Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like/Major Facilitator Superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9ANS1_LEIMU

TriTrypDb:

LmxM.11.1340

Length:

633

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 89
NetGPI	no	yes: 0, no: 89

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	83
GO:0110165	cellular anatomical entity	1	83
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9ANS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANS1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0022857	transmembrane transporter activity	2	41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.690
CLV_NRD_NRD_1	304	306	PF00675	0.418
CLV_NRD_NRD_1	489	491	PF00675	0.282
CLV_NRD_NRD_1	88	90	PF00675	0.337
CLV_PCSK_KEX2_1	304	306	PF00082	0.440
CLV_PCSK_KEX2_1	488	490	PF00082	0.268
CLV_PCSK_SKI1_1	157	161	PF00082	0.306
CLV_PCSK_SKI1_1	517	521	PF00082	0.455
CLV_PCSK_SKI1_1	621	625	PF00082	0.352
DEG_SCF_FBW7_2	294	301	PF00400	0.499
DEG_SPOP_SBC_1	544	548	PF00917	0.372
DOC_CDC14_PxL_1	497	505	PF14671	0.295
DOC_CKS1_1	295	300	PF01111	0.367
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.763
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.267
DOC_MAPK_gen_1	419	428	PF00069	0.455
DOC_MAPK_gen_1	89	96	PF00069	0.401
DOC_MAPK_HePTP_8	86	98	PF00069	0.364
DOC_MAPK_MEF2A_6	272	281	PF00069	0.385
DOC_MAPK_MEF2A_6	89	98	PF00069	0.404
DOC_PP1_RVXF_1	515	521	PF00149	0.181
DOC_PP2B_LxvP_1	210	213	PF13499	0.360
DOC_PP2B_LxvP_1	323	326	PF13499	0.787
DOC_PP2B_LxvP_1	498	501	PF13499	0.309
DOC_PP2B_LxvP_1	519	522	PF13499	0.276
DOC_PP4_FxxP_1	240	243	PF00568	0.498
DOC_PP4_FxxP_1	295	298	PF00568	0.465
DOC_PP4_FxxP_1	79	82	PF00568	0.315
DOC_USP7_MATH_1	452	456	PF00917	0.342
DOC_WW_Pin1_4	294	299	PF00397	0.358
DOC_WW_Pin1_4	48	53	PF00397	0.289
DOC_WW_Pin1_4	561	566	PF00397	0.351
LIG_14-3-3_CanoR_1	149	158	PF00244	0.387
LIG_14-3-3_CanoR_1	349	354	PF00244	0.753
LIG_14-3-3_CanoR_1	453	459	PF00244	0.332
LIG_14-3-3_CanoR_1	60	66	PF00244	0.367
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BIR_III_2	318	322	PF00653	0.558
LIG_BIR_III_4	4	8	PF00653	0.509
LIG_BRCT_BRCA1_1	134	138	PF00533	0.340
LIG_BRCT_BRCA1_1	253	257	PF00533	0.353
LIG_deltaCOP1_diTrp_1	24	31	PF00928	0.457
LIG_deltaCOP1_diTrp_1	274	281	PF00928	0.164
LIG_deltaCOP1_diTrp_1	422	431	PF00928	0.373
LIG_EH1_1	30	38	PF00400	0.277
LIG_FHA_1	139	145	PF00498	0.315
LIG_FHA_1	202	208	PF00498	0.380
LIG_FHA_1	215	221	PF00498	0.557
LIG_FHA_1	246	252	PF00498	0.290
LIG_FHA_1	254	260	PF00498	0.310
LIG_FHA_1	281	287	PF00498	0.373
LIG_FHA_1	289	295	PF00498	0.498
LIG_FHA_1	378	384	PF00498	0.709
LIG_FHA_1	460	466	PF00498	0.322
LIG_FHA_1	535	541	PF00498	0.260
LIG_FHA_1	597	603	PF00498	0.314
LIG_FHA_1	69	75	PF00498	0.357
LIG_FHA_1	81	87	PF00498	0.330
LIG_FHA_1	91	97	PF00498	0.439
LIG_FHA_2	350	356	PF00498	0.566
LIG_GBD_Chelix_1	123	131	PF00786	0.377
LIG_LIR_Apic_2	265	270	PF02991	0.424
LIG_LIR_Apic_2	77	82	PF02991	0.322
LIG_LIR_Gen_1	254	264	PF02991	0.398
LIG_LIR_Gen_1	289	298	PF02991	0.291
LIG_LIR_Gen_1	445	456	PF02991	0.279
LIG_LIR_Gen_1	462	471	PF02991	0.325
LIG_LIR_Nem_3	150	154	PF02991	0.483
LIG_LIR_Nem_3	164	168	PF02991	0.359
LIG_LIR_Nem_3	182	188	PF02991	0.263
LIG_LIR_Nem_3	254	260	PF02991	0.336
LIG_LIR_Nem_3	408	414	PF02991	0.485
LIG_LIR_Nem_3	445	451	PF02991	0.286
LIG_LIR_Nem_3	462	467	PF02991	0.333
LIG_LIR_Nem_3	48	53	PF02991	0.387
LIG_LYPXL_S_1	482	486	PF13949	0.184
LIG_LYPXL_yS_3	483	486	PF13949	0.384
LIG_MAD2	476	484	PF02301	0.193
LIG_PCNA_yPIPBox_3	374	383	PF02747	0.574
LIG_Pex14_1	107	111	PF04695	0.315
LIG_Pex14_1	27	31	PF04695	0.470
LIG_Pex14_1	424	428	PF04695	0.356
LIG_Pex14_2	181	185	PF04695	0.273
LIG_Pex14_2	240	244	PF04695	0.517
LIG_Pex14_2	253	257	PF04695	0.336
LIG_Pex14_2	520	524	PF04695	0.284
LIG_REV1ctd_RIR_1	178	185	PF16727	0.345
LIG_RPA_C_Fungi	485	497	PF08784	0.176
LIG_SH2_CRK	448	452	PF00017	0.332
LIG_SH2_CRK	554	558	PF00017	0.244
LIG_SH2_CRK	620	624	PF00017	0.334
LIG_SH2_PTP2	267	270	PF00017	0.508
LIG_SH2_SRC	267	270	PF00017	0.591
LIG_SH2_STAP1	198	202	PF00017	0.281
LIG_SH2_STAP1	554	558	PF00017	0.294
LIG_SH2_STAT5	177	180	PF00017	0.349
LIG_SH2_STAT5	209	212	PF00017	0.398
LIG_SH2_STAT5	21	24	PF00017	0.493
LIG_SH2_STAT5	267	270	PF00017	0.463
LIG_SH2_STAT5	558	561	PF00017	0.360
LIG_SH2_STAT5	78	81	PF00017	0.315
LIG_SH3_3	325	331	PF00018	0.668
LIG_SH3_3	382	388	PF00018	0.695
LIG_SH3_3	389	395	PF00018	0.397
LIG_SH3_3	503	509	PF00018	0.299
LIG_SH3_3	623	629	PF00018	0.552
LIG_SUMO_SIM_anti_2	536	543	PF11976	0.228
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.165
LIG_SUMO_SIM_par_1	536	543	PF11976	0.249
LIG_SUMO_SIM_par_1	93	100	PF11976	0.333
LIG_TYR_ITIM	207	212	PF00017	0.355
LIG_TYR_ITIM	409	414	PF00017	0.165
LIG_WRC_WIRS_1	148	153	PF05994	0.391
MOD_CDK_SPxxK_3	48	55	PF00069	0.314
MOD_CK1_1	132	138	PF00069	0.350
MOD_CK1_1	143	149	PF00069	0.374
MOD_CK1_1	377	383	PF00069	0.755
MOD_CK1_1	435	441	PF00069	0.336
MOD_CK1_1	442	448	PF00069	0.338
MOD_CK1_1	454	460	PF00069	0.361
MOD_CK1_1	48	54	PF00069	0.323
MOD_CK1_1	533	539	PF00069	0.354
MOD_CK1_1	543	549	PF00069	0.338
MOD_CK1_1	77	83	PF00069	0.326
MOD_CK2_1	134	140	PF00069	0.343
MOD_CK2_1	259	265	PF00069	0.311
MOD_CK2_1	304	310	PF00069	0.442
MOD_CK2_1	360	366	PF00069	0.600
MOD_CK2_1	59	65	PF00069	0.396
MOD_CMANNOS	424	427	PF00535	0.387
MOD_GlcNHglycan	120	123	PF01048	0.390
MOD_GlcNHglycan	134	137	PF01048	0.354
MOD_GlcNHglycan	198	201	PF01048	0.323
MOD_GlcNHglycan	306	309	PF01048	0.504
MOD_GlcNHglycan	434	437	PF01048	0.289
MOD_GlcNHglycan	471	474	PF01048	0.317
MOD_GSK3_1	112	119	PF00069	0.336
MOD_GSK3_1	134	141	PF00069	0.341
MOD_GSK3_1	143	150	PF00069	0.317
MOD_GSK3_1	435	442	PF00069	0.354
MOD_GSK3_1	452	459	PF00069	0.376
MOD_GSK3_1	530	537	PF00069	0.358
MOD_GSK3_1	539	546	PF00069	0.375
MOD_GSK3_1	552	559	PF00069	0.316
MOD_N-GLC_1	102	107	PF02516	0.406
MOD_N-GLC_1	442	447	PF02516	0.370
MOD_NEK2_1	118	123	PF00069	0.279
MOD_NEK2_1	134	139	PF00069	0.329
MOD_NEK2_1	168	173	PF00069	0.369
MOD_NEK2_1	196	201	PF00069	0.295
MOD_NEK2_1	251	256	PF00069	0.350
MOD_NEK2_1	259	264	PF00069	0.322
MOD_NEK2_1	286	291	PF00069	0.350
MOD_NEK2_1	45	50	PF00069	0.324
MOD_NEK2_1	456	461	PF00069	0.307
MOD_NEK2_1	539	544	PF00069	0.379
MOD_NEK2_1	545	550	PF00069	0.382
MOD_NEK2_1	556	561	PF00069	0.324
MOD_NEK2_1	59	64	PF00069	0.338
MOD_NEK2_1	619	624	PF00069	0.339
MOD_NEK2_1	97	102	PF00069	0.266
MOD_PIKK_1	129	135	PF00454	0.296
MOD_PIKK_1	59	65	PF00454	0.307
MOD_PKA_1	304	310	PF00069	0.547
MOD_PKA_2	304	310	PF00069	0.493
MOD_PKA_2	348	354	PF00069	0.718
MOD_PKA_2	393	399	PF00069	0.360
MOD_PKA_2	452	458	PF00069	0.417
MOD_PKA_2	59	65	PF00069	0.421
MOD_Plk_1	139	145	PF00069	0.355
MOD_Plk_1	19	25	PF00069	0.556
MOD_Plk_1	374	380	PF00069	0.644
MOD_Plk_1	442	448	PF00069	0.335
MOD_Plk_4	134	140	PF00069	0.339
MOD_Plk_4	161	167	PF00069	0.337
MOD_Plk_4	168	174	PF00069	0.362
MOD_Plk_4	246	252	PF00069	0.347
MOD_Plk_4	253	259	PF00069	0.342
MOD_Plk_4	435	441	PF00069	0.334
MOD_Plk_4	459	465	PF00069	0.298
MOD_Plk_4	534	540	PF00069	0.300
MOD_Plk_4	552	558	PF00069	0.333
MOD_Plk_4	74	80	PF00069	0.350
MOD_Plk_4	92	98	PF00069	0.302
MOD_ProDKin_1	294	300	PF00069	0.359
MOD_ProDKin_1	48	54	PF00069	0.340
MOD_ProDKin_1	561	567	PF00069	0.351
MOD_SUMO_for_1	54	57	PF00179	0.193
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.227
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.370
TRG_ENDOCYTIC_2	111	114	PF00928	0.403
TRG_ENDOCYTIC_2	177	180	PF00928	0.323
TRG_ENDOCYTIC_2	198	201	PF00928	0.330
TRG_ENDOCYTIC_2	209	212	PF00928	0.398
TRG_ENDOCYTIC_2	411	414	PF00928	0.188
TRG_ENDOCYTIC_2	448	451	PF00928	0.323
TRG_ENDOCYTIC_2	483	486	PF00928	0.295
TRG_ENDOCYTIC_2	554	557	PF00928	0.315
TRG_ENDOCYTIC_2	61	64	PF00928	0.385
TRG_ENDOCYTIC_2	620	623	PF00928	0.376
TRG_ENDOCYTIC_2	78	81	PF00928	0.307
TRG_ER_diArg_1	304	306	PF00400	0.599
TRG_ER_diArg_1	418	421	PF00400	0.199
TRG_ER_diArg_1	488	490	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.193

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	23%	100%
A0A0N1HZC2	Leptomonas seymouri	26%	100%
A0A0N1IKC5	Leptomonas seymouri	25%	100%
A0A0N1PB63	Leptomonas seymouri	24%	96%
A0A0N1PD04	Leptomonas seymouri	62%	99%
A0A0N1PFR4	Leptomonas seymouri	25%	96%
A0A1X0NKK0	Trypanosomatidae	23%	100%
A0A1X0NM09	Trypanosomatidae	24%	100%
A0A1X0NRW5	Trypanosomatidae	22%	91%
A0A1X0NVF9	Trypanosomatidae	47%	95%
A0A1X0NVM7	Trypanosomatidae	24%	98%
A0A1X0NZU2	Trypanosomatidae	26%	98%
A0A1X0NZW1	Trypanosomatidae	24%	100%
A0A381MMW5	Leishmania infantum	24%	96%
A0A3Q8IEC4	Leishmania donovani	24%	98%
A0A3Q8IF95	Leishmania donovani	22%	100%
A0A3Q8IIT5	Leishmania donovani	25%	94%
A0A3Q8ISY9	Leishmania donovani	24%	100%
A0A3R7KKN8	Trypanosoma rangeli	25%	100%
A0A3R7MAQ7	Trypanosoma rangeli	23%	90%
A0A3R7N3S6	Trypanosoma rangeli	47%	98%
A0A3R7N415	Trypanosoma rangeli	25%	100%
A0A3R7R443	Trypanosoma rangeli	24%	100%
A0A3S7WRJ4	Leishmania donovani	24%	99%
A0A3S7WRJ5	Leishmania donovani	25%	91%
A0A3S7WRS3	Leishmania donovani	87%	100%
A0A3S7WSR4	Leishmania donovani	25%	100%
A0A3S7WWU1	Leishmania donovani	23%	95%
A0A3S7X2G0	Leishmania donovani	24%	96%
A0A3S7X2K5	Leishmania donovani	25%	100%
A0A3S7XB11	Leishmania donovani	25%	100%
A0A422MSP6	Trypanosoma rangeli	22%	100%
A0A422MU68	Trypanosoma rangeli	25%	100%
A4H6J0	Leishmania braziliensis	24%	100%
A4H6J1	Leishmania braziliensis	24%	100%
A4H6Q5	Leishmania braziliensis	70%	100%
A4HC19	Leishmania braziliensis	23%	100%
A4HHG2	Leishmania braziliensis	24%	100%
A4HHG3	Leishmania braziliensis	24%	100%
A4HHG4	Leishmania braziliensis	25%	100%
A4HJW3	Leishmania braziliensis	23%	100%
A4HPE2	Leishmania braziliensis	26%	100%
A4HUX5	Leishmania infantum	24%	99%
A4HUX6	Leishmania infantum	25%	91%
A4HV40	Leishmania infantum	87%	100%
A4HZF5	Leishmania infantum	22%	100%
A4HZJ4	Leishmania infantum	23%	95%
A4I4L2	Leishmania infantum	25%	94%
A4I7C5	Leishmania infantum	24%	100%
A4ICI3	Leishmania infantum	24%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	93%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AE01	Leishmania major	24%	100%
E9AE09	Leishmania major	25%	100%
E9AE10	Leishmania major	25%	100%
E9AE11	Leishmania major	25%	100%
E9AGK5	Leishmania infantum	25%	100%
E9AHJ0	Leishmania infantum	24%	98%
E9AHJ1	Leishmania infantum	24%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	96%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q1E4	Leishmania major	25%	99%
Q4Q5T8	Leishmania major	23%	100%
Q4QC27	Leishmania major	22%	100%
Q4QFY5	Leishmania major	25%	100%
Q4QGU8	Leishmania major	83%	100%
Q4QH14	Leishmania major	25%	100%
Q4QH15	Leishmania major	24%	99%
V5B647	Trypanosoma cruzi	22%	100%
V5B983	Trypanosoma cruzi	23%	100%
V5BBB1	Trypanosoma cruzi	24%	100%
V5BQY6	Trypanosoma cruzi	24%	90%
V5BVP0	Trypanosoma cruzi	24%	100%
V5DT25	Trypanosoma cruzi	22%	100%