	0.565
MOD_PKA_1	41	47	PF00069	0.595
MOD_PKA_2	15	21	PF00069	0.565
MOD_PKA_2	260	266	PF00069	0.691
MOD_PKA_2	321	327	PF00069	0.729
MOD_PKA_2	41	47	PF00069	0.692
MOD_PKA_2	527	533	PF00069	0.670
MOD_PKA_2	688	694	PF00069	0.653
MOD_PKA_2	702	708	PF00069	0.703
MOD_PKA_2	860	866	PF00069	0.689
MOD_PKB_1	259	267	PF00069	0.588
MOD_PKB_1	39	47	PF00069	0.548
MOD_Plk_1	254	260	PF00069	0.569
MOD_Plk_1	58	64	PF00069	0.600
MOD_Plk_1	735	741	PF00069	0.528
MOD_Plk_1	846	852	PF00069	0.536
MOD_Plk_1	891	897	PF00069	0.561
MOD_Plk_4	148	154	PF00069	0.542
MOD_Plk_4	159	165	PF00069	0.503
MOD_Plk_4	224	230	PF00069	0.591
MOD_Plk_4	248	254	PF00069	0.695
MOD_Plk_4	478	484	PF00069	0.636
MOD_Plk_4	487	493	PF00069	0.576
MOD_Plk_4	518	524	PF00069	0.650
MOD_Plk_4	841	847	PF00069	0.650
MOD_ProDKin_1	125	131	PF00069	0.613
MOD_ProDKin_1	193	199	PF00069	0.595
MOD_ProDKin_1	240	246	PF00069	0.506
MOD_ProDKin_1	314	320	PF00069	0.594
MOD_ProDKin_1	322	328	PF00069	0.663
MOD_ProDKin_1	331	337	PF00069	0.598
MOD_ProDKin_1	340	346	PF00069	0.622
MOD_ProDKin_1	44	50	PF00069	0.610
MOD_ProDKin_1	498	504	PF00069	0.666
MOD_ProDKin_1	538	544	PF00069	0.727
MOD_ProDKin_1	596	602	PF00069	0.602
MOD_ProDKin_1	614	620	PF00069	0.645
MOD_ProDKin_1	65	71	PF00069	0.526
MOD_ProDKin_1	658	664	PF00069	0.683
MOD_ProDKin_1	822	828	PF00069	0.701
MOD_ProDKin_1	834	840	PF00069	0.570
MOD_ProDKin_1	854	860	PF00069	0.533
MOD_SUMO_for_1	773	776	PF00179	0.623
MOD_SUMO_rev_2	413	422	PF00179	0.547
MOD_SUMO_rev_2	768	775	PF00179	0.622
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.592
TRG_DiLeu_BaLyEn_6	624	629	PF01217	0.547
TRG_ENDOCYTIC_2	447	450	PF00928	0.799
TRG_ENDOCYTIC_2	717	720	PF00928	0.655
TRG_ER_diArg_1	14	16	PF00400	0.548
TRG_ER_diArg_1	258	261	PF00400	0.690
TRG_ER_diArg_1	318	320	PF00400	0.647
TRG_ER_diArg_1	378	380	PF00400	0.585
TRG_ER_diArg_1	386	389	PF00400	0.531
TRG_ER_diArg_1	39	42	PF00400	0.597
TRG_ER_diArg_1	4	6	PF00400	0.528
TRG_ER_diArg_1	415	417	PF00400	0.565
TRG_ER_diArg_1	447	449	PF00400	0.555
TRG_ER_diArg_1	523	525	PF00400	0.605
TRG_ER_diArg_1	527	529	PF00400	0.578
TRG_ER_diArg_1	724	727	PF00400	0.674
TRG_ER_diArg_1	899	901	PF00400	0.548
TRG_NES_CRM1_1	393	407	PF08389	0.586
TRG_NES_CRM1_1	573	586	PF08389	0.670
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	900	905	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I855	Leishmania donovani	83%	100%
A4H6U9	Leishmania braziliensis	66%	100%
E9AGC0	Leishmania infantum	82%	71%
Q4QGR0	Leishmania major	83%	99%