Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANS2_LEIMU

TriTrypDb:

LmxM.11.1350

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.646
CLV_NRD_NRD_1	143	145	PF00675	0.616
CLV_NRD_NRD_1	2	4	PF00675	0.770
CLV_PCSK_KEX2_1	14	16	PF00082	0.646
CLV_PCSK_KEX2_1	143	145	PF00082	0.602
CLV_PCSK_KEX2_1	2	4	PF00082	0.770
CLV_PCSK_PC7_1	139	145	PF00082	0.633
CLV_PCSK_SKI1_1	65	69	PF00082	0.649
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DOC_CKS1_1	74	79	PF01111	0.755
DOC_PP2B_LxvP_1	52	55	PF13499	0.544
DOC_USP7_MATH_1	191	195	PF00917	0.642
DOC_WW_Pin1_4	73	78	PF00397	0.753
DOC_WW_Pin1_4	89	94	PF00397	0.733
LIG_14-3-3_CanoR_1	115	125	PF00244	0.523
LIG_14-3-3_CanoR_1	17	22	PF00244	0.522
LIG_14-3-3_CanoR_1	2	9	PF00244	0.718
LIG_EVH1_1	52	56	PF00568	0.628
LIG_FHA_1	62	68	PF00498	0.716
LIG_FHA_1	95	101	PF00498	0.608
LIG_LIR_Gen_1	127	136	PF02991	0.455
LIG_LIR_Gen_1	178	187	PF02991	0.502
LIG_LIR_Gen_1	66	75	PF02991	0.642
LIG_LIR_Nem_3	124	128	PF02991	0.482
LIG_LIR_Nem_3	178	183	PF02991	0.523
LIG_LIR_Nem_3	57	62	PF02991	0.605
LIG_LIR_Nem_3	66	71	PF02991	0.563
LIG_LRP6_Inhibitor_1	109	115	PF00058	0.390
LIG_SH3_1	87	93	PF00018	0.778
LIG_SH3_3	19	25	PF00018	0.633
LIG_SH3_3	50	56	PF00018	0.653
LIG_SH3_3	68	74	PF00018	0.703
LIG_SH3_3	76	82	PF00018	0.638
LIG_SH3_3	87	93	PF00018	0.671
LIG_TRFH_1	59	63	PF08558	0.634
LIG_UBA3_1	169	176	PF00899	0.489
MOD_CK1_1	121	127	PF00069	0.454
MOD_GlcNHglycan	120	123	PF01048	0.588
MOD_GlcNHglycan	189	192	PF01048	0.591
MOD_GlcNHglycan	19	22	PF01048	0.604
MOD_GlcNHglycan	39	42	PF01048	0.532
MOD_GSK3_1	178	185	PF00069	0.483
MOD_GSK3_1	187	194	PF00069	0.599
MOD_GSK3_1	29	36	PF00069	0.739
MOD_GSK3_1	63	70	PF00069	0.607
MOD_N-GLC_1	33	38	PF02516	0.696
MOD_NEK2_1	116	121	PF00069	0.484
MOD_NEK2_1	37	42	PF00069	0.468
MOD_NEK2_2	63	68	PF00069	0.718
MOD_PKA_2	1	7	PF00069	0.695
MOD_PKB_1	15	23	PF00069	0.734
MOD_Plk_1	178	184	PF00069	0.523
MOD_Plk_1	47	53	PF00069	0.562
MOD_Plk_2-3	96	102	PF00069	0.629
MOD_Plk_4	33	39	PF00069	0.550
MOD_Plk_4	54	60	PF00069	0.631
MOD_Plk_4	63	69	PF00069	0.590
MOD_ProDKin_1	73	79	PF00069	0.753
MOD_ProDKin_1	89	95	PF00069	0.727
MOD_SUMO_for_1	103	106	PF00179	0.558
MOD_SUMO_rev_2	147	154	PF00179	0.570
MOD_SUMO_rev_2	172	177	PF00179	0.594
MOD_SUMO_rev_2	4	9	PF00179	0.676
TRG_DiLeu_BaEn_1	165	170	PF01217	0.468
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.611
TRG_ENDOCYTIC_2	128	131	PF00928	0.491
TRG_ENDOCYTIC_2	59	62	PF00928	0.586
TRG_ER_diArg_1	1	3	PF00400	0.770
TRG_ER_diArg_1	13	15	PF00400	0.628
TRG_ER_diArg_1	143	146	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P412	Leptomonas seymouri	50%	98%
A0A3Q8I940	Leishmania donovani	95%	100%
A4H6Q7	Leishmania braziliensis	77%	100%
A4HV41	Leishmania infantum	96%	100%
D0A7A7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QGU7	Leishmania major	92%	100%