Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANU5_LEIMU

TriTrypDb:

LmxM.12.0180

Length:

909

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.510
CLV_C14_Caspase3-7	239	243	PF00656	0.564
CLV_C14_Caspase3-7	603	607	PF00656	0.406
CLV_C14_Caspase3-7	617	621	PF00656	0.363
CLV_MEL_PAP_1	11	17	PF00089	0.553
CLV_NRD_NRD_1	182	184	PF00675	0.661
CLV_NRD_NRD_1	220	222	PF00675	0.432
CLV_NRD_NRD_1	246	248	PF00675	0.572
CLV_NRD_NRD_1	254	256	PF00675	0.315
CLV_NRD_NRD_1	289	291	PF00675	0.606
CLV_NRD_NRD_1	292	294	PF00675	0.537
CLV_NRD_NRD_1	384	386	PF00675	0.805
CLV_NRD_NRD_1	502	504	PF00675	0.539
CLV_NRD_NRD_1	526	528	PF00675	0.455
CLV_NRD_NRD_1	654	656	PF00675	0.495
CLV_NRD_NRD_1	66	68	PF00675	0.462
CLV_NRD_NRD_1	725	727	PF00675	0.639
CLV_NRD_NRD_1	732	734	PF00675	0.634
CLV_NRD_NRD_1	748	750	PF00675	0.612
CLV_PCSK_FUR_1	290	294	PF00082	0.624
CLV_PCSK_FUR_1	652	656	PF00082	0.401
CLV_PCSK_KEX2_1	184	186	PF00082	0.650
CLV_PCSK_KEX2_1	220	222	PF00082	0.432
CLV_PCSK_KEX2_1	246	248	PF00082	0.568
CLV_PCSK_KEX2_1	254	256	PF00082	0.318
CLV_PCSK_KEX2_1	289	291	PF00082	0.606
CLV_PCSK_KEX2_1	292	294	PF00082	0.537
CLV_PCSK_KEX2_1	502	504	PF00082	0.539
CLV_PCSK_KEX2_1	526	528	PF00082	0.455
CLV_PCSK_KEX2_1	654	656	PF00082	0.436
CLV_PCSK_KEX2_1	66	68	PF00082	0.462
CLV_PCSK_KEX2_1	732	734	PF00082	0.705
CLV_PCSK_KEX2_1	748	750	PF00082	0.612
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.706
CLV_PCSK_PC7_1	62	68	PF00082	0.467
CLV_PCSK_SKI1_1	101	105	PF00082	0.404
CLV_PCSK_SKI1_1	229	233	PF00082	0.447
CLV_PCSK_SKI1_1	254	258	PF00082	0.346
CLV_PCSK_SKI1_1	267	271	PF00082	0.517
CLV_PCSK_SKI1_1	62	66	PF00082	0.472
CLV_PCSK_SKI1_1	661	665	PF00082	0.568
CLV_PCSK_SKI1_1	703	707	PF00082	0.460
CLV_PCSK_SKI1_1	903	907	PF00082	0.518
DEG_APCC_DBOX_1	253	261	PF00400	0.413
DEG_APCC_DBOX_1	546	554	PF00400	0.427
DEG_ODPH_VHL_1	316	329	PF01847	0.327
DEG_ODPH_VHL_1	752	764	PF01847	0.591
DEG_SPOP_SBC_1	459	463	PF00917	0.537
DEG_SPOP_SBC_1	50	54	PF00917	0.565
DEG_SPOP_SBC_1	565	569	PF00917	0.558
DOC_CYCLIN_RxL_1	655	668	PF00134	0.519
DOC_CYCLIN_RxL_1	841	850	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	764	767	PF00134	0.436
DOC_MAPK_gen_1	254	260	PF00069	0.385
DOC_MAPK_gen_1	289	300	PF00069	0.490
DOC_MAPK_gen_1	526	532	PF00069	0.433
DOC_MAPK_gen_1	652	662	PF00069	0.461
DOC_MAPK_JIP1_4	324	330	PF00069	0.416
DOC_MAPK_MEF2A_6	293	302	PF00069	0.417
DOC_MAPK_MEF2A_6	352	359	PF00069	0.425
DOC_MAPK_MEF2A_6	547	555	PF00069	0.458
DOC_MAPK_MEF2A_6	655	664	PF00069	0.476
DOC_MAPK_MEF2A_6	862	871	PF00069	0.439
DOC_PP1_RVXF_1	265	271	PF00149	0.577
DOC_PP1_SILK_1	409	414	PF00149	0.486
DOC_PP2B_LxvP_1	135	138	PF13499	0.651
DOC_PP2B_LxvP_1	328	331	PF13499	0.359
DOC_PP2B_LxvP_1	437	440	PF13499	0.508
DOC_PP2B_LxvP_1	721	724	PF13499	0.447
DOC_PP2B_LxvP_1	764	767	PF13499	0.436
DOC_PP2B_LxvP_1	854	857	PF13499	0.538
DOC_PP4_FxxP_1	509	512	PF00568	0.472
DOC_PP4_FxxP_1	834	837	PF00568	0.456
DOC_USP7_MATH_1	245	249	PF00917	0.425
DOC_USP7_MATH_1	280	284	PF00917	0.737
DOC_USP7_MATH_1	378	382	PF00917	0.595
DOC_USP7_MATH_1	442	446	PF00917	0.581
DOC_USP7_MATH_1	454	458	PF00917	0.645
DOC_USP7_MATH_1	50	54	PF00917	0.638
DOC_USP7_MATH_1	546	550	PF00917	0.489
DOC_USP7_MATH_1	581	585	PF00917	0.699
DOC_USP7_MATH_1	722	726	PF00917	0.638
DOC_USP7_MATH_1	739	743	PF00917	0.607
DOC_USP7_MATH_1	767	771	PF00917	0.402
DOC_USP7_MATH_1	821	825	PF00917	0.639
DOC_USP7_MATH_1	95	99	PF00917	0.468
DOC_USP7_MATH_2	488	494	PF00917	0.476
DOC_WW_Pin1_4	169	174	PF00397	0.640
DOC_WW_Pin1_4	419	424	PF00397	0.586
DOC_WW_Pin1_4	460	465	PF00397	0.621
DOC_WW_Pin1_4	579	584	PF00397	0.579
DOC_WW_Pin1_4	587	592	PF00397	0.550
DOC_WW_Pin1_4	807	812	PF00397	0.534
LIG_14-3-3_CanoR_1	14	20	PF00244	0.564
LIG_14-3-3_CanoR_1	167	172	PF00244	0.655
LIG_14-3-3_CanoR_1	246	253	PF00244	0.502
LIG_14-3-3_CanoR_1	261	270	PF00244	0.470
LIG_14-3-3_CanoR_1	456	460	PF00244	0.628
LIG_14-3-3_CanoR_1	502	512	PF00244	0.521
LIG_14-3-3_CanoR_1	547	551	PF00244	0.461
LIG_14-3-3_CanoR_1	67	73	PF00244	0.623
LIG_14-3-3_CanoR_1	748	753	PF00244	0.587
LIG_Actin_WH2_2	436	451	PF00022	0.406
LIG_Actin_WH2_2	638	656	PF00022	0.385
LIG_APCC_ABBA_1	711	716	PF00400	0.526
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	109	113	PF00533	0.416
LIG_BRCT_BRCA1_1	15	19	PF00533	0.570
LIG_BRCT_BRCA1_1	505	509	PF00533	0.491
LIG_EH1_1	699	707	PF00400	0.449
LIG_FHA_1	116	122	PF00498	0.378
LIG_FHA_1	163	169	PF00498	0.495
LIG_FHA_1	390	396	PF00498	0.695
LIG_FHA_1	487	493	PF00498	0.578
LIG_FHA_1	599	605	PF00498	0.459
LIG_FHA_1	634	640	PF00498	0.403
LIG_FHA_1	682	688	PF00498	0.409
LIG_FHA_1	88	94	PF00498	0.488
LIG_FHA_2	144	150	PF00498	0.506
LIG_FHA_2	20	26	PF00498	0.489
LIG_FHA_2	204	210	PF00498	0.560
LIG_FHA_2	308	314	PF00498	0.431
LIG_FHA_2	420	426	PF00498	0.515
LIG_FHA_2	691	697	PF00498	0.497
LIG_FHA_2	815	821	PF00498	0.622
LIG_FHA_2	902	908	PF00498	0.580
LIG_Integrin_RGD_1	32	34	PF01839	0.479
LIG_LIR_Apic_2	506	512	PF02991	0.495
LIG_LIR_Apic_2	832	837	PF02991	0.542
LIG_LIR_Gen_1	110	121	PF02991	0.422
LIG_LIR_Gen_1	296	307	PF02991	0.451
LIG_LIR_Gen_1	636	646	PF02991	0.447
LIG_LIR_Nem_3	110	116	PF02991	0.413
LIG_LIR_Nem_3	296	302	PF02991	0.456
LIG_LIR_Nem_3	636	641	PF02991	0.480
LIG_LIR_Nem_3	77	82	PF02991	0.504
LIG_LIR_Nem_3	832	838	PF02991	0.546
LIG_MLH1_MIPbox_1	505	509	PF16413	0.491
LIG_NRBOX	252	258	PF00104	0.427
LIG_NRBOX	604	610	PF00104	0.434
LIG_NRBOX	636	642	PF00104	0.315
LIG_PCNA_PIPBox_1	1	10	PF02747	0.576
LIG_PCNA_PIPBox_1	24	33	PF02747	0.431
LIG_Pex14_1	354	358	PF04695	0.443
LIG_Pex14_2	113	117	PF04695	0.414
LIG_REV1ctd_RIR_1	506	511	PF16727	0.409
LIG_SH2_CRK	835	839	PF00017	0.646
LIG_SH2_GRB2like	7	10	PF00017	0.552
LIG_SH2_NCK_1	715	719	PF00017	0.542
LIG_SH2_SRC	7	10	PF00017	0.573
LIG_SH2_STAP1	204	208	PF00017	0.551
LIG_SH2_STAP1	312	316	PF00017	0.435
LIG_SH2_STAP1	642	646	PF00017	0.401
LIG_SH2_STAP1	715	719	PF00017	0.542
LIG_SH2_STAT5	299	302	PF00017	0.443
LIG_SH2_STAT5	7	10	PF00017	0.573
LIG_SH2_STAT5	847	850	PF00017	0.453
LIG_SH3_3	577	583	PF00018	0.633
LIG_SH3_3	67	73	PF00018	0.646
LIG_SH3_3	704	710	PF00018	0.604
LIG_SH3_3	834	840	PF00018	0.441
LIG_SUMO_SIM_anti_2	118	125	PF11976	0.502
LIG_SUMO_SIM_anti_2	759	766	PF11976	0.568
LIG_SUMO_SIM_anti_2	876	884	PF11976	0.444
LIG_SUMO_SIM_par_1	192	199	PF11976	0.545
LIG_SUMO_SIM_par_1	326	335	PF11976	0.402
LIG_SUMO_SIM_par_1	623	629	PF11976	0.520
LIG_SUMO_SIM_par_1	880	886	PF11976	0.437
LIG_TRFH_1	508	512	PF08558	0.488
LIG_TYR_ITIM	640	645	PF00017	0.364
LIG_TYR_ITIM	713	718	PF00017	0.534
LIG_UBA3_1	880	885	PF00899	0.433
LIG_WRC_WIRS_1	168	173	PF05994	0.493
LIG_WRC_WIRS_1	27	32	PF05994	0.414
MOD_CDK_SPxxK_3	419	426	PF00069	0.574
MOD_CK1_1	169	175	PF00069	0.630
MOD_CK1_1	199	205	PF00069	0.646
MOD_CK1_1	248	254	PF00069	0.493
MOD_CK1_1	284	290	PF00069	0.640
MOD_CK1_1	366	372	PF00069	0.530
MOD_CK1_1	399	405	PF00069	0.653
MOD_CK1_1	458	464	PF00069	0.656
MOD_CK1_1	542	548	PF00069	0.469
MOD_CK1_1	567	573	PF00069	0.637
MOD_CK1_1	824	830	PF00069	0.596
MOD_CK1_1	901	907	PF00069	0.524
MOD_CK1_1	94	100	PF00069	0.527
MOD_CK2_1	203	209	PF00069	0.579
MOD_CK2_1	307	313	PF00069	0.425
MOD_CK2_1	419	425	PF00069	0.529
MOD_CK2_1	470	476	PF00069	0.761
MOD_CK2_1	690	696	PF00069	0.565
MOD_CK2_1	728	734	PF00069	0.639
MOD_CK2_1	767	773	PF00069	0.514
MOD_Cter_Amidation	287	290	PF01082	0.623
MOD_GlcNHglycan	15	18	PF01048	0.564
MOD_GlcNHglycan	192	195	PF01048	0.454
MOD_GlcNHglycan	277	280	PF01048	0.627
MOD_GlcNHglycan	284	287	PF01048	0.597
MOD_GlcNHglycan	365	368	PF01048	0.670
MOD_GlcNHglycan	398	401	PF01048	0.651
MOD_GlcNHglycan	44	47	PF01048	0.654
MOD_GlcNHglycan	472	475	PF01048	0.540
MOD_GlcNHglycan	492	495	PF01048	0.560
MOD_GlcNHglycan	569	572	PF01048	0.577
MOD_GlcNHglycan	671	674	PF01048	0.503
MOD_GlcNHglycan	823	826	PF01048	0.583
MOD_GlcNHglycan	829	832	PF01048	0.477
MOD_GlcNHglycan	900	903	PF01048	0.602
MOD_GlcNHglycan	93	96	PF01048	0.506
MOD_GlcNHglycan	97	100	PF01048	0.515
MOD_GSK3_1	117	124	PF00069	0.496
MOD_GSK3_1	15	22	PF00069	0.555
MOD_GSK3_1	162	169	PF00069	0.594
MOD_GSK3_1	173	180	PF00069	0.598
MOD_GSK3_1	185	192	PF00069	0.513
MOD_GSK3_1	199	206	PF00069	0.469
MOD_GSK3_1	280	287	PF00069	0.748
MOD_GSK3_1	332	339	PF00069	0.643
MOD_GSK3_1	358	365	PF00069	0.517
MOD_GSK3_1	395	402	PF00069	0.697
MOD_GSK3_1	42	49	PF00069	0.660
MOD_GSK3_1	454	461	PF00069	0.747
MOD_GSK3_1	486	493	PF00069	0.789
MOD_GSK3_1	51	58	PF00069	0.680
MOD_GSK3_1	542	549	PF00069	0.479
MOD_GSK3_1	567	574	PF00069	0.575
MOD_GSK3_1	579	586	PF00069	0.607
MOD_GSK3_1	803	810	PF00069	0.535
MOD_GSK3_1	87	94	PF00069	0.424
MOD_GSK3_1	892	899	PF00069	0.515
MOD_GSK3_1	901	908	PF00069	0.531
MOD_N-GLC_1	173	178	PF02516	0.492
MOD_NEK2_1	107	112	PF00069	0.429
MOD_NEK2_1	117	122	PF00069	0.423
MOD_NEK2_1	162	167	PF00069	0.633
MOD_NEK2_1	564	569	PF00069	0.530
MOD_NEK2_1	74	79	PF00069	0.532
MOD_NEK2_1	756	761	PF00069	0.506
MOD_NEK2_1	892	897	PF00069	0.460
MOD_NEK2_2	307	312	PF00069	0.424
MOD_PIKK_1	162	168	PF00454	0.633
MOD_PIKK_1	824	830	PF00454	0.615
MOD_PKA_1	748	754	PF00069	0.607
MOD_PKA_2	13	19	PF00069	0.564
MOD_PKA_2	166	172	PF00069	0.636
MOD_PKA_2	202	208	PF00069	0.566
MOD_PKA_2	245	251	PF00069	0.408
MOD_PKA_2	455	461	PF00069	0.627
MOD_PKA_2	486	492	PF00069	0.632
MOD_PKA_2	510	516	PF00069	0.418
MOD_PKA_2	546	552	PF00069	0.495
MOD_PKA_2	65	71	PF00069	0.594
MOD_PKA_2	748	754	PF00069	0.569
MOD_PKA_2	814	820	PF00069	0.634
MOD_PKB_1	183	191	PF00069	0.689
MOD_Plk_1	177	183	PF00069	0.564
MOD_Plk_1	196	202	PF00069	0.529
MOD_Plk_1	332	338	PF00069	0.481
MOD_Plk_4	117	123	PF00069	0.473
MOD_Plk_4	15	21	PF00069	0.555
MOD_Plk_4	26	32	PF00069	0.370
MOD_Plk_4	307	313	PF00069	0.392
MOD_Plk_4	336	342	PF00069	0.516
MOD_Plk_4	546	552	PF00069	0.521
MOD_Plk_4	593	599	PF00069	0.453
MOD_Plk_4	633	639	PF00069	0.392
MOD_Plk_4	757	763	PF00069	0.560
MOD_Plk_4	767	773	PF00069	0.465
MOD_Plk_4	88	94	PF00069	0.449
MOD_ProDKin_1	169	175	PF00069	0.639
MOD_ProDKin_1	419	425	PF00069	0.579
MOD_ProDKin_1	460	466	PF00069	0.625
MOD_ProDKin_1	579	585	PF00069	0.582
MOD_ProDKin_1	587	593	PF00069	0.543
MOD_ProDKin_1	807	813	PF00069	0.533
MOD_SUMO_rev_2	224	231	PF00179	0.282
TRG_DiLeu_BaEn_1	227	232	PF01217	0.486
TRG_DiLeu_BaEn_1	878	883	PF01217	0.442
TRG_DiLeu_BaEn_4	227	233	PF01217	0.490
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.433
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.704
TRG_ENDOCYTIC_2	299	302	PF00928	0.443
TRG_ENDOCYTIC_2	642	645	PF00928	0.380
TRG_ENDOCYTIC_2	715	718	PF00928	0.541
TRG_ENDOCYTIC_2	835	838	PF00928	0.659
TRG_ER_diArg_1	182	185	PF00400	0.660
TRG_ER_diArg_1	220	222	PF00400	0.432
TRG_ER_diArg_1	253	255	PF00400	0.426
TRG_ER_diArg_1	289	292	PF00400	0.596
TRG_ER_diArg_1	390	393	PF00400	0.508
TRG_ER_diArg_1	412	415	PF00400	0.671
TRG_ER_diArg_1	501	503	PF00400	0.525
TRG_ER_diArg_1	525	527	PF00400	0.429
TRG_ER_diArg_1	652	655	PF00400	0.488
TRG_ER_diArg_1	66	69	PF00400	0.458
TRG_ER_diArg_1	747	749	PF00400	0.636
TRG_NES_CRM1_1	603	618	PF08389	0.442
TRG_NLS_MonoExtC_3	182	187	PF00514	0.705
TRG_NLS_MonoExtN_4	183	188	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE7	Leptomonas seymouri	50%	100%
A0A3S5H6K4	Leishmania donovani	89%	100%
A4H6T3	Leishmania braziliensis	74%	100%
C9ZQC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AGA7	Leishmania infantum	89%	100%
Q4QGS5	Leishmania major	88%	100%