LeishMANIAdb
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Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteasome subunit beta
Gene product:
proteasome beta-1 subunit, putative
Species:
Leishmania mexicana
UniProt:
E9ANS8_LEIMU
TriTrypDb:
LmxM.12.0030
Length:
283

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0005839 proteasome core complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902494 catalytic complex 2 12
GO:0019774 proteasome core complex, beta-subunit complex 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

E9ANS8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANS8

PDB structure(s): 6qm7_H , 6qm7_V , 6qm8_H , 6qm8_V

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006511 ubiquitin-dependent protein catabolic process 7 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009057 macromolecule catabolic process 4 12
GO:0009987 cellular process 1 12
GO:0010498 proteasomal protein catabolic process 5 12
GO:0019538 protein metabolic process 3 12
GO:0019941 modification-dependent protein catabolic process 6 12
GO:0030163 protein catabolic process 4 12
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043632 modification-dependent macromolecule catabolic process 5 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044265 obsolete cellular macromolecule catabolic process 4 12
GO:0051603 proteolysis involved in protein catabolic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901565 organonitrogen compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004175 endopeptidase activity 4 12
GO:0004298 threonine-type endopeptidase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0016787 hydrolase activity 2 12
GO:0070003 threonine-type peptidase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 109 115 PF00089 0.390
CLV_PCSK_SKI1_1 229 233 PF00082 0.567
CLV_PCSK_SKI1_1 33 37 PF00082 0.650
DEG_Nend_Nbox_1 1 3 PF02207 0.667
DEG_SPOP_SBC_1 267 271 PF00917 0.462
DOC_PP2B_LxvP_1 264 267 PF13499 0.448
DOC_USP7_MATH_1 199 203 PF00917 0.565
DOC_USP7_MATH_1 267 271 PF00917 0.462
DOC_USP7_MATH_1 69 73 PF00917 0.504
DOC_USP7_UBL2_3 33 37 PF12436 0.474
DOC_USP7_UBL2_3 90 94 PF12436 0.516
DOC_WW_Pin1_4 245 250 PF00397 0.458
LIG_14-3-3_CanoR_1 145 154 PF00244 0.620
LIG_14-3-3_CanoR_1 229 234 PF00244 0.567
LIG_14-3-3_CanoR_1 73 81 PF00244 0.504
LIG_14-3-3_CterR_2 278 283 PF00244 0.624
LIG_FHA_1 104 110 PF00498 0.469
LIG_FHA_1 228 234 PF00498 0.542
LIG_FHA_1 53 59 PF00498 0.590
LIG_FHA_1 76 82 PF00498 0.525
LIG_FHA_1 90 96 PF00498 0.484
LIG_LIR_Apic_2 164 169 PF02991 0.516
LIG_PDZ_Class_1 278 283 PF00595 0.490
LIG_Pex14_2 188 192 PF04695 0.516
LIG_PTB_Apo_2 262 269 PF02174 0.472
LIG_SH2_CRK 157 161 PF00017 0.509
LIG_SH2_CRK 166 170 PF00017 0.496
LIG_SH2_GRB2like 142 145 PF00017 0.516
LIG_SH2_NCK_1 157 161 PF00017 0.526
LIG_SH2_NCK_1 166 170 PF00017 0.477
LIG_SH2_STAT3 258 261 PF00017 0.602
LIG_SH2_STAT5 116 119 PF00017 0.373
LIG_SH2_STAT5 142 145 PF00017 0.582
LIG_SH2_STAT5 250 253 PF00017 0.452
LIG_SH2_STAT5 79 82 PF00017 0.496
LIG_SH2_STAT5 96 99 PF00017 0.504
LIG_SH3_3 10 16 PF00018 0.613
LIG_SH3_3 260 266 PF00018 0.490
LIG_SH3_3 39 45 PF00018 0.608
LIG_SUMO_SIM_par_1 229 234 PF11976 0.505
LIG_SUMO_SIM_par_1 55 61 PF11976 0.573
LIG_TRAF2_1 28 31 PF00917 0.468
LIG_WRC_WIRS_1 189 194 PF05994 0.516
MOD_CK1_1 119 125 PF00069 0.529
MOD_CK1_1 164 170 PF00069 0.506
MOD_CK1_1 52 58 PF00069 0.504
MOD_CK1_1 72 78 PF00069 0.504
MOD_CK2_1 199 205 PF00069 0.504
MOD_GlcNHglycan 148 151 PF01048 0.316
MOD_GlcNHglycan 169 172 PF01048 0.309
MOD_GlcNHglycan 183 186 PF01048 0.264
MOD_GlcNHglycan 223 226 PF01048 0.304
MOD_GlcNHglycan 270 273 PF01048 0.526
MOD_GlcNHglycan 75 78 PF01048 0.380
MOD_GlcNHglycan 99 102 PF01048 0.296
MOD_GSK3_1 216 223 PF00069 0.510
MOD_GSK3_1 268 275 PF00069 0.491
MOD_GSK3_1 45 52 PF00069 0.582
MOD_GSK3_1 69 76 PF00069 0.504
MOD_GSK3_1 82 89 PF00069 0.504
MOD_GSK3_1 99 106 PF00069 0.504
MOD_N-GLC_1 146 151 PF02516 0.302
MOD_N-GLC_1 245 250 PF02516 0.367
MOD_NEK2_1 181 186 PF00069 0.501
MOD_NEK2_1 188 193 PF00069 0.494
MOD_NEK2_1 227 232 PF00069 0.560
MOD_NEK2_1 268 273 PF00069 0.489
MOD_NEK2_1 53 58 PF00069 0.500
MOD_NEK2_2 183 188 PF00069 0.504
MOD_PIKK_1 103 109 PF00454 0.512
MOD_PKA_2 111 117 PF00069 0.590
MOD_PKA_2 277 283 PF00069 0.575
MOD_PKA_2 72 78 PF00069 0.504
MOD_PKA_2 82 88 PF00069 0.504
MOD_Plk_1 239 245 PF00069 0.447
MOD_Plk_1 5 11 PF00069 0.756
MOD_Plk_4 161 167 PF00069 0.509
MOD_Plk_4 183 189 PF00069 0.501
MOD_Plk_4 5 11 PF00069 0.643
MOD_Plk_4 53 59 PF00069 0.504
MOD_Plk_4 75 81 PF00069 0.516
MOD_ProDKin_1 245 251 PF00069 0.448
MOD_SUMO_rev_2 14 24 PF00179 0.692
MOD_SUMO_rev_2 25 35 PF00179 0.541
TRG_ENDOCYTIC_2 157 160 PF00928 0.516
TRG_ENDOCYTIC_2 190 193 PF00928 0.504

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVL0 Leptomonas seymouri 30% 100%
A0A0N1ILF0 Leptomonas seymouri 25% 100%
A0A0N1PB37 Leptomonas seymouri 90% 100%
A0A0S4IX63 Bodo saltans 34% 96%
A0A0S4J7A1 Bodo saltans 26% 100%
A0A0S4KNR5 Bodo saltans 68% 92%
A0A1X0NNS8 Trypanosomatidae 78% 100%
A0A3Q8IVH0 Leishmania donovani 31% 100%
A0A3R7KX47 Trypanosoma rangeli 26% 100%
A0A3R7M7V4 Trypanosoma rangeli 77% 100%
A0A3S5H6K1 Leishmania donovani 95% 100%
A0A3S7WPD8 Leishmania donovani 28% 100%
A0B5B1 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 28% 100%
A0LU50 Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B) 28% 98%
A0QFB5 Mycobacterium avium (strain 104) 28% 93%
A0QZ47 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 26% 93%
A0RXV1 Cenarchaeum symbiosum (strain A) 25% 100%
A1RSJ8 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 30% 100%
A1RX71 Thermofilum pendens (strain DSM 2475 / Hrk 5) 31% 100%
A1UHS7 Mycobacterium sp. (strain KMS) 26% 93%
A1XQU1 Sus scrofa 32% 100%
A2SS78 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 27% 100%
A3CUS9 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 27% 100%
A3DN27 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 28% 100%
A3MXQ6 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 29% 100%
A3Q193 Mycobacterium sp. (strain JLS) 26% 93%
A4FBY1 Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) 28% 100%
A4H6R7 Leishmania braziliensis 91% 100%
A4HN55 Leishmania braziliensis 30% 100%
A4HP29 Leishmania braziliensis 32% 94%
A4HSQ5 Leishmania infantum 28% 100%
A4HV47 Leishmania infantum 95% 100%
A4IBS2 Leishmania infantum 31% 100%
A4TB64 Mycolicibacterium gilvum (strain PYR-GCK) 28% 93%
A4WMZ0 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 28% 100%
A4X744 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) 28% 100%
A4YIE0 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 27% 100%
A5UJS2 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 26% 100%
A5UM14 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 27% 100%
A7I841 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 28% 100%
A7KE01 Salmo salar 38% 100%
A7KII6 Salmo salar 38% 100%
A8AA46 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 28% 100%
A8AB58 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 27% 100%
A9A2U7 Nitrosopumilus maritimus (strain SCM1) 28% 100%
A9A4A1 Nitrosopumilus maritimus (strain SCM1) 27% 100%
A9WSI1 Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) 27% 100%
B1L6X8 Korarchaeum cryptofilum (strain OPF8) 24% 100%
B1MAI2 Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) 30% 97%
B1YDJ0 Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) 30% 100%
B8D673 Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) 24% 100%
B8D683 Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) 28% 100%
B8GG66 Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) 30% 100%
B9LTS6 Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) 25% 100%
C1ASP7 Rhodococcus opacus (strain B4) 27% 96%
C3MRE5 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 25% 100%
C3MY41 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 25% 100%
C3MZI0 Sulfolobus islandicus (strain M.16.27) 25% 100%
C3N7K2 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 25% 100%
C3NFX2 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 25% 100%
C4KIR0 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 25% 100%
C6A3R1 Thermococcus sibiricus (strain DSM 12597 / MM 739) 29% 100%
C6WID8 Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) 28% 100%
C7LYP7 Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP) 25% 100%
C9Z4D0 Streptomyces scabiei (strain 87.22) 28% 100%
C9ZQD9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
C9ZTA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0KRX1 Saccharolobus solfataricus (strain 98/2) 26% 100%
D0LDT1 Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667) 26% 97%
D2PDG6 Sulfolobus islandicus (strain L.D.8.5 / Lassen #2) 25% 100%
D2RGT4 Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18) 28% 100%
D3RX66 Ferroglobus placidus (strain DSM 10642 / AEDII12DO) 29% 100%
E9AFK8 Leishmania major 33% 100%
E9AKP2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6R2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
O09061 Mus musculus 26% 100%
O24361 Spinacia oleracea 31% 100%
O24733 Thermococcus sp. (strain JCM 11816 / KS-1) 24% 100%
O35521 Mus terricolor 41% 100%
O35522 Mus musculus bactrianus 41% 100%
O35523 Mus platythrix 40% 100%
O35524 Mus spicilegus 41% 100%
O43063 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 55% 100%
O50110 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 30% 100%
O55234 Mus musculus 28% 100%
O57983 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 27% 100%
O73817 Oncorhynchus mykiss 22% 100%
O82531 Petunia hybrida 26% 100%
P18421 Rattus norvegicus 26% 100%
P28065 Homo sapiens 44% 100%
P28072 Homo sapiens 47% 100%
P28073 Rattus norvegicus 48% 100%
P28074 Homo sapiens 27% 100%
P28075 Rattus norvegicus 27% 100%
P28076 Mus musculus 41% 100%
P28077 Rattus norvegicus 42% 100%
P30656 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 99%
P34286 Caenorhabditis elegans 23% 100%
P40112 Rattus norvegicus 22% 100%
P40304 Drosophila melanogaster 28% 100%
P42742 Arabidopsis thaliana 26% 100%
Q09841 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
Q0SIF9 Rhodococcus jostii (strain RHA1) 27% 96%
Q0W2D6 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 28% 100%
Q1B797 Mycobacterium sp. (strain MCS) 26% 93%
Q2J9Q3 Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3) 28% 100%
Q32KL2 Bos taurus 28% 100%
Q3MHN0 Bos taurus 48% 100%
Q3SZC2 Bos taurus 42% 100%
Q3T112 Bos taurus 27% 100%
Q47NZ4 Thermobifida fusca (strain YX) 30% 100%
Q4JAA8 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 30% 100%
Q4QGU1 Leishmania major 96% 100%
Q4QJ65 Leishmania major 28% 100%
Q53079 Rhodococcus erythropolis 27% 96%
Q54QR2 Dictyostelium discoideum 37% 100%
Q55GJ6 Dictyostelium discoideum 50% 100%
Q5JIU9 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 24% 100%
Q5R8S2 Pongo abelii 27% 100%
Q5W416 Canis lupus familiaris 28% 100%
Q5YUX2 Nocardia farcinica (strain IFM 10152) 27% 98%
Q60692 Mus musculus 46% 100%
Q73YW8 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 28% 93%
Q82JE3 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 24% 100%
Q86A21 Dictyostelium discoideum 28% 100%
Q8LD27 Arabidopsis thaliana 42% 100%
Q8TPX5 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 26% 100%
Q8TW10 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 26% 100%
Q8TYB7 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 25% 100%
Q8U4C9 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 30% 100%
Q8UW64 Oryzias latipes 43% 100%
Q8ZST5 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 27% 100%
Q975D1 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 28% 100%
Q980L4 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 26% 100%
Q9DD33 Salmo salar 45% 100%
Q9P996 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 27% 100%
Q9PT26 Oncorhynchus mykiss 45% 100%
Q9R1P1 Mus musculus 22% 100%
Q9U794 Trypanosoma brucei brucei 26% 100%
Q9V0N9 Pyrococcus abyssi (strain GE5 / Orsay) 29% 100%
Q9V247 Pyrococcus abyssi (strain GE5 / Orsay) 27% 100%
Q9YER0 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 26% 100%
Q9YES4 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 25% 100%
V5BHX1 Trypanosoma cruzi 76% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS