SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANV4_LEIMU

TriTrypDb:

LmxM.12.0270

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.568
CLV_C14_Caspase3-7	24	28	PF00656	0.606
CLV_NRD_NRD_1	113	115	PF00675	0.512
CLV_NRD_NRD_1	18	20	PF00675	0.571
CLV_NRD_NRD_1	221	223	PF00675	0.551
CLV_NRD_NRD_1	304	306	PF00675	0.546
CLV_NRD_NRD_1	520	522	PF00675	0.384
CLV_PCSK_FUR_1	19	23	PF00082	0.562
CLV_PCSK_KEX2_1	112	114	PF00082	0.574
CLV_PCSK_KEX2_1	18	20	PF00082	0.572
CLV_PCSK_KEX2_1	21	23	PF00082	0.562
CLV_PCSK_KEX2_1	221	223	PF00082	0.552
CLV_PCSK_KEX2_1	304	306	PF00082	0.546
CLV_PCSK_KEX2_1	520	522	PF00082	0.385
CLV_PCSK_KEX2_1	524	526	PF00082	0.400
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.560
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.419
CLV_PCSK_PC7_1	520	526	PF00082	0.412
CLV_PCSK_SKI1_1	202	206	PF00082	0.340
CLV_PCSK_SKI1_1	222	226	PF00082	0.208
CLV_PCSK_SKI1_1	520	524	PF00082	0.394
CLV_PCSK_SKI1_1	525	529	PF00082	0.380
CLV_PCSK_SKI1_1	532	536	PF00082	0.353
CLV_PCSK_SKI1_1	72	76	PF00082	0.527
DEG_SPOP_SBC_1	56	60	PF00917	0.622
DOC_CKS1_1	81	86	PF01111	0.395
DOC_CYCLIN_RxL_1	199	206	PF00134	0.376
DOC_CYCLIN_RxL_1	447	459	PF00134	0.395
DOC_CYCLIN_RxL_1	520	530	PF00134	0.405
DOC_MAPK_gen_1	422	431	PF00069	0.324
DOC_MAPK_HePTP_8	109	121	PF00069	0.429
DOC_MAPK_MEF2A_6	112	121	PF00069	0.449
DOC_MAPK_MEF2A_6	422	431	PF00069	0.324
DOC_MAPK_MEF2A_6	72	80	PF00069	0.455
DOC_PP2B_LxvP_1	160	163	PF13499	0.533
DOC_PP2B_PxIxI_1	424	430	PF00149	0.264
DOC_USP7_MATH_1	12	16	PF00917	0.660
DOC_USP7_MATH_1	125	129	PF00917	0.701
DOC_USP7_MATH_1	141	145	PF00917	0.607
DOC_USP7_MATH_1	148	152	PF00917	0.687
DOC_USP7_MATH_1	17	21	PF00917	0.692
DOC_USP7_MATH_1	172	176	PF00917	0.607
DOC_USP7_MATH_1	198	202	PF00917	0.438
DOC_USP7_MATH_1	317	321	PF00917	0.602
DOC_USP7_MATH_1	394	398	PF00917	0.536
DOC_USP7_MATH_1	400	404	PF00917	0.533
DOC_USP7_MATH_1	467	471	PF00917	0.488
DOC_USP7_MATH_1	481	485	PF00917	0.474
DOC_WW_Pin1_4	164	169	PF00397	0.765
DOC_WW_Pin1_4	194	199	PF00397	0.400
DOC_WW_Pin1_4	32	37	PF00397	0.440
DOC_WW_Pin1_4	80	85	PF00397	0.392
LIG_14-3-3_CanoR_1	142	146	PF00244	0.467
LIG_14-3-3_CanoR_1	171	177	PF00244	0.661
LIG_14-3-3_CanoR_1	202	211	PF00244	0.358
LIG_14-3-3_CanoR_1	22	26	PF00244	0.623
LIG_14-3-3_CanoR_1	221	225	PF00244	0.520
LIG_14-3-3_CanoR_1	490	495	PF00244	0.516
LIG_14-3-3_CanoR_1	525	535	PF00244	0.447
LIG_14-3-3_CanoR_1	61	66	PF00244	0.561
LIG_14-3-3_CanoR_1	72	77	PF00244	0.383
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	174	178	PF00533	0.598
LIG_BRCT_BRCA1_1	279	283	PF00533	0.341
LIG_BRCT_BRCA1_1	339	343	PF00533	0.427
LIG_EH1_1	446	454	PF00400	0.454
LIG_FHA_1	212	218	PF00498	0.382
LIG_FHA_1	249	255	PF00498	0.391
LIG_FHA_1	332	338	PF00498	0.488
LIG_FHA_1	370	376	PF00498	0.374
LIG_FHA_1	443	449	PF00498	0.386
LIG_FHA_1	58	64	PF00498	0.533
LIG_FHA_1	73	79	PF00498	0.497
LIG_FHA_1	81	87	PF00498	0.355
LIG_FHA_1	88	94	PF00498	0.402
LIG_FHA_2	121	127	PF00498	0.509
LIG_FHA_2	280	286	PF00498	0.423
LIG_LIR_Apic_2	244	250	PF02991	0.435
LIG_LIR_Gen_1	228	235	PF02991	0.288
LIG_LIR_Nem_3	228	233	PF02991	0.432
LIG_LIR_Nem_3	358	363	PF02991	0.402
LIG_LIR_Nem_3	491	497	PF02991	0.415
LIG_LIR_Nem_3	529	534	PF02991	0.518
LIG_LIR_Nem_3	97	102	PF02991	0.348
LIG_MYND_1	164	168	PF01753	0.540
LIG_NRBOX	73	79	PF00104	0.528
LIG_REV1ctd_RIR_1	367	377	PF16727	0.336
LIG_SH2_CRK	247	251	PF00017	0.526
LIG_SH2_CRK	478	482	PF00017	0.473
LIG_SH2_CRK	531	535	PF00017	0.470
LIG_SH2_NCK_1	247	251	PF00017	0.410
LIG_SH2_NCK_1	25	29	PF00017	0.644
LIG_SH2_SRC	25	28	PF00017	0.641
LIG_SH2_SRC	476	479	PF00017	0.448
LIG_SH2_STAP1	385	389	PF00017	0.355
LIG_SH2_STAP1	99	103	PF00017	0.486
LIG_SH2_STAT5	102	105	PF00017	0.389
LIG_SH2_STAT5	193	196	PF00017	0.404
LIG_SH2_STAT5	247	250	PF00017	0.418
LIG_SH2_STAT5	362	365	PF00017	0.330
LIG_SH2_STAT5	419	422	PF00017	0.433
LIG_SH2_STAT5	476	479	PF00017	0.478
LIG_SH2_STAT5	533	536	PF00017	0.478
LIG_SH2_STAT5	85	88	PF00017	0.505
LIG_SH3_3	417	423	PF00018	0.435
LIG_SUMO_SIM_anti_2	458	465	PF11976	0.430
LIG_SUMO_SIM_par_1	253	259	PF11976	0.394
LIG_SUMO_SIM_par_1	458	465	PF11976	0.338
LIG_TRAF2_1	377	380	PF00917	0.419
LIG_WW_3	162	166	PF00397	0.541
MOD_CDK_SPxxK_3	164	171	PF00069	0.740
MOD_CK1_1	11	17	PF00069	0.688
MOD_CK1_1	2	8	PF00069	0.740
MOD_CK1_1	220	226	PF00069	0.446
MOD_CK1_1	277	283	PF00069	0.394
MOD_CK1_1	303	309	PF00069	0.697
MOD_CK1_1	331	337	PF00069	0.662
MOD_CK1_1	338	344	PF00069	0.663
MOD_CK1_1	503	509	PF00069	0.643
MOD_CK1_1	52	58	PF00069	0.661
MOD_CK1_1	64	70	PF00069	0.556
MOD_CK2_1	279	285	PF00069	0.422
MOD_CK2_1	4	10	PF00069	0.545
MOD_GlcNHglycan	14	17	PF01048	0.723
MOD_GlcNHglycan	150	153	PF01048	0.601
MOD_GlcNHglycan	160	163	PF01048	0.569
MOD_GlcNHglycan	276	279	PF01048	0.378
MOD_GlcNHglycan	349	352	PF01048	0.558
MOD_GlcNHglycan	37	40	PF01048	0.512
MOD_GlcNHglycan	396	399	PF01048	0.524
MOD_GlcNHglycan	469	472	PF01048	0.532
MOD_GlcNHglycan	503	506	PF01048	0.732
MOD_GlcNHglycan	7	10	PF01048	0.782
MOD_GlcNHglycan	95	99	PF01048	0.439
MOD_GSK3_1	1	8	PF00069	0.686
MOD_GSK3_1	120	127	PF00069	0.574
MOD_GSK3_1	137	144	PF00069	0.492
MOD_GSK3_1	148	155	PF00069	0.651
MOD_GSK3_1	17	24	PF00069	0.755
MOD_GSK3_1	172	179	PF00069	0.652
MOD_GSK3_1	194	201	PF00069	0.406
MOD_GSK3_1	225	232	PF00069	0.494
MOD_GSK3_1	241	248	PF00069	0.450
MOD_GSK3_1	300	307	PF00069	0.524
MOD_GSK3_1	328	335	PF00069	0.639
MOD_GSK3_1	365	372	PF00069	0.315
MOD_GSK3_1	379	386	PF00069	0.405
MOD_GSK3_1	462	469	PF00069	0.375
MOD_GSK3_1	486	493	PF00069	0.594
MOD_GSK3_1	497	504	PF00069	0.662
MOD_GSK3_1	52	59	PF00069	0.627
MOD_N-GLC_1	267	272	PF02516	0.350
MOD_N-GLC_2	274	276	PF02516	0.319
MOD_NEK2_1	1	6	PF00069	0.788
MOD_NEK2_1	225	230	PF00069	0.341
MOD_NEK2_1	267	272	PF00069	0.466
MOD_NEK2_1	279	284	PF00069	0.460
MOD_NEK2_1	383	388	PF00069	0.391
MOD_NEK2_1	430	435	PF00069	0.353
MOD_NEK2_1	488	493	PF00069	0.559
MOD_NEK2_1	497	502	PF00069	0.603
MOD_NEK2_1	94	99	PF00069	0.371
MOD_NEK2_2	425	430	PF00069	0.440
MOD_NEK2_2	87	92	PF00069	0.550
MOD_PIKK_1	143	149	PF00454	0.562
MOD_PIKK_1	245	251	PF00454	0.474
MOD_PIKK_1	256	262	PF00454	0.324
MOD_PIKK_1	488	494	PF00454	0.658
MOD_PKA_1	21	27	PF00069	0.689
MOD_PKA_1	304	310	PF00069	0.423
MOD_PKA_1	520	526	PF00069	0.504
MOD_PKA_2	141	147	PF00069	0.751
MOD_PKA_2	17	23	PF00069	0.546
MOD_PKA_2	170	176	PF00069	0.695
MOD_PKA_2	211	217	PF00069	0.401
MOD_PKA_2	220	226	PF00069	0.383
MOD_PKA_2	303	309	PF00069	0.619
MOD_PKA_2	355	361	PF00069	0.492
MOD_PKA_2	442	448	PF00069	0.356
MOD_PKA_2	5	11	PF00069	0.639
MOD_PKA_2	520	526	PF00069	0.394
MOD_Plk_1	331	337	PF00069	0.512
MOD_Plk_1	379	385	PF00069	0.339
MOD_Plk_1	425	431	PF00069	0.465
MOD_Plk_1	94	100	PF00069	0.430
MOD_Plk_2-3	285	291	PF00069	0.246
MOD_Plk_2-3	379	385	PF00069	0.455
MOD_Plk_4	103	109	PF00069	0.410
MOD_Plk_4	172	178	PF00069	0.688
MOD_Plk_4	229	235	PF00069	0.523
MOD_Plk_4	279	285	PF00069	0.422
MOD_Plk_4	332	338	PF00069	0.476
MOD_Plk_4	339	345	PF00069	0.457
MOD_Plk_4	365	371	PF00069	0.303
MOD_Plk_4	72	78	PF00069	0.496
MOD_ProDKin_1	164	170	PF00069	0.762
MOD_ProDKin_1	194	200	PF00069	0.405
MOD_ProDKin_1	32	38	PF00069	0.442
MOD_ProDKin_1	80	86	PF00069	0.392
MOD_SUMO_for_1	423	426	PF00179	0.404
TRG_DiLeu_BaEn_2	425	431	PF01217	0.446
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.416
TRG_ENDOCYTIC_2	531	534	PF00928	0.379
TRG_ER_diArg_1	112	114	PF00400	0.468
TRG_ER_diArg_1	17	19	PF00400	0.473
TRG_ER_diArg_1	519	521	PF00400	0.461
TRG_ER_diArg_1	65	68	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U7	Leptomonas seymouri	48%	95%
A0A1X0NNV4	Trypanosomatidae	39%	100%
A0A3Q8I958	Leishmania donovani	82%	96%
A4H6U2	Leishmania braziliensis	70%	100%
A4HV71	Leishmania infantum	82%	80%
C9ZQA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	98%
Q4QGR6	Leishmania major	81%	100%
V5BD95	Trypanosoma cruzi	34%	100%