Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,2-mannosyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9ANU3_LEIMU

TriTrypDb:

LmxM.12.0160

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ANU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANU3

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043413	macromolecule glycosylation	3	9
GO:0044238	primary metabolic process	2	9
GO:0070085	glycosylation	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0006487	protein N-linked glycosylation	5	1
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	1
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	9
GO:0000030	mannosyltransferase activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	9
GO:0016757	glycosyltransferase activity	3	9
GO:0016758	hexosyltransferase activity	4	9
GO:0052918	dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	9
GO:0052926	dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	755	759	PF00656	0.344
CLV_NRD_NRD_1	277	279	PF00675	0.385
CLV_NRD_NRD_1	336	338	PF00675	0.460
CLV_NRD_NRD_1	492	494	PF00675	0.531
CLV_NRD_NRD_1	566	568	PF00675	0.658
CLV_NRD_NRD_1	724	726	PF00675	0.630
CLV_NRD_NRD_1	783	785	PF00675	0.630
CLV_PCSK_KEX2_1	277	279	PF00082	0.385
CLV_PCSK_KEX2_1	336	338	PF00082	0.480
CLV_PCSK_KEX2_1	492	494	PF00082	0.506
CLV_PCSK_KEX2_1	561	563	PF00082	0.599
CLV_PCSK_KEX2_1	566	568	PF00082	0.630
CLV_PCSK_KEX2_1	724	726	PF00082	0.639
CLV_PCSK_KEX2_1	783	785	PF00082	0.605
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.635
CLV_PCSK_PC7_1	273	279	PF00082	0.385
CLV_PCSK_PC7_1	562	568	PF00082	0.674
CLV_PCSK_SKI1_1	337	341	PF00082	0.403
CLV_PCSK_SKI1_1	734	738	PF00082	0.667
CLV_PCSK_SKI1_1	754	758	PF00082	0.671
DEG_APCC_DBOX_1	420	428	PF00400	0.582
DEG_APCC_DBOX_1	724	732	PF00400	0.434
DEG_SPOP_SBC_1	290	294	PF00917	0.185
DOC_CKS1_1	623	628	PF01111	0.442
DOC_CKS1_1	636	641	PF01111	0.458
DOC_CYCLIN_RxL_1	731	741	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	775	781	PF00134	0.370
DOC_MAPK_MEF2A_6	121	129	PF00069	0.362
DOC_MAPK_MEF2A_6	65	72	PF00069	0.382
DOC_MAPK_NFAT4_5	65	73	PF00069	0.382
DOC_PP1_RVXF_1	207	214	PF00149	0.582
DOC_PP2B_LxvP_1	332	335	PF13499	0.450
DOC_PP2B_LxvP_1	648	651	PF13499	0.518
DOC_PP2B_LxvP_1	708	711	PF13499	0.493
DOC_PP4_FxxP_1	205	208	PF00568	0.385
DOC_PP4_FxxP_1	40	43	PF00568	0.301
DOC_PP4_FxxP_1	446	449	PF00568	0.293
DOC_PP4_FxxP_1	636	639	PF00568	0.465
DOC_USP7_MATH_1	139	143	PF00917	0.325
DOC_USP7_MATH_1	343	347	PF00917	0.730
DOC_USP7_MATH_1	348	352	PF00917	0.728
DOC_USP7_MATH_1	363	367	PF00917	0.804
DOC_USP7_MATH_1	370	374	PF00917	0.736
DOC_USP7_MATH_1	391	395	PF00917	0.677
DOC_USP7_MATH_1	412	416	PF00917	0.509
DOC_USP7_MATH_1	575	579	PF00917	0.548
DOC_USP7_MATH_1	63	67	PF00917	0.284
DOC_USP7_MATH_1	663	667	PF00917	0.590
DOC_USP7_MATH_1	671	675	PF00917	0.443
DOC_WW_Pin1_4	199	204	PF00397	0.594
DOC_WW_Pin1_4	366	371	PF00397	0.732
DOC_WW_Pin1_4	445	450	PF00397	0.355
DOC_WW_Pin1_4	494	499	PF00397	0.696
DOC_WW_Pin1_4	573	578	PF00397	0.520
DOC_WW_Pin1_4	622	627	PF00397	0.387
DOC_WW_Pin1_4	635	640	PF00397	0.431
DOC_WW_Pin1_4	659	664	PF00397	0.604
DOC_WW_Pin1_4	765	770	PF00397	0.376
LIG_14-3-3_CanoR_1	162	167	PF00244	0.500
LIG_14-3-3_CanoR_1	277	286	PF00244	0.355
LIG_14-3-3_CanoR_1	4	11	PF00244	0.661
LIG_14-3-3_CanoR_1	606	612	PF00244	0.274
LIG_14-3-3_CanoR_1	665	671	PF00244	0.510
LIG_14-3-3_CanoR_1	81	87	PF00244	0.437
LIG_BRCT_BRCA1_1	112	116	PF00533	0.379
LIG_BRCT_BRCA1_1	201	205	PF00533	0.385
LIG_BRCT_BRCA1_1	608	612	PF00533	0.319
LIG_BRCT_BRCA1_1	65	69	PF00533	0.301
LIG_Clathr_ClatBox_1	239	243	PF01394	0.474
LIG_Clathr_ClatBox_1	300	304	PF01394	0.382
LIG_deltaCOP1_diTrp_1	420	430	PF00928	0.385
LIG_deltaCOP1_diTrp_1	603	611	PF00928	0.315
LIG_EVH1_1	200	204	PF00568	0.385
LIG_FHA_1	103	109	PF00498	0.199
LIG_FHA_1	190	196	PF00498	0.475
LIG_FHA_1	369	375	PF00498	0.758
LIG_FHA_1	4	10	PF00498	0.666
LIG_FHA_1	457	463	PF00498	0.437
LIG_FHA_1	485	491	PF00498	0.610
LIG_FHA_1	587	593	PF00498	0.443
LIG_FHA_1	595	601	PF00498	0.309
LIG_FHA_1	731	737	PF00498	0.457
LIG_FHA_2	438	444	PF00498	0.199
LIG_FHA_2	753	759	PF00498	0.345
LIG_GBD_Chelix_1	253	261	PF00786	0.474
LIG_HP1_1	328	332	PF01393	0.474
LIG_IRF3_LxIS_1	26	32	PF10401	0.199
LIG_LIR_Apic_2	202	208	PF02991	0.385
LIG_LIR_Apic_2	37	43	PF02991	0.313
LIG_LIR_Apic_2	443	449	PF02991	0.284
LIG_LIR_Apic_2	603	608	PF02991	0.321
LIG_LIR_Apic_2	635	639	PF02991	0.462
LIG_LIR_Gen_1	146	156	PF02991	0.345
LIG_LIR_Gen_1	281	291	PF02991	0.304
LIG_LIR_Gen_1	35	46	PF02991	0.302
LIG_LIR_Gen_1	420	431	PF02991	0.417
LIG_LIR_Gen_1	66	77	PF02991	0.284
LIG_LIR_Gen_1	702	711	PF02991	0.378
LIG_LIR_Gen_1	758	767	PF02991	0.406
LIG_LIR_Gen_1	768	779	PF02991	0.331
LIG_LIR_LC3C_4	259	263	PF02991	0.349
LIG_LIR_Nem_3	113	118	PF02991	0.420
LIG_LIR_Nem_3	146	151	PF02991	0.303
LIG_LIR_Nem_3	21	26	PF02991	0.374
LIG_LIR_Nem_3	27	31	PF02991	0.378
LIG_LIR_Nem_3	281	286	PF02991	0.304
LIG_LIR_Nem_3	307	313	PF02991	0.203
LIG_LIR_Nem_3	35	41	PF02991	0.290
LIG_LIR_Nem_3	545	549	PF02991	0.378
LIG_LIR_Nem_3	60	64	PF02991	0.288
LIG_LIR_Nem_3	603	607	PF02991	0.313
LIG_LIR_Nem_3	609	615	PF02991	0.296
LIG_LIR_Nem_3	66	72	PF02991	0.281
LIG_LIR_Nem_3	691	696	PF02991	0.409
LIG_LIR_Nem_3	702	708	PF02991	0.308
LIG_LIR_Nem_3	752	756	PF02991	0.348
LIG_LIR_Nem_3	758	763	PF02991	0.388
LIG_LIR_Nem_3	768	774	PF02991	0.307
LIG_LYPXL_yS_3	451	454	PF13949	0.362
LIG_MLH1_MIPbox_1	608	612	PF16413	0.319
LIG_NRBOX	126	132	PF00104	0.362
LIG_NRBOX	241	247	PF00104	0.474
LIG_NRBOX	256	262	PF00104	0.231
LIG_Pex14_2	24	28	PF04695	0.420
LIG_Pex14_2	317	321	PF04695	0.437
LIG_Pex14_2	517	521	PF04695	0.437
LIG_Pex14_2	607	611	PF04695	0.306
LIG_SH2_CRK	605	609	PF00017	0.309
LIG_SH2_CRK	620	624	PF00017	0.252
LIG_SH2_CRK	753	757	PF00017	0.347
LIG_SH2_STAP1	526	530	PF00017	0.402
LIG_SH2_STAP1	596	600	PF00017	0.346
LIG_SH2_STAT3	134	137	PF00017	0.275
LIG_SH2_STAT5	23	26	PF00017	0.281
LIG_SH2_STAT5	275	278	PF00017	0.289
LIG_SH2_STAT5	46	49	PF00017	0.353
LIG_SH2_STAT5	533	536	PF00017	0.384
LIG_SH2_STAT5	596	599	PF00017	0.328
LIG_SH2_STAT5	627	630	PF00017	0.341
LIG_SH2_STAT5	693	696	PF00017	0.431
LIG_SH2_STAT5	92	95	PF00017	0.337
LIG_SH3_2	204	209	PF14604	0.475
LIG_SH3_2	491	496	PF14604	0.572
LIG_SH3_3	198	204	PF00018	0.470
LIG_SH3_3	446	452	PF00018	0.284
LIG_SH3_3	488	494	PF00018	0.699
LIG_SH3_3	634	640	PF00018	0.483
LIG_SH3_3	691	697	PF00018	0.423
LIG_SH3_3	784	790	PF00018	0.462
LIG_SH3_CIN85_PxpxPR_1	204	209	PF14604	0.475
LIG_Sin3_3	327	334	PF02671	0.349
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.324
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.390
LIG_SUMO_SIM_par_1	16	21	PF11976	0.392
LIG_SUMO_SIM_par_1	761	766	PF11976	0.445
LIG_TRAF2_1	641	644	PF00917	0.549
LIG_TYR_ITSM	19	26	PF00017	0.199
LIG_UBA3_1	433	442	PF00899	0.461
LIG_WW_3	206	210	PF00397	0.582
LIG_WW_3	709	713	PF00397	0.344
MOD_CDC14_SPxK_1	662	665	PF00782	0.493
MOD_CDK_SPxK_1	659	665	PF00069	0.497
MOD_CK1_1	165	171	PF00069	0.518
MOD_CK1_1	356	362	PF00069	0.794
MOD_CK1_1	366	372	PF00069	0.723
MOD_CK1_1	415	421	PF00069	0.538
MOD_CK1_1	576	582	PF00069	0.550
MOD_CK1_1	635	641	PF00069	0.459
MOD_CK1_1	664	670	PF00069	0.593
MOD_CK1_1	82	88	PF00069	0.439
MOD_CK2_1	437	443	PF00069	0.242
MOD_CK2_1	534	540	PF00069	0.395
MOD_GlcNHglycan	118	121	PF01048	0.378
MOD_GlcNHglycan	169	172	PF01048	0.323
MOD_GlcNHglycan	236	239	PF01048	0.362
MOD_GlcNHglycan	293	296	PF01048	0.555
MOD_GlcNHglycan	350	353	PF01048	0.554
MOD_GlcNHglycan	365	368	PF01048	0.563
MOD_GlcNHglycan	476	479	PF01048	0.501
MOD_GlcNHglycan	50	53	PF01048	0.501
MOD_GlcNHglycan	536	539	PF01048	0.607
MOD_GlcNHglycan	714	717	PF01048	0.627
MOD_GlcNHglycan	81	84	PF01048	0.291
MOD_GSK3_1	110	117	PF00069	0.432
MOD_GSK3_1	139	146	PF00069	0.330
MOD_GSK3_1	160	167	PF00069	0.392
MOD_GSK3_1	189	196	PF00069	0.555
MOD_GSK3_1	249	256	PF00069	0.498
MOD_GSK3_1	339	346	PF00069	0.704
MOD_GSK3_1	366	373	PF00069	0.764
MOD_GSK3_1	374	381	PF00069	0.737
MOD_GSK3_1	48	55	PF00069	0.301
MOD_GSK3_1	582	589	PF00069	0.486
MOD_GSK3_1	659	666	PF00069	0.581
MOD_LATS_1	376	382	PF00433	0.579
MOD_N-GLC_1	363	368	PF02516	0.509
MOD_N-GLC_1	737	742	PF02516	0.686
MOD_N-GLC_2	99	101	PF02516	0.382
MOD_NEK2_1	110	115	PF00069	0.365
MOD_NEK2_1	116	121	PF00069	0.366
MOD_NEK2_1	16	21	PF00069	0.402
MOD_NEK2_1	219	224	PF00069	0.396
MOD_NEK2_1	24	29	PF00069	0.382
MOD_NEK2_1	253	258	PF00069	0.371
MOD_NEK2_1	291	296	PF00069	0.382
MOD_NEK2_1	339	344	PF00069	0.705
MOD_NEK2_1	374	379	PF00069	0.744
MOD_NEK2_1	435	440	PF00069	0.432
MOD_NEK2_1	456	461	PF00069	0.374
MOD_NEK2_1	48	53	PF00069	0.301
MOD_NEK2_1	522	527	PF00069	0.400
MOD_NEK2_1	732	737	PF00069	0.466
MOD_NEK2_1	779	784	PF00069	0.455
MOD_NEK2_1	79	84	PF00069	0.340
MOD_NEK2_2	171	176	PF00069	0.385
MOD_PIKK_1	160	166	PF00454	0.474
MOD_PIKK_1	586	592	PF00454	0.514
MOD_PKA_1	492	498	PF00069	0.768
MOD_PKA_2	178	184	PF00069	0.523
MOD_PKA_2	276	282	PF00069	0.355
MOD_PKA_2	3	9	PF00069	0.673
MOD_PKA_2	415	421	PF00069	0.582
MOD_PKA_2	492	498	PF00069	0.755
MOD_PKA_2	664	670	PF00069	0.515
MOD_PKA_2	671	677	PF00069	0.488
MOD_Plk_1	34	40	PF00069	0.324
MOD_Plk_1	363	369	PF00069	0.799
MOD_Plk_1	737	743	PF00069	0.483
MOD_Plk_4	110	116	PF00069	0.377
MOD_Plk_4	139	145	PF00069	0.385
MOD_Plk_4	194	200	PF00069	0.470
MOD_Plk_4	24	30	PF00069	0.403
MOD_Plk_4	256	262	PF00069	0.404
MOD_Plk_4	264	270	PF00069	0.385
MOD_Plk_4	370	376	PF00069	0.774
MOD_Plk_4	57	63	PF00069	0.185
MOD_Plk_4	607	613	PF00069	0.340
MOD_Plk_4	632	638	PF00069	0.440
MOD_Plk_4	727	733	PF00069	0.500
MOD_ProDKin_1	199	205	PF00069	0.594
MOD_ProDKin_1	366	372	PF00069	0.731
MOD_ProDKin_1	445	451	PF00069	0.355
MOD_ProDKin_1	494	500	PF00069	0.695
MOD_ProDKin_1	573	579	PF00069	0.523
MOD_ProDKin_1	622	628	PF00069	0.386
MOD_ProDKin_1	635	641	PF00069	0.439
MOD_ProDKin_1	659	665	PF00069	0.604
MOD_ProDKin_1	765	771	PF00069	0.378
TRG_DiLeu_BaEn_2	303	309	PF01217	0.185
TRG_DiLeu_BaEn_2	35	41	PF01217	0.301
TRG_ENDOCYTIC_2	23	26	PF00928	0.268
TRG_ENDOCYTIC_2	288	291	PF00928	0.324
TRG_ENDOCYTIC_2	451	454	PF00928	0.362
TRG_ENDOCYTIC_2	595	598	PF00928	0.388
TRG_ENDOCYTIC_2	620	623	PF00928	0.352
TRG_ENDOCYTIC_2	753	756	PF00928	0.348
TRG_ENDOCYTIC_2	760	763	PF00928	0.390
TRG_ENDOCYTIC_2	776	779	PF00928	0.398
TRG_ENDOCYTIC_2	92	95	PF00928	0.359
TRG_ER_diArg_1	335	337	PF00400	0.657
TRG_ER_diArg_1	491	493	PF00400	0.787
TRG_ER_diArg_1	565	567	PF00400	0.501
TRG_ER_diArg_1	723	725	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C3	Leptomonas seymouri	53%	100%
A0A0S4ITY5	Bodo saltans	29%	100%
A0A3Q8IBE5	Leishmania donovani	81%	98%
A0A422NUF2	Trypanosoma rangeli	40%	100%
C9ZQC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGA5	Leishmania infantum	80%	98%
Q4QGS7	Leishmania major	81%	99%