Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANT3_LEIMU

TriTrypDb:

LmxM.12.0070

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.432
CLV_C14_Caspase3-7	453	457	PF00656	0.537
CLV_NRD_NRD_1	105	107	PF00675	0.614
CLV_NRD_NRD_1	123	125	PF00675	0.387
CLV_NRD_NRD_1	182	184	PF00675	0.482
CLV_NRD_NRD_1	190	192	PF00675	0.459
CLV_NRD_NRD_1	210	212	PF00675	0.373
CLV_NRD_NRD_1	258	260	PF00675	0.664
CLV_NRD_NRD_1	282	284	PF00675	0.497
CLV_NRD_NRD_1	304	306	PF00675	0.579
CLV_NRD_NRD_1	342	344	PF00675	0.556
CLV_NRD_NRD_1	38	40	PF00675	0.434
CLV_NRD_NRD_1	383	385	PF00675	0.562
CLV_NRD_NRD_1	446	448	PF00675	0.473
CLV_NRD_NRD_1	502	504	PF00675	0.500
CLV_NRD_NRD_1	548	550	PF00675	0.476
CLV_NRD_NRD_1	560	562	PF00675	0.426
CLV_NRD_NRD_1	570	572	PF00675	0.528
CLV_PCSK_FUR_1	208	212	PF00082	0.456
CLV_PCSK_FUR_1	340	344	PF00082	0.650
CLV_PCSK_FUR_1	444	448	PF00082	0.539
CLV_PCSK_KEX2_1	105	107	PF00082	0.604
CLV_PCSK_KEX2_1	123	125	PF00082	0.644
CLV_PCSK_KEX2_1	147	149	PF00082	0.475
CLV_PCSK_KEX2_1	182	184	PF00082	0.484
CLV_PCSK_KEX2_1	190	192	PF00082	0.464
CLV_PCSK_KEX2_1	210	212	PF00082	0.350
CLV_PCSK_KEX2_1	258	260	PF00082	0.602
CLV_PCSK_KEX2_1	281	283	PF00082	0.511
CLV_PCSK_KEX2_1	304	306	PF00082	0.554
CLV_PCSK_KEX2_1	342	344	PF00082	0.476
CLV_PCSK_KEX2_1	38	40	PF00082	0.449
CLV_PCSK_KEX2_1	383	385	PF00082	0.613
CLV_PCSK_KEX2_1	395	397	PF00082	0.471
CLV_PCSK_KEX2_1	410	412	PF00082	0.433
CLV_PCSK_KEX2_1	446	448	PF00082	0.475
CLV_PCSK_KEX2_1	502	504	PF00082	0.470
CLV_PCSK_KEX2_1	515	517	PF00082	0.491
CLV_PCSK_KEX2_1	560	562	PF00082	0.538
CLV_PCSK_KEX2_1	570	572	PF00082	0.546
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.660
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.480
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.617
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.439
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.559
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.679
CLV_PCSK_PC7_1	206	212	PF00082	0.460
CLV_PCSK_PC7_1	391	397	PF00082	0.475
CLV_PCSK_SKI1_1	182	186	PF00082	0.474
CLV_PCSK_SKI1_1	560	564	PF00082	0.432
CLV_PCSK_SKI1_1	76	80	PF00082	0.556
DEG_APCC_DBOX_1	182	190	PF00400	0.469
DOC_CYCLIN_RxL_1	180	188	PF00134	0.504
DOC_CYCLIN_RxL_1	247	257	PF00134	0.461
DOC_MAPK_gen_1	123	130	PF00069	0.497
DOC_MAPK_gen_1	395	402	PF00069	0.497
DOC_MAPK_gen_1	444	454	PF00069	0.440
DOC_MAPK_JIP1_4	39	45	PF00069	0.424
DOC_MAPK_MEF2A_6	395	404	PF00069	0.407
DOC_PP4_FxxP_1	11	14	PF00568	0.441
DOC_USP7_MATH_1	109	113	PF00917	0.597
DOC_USP7_MATH_1	14	18	PF00917	0.412
DOC_USP7_MATH_1	263	267	PF00917	0.470
DOC_USP7_MATH_1	371	375	PF00917	0.561
DOC_USP7_MATH_1	71	75	PF00917	0.720
DOC_WW_Pin1_4	159	164	PF00397	0.569
DOC_WW_Pin1_4	487	492	PF00397	0.568
DOC_WW_Pin1_4	9	14	PF00397	0.452
LIG_BRCT_BRCA1_1	11	15	PF00533	0.443
LIG_BRCT_BRCA1_1	45	49	PF00533	0.489
LIG_BRCT_BRCA1_1	500	504	PF00533	0.339
LIG_FHA_1	115	121	PF00498	0.478
LIG_FHA_1	288	294	PF00498	0.507
LIG_FHA_1	601	607	PF00498	0.400
LIG_FHA_1	96	102	PF00498	0.755
LIG_FHA_2	150	156	PF00498	0.617
LIG_FHA_2	92	98	PF00498	0.700
LIG_LIR_Apic_2	10	14	PF02991	0.408
LIG_LIR_Apic_2	111	116	PF02991	0.574
LIG_LIR_Gen_1	3	13	PF02991	0.510
LIG_LIR_Gen_1	376	382	PF02991	0.632
LIG_LIR_Gen_1	46	57	PF02991	0.482
LIG_LIR_Nem_3	12	18	PF02991	0.589
LIG_LIR_Nem_3	129	135	PF02991	0.369
LIG_LIR_Nem_3	21	25	PF02991	0.484
LIG_LIR_Nem_3	3	8	PF02991	0.510
LIG_LIR_Nem_3	376	381	PF02991	0.544
LIG_LIR_Nem_3	46	52	PF02991	0.476
LIG_NRP_CendR_1	618	620	PF00754	0.641
LIG_Pex14_2	11	15	PF04695	0.443
LIG_RPA_C_Fungi	337	349	PF08784	0.597
LIG_SH2_CRK	598	602	PF00017	0.394
LIG_SH2_NCK_1	113	117	PF00017	0.572
LIG_SH2_NCK_1	428	432	PF00017	0.479
LIG_SH2_SRC	113	116	PF00017	0.578
LIG_SH2_STAP1	424	428	PF00017	0.448
LIG_SH2_STAT5	132	135	PF00017	0.367
LIG_SH2_STAT5	164	167	PF00017	0.407
LIG_SH3_3	13	19	PF00018	0.410
LIG_SH3_3	78	84	PF00018	0.521
LIG_TRAF2_1	176	179	PF00917	0.571
LIG_TRAF2_1	227	230	PF00917	0.480
LIG_TRAF2_1	520	523	PF00917	0.527
LIG_TRAF2_1	540	543	PF00917	0.319
LIG_TRAF2_1	94	97	PF00917	0.622
LIG_WRC_WIRS_1	433	438	PF05994	0.433
LIG_WRC_WIRS_1	8	13	PF05994	0.408
MOD_CK2_1	149	155	PF00069	0.619
MOD_CK2_1	537	543	PF00069	0.484
MOD_CK2_1	91	97	PF00069	0.699
MOD_GlcNHglycan	270	273	PF01048	0.624
MOD_GlcNHglycan	373	376	PF01048	0.454
MOD_GlcNHglycan	45	48	PF01048	0.588
MOD_GlcNHglycan	539	542	PF01048	0.448
MOD_GlcNHglycan	609	612	PF01048	0.471
MOD_GlcNHglycan	63	67	PF01048	0.704
MOD_GlcNHglycan	73	76	PF01048	0.622
MOD_GSK3_1	134	141	PF00069	0.483
MOD_GSK3_1	14	21	PF00069	0.549
MOD_GSK3_1	43	50	PF00069	0.459
MOD_GSK3_1	87	94	PF00069	0.685
MOD_N-GLC_1	231	236	PF02516	0.438
MOD_NEK2_1	149	154	PF00069	0.427
MOD_NEK2_1	4	9	PF00069	0.424
MOD_NEK2_2	373	378	PF00069	0.634
MOD_NEK2_2	95	100	PF00069	0.459
MOD_OFUCOSY	92	99	PF10250	0.626
MOD_PIKK_1	231	237	PF00454	0.369
MOD_PIKK_1	82	88	PF00454	0.668
MOD_PK_1	138	144	PF00069	0.430
MOD_PKA_1	549	555	PF00069	0.476
MOD_PKA_1	571	577	PF00069	0.680
MOD_PKA_2	43	49	PF00069	0.463
MOD_PKB_1	473	481	PF00069	0.575
MOD_PKB_1	547	555	PF00069	0.419
MOD_Plk_1	47	53	PF00069	0.541
MOD_Plk_1	475	481	PF00069	0.627
MOD_Plk_1	584	590	PF00069	0.577
MOD_Plk_4	18	24	PF00069	0.407
MOD_Plk_4	373	379	PF00069	0.521
MOD_ProDKin_1	159	165	PF00069	0.571
MOD_ProDKin_1	487	493	PF00069	0.557
MOD_ProDKin_1	9	15	PF00069	0.453
MOD_SUMO_for_1	199	202	PF00179	0.390
MOD_SUMO_for_1	429	432	PF00179	0.478
MOD_SUMO_rev_2	543	552	PF00179	0.588
TRG_DiLeu_BaEn_1	180	185	PF01217	0.349
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.530
TRG_DiLeu_LyEn_5	180	185	PF01217	0.349
TRG_ER_diArg_1	122	124	PF00400	0.501
TRG_ER_diArg_1	182	184	PF00400	0.480
TRG_ER_diArg_1	189	191	PF00400	0.509
TRG_ER_diArg_1	208	211	PF00400	0.375
TRG_ER_diArg_1	281	283	PF00400	0.501
TRG_ER_diArg_1	340	343	PF00400	0.518
TRG_ER_diArg_1	358	361	PF00400	0.542
TRG_ER_diArg_1	37	39	PF00400	0.444
TRG_ER_diArg_1	383	386	PF00400	0.494
TRG_ER_diArg_1	444	447	PF00400	0.503
TRG_ER_diArg_1	502	504	PF00400	0.505
TRG_ER_diArg_1	559	561	PF00400	0.561
TRG_NLS_Bipartite_1	560	574	PF00514	0.455
TRG_NLS_MonoExtN_4	104	109	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK43	Leptomonas seymouri	47%	100%
A0A1X0NM25	Trypanosomatidae	29%	100%
A0A3Q8I971	Leishmania donovani	86%	100%
A0A422N6D2	Trypanosoma rangeli	29%	100%
A4H6S2	Leishmania braziliensis	71%	100%
A4HV51	Leishmania infantum	86%	100%
C9ZQD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QGT6	Leishmania major	83%	100%