Ribosomal protein L4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L4/L1 family, putative

Species:

Leishmania mexicana

UniProt:

E9ANS3_LEIMU

TriTrypDb:

LmxM.11.1360

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

E9ANS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANS3

PDB structure(s): 7aih_B , 7am2_B , 7ane_B

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.328
CLV_NRD_NRD_1	166	168	PF00675	0.328
CLV_NRD_NRD_1	427	429	PF00675	0.578
CLV_PCSK_SKI1_1	148	152	PF00082	0.328
CLV_PCSK_SKI1_1	179	183	PF00082	0.475
CLV_PCSK_SKI1_1	264	268	PF00082	0.328
CLV_PCSK_SKI1_1	359	363	PF00082	0.592
CLV_PCSK_SKI1_1	423	427	PF00082	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DEG_SCF_FBW7_2	256	261	PF00400	0.328
DOC_CYCLIN_yClb5_NLxxxL_5	123	129	PF00134	0.443
DOC_MAPK_gen_1	198	206	PF00069	0.344
DOC_MAPK_gen_1	304	312	PF00069	0.337
DOC_MAPK_MEF2A_6	198	206	PF00069	0.330
DOC_PP2B_LxvP_1	219	222	PF13499	0.449
DOC_PP4_MxPP_1	347	350	PF00568	0.507
DOC_USP7_MATH_1	40	44	PF00917	0.554
DOC_USP7_UBL2_3	194	198	PF12436	0.363
DOC_USP7_UBL2_3	297	301	PF12436	0.363
DOC_WW_Pin1_4	254	259	PF00397	0.328
DOC_WW_Pin1_4	47	52	PF00397	0.449
LIG_14-3-3_CanoR_1	201	207	PF00244	0.328
LIG_14-3-3_CanoR_1	218	222	PF00244	0.328
LIG_14-3-3_CanoR_1	428	433	PF00244	0.561
LIG_AP2alpha_2	108	110	PF02296	0.363
LIG_BIR_III_2	11	15	PF00653	0.350
LIG_Clathr_ClatBox_1	333	337	PF01394	0.385
LIG_deltaCOP1_diTrp_1	145	154	PF00928	0.328
LIG_FHA_1	102	108	PF00498	0.365
LIG_FHA_1	188	194	PF00498	0.332
LIG_FHA_1	323	329	PF00498	0.455
LIG_FHA_1	340	346	PF00498	0.276
LIG_FHA_1	62	68	PF00498	0.549
LIG_FHA_1	74	80	PF00498	0.420
LIG_FHA_2	218	224	PF00498	0.328
LIG_G3BP_FGDF_1	266	271	PF02136	0.328
LIG_IBAR_NPY_1	399	401	PF08397	0.439
LIG_Integrin_isoDGR_2	273	275	PF01839	0.328
LIG_LIR_Apic_2	19	25	PF02991	0.544
LIG_LIR_Gen_1	227	236	PF02991	0.344
LIG_LIR_Nem_3	126	130	PF02991	0.391
LIG_LIR_Nem_3	227	232	PF02991	0.328
LIG_LIR_Nem_3	430	435	PF02991	0.435
LIG_Pex14_2	110	114	PF04695	0.477
LIG_Pex14_2	135	139	PF04695	0.418
LIG_Pex14_2	267	271	PF04695	0.348
LIG_Rb_LxCxE_1	282	300	PF01857	0.385
LIG_REV1ctd_RIR_1	269	279	PF16727	0.344
LIG_SH2_CRK	318	322	PF00017	0.449
LIG_SH2_CRK	397	401	PF00017	0.559
LIG_SH2_GRB2like	141	144	PF00017	0.566
LIG_SH2_GRB2like	397	400	PF00017	0.589
LIG_SH2_NCK_1	262	266	PF00017	0.449
LIG_SH2_NCK_1	397	401	PF00017	0.559
LIG_SH2_SRC	397	400	PF00017	0.571
LIG_SH2_SRC	52	55	PF00017	0.470
LIG_SH2_STAP1	262	266	PF00017	0.449
LIG_SH2_STAP1	341	345	PF00017	0.444
LIG_SH2_STAP1	412	416	PF00017	0.490
LIG_SH2_STAT5	229	232	PF00017	0.344
LIG_SH2_STAT5	341	344	PF00017	0.561
LIG_SH2_STAT5	424	427	PF00017	0.540
LIG_SH2_STAT5	52	55	PF00017	0.467
LIG_SH2_STAT5	62	65	PF00017	0.411
LIG_SH2_STAT5	81	84	PF00017	0.428
LIG_SH3_1	397	403	PF00018	0.562
LIG_SH3_2	400	405	PF14604	0.480
LIG_SH3_3	177	183	PF00018	0.328
LIG_SH3_3	397	403	PF00018	0.460
LIG_SH3_3	41	47	PF00018	0.468
LIG_SH3_3	48	54	PF00018	0.431
LIG_SH3_3	65	71	PF00018	0.410
LIG_SUMO_SIM_par_1	324	330	PF11976	0.413
LIG_TRAF2_1	224	227	PF00917	0.331
LIG_TYR_ITIM	125	130	PF00017	0.406
LIG_UBA3_1	187	194	PF00899	0.340
LIG_UBA3_1	202	207	PF00899	0.293
LIG_WRC_WIRS_1	268	273	PF05994	0.328
MOD_CDC14_SPxK_1	55	58	PF00782	0.441
MOD_CDK_SPxK_1	52	58	PF00069	0.441
MOD_CK1_1	254	260	PF00069	0.328
MOD_CK1_1	4	10	PF00069	0.553
MOD_CK1_1	427	433	PF00069	0.503
MOD_CK2_1	217	223	PF00069	0.344
MOD_GlcNHglycan	6	9	PF01048	0.494
MOD_GSK3_1	192	199	PF00069	0.328
MOD_GSK3_1	293	300	PF00069	0.449
MOD_GSK3_1	322	329	PF00069	0.475
MOD_GSK3_1	339	346	PF00069	0.276
MOD_GSK3_1	424	431	PF00069	0.551
MOD_N-GLC_1	123	128	PF02516	0.381
MOD_N-GLC_1	133	138	PF02516	0.401
MOD_N-GLC_1	291	296	PF02516	0.344
MOD_N-GLC_1	99	104	PF02516	0.471
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	202	207	PF00069	0.328
MOD_NEK2_1	232	237	PF00069	0.385
MOD_NEK2_1	267	272	PF00069	0.336
MOD_NEK2_1	73	78	PF00069	0.425
MOD_PIKK_1	222	228	PF00454	0.328
MOD_PKA_1	428	434	PF00069	0.482
MOD_PKA_2	217	223	PF00069	0.344
MOD_PKA_2	279	285	PF00069	0.328
MOD_PKA_2	292	298	PF00069	0.328
MOD_PKA_2	4	10	PF00069	0.505
MOD_PKA_2	427	433	PF00069	0.546
MOD_Plk_1	123	129	PF00069	0.386
MOD_Plk_1	40	46	PF00069	0.577
MOD_Plk_1	408	414	PF00069	0.516
MOD_Plk_2-3	217	223	PF00069	0.328
MOD_Plk_4	123	129	PF00069	0.402
MOD_Plk_4	267	273	PF00069	0.328
MOD_Plk_4	279	285	PF00069	0.328
MOD_Plk_4	322	328	PF00069	0.428
MOD_Plk_4	343	349	PF00069	0.564
MOD_ProDKin_1	254	260	PF00069	0.328
MOD_ProDKin_1	47	53	PF00069	0.453
TRG_DiLeu_BaEn_2	105	111	PF01217	0.362
TRG_ENDOCYTIC_2	127	130	PF00928	0.391
TRG_ENDOCYTIC_2	229	232	PF00928	0.344
TRG_ENDOCYTIC_2	318	321	PF00928	0.344
TRG_NLS_MonoExtC_3	147	152	PF00514	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F3	Leptomonas seymouri	90%	95%
A0A0S4JS84	Bodo saltans	66%	94%
A0A1X0NV94	Trypanosomatidae	75%	95%
A0A3S5H6K0	Leishmania donovani	98%	100%
A0A422N538	Trypanosoma rangeli	74%	95%
A4H6Q8	Leishmania braziliensis	96%	100%
A4HV42	Leishmania infantum	97%	100%
D0A7A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	95%
Q4QGU6	Leishmania major	98%	100%
V5BRW7	Trypanosoma cruzi	76%	95%