LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ANT4_LEIMU
TriTrypDb:
LmxM.12.0075
Length:
90

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9ANT4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANT4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 54 58 PF00656 0.708
CLV_PCSK_SKI1_1 31 35 PF00082 0.544
CLV_PCSK_SKI1_1 61 65 PF00082 0.388
CLV_PCSK_SKI1_1 73 77 PF00082 0.426
DEG_APCC_DBOX_1 60 68 PF00400 0.546
DEG_APCC_DBOX_1 72 80 PF00400 0.561
DEG_Nend_UBRbox_2 1 3 PF02207 0.794
DOC_CYCLIN_RxL_1 28 37 PF00134 0.740
DOC_MAPK_MEF2A_6 69 78 PF00069 0.429
DOC_MAPK_NFAT4_5 73 81 PF00069 0.426
DOC_PP1_RVXF_1 59 66 PF00149 0.552
DOC_PP4_FxxP_1 47 50 PF00568 0.732
DOC_WW_Pin1_4 16 21 PF00397 0.667
LIG_14-3-3_CanoR_1 35 42 PF00244 0.744
LIG_14-3-3_CanoR_1 73 79 PF00244 0.529
LIG_Actin_WH2_2 22 37 PF00022 0.662
LIG_FHA_2 17 23 PF00498 0.729
LIG_FHA_2 25 31 PF00498 0.748
LIG_FHA_2 52 58 PF00498 0.709
LIG_LIR_Gen_1 62 70 PF02991 0.621
LIG_LIR_Gen_1 72 82 PF02991 0.429
LIG_LIR_Nem_3 62 68 PF02991 0.626
LIG_LIR_Nem_3 72 78 PF02991 0.429
LIG_NRBOX 77 83 PF00104 0.405
LIG_SH2_STAT5 25 28 PF00017 0.750
LIG_SH3_3 47 53 PF00018 0.781
LIG_SUMO_SIM_anti_2 77 82 PF11976 0.405
MOD_CK2_1 16 22 PF00069 0.733
MOD_CK2_1 24 30 PF00069 0.752
MOD_CK2_1 34 40 PF00069 0.696
MOD_GlcNHglycan 36 39 PF01048 0.536
MOD_GSK3_1 59 66 PF00069 0.597
MOD_NEK2_1 24 29 PF00069 0.754
MOD_NEK2_1 34 39 PF00069 0.621
MOD_NEK2_1 63 68 PF00069 0.719
MOD_PKA_2 34 40 PF00069 0.742
MOD_PKA_2 68 74 PF00069 0.580
MOD_Plk_1 59 65 PF00069 0.609
MOD_Plk_1 69 75 PF00069 0.559
MOD_Plk_4 74 80 PF00069 0.389
MOD_ProDKin_1 16 22 PF00069 0.666

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I949 Leishmania donovani 89% 100%
A4H6S3 Leishmania braziliensis 74% 100%
E9ACR2 Leishmania major 87% 100%
E9AGA4 Leishmania infantum 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS