MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANR9_LEIMU

TriTrypDb:

LmxM.11.1320

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ANR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANR9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	287	289	PF00675	0.321
CLV_PCSK_KEX2_1	283	285	PF00082	0.344
CLV_PCSK_KEX2_1	287	289	PF00082	0.371
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.369
CLV_PCSK_SKI1_1	130	134	PF00082	0.435
DOC_CYCLIN_RxL_1	127	136	PF00134	0.392
DOC_MAPK_FxFP_2	66	69	PF00069	0.174
DOC_MAPK_gen_1	287	295	PF00069	0.593
DOC_PP2B_LxvP_1	140	143	PF13499	0.480
DOC_PP4_FxxP_1	380	383	PF00568	0.564
DOC_PP4_FxxP_1	66	69	PF00568	0.413
DOC_USP7_MATH_1	205	209	PF00917	0.550
DOC_USP7_MATH_1	319	323	PF00917	0.338
DOC_USP7_MATH_1	49	53	PF00917	0.434
DOC_WW_Pin1_4	14	19	PF00397	0.726
LIG_14-3-3_CanoR_1	111	116	PF00244	0.390
LIG_14-3-3_CanoR_1	127	133	PF00244	0.278
LIG_14-3-3_CanoR_1	197	202	PF00244	0.579
LIG_14-3-3_CanoR_1	206	214	PF00244	0.545
LIG_14-3-3_CanoR_1	385	392	PF00244	0.558
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BRCT_BRCA1_1	113	117	PF00533	0.343
LIG_Clathr_ClatBox_1	334	338	PF01394	0.362
LIG_eIF4E_1	330	336	PF01652	0.298
LIG_eIF4E_1	401	407	PF01652	0.471
LIG_eIF4E_1	62	68	PF01652	0.312
LIG_FHA_1	127	133	PF00498	0.483
LIG_FHA_1	142	148	PF00498	0.635
LIG_FHA_1	186	192	PF00498	0.290
LIG_FHA_1	198	204	PF00498	0.625
LIG_FHA_1	304	310	PF00498	0.268
LIG_FHA_1	365	371	PF00498	0.534
LIG_FHA_1	372	378	PF00498	0.557
LIG_FHA_1	406	412	PF00498	0.483
LIG_FHA_1	414	420	PF00498	0.538
LIG_FHA_1	432	438	PF00498	0.281
LIG_FHA_1	71	77	PF00498	0.459
LIG_FHA_1	79	85	PF00498	0.582
LIG_FHA_2	294	300	PF00498	0.444
LIG_LIR_Gen_1	228	238	PF02991	0.423
LIG_LIR_Gen_1	408	413	PF02991	0.506
LIG_LIR_LC3C_4	17	21	PF02991	0.496
LIG_LIR_Nem_3	228	233	PF02991	0.355
LIG_LIR_Nem_3	408	412	PF02991	0.469
LIG_LYPXL_SIV_4	256	264	PF13949	0.266
LIG_MLH1_MIPbox_1	113	117	PF16413	0.343
LIG_NRBOX	190	196	PF00104	0.224
LIG_PTB_Apo_2	120	127	PF02174	0.275
LIG_RPA_C_Fungi	194	206	PF08784	0.506
LIG_SH2_CRK	253	257	PF00017	0.438
LIG_SH2_CRK	395	399	PF00017	0.373
LIG_SH2_NCK_1	421	425	PF00017	0.381
LIG_SH2_PTP2	401	404	PF00017	0.457
LIG_SH2_PTP2	409	412	PF00017	0.420
LIG_SH2_STAP1	211	215	PF00017	0.484
LIG_SH2_STAT5	401	404	PF00017	0.457
LIG_SH2_STAT5	409	412	PF00017	0.420
LIG_SH2_STAT5	413	416	PF00017	0.439
LIG_SH2_STAT5	50	53	PF00017	0.477
LIG_SH3_3	18	24	PF00018	0.319
LIG_SH3_3	241	247	PF00018	0.374
LIG_SH3_3	270	276	PF00018	0.378
LIG_SH3_3	325	331	PF00018	0.453
LIG_SH3_3	334	340	PF00018	0.385
LIG_SH3_3	48	54	PF00018	0.499
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.359
LIG_SUMO_SIM_par_1	102	107	PF11976	0.409
LIG_SUMO_SIM_par_1	17	23	PF11976	0.438
LIG_SUMO_SIM_par_1	198	204	PF11976	0.619
LIG_SUMO_SIM_par_1	33	39	PF11976	0.266
LIG_SUMO_SIM_par_1	333	338	PF11976	0.415
LIG_TRAF2_1	207	210	PF00917	0.477
LIG_TRAF2_1	351	354	PF00917	0.467
LIG_TYR_ITIM	399	404	PF00017	0.323
LIG_UBA3_1	369	378	PF00899	0.386
LIG_WRC_WIRS_1	437	442	PF05994	0.673
MOD_CK1_1	435	441	PF00069	0.525
MOD_CK1_1	52	58	PF00069	0.367
MOD_CK1_1	97	103	PF00069	0.343
MOD_CK2_1	274	280	PF00069	0.271
MOD_CK2_1	293	299	PF00069	0.308
MOD_GlcNHglycan	146	150	PF01048	0.529
MOD_GlcNHglycan	161	164	PF01048	0.331
MOD_GlcNHglycan	359	362	PF01048	0.533
MOD_GlcNHglycan	38	41	PF01048	0.368
MOD_GlcNHglycan	54	57	PF01048	0.461
MOD_GlcNHglycan	84	87	PF01048	0.416
MOD_GlcNHglycan	99	102	PF01048	0.411
MOD_GSK3_1	141	148	PF00069	0.550
MOD_GSK3_1	197	204	PF00069	0.550
MOD_GSK3_1	413	420	PF00069	0.340
MOD_GSK3_1	431	438	PF00069	0.335
MOD_GSK3_1	78	85	PF00069	0.418
MOD_GSK3_1	90	97	PF00069	0.248
MOD_N-GLC_1	417	422	PF02516	0.249
MOD_NEK2_1	106	111	PF00069	0.423
MOD_NEK2_1	116	121	PF00069	0.353
MOD_NEK2_1	126	131	PF00069	0.240
MOD_NEK2_1	133	138	PF00069	0.306
MOD_NEK2_1	159	164	PF00069	0.426
MOD_NEK2_1	195	200	PF00069	0.499
MOD_NEK2_1	236	241	PF00069	0.329
MOD_NEK2_1	303	308	PF00069	0.213
MOD_NEK2_1	411	416	PF00069	0.298
MOD_NEK2_1	431	436	PF00069	0.359
MOD_NEK2_1	71	76	PF00069	0.322
MOD_NEK2_1	82	87	PF00069	0.371
MOD_NEK2_1	90	95	PF00069	0.281
MOD_PIKK_1	106	112	PF00454	0.448
MOD_PIKK_1	205	211	PF00454	0.429
MOD_PIKK_1	371	377	PF00454	0.489
MOD_PK_1	4	10	PF00069	0.668
MOD_PK_1	400	406	PF00069	0.486
MOD_PKA_2	126	132	PF00069	0.313
MOD_PKA_2	205	211	PF00069	0.446
MOD_Plk_1	417	423	PF00069	0.364
MOD_Plk_4	111	117	PF00069	0.442
MOD_Plk_4	128	134	PF00069	0.267
MOD_Plk_4	185	191	PF00069	0.306
MOD_Plk_4	274	280	PF00069	0.453
MOD_Plk_4	313	319	PF00069	0.269
MOD_Plk_4	330	336	PF00069	0.194
MOD_Plk_4	405	411	PF00069	0.450
MOD_Plk_4	425	431	PF00069	0.335
MOD_Plk_4	71	77	PF00069	0.463
MOD_ProDKin_1	14	20	PF00069	0.666
MOD_SUMO_rev_2	298	304	PF00179	0.373
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.460
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.377
TRG_ENDOCYTIC_2	153	156	PF00928	0.413
TRG_ENDOCYTIC_2	401	404	PF00928	0.457
TRG_ENDOCYTIC_2	409	412	PF00928	0.420
TRG_ENDOCYTIC_2	50	53	PF00928	0.440
TRG_ER_diArg_1	196	199	PF00400	0.445
TRG_ER_diArg_1	287	289	PF00400	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ5	Leptomonas seymouri	53%	100%
A0A1X0NUV1	Trypanosomatidae	25%	95%
A0A3Q8I960	Leishmania donovani	90%	100%
A0A3R7NA95	Trypanosoma rangeli	24%	100%
A4H6Q3	Leishmania braziliensis	72%	100%
A4HV38	Leishmania infantum	89%	100%
D0A7B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	96%
Q4QGV0	Leishmania major	88%	100%
V5C1D7	Trypanosoma cruzi	24%	95%