SER_THR_PHOSPHATASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANT1_LEIMU

TriTrypDb:

LmxM.12.0050

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005955	calcineurin complex	3	2
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	3
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2
GO:0016020	membrane	2	2

Expansion

Sequence features

E9ANT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANT1

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	24
GO:0009987	cellular process	1	24
GO:0019722	calcium-mediated signaling	5	24
GO:0019932	second-messenger-mediated signaling	4	24
GO:0035556	intracellular signal transduction	3	24
GO:0050789	regulation of biological process	2	24
GO:0050794	regulation of cellular process	3	24
GO:0065007	biological regulation	1	24
GO:0097720	calcineurin-mediated signaling	6	24

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	28
GO:0004721	phosphoprotein phosphatase activity	3	28
GO:0004722	protein serine/threonine phosphatase activity	4	28
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	24
GO:0016787	hydrolase activity	2	28
GO:0016788	hydrolase activity, acting on ester bonds	3	28
GO:0016791	phosphatase activity	5	28
GO:0033192	calmodulin-dependent protein phosphatase activity	6	24
GO:0042578	phosphoric ester hydrolase activity	4	28
GO:0140096	catalytic activity, acting on a protein	2	28
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0005516	calmodulin binding	3	10
GO:0017018	myosin phosphatase activity	5	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.387
CLV_NRD_NRD_1	153	155	PF00675	0.509
CLV_NRD_NRD_1	388	390	PF00675	0.511
CLV_NRD_NRD_1	401	403	PF00675	0.394
CLV_PCSK_KEX2_1	152	154	PF00082	0.551
CLV_PCSK_KEX2_1	341	343	PF00082	0.490
CLV_PCSK_KEX2_1	390	392	PF00082	0.493
CLV_PCSK_KEX2_1	401	403	PF00082	0.369
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.490
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.407
CLV_PCSK_SKI1_1	165	169	PF00082	0.317
CLV_PCSK_SKI1_1	44	48	PF00082	0.404
DEG_APCC_DBOX_1	252	260	PF00400	0.473
DEG_APCC_DBOX_1	388	396	PF00400	0.593
DOC_CDC14_PxL_1	414	422	PF14671	0.609
DOC_CKS1_1	344	349	PF01111	0.520
DOC_MAPK_gen_1	191	200	PF00069	0.500
DOC_MAPK_gen_1	23	32	PF00069	0.483
DOC_MAPK_gen_1	253	261	PF00069	0.429
DOC_MAPK_gen_1	389	397	PF00069	0.571
DOC_MAPK_gen_1	399	407	PF00069	0.430
DOC_MAPK_gen_1	85	93	PF00069	0.383
DOC_MAPK_MEF2A_6	255	263	PF00069	0.409
DOC_PP1_RVXF_1	86	93	PF00149	0.224
DOC_PP4_FxxP_1	275	278	PF00568	0.427
DOC_PP4_FxxP_1	308	311	PF00568	0.283
DOC_SPAK_OSR1_1	118	122	PF12202	0.384
DOC_USP7_MATH_1	100	104	PF00917	0.437
DOC_USP7_MATH_1	4	8	PF00917	0.634
DOC_USP7_MATH_2	4	10	PF00917	0.398
DOC_USP7_UBL2_3	47	51	PF12436	0.561
DOC_WW_Pin1_4	343	348	PF00397	0.517
LIG_14-3-3_CanoR_1	241	245	PF00244	0.322
LIG_14-3-3_CanoR_1	25	31	PF00244	0.281
LIG_14-3-3_CanoR_1	37	46	PF00244	0.217
LIG_Actin_WH2_2	32	49	PF00022	0.288
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BIR_III_1	1	5	PF00653	0.479
LIG_BIR_III_3	1	5	PF00653	0.479
LIG_BRCT_BRCA1_1	188	192	PF00533	0.422
LIG_BRCT_BRCA1_1	207	211	PF00533	0.471
LIG_BRCT_BRCA1_1	283	287	PF00533	0.476
LIG_EH1_1	107	115	PF00400	0.385
LIG_eIF4E_1	339	345	PF01652	0.466
LIG_FHA_1	407	413	PF00498	0.584
LIG_FHA_1	41	47	PF00498	0.403
LIG_FHA_1	77	83	PF00498	0.370
LIG_FHA_2	192	198	PF00498	0.401
LIG_LIR_Apic_2	273	278	PF02991	0.424
LIG_LIR_Apic_2	306	311	PF02991	0.373
LIG_LIR_Apic_2	355	359	PF02991	0.429
LIG_LIR_Gen_1	117	125	PF02991	0.476
LIG_LIR_Gen_1	158	168	PF02991	0.340
LIG_LIR_Gen_1	271	278	PF02991	0.599
LIG_LIR_Gen_1	351	361	PF02991	0.479
LIG_LIR_Gen_1	72	81	PF02991	0.388
LIG_LIR_LC3C_4	12	17	PF02991	0.491
LIG_LIR_Nem_3	117	122	PF02991	0.348
LIG_LIR_Nem_3	137	142	PF02991	0.425
LIG_LIR_Nem_3	158	163	PF02991	0.331
LIG_LIR_Nem_3	166	171	PF02991	0.303
LIG_LIR_Nem_3	178	184	PF02991	0.290
LIG_LIR_Nem_3	189	195	PF02991	0.284
LIG_LIR_Nem_3	271	275	PF02991	0.535
LIG_LIR_Nem_3	284	290	PF02991	0.371
LIG_LIR_Nem_3	312	316	PF02991	0.466
LIG_LIR_Nem_3	351	357	PF02991	0.391
LIG_LIR_Nem_3	60	66	PF02991	0.441
LIG_LIR_Nem_3	72	76	PF02991	0.346
LIG_MLH1_MIPbox_1	283	287	PF16413	0.484
LIG_NBox_RRM_1	167	177	PF00076	0.158
LIG_PCNA_yPIPBox_3	75	88	PF02747	0.442
LIG_Pex14_2	240	244	PF04695	0.328
LIG_PTB_Apo_2	176	183	PF02174	0.296
LIG_PTB_Apo_2	86	93	PF02174	0.395
LIG_SH2_SRC	96	99	PF00017	0.309
LIG_SH2_STAP1	160	164	PF00017	0.358
LIG_SH2_STAP1	242	246	PF00017	0.319
LIG_SH2_STAT5	242	245	PF00017	0.331
LIG_SH2_STAT5	286	289	PF00017	0.403
LIG_SH2_STAT5	290	293	PF00017	0.386
LIG_SH2_STAT5	96	99	PF00017	0.315
LIG_SH3_3	130	136	PF00018	0.386
LIG_SH3_3	412	418	PF00018	0.574
LIG_SH3_3	59	65	PF00018	0.370
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.382
LIG_SUMO_SIM_par_1	199	204	PF11976	0.299
LIG_TRAF2_1	194	197	PF00917	0.264
LIG_UBA3_1	373	378	PF00899	0.355
LIG_WRC_WIRS_1	272	277	PF05994	0.530
MOD_CK1_1	306	312	PF00069	0.328
MOD_CK1_1	9	15	PF00069	0.518
MOD_CK2_1	191	197	PF00069	0.497
MOD_CK2_1	8	14	PF00069	0.618
MOD_GlcNHglycan	110	113	PF01048	0.275
MOD_GlcNHglycan	168	171	PF01048	0.351
MOD_GlcNHglycan	308	311	PF01048	0.320
MOD_GlcNHglycan	40	43	PF01048	0.280
MOD_GlcNHglycan	6	9	PF01048	0.672
MOD_GSK3_1	187	194	PF00069	0.308
MOD_GSK3_1	201	208	PF00069	0.338
MOD_GSK3_1	26	33	PF00069	0.435
MOD_GSK3_1	4	11	PF00069	0.579
MOD_N-GLC_2	320	322	PF02516	0.346
MOD_N-GLC_2	84	86	PF02516	0.290
MOD_NEK2_1	108	113	PF00069	0.322
MOD_NEK2_1	148	153	PF00069	0.473
MOD_NEK2_1	230	235	PF00069	0.383
MOD_NEK2_1	240	245	PF00069	0.352
MOD_NEK2_1	30	35	PF00069	0.410
MOD_NEK2_1	406	411	PF00069	0.456
MOD_NEK2_2	281	286	PF00069	0.607
MOD_NEK2_2	303	308	PF00069	0.354
MOD_PIKK_1	201	207	PF00454	0.417
MOD_PIKK_1	230	236	PF00454	0.450
MOD_PIKK_1	296	302	PF00454	0.474
MOD_PIKK_1	346	352	PF00454	0.493
MOD_PKA_2	240	246	PF00069	0.367
MOD_Plk_2-3	380	386	PF00069	0.406
MOD_Plk_4	159	165	PF00069	0.308
MOD_Plk_4	281	287	PF00069	0.514
MOD_Plk_4	303	309	PF00069	0.314
MOD_Plk_4	57	63	PF00069	0.344
MOD_ProDKin_1	343	349	PF00069	0.520
TRG_DiLeu_BaEn_1	196	201	PF01217	0.430
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.331
TRG_ENDOCYTIC_2	160	163	PF00928	0.362
TRG_ENDOCYTIC_2	272	275	PF00928	0.589
TRG_ER_diArg_1	152	154	PF00400	0.437
TRG_ER_diArg_1	389	392	PF00400	0.487
TRG_ER_diArg_1	400	402	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	22%	100%
A0A0N0P7Y2	Leptomonas seymouri	24%	77%
A0A0N1ILH2	Leptomonas seymouri	26%	100%
A0A0N1PD03	Leptomonas seymouri	73%	95%
A0A0S4IIW0	Bodo saltans	24%	100%
A0A0S4JDD1	Bodo saltans	25%	94%
A0A0S4JKZ6	Bodo saltans	25%	85%
A0A0S4KLF4	Bodo saltans	33%	100%
A0A1X0NMS7	Trypanosomatidae	42%	100%
A0A1X0NYR5	Trypanosomatidae	22%	100%
A0A1X0P6J3	Trypanosomatidae	26%	100%
A0A1X0P7H9	Trypanosomatidae	26%	95%
A0A1X0P7Q5	Trypanosomatidae	26%	100%
A0A3Q8ID20	Leishmania donovani	26%	88%
A0A3R7LPS5	Trypanosoma rangeli	42%	100%
A0A3R7MBA3	Trypanosoma rangeli	26%	94%
A0A3R7N275	Trypanosoma rangeli	22%	100%
A0A3S5H6K2	Leishmania donovani	91%	100%
A0A3S7X190	Leishmania donovani	21%	100%
A0A3S7X1Y0	Leishmania donovani	25%	100%
A0A3S7X8K6	Leishmania donovani	25%	100%
A0A3S7XAY3	Leishmania donovani	24%	100%
A0A422N9D5	Trypanosoma rangeli	24%	100%
A0C1E4	Paramecium tetraurelia	23%	100%
A0CCD2	Paramecium tetraurelia	23%	100%
A0CNL9	Paramecium tetraurelia	24%	100%
A4H6S0	Leishmania braziliensis	83%	100%
A4H7Z3	Leishmania braziliensis	22%	100%
A4HBE2	Leishmania braziliensis	24%	100%
A4HF98	Leishmania braziliensis	26%	77%
A4HGA9	Leishmania braziliensis	21%	100%
A4HP65	Leishmania braziliensis	23%	100%
A4HV49	Leishmania infantum	91%	100%
A4I2J0	Leishmania infantum	26%	88%
A4I3E3	Leishmania infantum	21%	100%
A4I400	Leishmania infantum	25%	100%
A4IAJ0	Leishmania infantum	25%	100%
A4IDH0	Leishmania infantum	24%	100%
A6H772	Bos taurus	22%	100%
C9ZJZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZQD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A805	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AYN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9AZN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B090	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B5L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O42773	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	24%	66%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	70%
P16298	Homo sapiens	23%	81%
P20651	Rattus norvegicus	22%	81%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	76%
P32945	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	77%
P48452	Bos taurus	22%	81%
P48453	Mus musculus	22%	81%
P48454	Homo sapiens	22%	83%
P48455	Mus musculus	22%	82%
P48456	Drosophila melanogaster	22%	68%
P48457	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	77%
P48461	Drosophila melanogaster	23%	100%
P48480	Acetabularia peniculus	23%	100%
P48726	Paramecium tetraurelia	24%	100%
P60510	Homo sapiens	22%	100%
P61292	Sus scrofa	23%	100%
P62140	Homo sapiens	23%	100%
P62141	Mus musculus	23%	100%
P62142	Rattus norvegicus	23%	100%
P62143	Oryctolagus cuniculus	23%	100%
P62207	Gallus gallus	23%	100%
P63328	Mus musculus	22%	81%
P63329	Rattus norvegicus	22%	81%
P97470	Mus musculus	22%	100%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	76%
Q08209	Homo sapiens	22%	81%
Q0G819	Caenorhabditis elegans	24%	78%
Q12705	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	76%
Q27889	Drosophila melanogaster	22%	74%
Q3SWW9	Bos taurus	23%	100%
Q4Q1M5	Leishmania major	23%	100%
Q4Q2C2	Leishmania major	25%	100%
Q4Q7Z5	Leishmania major	23%	98%
Q4Q8K1	Leishmania major	21%	100%
Q4Q8T8	Leishmania major	26%	85%
Q4QGT8	Leishmania major	92%	100%
Q4WUR1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	79%
Q54RD6	Dictyostelium discoideum	22%	100%
Q5I085	Xenopus tropicalis	23%	100%
Q5R6K8	Pongo abelii	22%	100%
Q5R740	Pongo abelii	23%	100%
Q6BFF6	Paramecium tetraurelia	24%	100%
Q6GQL2	Xenopus laevis	23%	100%
Q6IP91	Xenopus laevis	22%	100%
Q6P861	Xenopus tropicalis	22%	100%
Q7YSW8	Dictyostelium discoideum	24%	68%
Q8MJ47	Canis lupus familiaris	23%	100%
Q9VXF1	Drosophila melanogaster	22%	72%
V5B3V2	Trypanosoma cruzi	27%	100%
V5BBR3	Trypanosoma cruzi	24%	100%
V5BKU4	Trypanosoma cruzi	22%	100%