Putative ornithine decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ornithine decarboxylase, putative

Species:

Leishmania mexicana

UniProt:

E9ANV5_LEIMU

TriTrypDb:

LmxM.12.0280

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANV5

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	8
GO:0006595	polyamine metabolic process	6	8
GO:0006596	polyamine biosynthetic process	7	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009308	amine metabolic process	4	8
GO:0009309	amine biosynthetic process	5	8
GO:0009987	cellular process	1	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0042401	biogenic amine biosynthetic process	6	8
GO:0044237	cellular metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006591	ornithine metabolic process	5	1
GO:0009445	putrescine metabolic process	7	1
GO:0009446	putrescine biosynthetic process	8	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0033387	putrescine biosynthetic process from ornithine	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:1901605	alpha-amino acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004586	ornithine decarboxylase activity	5	6
GO:0016829	lyase activity	2	8
GO:0016830	carbon-carbon lyase activity	3	8
GO:0016831	carboxy-lyase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.391
CLV_C14_Caspase3-7	584	588	PF00656	0.523
CLV_C14_Caspase3-7	88	92	PF00656	0.664
CLV_NRD_NRD_1	187	189	PF00675	0.465
CLV_NRD_NRD_1	242	244	PF00675	0.427
CLV_NRD_NRD_1	625	627	PF00675	0.304
CLV_NRD_NRD_1	630	632	PF00675	0.313
CLV_NRD_NRD_1	686	688	PF00675	0.413
CLV_NRD_NRD_1	69	71	PF00675	0.584
CLV_NRD_NRD_1	95	97	PF00675	0.602
CLV_PCSK_KEX2_1	187	189	PF00082	0.465
CLV_PCSK_KEX2_1	242	244	PF00082	0.427
CLV_PCSK_KEX2_1	44	46	PF00082	0.548
CLV_PCSK_KEX2_1	624	626	PF00082	0.303
CLV_PCSK_KEX2_1	630	632	PF00082	0.314
CLV_PCSK_KEX2_1	652	654	PF00082	0.203
CLV_PCSK_KEX2_1	686	688	PF00082	0.353
CLV_PCSK_KEX2_1	69	71	PF00082	0.588
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.564
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.203
CLV_PCSK_PC7_1	626	632	PF00082	0.291
CLV_PCSK_SKI1_1	251	255	PF00082	0.526
CLV_PCSK_SKI1_1	490	494	PF00082	0.308
CLV_PCSK_SKI1_1	510	514	PF00082	0.171
CLV_PCSK_SKI1_1	538	542	PF00082	0.631
CLV_PCSK_SKI1_1	69	73	PF00082	0.609
DEG_APCC_DBOX_1	283	291	PF00400	0.508
DEG_APCC_DBOX_1	489	497	PF00400	0.508
DOC_CYCLIN_RxL_1	524	535	PF00134	0.454
DOC_CYCLIN_RxL_1	66	73	PF00134	0.565
DOC_MAPK_gen_1	242	249	PF00069	0.391
DOC_MAPK_gen_1	487	496	PF00069	0.451
DOC_MAPK_gen_1	651	660	PF00069	0.389
DOC_MAPK_MEF2A_6	487	496	PF00069	0.389
DOC_PP2B_LxvP_1	118	121	PF13499	0.494
DOC_PP2B_LxvP_1	608	611	PF13499	0.389
DOC_PP2B_LxvP_1	664	667	PF13499	0.450
DOC_PP4_FxxP_1	340	343	PF00568	0.508
DOC_PP4_FxxP_1	400	403	PF00568	0.523
DOC_PP4_MxPP_1	48	51	PF00568	0.692
DOC_USP7_MATH_1	107	111	PF00917	0.585
DOC_USP7_MATH_1	113	117	PF00917	0.566
DOC_USP7_MATH_1	121	125	PF00917	0.710
DOC_USP7_MATH_1	139	143	PF00917	0.695
DOC_USP7_MATH_1	26	30	PF00917	0.758
DOC_USP7_MATH_1	295	299	PF00917	0.523
DOC_USP7_MATH_1	392	396	PF00917	0.470
DOC_USP7_MATH_1	437	441	PF00917	0.462
DOC_USP7_MATH_1	534	538	PF00917	0.502
DOC_USP7_MATH_1	540	544	PF00917	0.618
DOC_USP7_UBL2_3	297	301	PF12436	0.389
DOC_WW_Pin1_4	116	121	PF00397	0.525
DOC_WW_Pin1_4	124	129	PF00397	0.686
DOC_WW_Pin1_4	171	176	PF00397	0.605
DOC_WW_Pin1_4	204	209	PF00397	0.522
DOC_WW_Pin1_4	331	336	PF00397	0.511
DOC_WW_Pin1_4	38	43	PF00397	0.538
DOC_WW_Pin1_4	82	87	PF00397	0.660
LIG_14-3-3_CanoR_1	510	519	PF00244	0.495
LIG_14-3-3_CanoR_1	530	536	PF00244	0.473
LIG_14-3-3_CanoR_1	624	629	PF00244	0.494
LIG_14-3-3_CanoR_1	634	641	PF00244	0.442
LIG_Actin_WH2_2	516	532	PF00022	0.419
LIG_AP2alpha_2	266	268	PF02296	0.417
LIG_BRCT_BRCA1_1	396	400	PF00533	0.465
LIG_Clathr_ClatBox_1	159	163	PF01394	0.472
LIG_FHA_1	112	118	PF00498	0.528
LIG_FHA_1	195	201	PF00498	0.364
LIG_FHA_1	224	230	PF00498	0.461
LIG_FHA_1	469	475	PF00498	0.487
LIG_FHA_1	526	532	PF00498	0.466
LIG_FHA_1	574	580	PF00498	0.508
LIG_FHA_2	181	187	PF00498	0.482
LIG_FHA_2	25	31	PF00498	0.611
LIG_FHA_2	384	390	PF00498	0.389
LIG_FHA_2	458	464	PF00498	0.508
LIG_FHA_2	478	484	PF00498	0.371
LIG_LIR_Apic_2	337	343	PF02991	0.465
LIG_LIR_Apic_2	397	403	PF02991	0.523
LIG_LIR_Gen_1	197	206	PF02991	0.385
LIG_LIR_Gen_1	359	367	PF02991	0.470
LIG_LIR_Gen_1	444	453	PF02991	0.523
LIG_LIR_Gen_1	480	489	PF02991	0.468
LIG_LIR_Gen_1	559	570	PF02991	0.465
LIG_LIR_Gen_1	662	669	PF02991	0.465
LIG_LIR_Gen_1	685	696	PF02991	0.301
LIG_LIR_Nem_3	174	179	PF02991	0.505
LIG_LIR_Nem_3	193	198	PF02991	0.409
LIG_LIR_Nem_3	21	25	PF02991	0.519
LIG_LIR_Nem_3	238	244	PF02991	0.433
LIG_LIR_Nem_3	265	271	PF02991	0.375
LIG_LIR_Nem_3	359	363	PF02991	0.470
LIG_LIR_Nem_3	444	449	PF02991	0.508
LIG_LIR_Nem_3	480	485	PF02991	0.468
LIG_LIR_Nem_3	551	556	PF02991	0.507
LIG_LIR_Nem_3	559	565	PF02991	0.472
LIG_LIR_Nem_3	662	666	PF02991	0.465
LIG_LIR_Nem_3	685	691	PF02991	0.302
LIG_Pex14_2	396	400	PF04695	0.465
LIG_Pex14_2	618	622	PF04695	0.491
LIG_SH2_CRK	198	202	PF00017	0.451
LIG_SH2_GRB2like	556	559	PF00017	0.465
LIG_SH2_NCK_1	14	18	PF00017	0.540
LIG_SH2_NCK_1	198	202	PF00017	0.501
LIG_SH2_NCK_1	672	676	PF00017	0.369
LIG_SH2_PTP2	360	363	PF00017	0.508
LIG_SH2_STAP1	672	676	PF00017	0.369
LIG_SH2_STAT5	248	251	PF00017	0.474
LIG_SH2_STAT5	293	296	PF00017	0.544
LIG_SH2_STAT5	360	363	PF00017	0.491
LIG_SH2_STAT5	438	441	PF00017	0.465
LIG_SH2_STAT5	511	514	PF00017	0.494
LIG_SH2_STAT5	556	559	PF00017	0.490
LIG_SH2_STAT5	672	675	PF00017	0.360
LIG_SH2_STAT5	704	707	PF00017	0.655
LIG_SH3_1	626	632	PF00018	0.389
LIG_SH3_2	629	634	PF14604	0.389
LIG_SH3_3	114	120	PF00018	0.534
LIG_SH3_3	20	26	PF00018	0.618
LIG_SH3_3	202	208	PF00018	0.510
LIG_SH3_3	261	267	PF00018	0.437
LIG_SH3_3	329	335	PF00018	0.523
LIG_SH3_3	360	366	PF00018	0.559
LIG_SH3_3	626	632	PF00018	0.398
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.508
LIG_SUMO_SIM_anti_2	576	582	PF11976	0.508
LIG_SUMO_SIM_par_1	490	495	PF11976	0.389
LIG_SUMO_SIM_par_1	576	582	PF11976	0.508
LIG_TRAF2_1	183	186	PF00917	0.486
LIG_TRAF2_1	319	322	PF00917	0.565
LIG_TRAF2_1	59	62	PF00917	0.656
LIG_TYR_ITIM	358	363	PF00017	0.508
LIG_WRC_WIRS_1	562	567	PF05994	0.465
MOD_CDC14_SPxK_1	41	44	PF00782	0.486
MOD_CDK_SPK_2	82	87	PF00069	0.505
MOD_CDK_SPxK_1	38	44	PF00069	0.487
MOD_CDK_SPxxK_3	38	45	PF00069	0.488
MOD_CK1_1	116	122	PF00069	0.514
MOD_CK1_1	124	130	PF00069	0.518
MOD_CK1_1	29	35	PF00069	0.636
MOD_CK1_1	395	401	PF00069	0.442
MOD_CK1_1	477	483	PF00069	0.533
MOD_CK1_1	543	549	PF00069	0.487
MOD_CK1_1	671	677	PF00069	0.371
MOD_CK1_1	85	91	PF00069	0.524
MOD_CK2_1	116	122	PF00069	0.585
MOD_CK2_1	180	186	PF00069	0.495
MOD_CK2_1	229	235	PF00069	0.613
MOD_CK2_1	316	322	PF00069	0.465
MOD_CK2_1	477	483	PF00069	0.475
MOD_CK2_1	529	535	PF00069	0.431
MOD_CK2_1	543	549	PF00069	0.450
MOD_Cter_Amidation	94	97	PF01082	0.569
MOD_GlcNHglycan	122	126	PF01048	0.641
MOD_GlcNHglycan	134	137	PF01048	0.606
MOD_GlcNHglycan	231	234	PF01048	0.593
MOD_GlcNHglycan	308	311	PF01048	0.345
MOD_GlcNHglycan	377	380	PF01048	0.287
MOD_GlcNHglycan	429	432	PF01048	0.267
MOD_GlcNHglycan	433	438	PF01048	0.280
MOD_GlcNHglycan	439	442	PF01048	0.310
MOD_GlcNHglycan	475	479	PF01048	0.329
MOD_GlcNHglycan	52	55	PF01048	0.743
MOD_GlcNHglycan	619	622	PF01048	0.254
MOD_GlcNHglycan	87	90	PF01048	0.730
MOD_GlcNHglycan	91	94	PF01048	0.710
MOD_GSK3_1	107	114	PF00069	0.549
MOD_GSK3_1	229	236	PF00069	0.532
MOD_GSK3_1	29	36	PF00069	0.674
MOD_GSK3_1	383	390	PF00069	0.389
MOD_GSK3_1	433	440	PF00069	0.501
MOD_GSK3_1	474	481	PF00069	0.521
MOD_GSK3_1	525	532	PF00069	0.433
MOD_GSK3_1	85	92	PF00069	0.675
MOD_N-GLC_1	229	234	PF02516	0.590
MOD_N-GLC_1	387	392	PF02516	0.308
MOD_N-GLC_1	417	422	PF02516	0.242
MOD_N-GLC_1	457	462	PF02516	0.246
MOD_N-GLC_1	478	483	PF02516	0.287
MOD_NEK2_1	162	167	PF00069	0.513
MOD_NEK2_1	457	462	PF00069	0.508
MOD_NEK2_1	561	566	PF00069	0.465
MOD_NEK2_1	617	622	PF00069	0.481
MOD_NEK2_1	633	638	PF00069	0.546
MOD_NEK2_2	417	422	PF00069	0.517
MOD_NEK2_2	525	530	PF00069	0.430
MOD_NEK2_2	708	713	PF00069	0.614
MOD_PIKK_1	150	156	PF00454	0.509
MOD_PIKK_1	162	168	PF00454	0.533
MOD_PK_1	634	640	PF00069	0.389
MOD_PKA_1	242	248	PF00069	0.425
MOD_PKA_1	624	630	PF00069	0.487
MOD_PKA_2	216	222	PF00069	0.598
MOD_PKA_2	242	248	PF00069	0.432
MOD_PKA_2	383	389	PF00069	0.389
MOD_PKA_2	529	535	PF00069	0.508
MOD_PKA_2	590	596	PF00069	0.389
MOD_PKA_2	624	630	PF00069	0.537
MOD_PKA_2	633	639	PF00069	0.482
MOD_Plk_1	229	235	PF00069	0.540
MOD_Plk_1	417	423	PF00069	0.474
MOD_Plk_1	433	439	PF00069	0.491
MOD_Plk_1	457	463	PF00069	0.446
MOD_Plk_1	478	484	PF00069	0.508
MOD_Plk_1	500	506	PF00069	0.508
MOD_Plk_4	107	113	PF00069	0.591
MOD_Plk_4	356	362	PF00069	0.508
MOD_Plk_4	457	463	PF00069	0.508
MOD_Plk_4	500	506	PF00069	0.496
MOD_Plk_4	540	546	PF00069	0.398
MOD_Plk_4	573	579	PF00069	0.481
MOD_Plk_4	634	640	PF00069	0.465
MOD_ProDKin_1	116	122	PF00069	0.528
MOD_ProDKin_1	124	130	PF00069	0.688
MOD_ProDKin_1	171	177	PF00069	0.606
MOD_ProDKin_1	204	210	PF00069	0.527
MOD_ProDKin_1	331	337	PF00069	0.511
MOD_ProDKin_1	38	44	PF00069	0.540
MOD_ProDKin_1	82	88	PF00069	0.661
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.607
TRG_ENDOCYTIC_2	19	22	PF00928	0.586
TRG_ENDOCYTIC_2	198	201	PF00928	0.450
TRG_ENDOCYTIC_2	293	296	PF00928	0.523
TRG_ENDOCYTIC_2	360	363	PF00928	0.465
TRG_ENDOCYTIC_2	446	449	PF00928	0.508
TRG_ENDOCYTIC_2	562	565	PF00928	0.481
TRG_ER_diArg_1	241	243	PF00400	0.427
TRG_ER_diArg_1	45	48	PF00400	0.641
TRG_ER_diArg_1	624	626	PF00400	0.505
TRG_ER_diArg_1	629	631	PF00400	0.512
TRG_ER_diArg_1	686	688	PF00400	0.411
TRG_ER_diArg_1	69	71	PF00400	0.710
TRG_ER_diArg_1	699	702	PF00400	0.533
TRG_NLS_MonoExtN_4	42	48	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I681	Leptomonas seymouri	63%	99%
A0A0S4JJ84	Bodo saltans	43%	100%
A0A3S5H6K6	Leishmania donovani	83%	100%
A4H6U3	Leishmania braziliensis	69%	96%
E9AGB5	Leishmania infantum	83%	100%
P27116	Leishmania donovani	83%	100%
Q4QGR5	Leishmania major	82%	96%