LeishMANIAdb
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PITH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PITH domain-containing protein
Gene product:
PITH domain-containing protein
Species:
Leishmania mexicana
UniProt:
E9ANS7_LEIMU
TriTrypDb:
LmxM.12.0020
Length:
215

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANS7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANS7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 209 213 PF00082 0.656
DOC_CDC14_PxL_1 76 84 PF14671 0.469
DOC_MAPK_gen_1 103 110 PF00069 0.584
DOC_MAPK_MEF2A_6 103 110 PF00069 0.584
DOC_PP1_RVXF_1 86 93 PF00149 0.552
DOC_PP2B_LxvP_1 27 30 PF13499 0.545
DOC_PP4_FxxP_1 92 95 PF00568 0.585
DOC_USP7_MATH_1 10 14 PF00917 0.718
DOC_USP7_MATH_1 66 70 PF00917 0.504
DOC_WW_Pin1_4 45 50 PF00397 0.597
LIG_APCC_ABBA_1 172 177 PF00400 0.533
LIG_APCC_ABBAyCdc20_2 171 177 PF00400 0.518
LIG_BRCT_BRCA1_1 152 156 PF00533 0.584
LIG_FHA_1 165 171 PF00498 0.512
LIG_FHA_1 187 193 PF00498 0.613
LIG_FHA_2 46 52 PF00498 0.566
LIG_LIR_Apic_2 91 95 PF02991 0.613
LIG_Pex14_2 158 162 PF04695 0.502
LIG_TRAF2_1 204 207 PF00917 0.591
MOD_CK1_1 149 155 PF00069 0.535
MOD_CK1_1 45 51 PF00069 0.561
MOD_CK2_1 201 207 PF00069 0.711
MOD_CK2_1 45 51 PF00069 0.524
MOD_GlcNHglycan 36 40 PF01048 0.355
MOD_GlcNHglycan 60 63 PF01048 0.369
MOD_GlcNHglycan 77 80 PF01048 0.358
MOD_GSK3_1 146 153 PF00069 0.556
MOD_GSK3_1 158 165 PF00069 0.556
MOD_GSK3_1 176 183 PF00069 0.682
MOD_GSK3_1 6 13 PF00069 0.682
MOD_N-GLC_1 162 167 PF02516 0.264
MOD_N-GLC_1 58 63 PF02516 0.199
MOD_N-GLC_1 96 101 PF02516 0.408
MOD_NEK2_1 158 163 PF00069 0.526
MOD_NEK2_1 42 47 PF00069 0.547
MOD_NEK2_1 75 80 PF00069 0.595
MOD_PK_1 147 153 PF00069 0.552
MOD_Plk_1 158 164 PF00069 0.519
MOD_Plk_1 35 41 PF00069 0.566
MOD_Plk_2-3 207 213 PF00069 0.588
MOD_Plk_4 152 158 PF00069 0.556
MOD_Plk_4 207 213 PF00069 0.710
MOD_Plk_4 88 94 PF00069 0.560
MOD_ProDKin_1 45 51 PF00069 0.597
MOD_SUMO_rev_2 201 211 PF00179 0.671
TRG_DiLeu_BaLyEn_6 77 82 PF01217 0.469
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.756

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5T0 Leptomonas seymouri 75% 100%
A0A0S4KLB0 Bodo saltans 42% 98%
A0A1X0NNQ9 Trypanosomatidae 51% 100%
A0A3S7WRT2 Leishmania donovani 94% 100%
A0A422N6F9 Trypanosoma rangeli 55% 100%
A4H6R6 Leishmania braziliensis 86% 100%
A4HV46 Leishmania infantum 94% 75%
C9ZQE0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
Q4QGU2 Leishmania major 94% 100%
Q6DJI5 Xenopus laevis 30% 100%
Q8BWR2 Mus musculus 28% 100%
Q9GZP4 Homo sapiens 28% 100%
Q9SQZ9 Arabidopsis thaliana 28% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS