Putative S-phase kinase-associated protein (Putative skp1 family protein) (Cyclin a/cdk2-associated protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKP1-like protein

Species:

Leishmania mexicana

UniProt:

E9ANR0_LEIMU

TriTrypDb:

LmxM.11.1210

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANR0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	10
GO:0016567	protein ubiquitination	7	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0032446	protein modification by small protein conjugation	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0097602	cullin family protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	133	137	PF00082	0.272
CLV_PCSK_SKI1_1	156	160	PF00082	0.199
CLV_PCSK_SKI1_1	43	47	PF00082	0.207
CLV_PCSK_SKI1_1	67	71	PF00082	0.244
CLV_PCSK_SKI1_1	86	90	PF00082	0.521
DEG_APCC_DBOX_1	66	74	PF00400	0.466
DOC_CYCLIN_RxL_1	150	162	PF00134	0.399
DOC_MAPK_MEF2A_6	115	123	PF00069	0.472
DOC_USP7_MATH_1	36	40	PF00917	0.417
DOC_USP7_MATH_1	59	63	PF00917	0.410
DOC_WW_Pin1_4	163	168	PF00397	0.419
LIG_14-3-3_CanoR_1	148	155	PF00244	0.410
LIG_Clathr_ClatBox_1	158	162	PF01394	0.399
LIG_deltaCOP1_diTrp_1	98	105	PF00928	0.536
LIG_EVH1_2	25	29	PF00568	0.441
LIG_FHA_1	63	69	PF00498	0.446
LIG_FHA_2	164	170	PF00498	0.401
LIG_FHA_2	88	94	PF00498	0.610
LIG_LIR_Gen_1	14	23	PF02991	0.242
LIG_LIR_Nem_3	10	16	PF02991	0.464
LIG_LIR_Nem_3	71	75	PF02991	0.510
LIG_Pex14_1	99	103	PF04695	0.476
LIG_SH2_CRK	16	20	PF00017	0.267
LIG_SH2_STAT5	16	19	PF00017	0.518
LIG_SH3_3	77	83	PF00018	0.627
LIG_SUMO_SIM_par_1	134	139	PF11976	0.399
LIG_TRAF2_1	166	169	PF00917	0.399
LIG_UBA3_1	104	110	PF00899	0.550
MOD_CK1_1	32	38	PF00069	0.503
MOD_CK1_1	62	68	PF00069	0.410
MOD_CK2_1	163	169	PF00069	0.399
MOD_CK2_1	87	93	PF00069	0.612
MOD_GlcNHglycan	34	37	PF01048	0.210
MOD_GlcNHglycan	38	41	PF01048	0.189
MOD_GlcNHglycan	61	64	PF01048	0.210
MOD_GSK3_1	32	39	PF00069	0.498
MOD_GSK3_1	87	94	PF00069	0.535
MOD_N-GLC_1	59	64	PF02516	0.229
MOD_NEK2_1	136	141	PF00069	0.405
MOD_PIKK_1	11	17	PF00454	0.623
MOD_Plk_1	11	17	PF00069	0.638
MOD_Plk_4	142	148	PF00069	0.410
MOD_Plk_4	91	97	PF00069	0.509
MOD_ProDKin_1	163	169	PF00069	0.419
MOD_SUMO_rev_2	164	173	PF00179	0.399
MOD_SUMO_rev_2	23	32	PF00179	0.423
TRG_ENDOCYTIC_2	16	19	PF00928	0.498
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSC5	Leptomonas seymouri	95%	100%
A0A0N1I7P1	Leptomonas seymouri	23%	77%
A0A0S4IX54	Bodo saltans	33%	97%
A0A0S4J0Y1	Bodo saltans	33%	100%
A0A0S4J983	Bodo saltans	30%	71%
A0A0S4JSD6	Bodo saltans	32%	74%
A0A0S4KKL0	Bodo saltans	73%	100%
A0A1X0NIG1	Trypanosomatidae	26%	100%
A0A1X0NUV8	Trypanosomatidae	76%	100%
A0A3S7WRR3	Leishmania donovani	99%	100%
A0A422NRM4	Trypanosoma rangeli	74%	100%
A0A422NZK1	Trypanosoma rangeli	27%	100%
A0PGB3	Tetrahymena thermophila (strain SB210)	47%	100%
A1C9U5	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	39%	100%
A1CZG3	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	39%	100%
A4H6P1	Leishmania braziliensis	96%	100%
A4HJZ3	Leishmania braziliensis	25%	100%
A4HV28	Leishmania infantum	99%	100%
B0Y3B5	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	39%	100%
B6QGB9	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	39%	100%
B8MDP8	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	39%	100%
B8NSJ0	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	39%	100%
C5FHU9	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	38%	100%
D0A7C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D4ARL8	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	39%	100%
G5ECU1	Caenorhabditis elegans	40%	100%
O49484	Arabidopsis thaliana	40%	100%
O65674	Arabidopsis thaliana	39%	100%
O81055	Arabidopsis thaliana	37%	100%
O81057	Arabidopsis thaliana	37%	100%
O81058	Arabidopsis thaliana	36%	92%
P52285	Dictyostelium discoideum	41%	100%
P52286	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	94%
P63208	Homo sapiens	40%	100%
P63209	Cavia porcellus	40%	100%
Q0CA59	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	39%	100%
Q1PEL7	Arabidopsis thaliana	40%	100%
Q39255	Arabidopsis thaliana	38%	100%
Q3ZCF3	Bos taurus	40%	100%
Q4QGW1	Leishmania major	99%	100%
Q4R5B9	Macaca fascicularis	40%	100%
Q4WTT8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	100%
Q557E4	Dictyostelium discoideum	42%	100%
Q5BAX8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	40%	100%
Q5KU00	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	39%	100%
Q5R512	Pongo abelii	40%	100%
Q5ZKF5	Gallus gallus	40%	100%
Q651E8	Oryza sativa subsp. japonica	41%	100%
Q6H4D6	Oryza sativa subsp. japonica	39%	100%
Q6PEC4	Rattus norvegicus	40%	100%
Q6PL11	Oryza sativa subsp. japonica	40%	100%
Q71U00	Xenopus laevis	40%	100%
Q8NK13	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q8TGW7	Arthroderma otae	37%	100%
Q9FHW7	Arabidopsis thaliana	37%	100%
Q9LNT9	Arabidopsis thaliana	39%	100%
Q9LSX8	Arabidopsis thaliana	39%	100%
Q9LSX9	Arabidopsis thaliana	38%	100%
Q9LSY1	Arabidopsis thaliana	35%	100%
Q9M1X4	Arabidopsis thaliana	37%	100%
Q9M1X5	Arabidopsis thaliana	40%	100%
Q9SL65	Arabidopsis thaliana	32%	100%
Q9SL93	Arabidopsis thaliana	39%	100%
Q9SY65	Arabidopsis thaliana	37%	100%
Q9WTX5	Mus musculus	40%	100%
Q9Y709	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
V5BRY3	Trypanosoma cruzi	76%	100%