Cytochrome c oxidase assembly protein COX18, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANQ7_LEIMU

TriTrypDb:

LmxM.11.1180

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ANQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0032978	protein insertion into membrane from inner side	6	1
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140597	protein carrier chaperone	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.570
CLV_NRD_NRD_1	262	264	PF00675	0.455
CLV_NRD_NRD_1	409	411	PF00675	0.452
CLV_PCSK_KEX2_1	219	221	PF00082	0.255
CLV_PCSK_KEX2_1	262	264	PF00082	0.455
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.255
CLV_PCSK_SKI1_1	119	123	PF00082	0.558
CLV_PCSK_SKI1_1	174	178	PF00082	0.329
CLV_PCSK_SKI1_1	220	224	PF00082	0.255
CLV_PCSK_SKI1_1	230	234	PF00082	0.255
CLV_PCSK_SKI1_1	243	247	PF00082	0.271
CLV_PCSK_SKI1_1	280	284	PF00082	0.480
CLV_PCSK_SKI1_1	367	371	PF00082	0.337
CLV_Separin_Metazoa	144	148	PF03568	0.348
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DOC_CDC14_PxL_1	176	184	PF14671	0.358
DOC_CDC14_PxL_1	271	279	PF14671	0.266
DOC_CKS1_1	25	30	PF01111	0.453
DOC_CYCLIN_RxL_1	171	181	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.314
DOC_MAPK_FxFP_2	370	373	PF00069	0.548
DOC_MAPK_gen_1	147	157	PF00069	0.376
DOC_MAPK_gen_1	311	321	PF00069	0.455
DOC_MAPK_gen_1	57	67	PF00069	0.471
DOC_MAPK_MEF2A_6	326	335	PF00069	0.358
DOC_MAPK_MEF2A_6	60	69	PF00069	0.470
DOC_MIT_MIM_1	168	178	PF04212	0.265
DOC_PP1_RVXF_1	72	79	PF00149	0.425
DOC_PP2B_LxvP_1	282	285	PF13499	0.262
DOC_PP4_FxxP_1	135	138	PF00568	0.346
DOC_PP4_FxxP_1	249	252	PF00568	0.382
DOC_PP4_FxxP_1	370	373	PF00568	0.537
DOC_USP7_MATH_1	117	121	PF00917	0.370
DOC_USP7_MATH_1	12	16	PF00917	0.491
DOC_USP7_MATH_1	378	382	PF00917	0.630
DOC_USP7_UBL2_3	219	223	PF12436	0.455
DOC_WW_Pin1_4	24	29	PF00397	0.524
LIG_14-3-3_CanoR_1	174	179	PF00244	0.299
LIG_14-3-3_CanoR_1	186	190	PF00244	0.455
LIG_14-3-3_CanoR_1	212	222	PF00244	0.469
LIG_14-3-3_CanoR_1	31	41	PF00244	0.493
LIG_14-3-3_CanoR_1	311	321	PF00244	0.455
LIG_14-3-3_CanoR_1	326	331	PF00244	0.390
LIG_14-3-3_CanoR_1	414	422	PF00244	0.674
LIG_14-3-3_CanoR_1	60	67	PF00244	0.509
LIG_14-3-3_CanoR_1	74	79	PF00244	0.378
LIG_AP2alpha_1	366	370	PF02296	0.550
LIG_BRCT_BRCA1_1	340	344	PF00533	0.266
LIG_BRCT_BRCA1_1	43	47	PF00533	0.404
LIG_Clathr_ClatBox_1	300	304	PF01394	0.334
LIG_deltaCOP1_diTrp_1	126	135	PF00928	0.339
LIG_EVH1_1	372	376	PF00568	0.543
LIG_FHA_1	15	21	PF00498	0.444
LIG_FHA_1	248	254	PF00498	0.299
LIG_FHA_1	286	292	PF00498	0.255
LIG_FHA_1	350	356	PF00498	0.314
LIG_FHA_2	107	113	PF00498	0.467
LIG_FHA_2	267	273	PF00498	0.271
LIG_FHA_2	281	287	PF00498	0.230
LIG_FHA_2	397	403	PF00498	0.634
LIG_LIR_Apic_2	112	117	PF02991	0.400
LIG_LIR_Apic_2	134	138	PF02991	0.358
LIG_LIR_Apic_2	247	252	PF02991	0.382
LIG_LIR_Apic_2	286	292	PF02991	0.255
LIG_LIR_Apic_2	368	373	PF02991	0.551
LIG_LIR_Gen_1	120	128	PF02991	0.335
LIG_LIR_Gen_1	152	159	PF02991	0.423
LIG_LIR_Gen_1	224	233	PF02991	0.466
LIG_LIR_Gen_1	256	266	PF02991	0.346
LIG_LIR_Gen_1	391	398	PF02991	0.678
LIG_LIR_Gen_1	42	51	PF02991	0.470
LIG_LIR_Gen_1	426	436	PF02991	0.631
LIG_LIR_Nem_3	120	125	PF02991	0.337
LIG_LIR_Nem_3	152	157	PF02991	0.405
LIG_LIR_Nem_3	240	245	PF02991	0.584
LIG_LIR_Nem_3	256	261	PF02991	0.290
LIG_LIR_Nem_3	368	372	PF02991	0.552
LIG_LIR_Nem_3	391	396	PF02991	0.684
LIG_LIR_Nem_3	42	46	PF02991	0.479
LIG_LIR_Nem_3	426	431	PF02991	0.622
LIG_LIR_Nem_3	77	81	PF02991	0.491
LIG_NRP_CendR_1	444	445	PF00754	0.555
LIG_Pex14_1	131	135	PF04695	0.364
LIG_Pex14_1	162	166	PF04695	0.255
LIG_Pex14_2	245	249	PF04695	0.382
LIG_Pex14_2	299	303	PF04695	0.299
LIG_Pex14_2	366	370	PF04695	0.525
LIG_Pex14_2	43	47	PF04695	0.443
LIG_SH2_CRK	289	293	PF00017	0.334
LIG_SH2_NCK_1	289	293	PF00017	0.419
LIG_SH2_NCK_1	428	432	PF00017	0.682
LIG_SH2_PTP2	114	117	PF00017	0.463
LIG_SH2_STAP1	267	271	PF00017	0.255
LIG_SH2_STAP1	393	397	PF00017	0.682
LIG_SH2_STAP1	428	432	PF00017	0.615
LIG_SH2_STAT5	114	117	PF00017	0.463
LIG_SH2_STAT5	320	323	PF00017	0.455
LIG_SH2_STAT5	334	337	PF00017	0.351
LIG_SH3_3	22	28	PF00018	0.476
LIG_SH3_3	370	376	PF00018	0.545
LIG_SxIP_EBH_1	172	186	PF03271	0.334
LIG_TRAF2_1	398	401	PF00917	0.566
LIG_UBA3_1	383	388	PF00899	0.635
LIG_WRC_WIRS_1	154	159	PF05994	0.372
LIG_WRC_WIRS_1	246	251	PF05994	0.266
MOD_CDK_SPxxK_3	24	31	PF00069	0.453
MOD_CK1_1	15	21	PF00069	0.418
MOD_CK1_1	181	187	PF00069	0.467
MOD_CK1_1	199	205	PF00069	0.467
MOD_CK1_1	244	250	PF00069	0.317
MOD_CK1_1	45	51	PF00069	0.425
MOD_CK2_1	117	123	PF00069	0.365
MOD_CK2_1	212	218	PF00069	0.460
MOD_CK2_1	266	272	PF00069	0.258
MOD_CK2_1	388	394	PF00069	0.595
MOD_CK2_1	396	402	PF00069	0.590
MOD_GlcNHglycan	14	17	PF01048	0.712
MOD_GlcNHglycan	215	218	PF01048	0.297
MOD_GlcNHglycan	255	258	PF01048	0.299
MOD_GlcNHglycan	314	317	PF01048	0.296
MOD_GlcNHglycan	340	343	PF01048	0.468
MOD_GlcNHglycan	417	420	PF01048	0.449
MOD_GlcNHglycan	57	60	PF01048	0.750
MOD_GlcNHglycan	62	65	PF01048	0.710
MOD_GSK3_1	15	22	PF00069	0.419
MOD_GSK3_1	174	181	PF00069	0.299
MOD_GSK3_1	237	244	PF00069	0.591
MOD_GSK3_1	247	254	PF00069	0.301
MOD_GSK3_1	378	385	PF00069	0.621
MOD_GSK3_1	41	48	PF00069	0.455
MOD_GSK3_1	55	62	PF00069	0.483
MOD_NEK2_1	19	24	PF00069	0.539
MOD_NEK2_1	2	7	PF00069	0.522
MOD_NEK2_1	245	250	PF00069	0.343
MOD_NEK2_1	46	51	PF00069	0.486
MOD_NEK2_2	117	122	PF00069	0.375
MOD_NEK2_2	257	262	PF00069	0.299
MOD_PIKK_1	237	243	PF00454	0.486
MOD_PIKK_1	396	402	PF00454	0.646
MOD_PKA_2	185	191	PF00069	0.490
MOD_PKA_2	325	331	PF00069	0.433
MOD_PKA_2	59	65	PF00069	0.514
MOD_PKA_2	89	95	PF00069	0.428
MOD_Plk_1	117	123	PF00069	0.359
MOD_Plk_1	210	216	PF00069	0.455
MOD_Plk_1	280	286	PF00069	0.259
MOD_Plk_1	401	407	PF00069	0.642
MOD_Plk_4	117	123	PF00069	0.370
MOD_Plk_4	131	137	PF00069	0.356
MOD_Plk_4	15	21	PF00069	0.374
MOD_Plk_4	174	180	PF00069	0.305
MOD_Plk_4	241	247	PF00069	0.476
MOD_Plk_4	326	332	PF00069	0.334
MOD_Plk_4	388	394	PF00069	0.592
MOD_Plk_4	42	48	PF00069	0.376
MOD_ProDKin_1	24	30	PF00069	0.527
MOD_SUMO_rev_2	381	390	PF00179	0.644
TRG_DiLeu_BaEn_2	271	277	PF01217	0.255
TRG_DiLeu_BaEn_4	401	407	PF01217	0.625
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.265
TRG_ENDOCYTIC_2	226	229	PF00928	0.466
TRG_ENDOCYTIC_2	393	396	PF00928	0.683
TRG_ENDOCYTIC_2	428	431	PF00928	0.614
TRG_ER_diArg_1	261	263	PF00400	0.255
TRG_NLS_Bipartite_1	219	239	PF00514	0.421
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y9	Leptomonas seymouri	85%	99%
A0A0S4IZY1	Bodo saltans	61%	100%
A0A1X0NWK5	Trypanosomatidae	71%	100%
A0A3R7NUU3	Trypanosoma rangeli	71%	100%
A0A3S7WRQ0	Leishmania donovani	94%	100%
A4H6P4	Leishmania braziliensis	89%	100%
A4HV25	Leishmania infantum	94%	100%
D0A7C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
Q4QGW4	Leishmania major	95%	100%
V5C1D0	Trypanosoma cruzi	75%	100%