Piezo_RRas_bdg domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANU1_LEIMU

TriTrypDb:

LmxM.12.0140

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070765	gamma-secretase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9ANU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANU1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0016485	protein processing	5	7
GO:0019538	protein metabolic process	3	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044093	positive regulation of molecular function	3	7
GO:0044238	primary metabolic process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0051604	protein maturation	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	286	288	PF00675	0.464
CLV_PCSK_KEX2_1	286	288	PF00082	0.464
CLV_PCSK_SKI1_1	142	146	PF00082	0.412
DEG_APCC_DBOX_1	106	114	PF00400	0.266
DEG_SPOP_SBC_1	231	235	PF00917	0.655
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.358
DOC_MAPK_DCC_7	105	115	PF00069	0.250
DOC_MAPK_gen_1	105	113	PF00069	0.318
DOC_MAPK_MEF2A_6	105	113	PF00069	0.334
DOC_PP1_RVXF_1	92	98	PF00149	0.333
DOC_PP2B_LxvP_1	13	16	PF13499	0.358
DOC_USP7_MATH_1	122	126	PF00917	0.389
DOC_USP7_MATH_1	251	255	PF00917	0.685
DOC_USP7_MATH_1	308	312	PF00917	0.772
DOC_USP7_MATH_1	329	333	PF00917	0.764
DOC_USP7_MATH_1	342	346	PF00917	0.614
DOC_USP7_MATH_1	388	392	PF00917	0.413
DOC_USP7_MATH_1	393	397	PF00917	0.481
DOC_USP7_MATH_1	403	407	PF00917	0.443
DOC_USP7_MATH_1	411	415	PF00917	0.267
DOC_WW_Pin1_4	396	401	PF00397	0.402
DOC_WW_Pin1_4	443	448	PF00397	0.551
LIG_14-3-3_CanoR_1	175	185	PF00244	0.553
LIG_14-3-3_CanoR_1	287	297	PF00244	0.616
LIG_14-3-3_CanoR_1	307	315	PF00244	0.688
LIG_14-3-3_CanoR_1	435	441	PF00244	0.628
LIG_Actin_WH2_2	41	59	PF00022	0.358
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_Clathr_ClatBox_1	262	266	PF01394	0.673
LIG_FHA_1	224	230	PF00498	0.808
LIG_FHA_1	3	9	PF00498	0.483
LIG_FHA_1	32	38	PF00498	0.297
LIG_FHA_1	437	443	PF00498	0.643
LIG_FHA_1	47	53	PF00498	0.460
LIG_FHA_2	233	239	PF00498	0.650
LIG_FHA_2	332	338	PF00498	0.632
LIG_GBD_Chelix_1	373	381	PF00786	0.253
LIG_Integrin_isoDGR_2	147	149	PF01839	0.382
LIG_LIR_Gen_1	160	171	PF02991	0.521
LIG_LIR_Gen_1	39	48	PF02991	0.273
LIG_LIR_Gen_1	439	447	PF02991	0.614
LIG_LIR_Gen_1	66	77	PF02991	0.311
LIG_LIR_Nem_3	106	111	PF02991	0.374
LIG_LIR_Nem_3	160	166	PF02991	0.516
LIG_LIR_Nem_3	2	6	PF02991	0.467
LIG_LIR_Nem_3	39	43	PF02991	0.273
LIG_LIR_Nem_3	439	443	PF02991	0.608
LIG_LIR_Nem_3	66	72	PF02991	0.311
LIG_NRBOX	172	178	PF00104	0.591
LIG_Pex14_2	181	185	PF04695	0.540
LIG_SH2_CRK	201	205	PF00017	0.477
LIG_SH2_CRK	3	7	PF00017	0.450
LIG_SH2_CRK	440	444	PF00017	0.616
LIG_SH2_SRC	14	17	PF00017	0.358
LIG_SH2_STAP1	216	220	PF00017	0.587
LIG_SH2_STAT5	216	219	PF00017	0.572
LIG_SH3_3	106	112	PF00018	0.371
LIG_SH3_3	377	383	PF00018	0.270
LIG_Sin3_3	371	378	PF02671	0.250
LIG_SUMO_SIM_anti_2	260	268	PF11976	0.640
LIG_SUMO_SIM_anti_2	420	426	PF11976	0.358
LIG_SUMO_SIM_par_1	100	106	PF11976	0.331
LIG_SUMO_SIM_par_1	260	268	PF11976	0.671
LIG_SUMO_SIM_par_1	29	35	PF11976	0.361
LIG_SUMO_SIM_par_1	429	434	PF11976	0.420
LIG_TRAF2_1	157	160	PF00917	0.574
LIG_TRAF2_1	298	301	PF00917	0.731
LIG_TRFH_1	108	112	PF08558	0.308
LIG_TRFH_1	379	383	PF08558	0.299
LIG_WRC_WIRS_1	37	42	PF05994	0.270
MOD_CDK_SPxxK_3	398	405	PF00069	0.371
MOD_CK1_1	151	157	PF00069	0.762
MOD_CK1_1	2	8	PF00069	0.474
MOD_CK1_1	327	333	PF00069	0.786
MOD_CK1_1	396	402	PF00069	0.455
MOD_CK2_1	232	238	PF00069	0.649
MOD_CK2_1	251	257	PF00069	0.683
MOD_CK2_1	331	337	PF00069	0.693
MOD_CK2_1	401	407	PF00069	0.353
MOD_GlcNHglycan	241	244	PF01048	0.489
MOD_GlcNHglycan	290	293	PF01048	0.472
MOD_GlcNHglycan	310	313	PF01048	0.629
MOD_GlcNHglycan	320	323	PF01048	0.516
MOD_GlcNHglycan	344	347	PF01048	0.405
MOD_GlcNHglycan	390	393	PF01048	0.638
MOD_GSK3_1	147	154	PF00069	0.676
MOD_GSK3_1	277	284	PF00069	0.693
MOD_GSK3_1	32	39	PF00069	0.420
MOD_GSK3_1	327	334	PF00069	0.677
MOD_GSK3_1	442	449	PF00069	0.597
MOD_GSK3_1	78	85	PF00069	0.321
MOD_N-GLC_1	152	157	PF02516	0.359
MOD_N-GLC_1	78	83	PF02516	0.536
MOD_NEK2_1	103	108	PF00069	0.377
MOD_NEK2_1	176	181	PF00069	0.556
MOD_NEK2_1	31	36	PF00069	0.324
MOD_NEK2_1	46	51	PF00069	0.385
MOD_NEK2_2	251	256	PF00069	0.718
MOD_NEK2_2	281	286	PF00069	0.665
MOD_PKA_2	148	154	PF00069	0.655
MOD_PKA_2	171	177	PF00069	0.568
MOD_PKA_2	214	220	PF00069	0.572
MOD_PKA_2	330	336	PF00069	0.845
MOD_Plk_1	251	257	PF00069	0.758
MOD_Plk_1	78	84	PF00069	0.340
MOD_Plk_4	122	128	PF00069	0.299
MOD_Plk_4	181	187	PF00069	0.568
MOD_Plk_4	32	38	PF00069	0.379
MOD_Plk_4	353	359	PF00069	0.567
MOD_Plk_4	417	423	PF00069	0.299
MOD_ProDKin_1	396	402	PF00069	0.398
MOD_ProDKin_1	443	449	PF00069	0.556
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.560
TRG_ENDOCYTIC_2	201	204	PF00928	0.587
TRG_ENDOCYTIC_2	3	6	PF00928	0.450
TRG_ENDOCYTIC_2	440	443	PF00928	0.608
TRG_ER_diArg_1	104	107	PF00400	0.383
TRG_ER_diArg_1	285	287	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY04	Leptomonas seymouri	42%	94%
A0A3S7WRT9	Leishmania donovani	83%	99%
A4H6T0	Leishmania braziliensis	66%	100%
A4HV58	Leishmania infantum	83%	67%
Q4QGS9	Leishmania major	82%	100%