Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cell division protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ANU0_LEIMU

TriTrypDb:

LmxM.12.0130

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9ANU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANU0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0051301	cell division	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.513
CLV_PCSK_KEX2_1	139	141	PF00082	0.513
CLV_PCSK_KEX2_1	563	565	PF00082	0.522
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.522
CLV_PCSK_SKI1_1	139	143	PF00082	0.465
CLV_PCSK_SKI1_1	160	164	PF00082	0.515
CLV_PCSK_SKI1_1	212	216	PF00082	0.817
CLV_PCSK_SKI1_1	270	274	PF00082	0.532
CLV_PCSK_SKI1_1	554	558	PF00082	0.467
CLV_PCSK_SKI1_1	563	567	PF00082	0.526
CLV_PCSK_SKI1_1	83	87	PF00082	0.408
CLV_PCSK_SKI1_1	96	100	PF00082	0.318
DEG_APCC_DBOX_1	138	146	PF00400	0.465
DEG_SCF_FBW7_1	351	356	PF00400	0.411
DEG_SCF_FBW7_2	425	431	PF00400	0.408
DOC_CKS1_1	355	360	PF01111	0.411
DOC_CKS1_1	425	430	PF01111	0.481
DOC_CYCLIN_RxL_1	551	560	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.487
DOC_MAPK_gen_1	160	169	PF00069	0.411
DOC_MAPK_gen_1	79	88	PF00069	0.436
DOC_PP2B_LxvP_1	313	316	PF13499	0.629
DOC_PP2B_PxIxI_1	133	139	PF00149	0.513
DOC_PP4_FxxP_1	575	578	PF00568	0.644
DOC_SPAK_OSR1_1	8	12	PF12202	0.411
DOC_USP7_MATH_1	107	111	PF00917	0.513
DOC_USP7_MATH_1	184	188	PF00917	0.734
DOC_USP7_MATH_1	519	523	PF00917	0.829
DOC_WW_Pin1_4	315	320	PF00397	0.700
DOC_WW_Pin1_4	349	354	PF00397	0.404
DOC_WW_Pin1_4	424	429	PF00397	0.420
DOC_WW_Pin1_4	574	579	PF00397	0.591
DOC_WW_Pin1_4	64	69	PF00397	0.513
LIG_14-3-3_CanoR_1	232	236	PF00244	0.629
LIG_14-3-3_CanoR_1	370	376	PF00244	0.521
LIG_14-3-3_CanoR_1	520	524	PF00244	0.770
LIG_14-3-3_CanoR_1	564	571	PF00244	0.449
LIG_14-3-3_CanoR_1	8	12	PF00244	0.411
LIG_Actin_WH2_2	41	57	PF00022	0.436
LIG_APCC_ABBA_1	235	240	PF00400	0.586
LIG_CtBP_PxDLS_1	534	538	PF00389	0.382
LIG_CtBP_PxDLS_1	92	96	PF00389	0.411
LIG_deltaCOP1_diTrp_1	376	385	PF00928	0.389
LIG_FHA_1	118	124	PF00498	0.222
LIG_FHA_1	336	342	PF00498	0.364
LIG_FHA_1	354	360	PF00498	0.411
LIG_FHA_1	39	45	PF00498	0.411
LIG_FHA_1	425	431	PF00498	0.548
LIG_FHA_2	240	246	PF00498	0.549
LIG_FHA_2	31	37	PF00498	0.513
LIG_FHA_2	371	377	PF00498	0.411
LIG_FHA_2	485	491	PF00498	0.744
LIG_FHA_2	564	570	PF00498	0.502
LIG_FHA_2	8	14	PF00498	0.355
LIG_LIR_Apic_2	357	363	PF02991	0.411
LIG_LIR_Gen_1	410	418	PF02991	0.530
LIG_LIR_Gen_1	539	550	PF02991	0.528
LIG_LIR_Gen_1	7	15	PF02991	0.411
LIG_LIR_Nem_3	17	23	PF02991	0.411
LIG_LIR_Nem_3	391	396	PF02991	0.411
LIG_LIR_Nem_3	431	436	PF02991	0.489
LIG_LIR_Nem_3	539	545	PF02991	0.539
LIG_LIR_Nem_3	7	12	PF02991	0.378
LIG_LIR_Nem_3	89	93	PF02991	0.411
LIG_MYND_1	319	323	PF01753	0.582
LIG_MYND_1	574	578	PF01753	0.647
LIG_NRBOX	552	558	PF00104	0.479
LIG_Pex14_2	98	102	PF04695	0.411
LIG_PTB_Apo_2	97	104	PF02174	0.411
LIG_PTB_Phospho_1	97	103	PF10480	0.411
LIG_REV1ctd_RIR_1	227	236	PF16727	0.644
LIG_SH2_CRK	20	24	PF00017	0.411
LIG_SH2_PTP2	90	93	PF00017	0.411
LIG_SH2_SRC	542	545	PF00017	0.545
LIG_SH2_SRC	559	562	PF00017	0.603
LIG_SH2_STAT3	103	106	PF00017	0.436
LIG_SH2_STAT5	103	106	PF00017	0.411
LIG_SH2_STAT5	137	140	PF00017	0.411
LIG_SH2_STAT5	360	363	PF00017	0.411
LIG_SH2_STAT5	412	415	PF00017	0.526
LIG_SH2_STAT5	90	93	PF00017	0.411
LIG_SH3_3	178	184	PF00018	0.590
LIG_SH3_3	196	202	PF00018	0.745
LIG_SH3_3	211	217	PF00018	0.670
LIG_SH3_3	313	319	PF00018	0.716
LIG_SH3_3	352	358	PF00018	0.411
LIG_SH3_3	459	465	PF00018	0.435
LIG_SUMO_SIM_par_1	91	97	PF11976	0.513
LIG_TRAF2_1	207	210	PF00917	0.812
LIG_TRAF2_1	343	346	PF00917	0.513
LIG_TRAF2_1	429	432	PF00917	0.482
LIG_TYR_ITIM	88	93	PF00017	0.411
LIG_WRC_WIRS_1	185	190	PF05994	0.664
LIG_WRC_WIRS_1	399	404	PF05994	0.580
LIG_WRC_WIRS_1	95	100	PF05994	0.513
LIG_WW_3	523	527	PF00397	0.758
MOD_CK1_1	110	116	PF00069	0.418
MOD_CK1_1	499	505	PF00069	0.749
MOD_CK1_1	7	13	PF00069	0.397
MOD_CK2_1	239	245	PF00069	0.649
MOD_CK2_1	277	283	PF00069	0.640
MOD_CK2_1	340	346	PF00069	0.411
MOD_CK2_1	426	432	PF00069	0.489
MOD_CK2_1	484	490	PF00069	0.679
MOD_CK2_1	563	569	PF00069	0.510
MOD_CK2_1	7	13	PF00069	0.400
MOD_GlcNHglycan	109	112	PF01048	0.438
MOD_GlcNHglycan	117	120	PF01048	0.378
MOD_GlcNHglycan	124	127	PF01048	0.344
MOD_GlcNHglycan	16	19	PF01048	0.411
MOD_GlcNHglycan	247	250	PF01048	0.507
MOD_GlcNHglycan	331	334	PF01048	0.492
MOD_GlcNHglycan	342	345	PF01048	0.411
MOD_GlcNHglycan	402	405	PF01048	0.635
MOD_GlcNHglycan	475	478	PF01048	0.812
MOD_GlcNHglycan	498	501	PF01048	0.769
MOD_GlcNHglycan	504	507	PF01048	0.718
MOD_GlcNHglycan	521	524	PF01048	0.745
MOD_GlcNHglycan	547	550	PF01048	0.431
MOD_GlcNHglycan	566	569	PF01048	0.621
MOD_GSK3_1	106	113	PF00069	0.389
MOD_GSK3_1	184	191	PF00069	0.524
MOD_GSK3_1	277	284	PF00069	0.661
MOD_GSK3_1	311	318	PF00069	0.624
MOD_GSK3_1	349	356	PF00069	0.390
MOD_N-GLC_1	510	515	PF02516	0.748
MOD_N-GLC_1	535	540	PF02516	0.563
MOD_NEK2_1	188	193	PF00069	0.657
MOD_NEK2_1	44	49	PF00069	0.513
MOD_NEK2_1	552	557	PF00069	0.471
MOD_NEK2_2	395	400	PF00069	0.568
MOD_PIKK_1	286	292	PF00454	0.738
MOD_PK_1	55	61	PF00069	0.389
MOD_PKA_1	563	569	PF00069	0.534
MOD_PKA_2	220	226	PF00069	0.642
MOD_PKA_2	231	237	PF00069	0.547
MOD_PKA_2	276	282	PF00069	0.676
MOD_PKA_2	496	502	PF00069	0.737
MOD_PKA_2	519	525	PF00069	0.752
MOD_PKA_2	563	569	PF00069	0.476
MOD_PKA_2	7	13	PF00069	0.411
MOD_Plk_1	55	61	PF00069	0.389
MOD_Plk_2-3	240	246	PF00069	0.380
MOD_Plk_2-3	30	36	PF00069	0.411
MOD_Plk_4	19	25	PF00069	0.381
MOD_ProDKin_1	315	321	PF00069	0.680
MOD_ProDKin_1	349	355	PF00069	0.404
MOD_ProDKin_1	424	430	PF00069	0.423
MOD_ProDKin_1	574	580	PF00069	0.599
MOD_ProDKin_1	64	70	PF00069	0.513
MOD_SUMO_for_1	162	165	PF00179	0.411
MOD_SUMO_rev_2	118	126	PF00179	0.304
MOD_SUMO_rev_2	306	314	PF00179	0.815
MOD_SUMO_rev_2	318	327	PF00179	0.496
MOD_SUMO_rev_2	475	481	PF00179	0.740
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.513
TRG_ENDOCYTIC_2	20	23	PF00928	0.411
TRG_ENDOCYTIC_2	24	27	PF00928	0.411
TRG_ENDOCYTIC_2	412	415	PF00928	0.638
TRG_ENDOCYTIC_2	542	545	PF00928	0.545
TRG_ENDOCYTIC_2	90	93	PF00928	0.411
TRG_ER_diArg_1	138	140	PF00400	0.513
TRG_ER_diArg_1	262	265	PF00400	0.536
TRG_ER_diArg_1	339	342	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4P5	Leptomonas seymouri	53%	92%
A0A3Q8ICJ0	Leishmania donovani	91%	100%
A4H6S9	Leishmania braziliensis	79%	100%
A4HV57	Leishmania infantum	91%	100%
Q4QGT0	Leishmania major	91%	100%