Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANR8_LEIMU

TriTrypDb:

LmxM.11.1310

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.505
CLV_NRD_NRD_1	61	63	PF00675	0.451
CLV_NRD_NRD_1	7	9	PF00675	0.540
CLV_PCSK_KEX2_1	278	280	PF00082	0.505
CLV_PCSK_KEX2_1	6	8	PF00082	0.542
CLV_PCSK_KEX2_1	61	63	PF00082	0.436
CLV_PCSK_KEX2_1	86	88	PF00082	0.510
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.504
CLV_PCSK_SKI1_1	133	137	PF00082	0.551
CLV_PCSK_SKI1_1	180	184	PF00082	0.468
CLV_PCSK_SKI1_1	227	231	PF00082	0.405
CLV_PCSK_SKI1_1	341	345	PF00082	0.401
CLV_PCSK_SKI1_1	393	397	PF00082	0.538
CLV_PCSK_SKI1_1	62	66	PF00082	0.505
DEG_APCC_DBOX_1	340	348	PF00400	0.395
DEG_APCC_DBOX_1	364	372	PF00400	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DEG_SPOP_SBC_1	145	149	PF00917	0.422
DOC_CDC14_PxL_1	96	104	PF14671	0.497
DOC_CYCLIN_RxL_1	224	234	PF00134	0.452
DOC_CYCLIN_RxL_1	59	67	PF00134	0.533
DOC_MAPK_gen_1	115	124	PF00069	0.405
DOC_MAPK_HePTP_8	114	126	PF00069	0.476
DOC_MAPK_MEF2A_6	115	124	PF00069	0.464
DOC_MAPK_NFAT4_5	117	125	PF00069	0.493
DOC_USP7_MATH_2	13	19	PF00917	0.531
DOC_WW_Pin1_4	154	159	PF00397	0.614
DOC_WW_Pin1_4	19	24	PF00397	0.566
DOC_WW_Pin1_4	41	46	PF00397	0.580
LIG_14-3-3_CanoR_1	361	365	PF00244	0.507
LIG_14-3-3_CanoR_1	370	377	PF00244	0.494
LIG_Actin_WH2_2	225	243	PF00022	0.532
LIG_APCC_ABBA_1	80	85	PF00400	0.525
LIG_EH1_1	88	96	PF00400	0.247
LIG_FHA_1	129	135	PF00498	0.470
LIG_FHA_1	155	161	PF00498	0.579
LIG_FHA_1	212	218	PF00498	0.428
LIG_FHA_1	224	230	PF00498	0.368
LIG_FHA_1	247	253	PF00498	0.359
LIG_FHA_1	298	304	PF00498	0.398
LIG_FHA_1	357	363	PF00498	0.519
LIG_FHA_1	370	376	PF00498	0.454
LIG_FHA_2	311	317	PF00498	0.393
LIG_FHA_2	361	367	PF00498	0.503
LIG_GBD_Chelix_1	175	183	PF00786	0.473
LIG_LIR_Apic_2	39	45	PF02991	0.460
LIG_LIR_Gen_1	54	65	PF02991	0.420
LIG_LIR_Gen_1	93	103	PF02991	0.496
LIG_LIR_Nem_3	49	55	PF02991	0.438
LIG_LIR_Nem_3	93	99	PF02991	0.396
LIG_MAD2	393	401	PF02301	0.579
LIG_PCNA_yPIPBox_3	250	261	PF02747	0.238
LIG_PCNA_yPIPBox_3	86	99	PF02747	0.249
LIG_PDZ_Class_2	397	402	PF00595	0.630
LIG_SH2_CRK	57	61	PF00017	0.528
LIG_SH2_CRK	96	100	PF00017	0.503
LIG_SH2_NCK_1	306	310	PF00017	0.486
LIG_SH2_NCK_1	352	356	PF00017	0.482
LIG_SH2_PTP2	42	45	PF00017	0.594
LIG_SH2_STAP1	306	310	PF00017	0.486
LIG_SH2_STAT3	327	330	PF00017	0.548
LIG_SH2_STAT5	42	45	PF00017	0.603
LIG_SH3_3	322	328	PF00018	0.535
LIG_SH3_3	35	41	PF00018	0.512
LIG_SUMO_SIM_par_1	372	379	PF11976	0.276
LIG_SUMO_SIM_par_1	99	105	PF11976	0.499
LIG_TYR_ITIM	94	99	PF00017	0.401
LIG_UBA3_1	102	108	PF00899	0.535
MOD_CK1_1	213	219	PF00069	0.504
MOD_CK1_1	297	303	PF00069	0.459
MOD_CK1_1	44	50	PF00069	0.542
MOD_CK2_1	101	107	PF00069	0.522
MOD_CK2_1	310	316	PF00069	0.383
MOD_CK2_1	334	340	PF00069	0.470
MOD_CK2_1	360	366	PF00069	0.521
MOD_Cter_Amidation	276	279	PF01082	0.416
MOD_GlcNHglycan	109	113	PF01048	0.502
MOD_GlcNHglycan	148	151	PF01048	0.523
MOD_GlcNHglycan	223	226	PF01048	0.376
MOD_GlcNHglycan	24	27	PF01048	0.634
MOD_GlcNHglycan	306	309	PF01048	0.459
MOD_GSK3_1	15	22	PF00069	0.541
MOD_GSK3_1	211	218	PF00069	0.493
MOD_GSK3_1	356	363	PF00069	0.535
MOD_N-GLC_1	297	302	PF02516	0.515
MOD_NEK2_1	146	151	PF00069	0.724
MOD_NEK2_1	192	197	PF00069	0.448
MOD_NEK2_1	210	215	PF00069	0.501
MOD_NEK2_1	294	299	PF00069	0.525
MOD_NEK2_1	386	391	PF00069	0.428
MOD_NEK2_2	360	365	PF00069	0.525
MOD_PIKK_1	128	134	PF00454	0.506
MOD_PIKK_1	215	221	PF00454	0.481
MOD_PIKK_1	272	278	PF00454	0.384
MOD_PIKK_1	386	392	PF00454	0.431
MOD_PKA_2	360	366	PF00069	0.533
MOD_PKA_2	369	375	PF00069	0.393
MOD_Plk_1	297	303	PF00069	0.510
MOD_Plk_2-3	334	340	PF00069	0.345
MOD_Plk_4	266	272	PF00069	0.467
MOD_Plk_4	286	292	PF00069	0.191
MOD_Plk_4	90	96	PF00069	0.380
MOD_ProDKin_1	154	160	PF00069	0.600
MOD_ProDKin_1	19	25	PF00069	0.551
MOD_ProDKin_1	41	47	PF00069	0.579
TRG_DiLeu_BaEn_1	266	271	PF01217	0.432
TRG_DiLeu_BaEn_1	340	345	PF01217	0.368
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.543
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.466
TRG_ENDOCYTIC_2	52	55	PF00928	0.451
TRG_ENDOCYTIC_2	57	60	PF00928	0.356
TRG_ENDOCYTIC_2	96	99	PF00928	0.392
TRG_ER_diArg_1	5	8	PF00400	0.538
TRG_ER_diArg_1	60	62	PF00400	0.461
TRG_NES_CRM1_1	366	381	PF08389	0.480
TRG_NLS_MonoExtN_4	393	400	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVS3	Leptomonas seymouri	65%	99%
A0A0S4KKN0	Bodo saltans	33%	100%
A0A1X0NUU6	Trypanosomatidae	37%	100%
A0A3R7M4V0	Trypanosoma rangeli	37%	100%
A0A3S7WRS2	Leishmania donovani	91%	100%
A4H6Q2	Leishmania braziliensis	82%	100%
A4HV37	Leishmania infantum	91%	100%
D0A7B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	76%
Q4QGV1	Leishmania major	92%	100%
V5BWJ3	Trypanosoma cruzi	37%	100%