LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9ANV1_LEIMU
TriTrypDb:
LmxM.12.0240
Length:
700

Annotations

LeishMANIAdb annotations

This membrane protein has considerable similarity to beta-lactamases found in Streptomyces species. A protein family found in a single copy in parazitic species, while multiple paralogs exist in B.saltans.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 6
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9ANV1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANV1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 670 674 PF00656 0.745
CLV_NRD_NRD_1 643 645 PF00675 0.605
CLV_NRD_NRD_1 650 652 PF00675 0.505
CLV_PCSK_FUR_1 639 643 PF00082 0.497
CLV_PCSK_FUR_1 646 650 PF00082 0.491
CLV_PCSK_KEX2_1 125 127 PF00082 0.673
CLV_PCSK_KEX2_1 639 641 PF00082 0.599
CLV_PCSK_KEX2_1 642 644 PF00082 0.608
CLV_PCSK_KEX2_1 648 650 PF00082 0.632
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.673
CLV_PCSK_PC7_1 639 645 PF00082 0.605
CLV_PCSK_PC7_1 646 652 PF00082 0.513
CLV_PCSK_SKI1_1 109 113 PF00082 0.573
CLV_PCSK_SKI1_1 326 330 PF00082 0.628
CLV_PCSK_SKI1_1 691 695 PF00082 0.570
CLV_PCSK_SKI1_1 75 79 PF00082 0.590
DEG_APCC_DBOX_1 24 32 PF00400 0.654
DEG_COP1_1 212 222 PF00400 0.319
DEG_SPOP_SBC_1 86 90 PF00917 0.354
DOC_CYCLIN_RxL_1 72 81 PF00134 0.336
DOC_MAPK_DCC_7 23 33 PF00069 0.548
DOC_MAPK_MEF2A_6 25 33 PF00069 0.435
DOC_MAPK_MEF2A_6 489 497 PF00069 0.264
DOC_PP4_FxxP_1 112 115 PF00568 0.354
DOC_PP4_FxxP_1 180 183 PF00568 0.290
DOC_USP7_MATH_1 164 168 PF00917 0.394
DOC_USP7_MATH_1 224 228 PF00917 0.410
DOC_USP7_MATH_1 311 315 PF00917 0.500
DOC_USP7_MATH_1 433 437 PF00917 0.456
DOC_USP7_MATH_1 479 483 PF00917 0.319
DOC_USP7_MATH_1 496 500 PF00917 0.298
DOC_USP7_MATH_1 509 513 PF00917 0.434
DOC_USP7_MATH_1 632 636 PF00917 0.744
DOC_WW_Pin1_4 428 433 PF00397 0.301
DOC_WW_Pin1_4 54 59 PF00397 0.523
DOC_WW_Pin1_4 593 598 PF00397 0.766
DOC_WW_Pin1_4 619 624 PF00397 0.761
LIG_14-3-3_CanoR_1 126 134 PF00244 0.395
LIG_14-3-3_CanoR_1 292 298 PF00244 0.341
LIG_14-3-3_CanoR_1 332 340 PF00244 0.289
LIG_14-3-3_CanoR_1 462 468 PF00244 0.308
LIG_14-3-3_CanoR_1 633 639 PF00244 0.801
LIG_14-3-3_CanoR_1 680 688 PF00244 0.774
LIG_Actin_WH2_2 276 294 PF00022 0.217
LIG_BRCT_BRCA1_1 226 230 PF00533 0.345
LIG_BRCT_BRCA1_1 293 297 PF00533 0.346
LIG_Clathr_ClatBox_1 148 152 PF01394 0.344
LIG_eIF4E_1 544 550 PF01652 0.515
LIG_FHA_1 152 158 PF00498 0.371
LIG_FHA_1 160 166 PF00498 0.349
LIG_FHA_1 185 191 PF00498 0.346
LIG_FHA_1 232 238 PF00498 0.415
LIG_FHA_1 294 300 PF00498 0.310
LIG_FHA_1 398 404 PF00498 0.324
LIG_FHA_1 533 539 PF00498 0.338
LIG_FHA_1 544 550 PF00498 0.543
LIG_FHA_1 55 61 PF00498 0.452
LIG_FHA_1 620 626 PF00498 0.761
LIG_FHA_1 87 93 PF00498 0.388
LIG_FHA_2 203 209 PF00498 0.462
LIG_FHA_2 353 359 PF00498 0.294
LIG_FHA_2 432 438 PF00498 0.399
LIG_FHA_2 61 67 PF00498 0.473
LIG_Integrin_isoDGR_2 603 605 PF01839 0.512
LIG_LIR_Apic_2 110 115 PF02991 0.341
LIG_LIR_Apic_2 179 183 PF02991 0.380
LIG_LIR_Gen_1 248 259 PF02991 0.216
LIG_LIR_Gen_1 270 279 PF02991 0.391
LIG_LIR_Gen_1 281 291 PF02991 0.370
LIG_LIR_Gen_1 348 357 PF02991 0.327
LIG_LIR_Gen_1 413 421 PF02991 0.377
LIG_LIR_Gen_1 466 475 PF02991 0.346
LIG_LIR_LC3C_4 535 538 PF02991 0.397
LIG_LIR_Nem_3 184 188 PF02991 0.391
LIG_LIR_Nem_3 248 254 PF02991 0.218
LIG_LIR_Nem_3 270 276 PF02991 0.396
LIG_LIR_Nem_3 281 287 PF02991 0.339
LIG_LIR_Nem_3 345 350 PF02991 0.298
LIG_LIR_Nem_3 413 419 PF02991 0.381
LIG_LIR_Nem_3 466 470 PF02991 0.340
LIG_LIR_Nem_3 71 77 PF02991 0.357
LIG_LYPXL_yS_3 99 102 PF13949 0.410
LIG_NRBOX 191 197 PF00104 0.291
LIG_PALB2_WD40_1 522 530 PF16756 0.285
LIG_Pex14_2 523 527 PF04695 0.285
LIG_PTB_Apo_2 179 186 PF02174 0.304
LIG_RPA_C_Fungi 484 496 PF08784 0.276
LIG_SH2_CRK 273 277 PF00017 0.496
LIG_SH2_CRK 416 420 PF00017 0.498
LIG_SH2_CRK 74 78 PF00017 0.440
LIG_SH2_NCK_1 251 255 PF00017 0.440
LIG_SH2_NCK_1 416 420 PF00017 0.474
LIG_SH2_NCK_1 430 434 PF00017 0.311
LIG_SH2_SRC 150 153 PF00017 0.463
LIG_SH2_SRC 169 172 PF00017 0.478
LIG_SH2_SRC 249 252 PF00017 0.301
LIG_SH2_STAT3 548 551 PF00017 0.544
LIG_SH2_STAT5 150 153 PF00017 0.369
LIG_SH2_STAT5 169 172 PF00017 0.424
LIG_SH2_STAT5 174 177 PF00017 0.453
LIG_SH2_STAT5 261 264 PF00017 0.280
LIG_SH2_STAT5 346 349 PF00017 0.383
LIG_SH2_STAT5 395 398 PF00017 0.462
LIG_SH2_STAT5 427 430 PF00017 0.459
LIG_SH2_STAT5 544 547 PF00017 0.559
LIG_SH2_STAT5 548 551 PF00017 0.513
LIG_SH2_STAT5 624 627 PF00017 0.742
LIG_SH3_2 552 557 PF14604 0.671
LIG_SH3_3 112 118 PF00018 0.594
LIG_SH3_3 180 186 PF00018 0.366
LIG_SH3_3 283 289 PF00018 0.450
LIG_SH3_3 363 369 PF00018 0.449
LIG_SH3_3 453 459 PF00018 0.504
LIG_SH3_3 512 518 PF00018 0.673
LIG_SH3_3 549 555 PF00018 0.590
LIG_SH3_3 94 100 PF00018 0.478
LIG_Sin3_3 534 541 PF02671 0.179
LIG_SUMO_SIM_anti_2 451 457 PF11976 0.446
LIG_SUMO_SIM_anti_2 535 541 PF11976 0.350
LIG_SUMO_SIM_anti_2 81 86 PF11976 0.253
LIG_SUMO_SIM_par_1 386 392 PF11976 0.481
LIG_SxIP_EBH_1 332 342 PF03271 0.319
LIG_TYR_ITIM 97 102 PF00017 0.525
LIG_TYR_ITSM 412 419 PF00017 0.471
LIG_UBA3_1 59 67 PF00899 0.532
MOD_CK1_1 184 190 PF00069 0.425
MOD_CK1_1 200 206 PF00069 0.346
MOD_CK1_1 228 234 PF00069 0.447
MOD_CK1_1 274 280 PF00069 0.396
MOD_CK1_1 313 319 PF00069 0.589
MOD_CK1_1 345 351 PF00069 0.391
MOD_CK1_1 431 437 PF00069 0.510
MOD_CK1_1 463 469 PF00069 0.293
MOD_CK1_1 543 549 PF00069 0.561
MOD_CK1_1 660 666 PF00069 0.760
MOD_CK1_1 682 688 PF00069 0.667
MOD_CK2_1 198 204 PF00069 0.326
MOD_CK2_1 431 437 PF00069 0.432
MOD_CK2_1 466 472 PF00069 0.417
MOD_CK2_1 663 669 PF00069 0.494
MOD_GlcNHglycan 215 218 PF01048 0.561
MOD_GlcNHglycan 222 225 PF01048 0.515
MOD_GlcNHglycan 238 241 PF01048 0.496
MOD_GlcNHglycan 276 279 PF01048 0.434
MOD_GlcNHglycan 313 316 PF01048 0.647
MOD_GlcNHglycan 347 350 PF01048 0.475
MOD_GlcNHglycan 406 409 PF01048 0.514
MOD_GlcNHglycan 421 424 PF01048 0.553
MOD_GlcNHglycan 437 440 PF01048 0.547
MOD_GlcNHglycan 475 478 PF01048 0.482
MOD_GlcNHglycan 481 484 PF01048 0.515
MOD_GlcNHglycan 510 514 PF01048 0.558
MOD_GlcNHglycan 570 573 PF01048 0.736
MOD_GlcNHglycan 613 616 PF01048 0.803
MOD_GlcNHglycan 627 630 PF01048 0.661
MOD_GlcNHglycan 657 660 PF01048 0.653
MOD_GlcNHglycan 665 668 PF01048 0.710
MOD_GlcNHglycan 691 694 PF01048 0.563
MOD_GSK3_1 172 179 PF00069 0.582
MOD_GSK3_1 184 191 PF00069 0.411
MOD_GSK3_1 198 205 PF00069 0.307
MOD_GSK3_1 220 227 PF00069 0.430
MOD_GSK3_1 228 235 PF00069 0.418
MOD_GSK3_1 245 252 PF00069 0.374
MOD_GSK3_1 267 274 PF00069 0.459
MOD_GSK3_1 313 320 PF00069 0.616
MOD_GSK3_1 332 339 PF00069 0.404
MOD_GSK3_1 389 396 PF00069 0.492
MOD_GSK3_1 431 438 PF00069 0.553
MOD_GSK3_1 471 478 PF00069 0.353
MOD_GSK3_1 581 588 PF00069 0.620
MOD_GSK3_1 663 670 PF00069 0.699
MOD_GSK3_1 76 83 PF00069 0.453
MOD_GSK3_1 86 93 PF00069 0.435
MOD_N-GLC_1 271 276 PF02516 0.537
MOD_N-GLC_1 60 65 PF02516 0.515
MOD_NEK2_1 1 6 PF00069 0.488
MOD_NEK2_1 151 156 PF00069 0.459
MOD_NEK2_1 159 164 PF00069 0.403
MOD_NEK2_1 202 207 PF00069 0.394
MOD_NEK2_1 225 230 PF00069 0.365
MOD_NEK2_1 238 243 PF00069 0.407
MOD_NEK2_1 245 250 PF00069 0.362
MOD_NEK2_1 267 272 PF00069 0.479
MOD_NEK2_1 282 287 PF00069 0.268
MOD_NEK2_1 291 296 PF00069 0.351
MOD_NEK2_1 342 347 PF00069 0.379
MOD_NEK2_1 351 356 PF00069 0.342
MOD_NEK2_1 372 377 PF00069 0.445
MOD_NEK2_1 404 409 PF00069 0.501
MOD_NEK2_1 411 416 PF00069 0.454
MOD_NEK2_1 42 47 PF00069 0.612
MOD_NEK2_1 473 478 PF00069 0.470
MOD_NEK2_1 60 65 PF00069 0.338
MOD_NEK2_1 625 630 PF00069 0.731
MOD_NEK2_1 85 90 PF00069 0.406
MOD_NEK2_2 107 112 PF00069 0.440
MOD_NEK2_2 634 639 PF00069 0.675
MOD_PIKK_1 238 244 PF00454 0.516
MOD_PIKK_1 562 568 PF00454 0.522
MOD_PIKK_1 682 688 PF00454 0.703
MOD_PIKK_1 76 82 PF00454 0.422
MOD_PK_1 332 338 PF00069 0.366
MOD_PKA_2 291 297 PF00069 0.344
MOD_PKA_2 331 337 PF00069 0.502
MOD_PKA_2 393 399 PF00069 0.416
MOD_PKA_2 632 638 PF00069 0.674
MOD_PKA_2 679 685 PF00069 0.729
MOD_PKB_1 25 33 PF00069 0.379
MOD_Plk_1 271 277 PF00069 0.527
MOD_Plk_1 471 477 PF00069 0.350
MOD_Plk_1 52 58 PF00069 0.591
MOD_Plk_1 660 666 PF00069 0.498
MOD_Plk_1 667 673 PF00069 0.478
MOD_Plk_1 80 86 PF00069 0.457
MOD_Plk_4 165 171 PF00069 0.491
MOD_Plk_4 176 182 PF00069 0.515
MOD_Plk_4 225 231 PF00069 0.399
MOD_Plk_4 233 239 PF00069 0.297
MOD_Plk_4 27 33 PF00069 0.569
MOD_Plk_4 293 299 PF00069 0.434
MOD_Plk_4 342 348 PF00069 0.396
MOD_Plk_4 411 417 PF00069 0.467
MOD_Plk_4 532 538 PF00069 0.343
MOD_Plk_4 540 546 PF00069 0.372
MOD_Plk_4 87 93 PF00069 0.398
MOD_ProDKin_1 428 434 PF00069 0.357
MOD_ProDKin_1 54 60 PF00069 0.662
MOD_ProDKin_1 593 599 PF00069 0.733
MOD_ProDKin_1 619 625 PF00069 0.729
TRG_DiLeu_BaLyEn_6 55 60 PF01217 0.587
TRG_ENDOCYTIC_2 251 254 PF00928 0.249
TRG_ENDOCYTIC_2 273 276 PF00928 0.489
TRG_ENDOCYTIC_2 350 353 PF00928 0.455
TRG_ENDOCYTIC_2 416 419 PF00928 0.483
TRG_ENDOCYTIC_2 73 76 PF00928 0.438
TRG_ENDOCYTIC_2 99 102 PF00928 0.555
TRG_ER_diArg_1 25 28 PF00400 0.678
TRG_ER_diArg_1 638 641 PF00400 0.757
TRG_ER_diArg_1 642 644 PF00400 0.747
TRG_ER_diArg_1 645 648 PF00400 0.736
TRG_ER_diArg_1 649 651 PF00400 0.760
TRG_NES_CRM1_1 137 152 PF08389 0.420

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZA5 Leptomonas seymouri 44% 100%
A0A0S4JQ75 Bodo saltans 27% 100%
A0A1X0NMU7 Trypanosomatidae 30% 100%
A0A3S7WRU5 Leishmania donovani 86% 100%
A0A422NUF1 Trypanosoma rangeli 30% 100%
A4H6T9 Leishmania braziliensis 63% 99%
E9AGB3 Leishmania infantum 86% 100%
Q4QGR9 Leishmania major 85% 100%
V5BD98 Trypanosoma cruzi 32% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS