LeishMANIAdb
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WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WD_REPEATS_REGION domain-containing protein
Gene product:
protein transport protein SEC31, putative
Species:
Leishmania mexicana
UniProt:
E9ANQ5_LEIMU
TriTrypDb:
LmxM.11.1160
Length:
1164

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 1
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 5
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5
GO:0110165 cellular anatomical entity 1 6
GO:0030117 membrane coat 3 1
GO:0030120 vesicle coat 4 1
GO:0030127 COPII vesicle coat 5 1
GO:0032991 protein-containing complex 1 1
GO:0070971 endoplasmic reticulum exit site 2 1
GO:0098796 membrane protein complex 2 1

Expansion

Sequence features

E9ANQ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANQ5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 6
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 5
GO:0009987 cellular process 1 6
GO:0016192 vesicle-mediated transport 4 5
GO:0046907 intracellular transport 3 6
GO:0048193 Golgi vesicle transport 5 5
GO:0051179 localization 1 6
GO:0051234 establishment of localization 2 6
GO:0051641 cellular localization 2 6
GO:0051649 establishment of localization in cell 3 6
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007029 endoplasmic reticulum organization 5 1
GO:0008104 protein localization 4 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0033036 macromolecule localization 2 1
GO:0035459 vesicle cargo loading 4 1
GO:0045184 establishment of protein localization 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090110 COPII-coated vesicle cargo loading 4 1
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 160 164 PF00656 0.469
CLV_NRD_NRD_1 1100 1102 PF00675 0.445
CLV_NRD_NRD_1 411 413 PF00675 0.354
CLV_NRD_NRD_1 534 536 PF00675 0.397
CLV_NRD_NRD_1 739 741 PF00675 0.462
CLV_PCSK_KEX2_1 1099 1101 PF00082 0.461
CLV_PCSK_KEX2_1 411 413 PF00082 0.354
CLV_PCSK_KEX2_1 491 493 PF00082 0.493
CLV_PCSK_KEX2_1 552 554 PF00082 0.420
CLV_PCSK_KEX2_1 739 741 PF00082 0.483
CLV_PCSK_PC1ET2_1 491 493 PF00082 0.493
CLV_PCSK_PC1ET2_1 552 554 PF00082 0.420
CLV_PCSK_SKI1_1 1043 1047 PF00082 0.529
CLV_PCSK_SKI1_1 120 124 PF00082 0.598
CLV_PCSK_SKI1_1 215 219 PF00082 0.422
CLV_PCSK_SKI1_1 411 415 PF00082 0.354
CLV_PCSK_SKI1_1 553 557 PF00082 0.406
CLV_PCSK_SKI1_1 577 581 PF00082 0.354
CLV_PCSK_SKI1_1 669 673 PF00082 0.492
CLV_PCSK_SKI1_1 702 706 PF00082 0.569
CLV_Separin_Metazoa 1123 1127 PF03568 0.262
CLV_Separin_Metazoa 532 536 PF03568 0.486
DEG_APCC_DBOX_1 119 127 PF00400 0.408
DEG_Nend_UBRbox_1 1 4 PF02207 0.372
DOC_CKS1_1 957 962 PF01111 0.569
DOC_CYCLIN_yCln2_LP_2 854 860 PF00134 0.604
DOC_MAPK_HePTP_8 502 514 PF00069 0.485
DOC_MAPK_MEF2A_6 505 514 PF00069 0.378
DOC_PP1_RVXF_1 118 125 PF00149 0.421
DOC_PP1_RVXF_1 71 77 PF00149 0.354
DOC_PP2B_LxvP_1 1034 1037 PF13499 0.512
DOC_PP2B_LxvP_1 779 782 PF13499 0.503
DOC_PP2B_LxvP_1 844 847 PF13499 0.643
DOC_PP2B_LxvP_1 854 857 PF13499 0.540
DOC_PP4_FxxP_1 1076 1079 PF00568 0.438
DOC_USP7_MATH_1 1005 1009 PF00917 0.668
DOC_USP7_MATH_1 1017 1021 PF00917 0.537
DOC_USP7_MATH_1 1054 1058 PF00917 0.606
DOC_USP7_MATH_1 26 30 PF00917 0.348
DOC_USP7_MATH_1 337 341 PF00917 0.350
DOC_USP7_MATH_1 441 445 PF00917 0.407
DOC_USP7_MATH_1 560 564 PF00917 0.413
DOC_USP7_MATH_1 769 773 PF00917 0.605
DOC_USP7_MATH_1 819 823 PF00917 0.738
DOC_USP7_MATH_1 848 852 PF00917 0.733
DOC_USP7_MATH_1 950 954 PF00917 0.600
DOC_USP7_MATH_1 982 986 PF00917 0.741
DOC_USP7_UBL2_3 366 370 PF12436 0.474
DOC_WW_Pin1_4 1006 1011 PF00397 0.646
DOC_WW_Pin1_4 1069 1074 PF00397 0.460
DOC_WW_Pin1_4 1075 1080 PF00397 0.389
DOC_WW_Pin1_4 1134 1139 PF00397 0.414
DOC_WW_Pin1_4 12 17 PF00397 0.330
DOC_WW_Pin1_4 401 406 PF00397 0.506
DOC_WW_Pin1_4 421 426 PF00397 0.439
DOC_WW_Pin1_4 74 79 PF00397 0.363
DOC_WW_Pin1_4 849 854 PF00397 0.536
DOC_WW_Pin1_4 877 882 PF00397 0.662
DOC_WW_Pin1_4 891 896 PF00397 0.669
DOC_WW_Pin1_4 897 902 PF00397 0.489
DOC_WW_Pin1_4 916 921 PF00397 0.639
DOC_WW_Pin1_4 956 961 PF00397 0.588
DOC_WW_Pin1_4 962 967 PF00397 0.615
LIG_14-3-3_CanoR_1 157 162 PF00244 0.522
LIG_14-3-3_CanoR_1 2 12 PF00244 0.435
LIG_14-3-3_CanoR_1 219 225 PF00244 0.392
LIG_14-3-3_CanoR_1 496 502 PF00244 0.520
LIG_Actin_WH2_2 201 217 PF00022 0.356
LIG_AP2alpha_1 519 523 PF02296 0.362
LIG_AP2alpha_2 480 482 PF02296 0.507
LIG_BRCT_BRCA1_1 39 43 PF00533 0.421
LIG_BRCT_BRCA1_1 562 566 PF00533 0.417
LIG_CSL_BTD_1 13 16 PF09270 0.320
LIG_CtBP_PxDLS_1 1121 1125 PF00389 0.403
LIG_deltaCOP1_diTrp_1 152 159 PF00928 0.523
LIG_EVH1_1 844 848 PF00568 0.639
LIG_FHA_1 164 170 PF00498 0.458
LIG_FHA_1 200 206 PF00498 0.341
LIG_FHA_1 243 249 PF00498 0.377
LIG_FHA_1 263 269 PF00498 0.421
LIG_FHA_1 275 281 PF00498 0.457
LIG_FHA_1 426 432 PF00498 0.424
LIG_FHA_1 495 501 PF00498 0.520
LIG_FHA_1 641 647 PF00498 0.389
LIG_FHA_1 691 697 PF00498 0.417
LIG_FHA_1 913 919 PF00498 0.544
LIG_FHA_1 926 932 PF00498 0.728
LIG_FHA_2 1100 1106 PF00498 0.391
LIG_FHA_2 147 153 PF00498 0.457
LIG_FHA_2 158 164 PF00498 0.521
LIG_FHA_2 347 353 PF00498 0.416
LIG_FHA_2 354 360 PF00498 0.544
LIG_FHA_2 387 393 PF00498 0.470
LIG_FHA_2 405 411 PF00498 0.459
LIG_FHA_2 432 438 PF00498 0.433
LIG_LIR_Apic_2 302 307 PF02991 0.457
LIG_LIR_Apic_2 77 82 PF02991 0.491
LIG_LIR_Gen_1 1141 1152 PF02991 0.492
LIG_LIR_Gen_1 40 51 PF02991 0.365
LIG_LIR_Gen_1 479 488 PF02991 0.526
LIG_LIR_Gen_1 952 960 PF02991 0.624
LIG_LIR_LC3C_4 245 249 PF02991 0.354
LIG_LIR_Nem_3 1141 1147 PF02991 0.492
LIG_LIR_Nem_3 325 331 PF02991 0.426
LIG_LIR_Nem_3 338 344 PF02991 0.284
LIG_LIR_Nem_3 40 46 PF02991 0.360
LIG_LIR_Nem_3 479 485 PF02991 0.518
LIG_LIR_Nem_3 563 569 PF02991 0.408
LIG_LIR_Nem_3 610 616 PF02991 0.346
LIG_LIR_Nem_3 75 79 PF02991 0.365
LIG_MYND_1 832 836 PF01753 0.640
LIG_MYND_1 856 860 PF01753 0.582
LIG_MYND_1 944 948 PF01753 0.613
LIG_Pex14_1 192 196 PF04695 0.356
LIG_Pex14_2 519 523 PF04695 0.362
LIG_PTB_Apo_2 1157 1164 PF02174 0.348
LIG_PTB_Phospho_1 1157 1163 PF10480 0.348
LIG_SH2_CRK 79 83 PF00017 0.502
LIG_SH2_CRK 811 815 PF00017 0.685
LIG_SH2_NCK_1 196 200 PF00017 0.354
LIG_SH2_SRC 196 199 PF00017 0.362
LIG_SH2_SRC 716 719 PF00017 0.670
LIG_SH2_SRC 805 808 PF00017 0.710
LIG_SH2_STAP1 196 200 PF00017 0.354
LIG_SH2_STAP1 994 998 PF00017 0.720
LIG_SH2_STAT5 322 325 PF00017 0.347
LIG_SH2_STAT5 541 544 PF00017 0.403
LIG_SH2_STAT5 616 619 PF00017 0.332
LIG_SH2_STAT5 682 685 PF00017 0.444
LIG_SH2_STAT5 703 706 PF00017 0.483
LIG_SH2_STAT5 716 719 PF00017 0.581
LIG_SH2_STAT5 805 808 PF00017 0.710
LIG_SH2_STAT5 96 99 PF00017 0.466
LIG_SH3_2 1038 1043 PF14604 0.559
LIG_SH3_3 1033 1039 PF00018 0.615
LIG_SH3_3 1047 1053 PF00018 0.644
LIG_SH3_3 138 144 PF00018 0.457
LIG_SH3_3 166 172 PF00018 0.442
LIG_SH3_3 327 333 PF00018 0.353
LIG_SH3_3 399 405 PF00018 0.607
LIG_SH3_3 62 68 PF00018 0.387
LIG_SH3_3 712 718 PF00018 0.580
LIG_SH3_3 765 771 PF00018 0.598
LIG_SH3_3 792 798 PF00018 0.537
LIG_SH3_3 822 828 PF00018 0.598
LIG_SH3_3 842 848 PF00018 0.700
LIG_SH3_3 850 856 PF00018 0.724
LIG_SH3_3 863 869 PF00018 0.628
LIG_SH3_3 892 898 PF00018 0.770
LIG_SH3_3 929 935 PF00018 0.641
LIG_SH3_3 936 942 PF00018 0.629
LIG_SH3_3 968 974 PF00018 0.696
LIG_SH3_3 993 999 PF00018 0.656
LIG_SUMO_SIM_anti_2 173 179 PF11976 0.413
LIG_SUMO_SIM_par_1 642 650 PF11976 0.392
LIG_TRAF2_1 286 289 PF00917 0.457
LIG_TRAF2_1 735 738 PF00917 0.482
LIG_TRAF2_2 1016 1021 PF00917 0.680
LIG_WW_3 1040 1044 PF00397 0.568
MOD_CDC14_SPxK_1 424 427 PF00782 0.417
MOD_CDK_SPxK_1 421 427 PF00069 0.431
MOD_CDK_SPxK_1 849 855 PF00069 0.521
MOD_CK1_1 1030 1036 PF00069 0.534
MOD_CK1_1 176 182 PF00069 0.510
MOD_CK1_1 226 232 PF00069 0.438
MOD_CK1_1 274 280 PF00069 0.273
MOD_CK1_1 384 390 PF00069 0.337
MOD_CK1_1 404 410 PF00069 0.523
MOD_CK1_1 913 919 PF00069 0.676
MOD_CK1_1 952 958 PF00069 0.629
MOD_CK1_1 985 991 PF00069 0.608
MOD_CK2_1 1099 1105 PF00069 0.397
MOD_CK2_1 283 289 PF00069 0.297
MOD_CK2_1 384 390 PF00069 0.390
MOD_CK2_1 431 437 PF00069 0.529
MOD_CK2_1 526 532 PF00069 0.410
MOD_CK2_1 96 102 PF00069 0.430
MOD_CMANNOS 156 159 PF00535 0.297
MOD_Cter_Amidation 309 312 PF01082 0.527
MOD_GlcNHglycan 1056 1059 PF01048 0.608
MOD_GlcNHglycan 1138 1141 PF01048 0.415
MOD_GlcNHglycan 131 134 PF01048 0.390
MOD_GlcNHglycan 183 186 PF01048 0.396
MOD_GlcNHglycan 272 276 PF01048 0.273
MOD_GlcNHglycan 30 33 PF01048 0.397
MOD_GlcNHglycan 386 389 PF01048 0.348
MOD_GlcNHglycan 443 446 PF01048 0.436
MOD_GlcNHglycan 470 473 PF01048 0.678
MOD_GlcNHglycan 502 505 PF01048 0.432
MOD_GlcNHglycan 528 531 PF01048 0.420
MOD_GlcNHglycan 562 565 PF01048 0.419
MOD_GlcNHglycan 580 583 PF01048 0.338
MOD_GlcNHglycan 654 657 PF01048 0.421
MOD_GlcNHglycan 802 805 PF01048 0.635
MOD_GlcNHglycan 901 904 PF01048 0.811
MOD_GlcNHglycan 910 913 PF01048 0.627
MOD_GlcNHglycan 98 101 PF01048 0.334
MOD_GSK3_1 1063 1070 PF00069 0.540
MOD_GSK3_1 1134 1141 PF00069 0.503
MOD_GSK3_1 24 31 PF00069 0.350
MOD_GSK3_1 274 281 PF00069 0.297
MOD_GSK3_1 283 290 PF00069 0.301
MOD_GSK3_1 372 379 PF00069 0.454
MOD_GSK3_1 401 408 PF00069 0.580
MOD_GSK3_1 421 428 PF00069 0.442
MOD_GSK3_1 441 448 PF00069 0.411
MOD_GSK3_1 719 726 PF00069 0.570
MOD_GSK3_1 867 874 PF00069 0.643
MOD_GSK3_1 904 911 PF00069 0.637
MOD_GSK3_1 912 919 PF00069 0.648
MOD_GSK3_1 949 956 PF00069 0.622
MOD_GSK3_1 958 965 PF00069 0.633
MOD_GSK3_1 994 1001 PF00069 0.638
MOD_N-GLC_1 223 228 PF02516 0.412
MOD_N-GLC_1 36 41 PF02516 0.440
MOD_N-GLC_1 376 381 PF02516 0.445
MOD_N-GLC_1 877 882 PF02516 0.662
MOD_N-GLC_1 913 918 PF02516 0.530
MOD_N-GLC_2 1160 1162 PF02516 0.325
MOD_N-GLC_2 92 94 PF02516 0.339
MOD_NEK2_1 1067 1072 PF00069 0.529
MOD_NEK2_1 146 151 PF00069 0.297
MOD_NEK2_1 223 228 PF00069 0.412
MOD_NEK2_1 24 29 PF00069 0.344
MOD_NEK2_1 292 297 PF00069 0.310
MOD_NEK2_1 3 8 PF00069 0.349
MOD_NEK2_1 345 350 PF00069 0.411
MOD_NEK2_1 378 383 PF00069 0.319
MOD_NEK2_1 431 436 PF00069 0.564
MOD_NEK2_1 500 505 PF00069 0.422
MOD_NEK2_1 646 651 PF00069 0.403
MOD_NEK2_1 882 887 PF00069 0.511
MOD_NEK2_1 908 913 PF00069 0.676
MOD_PIKK_1 1138 1144 PF00454 0.498
MOD_PIKK_1 242 248 PF00454 0.370
MOD_PIKK_1 425 431 PF00454 0.417
MOD_PIKK_1 647 653 PF00454 0.418
MOD_PIKK_1 782 788 PF00454 0.704
MOD_PIKK_1 819 825 PF00454 0.667
MOD_PIKK_1 982 988 PF00454 0.616
MOD_PIKK_1 998 1004 PF00454 0.600
MOD_PKA_1 1099 1105 PF00069 0.397
MOD_PKA_2 1099 1105 PF00069 0.397
MOD_PKA_2 218 224 PF00069 0.398
MOD_PKA_2 431 437 PF00069 0.411
MOD_PKA_2 495 501 PF00069 0.427
MOD_PKA_2 633 639 PF00069 0.400
MOD_Plk_1 288 294 PF00069 0.297
MOD_Plk_1 376 382 PF00069 0.438
MOD_Plk_1 425 431 PF00069 0.428
MOD_Plk_1 913 919 PF00069 0.603
MOD_Plk_4 1027 1033 PF00069 0.654
MOD_Plk_4 1063 1069 PF00069 0.586
MOD_Plk_4 173 179 PF00069 0.435
MOD_Plk_4 204 210 PF00069 0.237
MOD_Plk_4 288 294 PF00069 0.297
MOD_Plk_4 640 646 PF00069 0.418
MOD_Plk_4 830 836 PF00069 0.664
MOD_Plk_4 871 877 PF00069 0.671
MOD_ProDKin_1 1006 1012 PF00069 0.646
MOD_ProDKin_1 1069 1075 PF00069 0.462
MOD_ProDKin_1 1134 1140 PF00069 0.406
MOD_ProDKin_1 12 18 PF00069 0.342
MOD_ProDKin_1 401 407 PF00069 0.494
MOD_ProDKin_1 421 427 PF00069 0.431
MOD_ProDKin_1 74 80 PF00069 0.370
MOD_ProDKin_1 849 855 PF00069 0.536
MOD_ProDKin_1 877 883 PF00069 0.660
MOD_ProDKin_1 891 897 PF00069 0.666
MOD_ProDKin_1 916 922 PF00069 0.639
MOD_ProDKin_1 956 962 PF00069 0.591
MOD_SUMO_rev_2 45 54 PF00179 0.386
MOD_SUMO_rev_2 743 750 PF00179 0.469
TRG_DiLeu_BaEn_3 1122 1128 PF01217 0.396
TRG_DiLeu_BaEn_4 507 513 PF01217 0.375
TRG_DiLeu_BaLyEn_6 20 25 PF01217 0.373
TRG_DiLeu_BaLyEn_6 340 345 PF01217 0.366
TRG_DiLeu_BaLyEn_6 565 570 PF01217 0.421
TRG_ENDOCYTIC_2 196 199 PF00928 0.362
TRG_ENDOCYTIC_2 954 957 PF00928 0.724
TRG_ER_diArg_1 1098 1101 PF00400 0.466
TRG_ER_diArg_1 411 413 PF00400 0.354
TRG_ER_diArg_1 64 67 PF00400 0.381
TRG_ER_diArg_1 739 742 PF00400 0.466
TRG_NES_CRM1_1 578 590 PF08389 0.469
TRG_NES_CRM1_1 58 69 PF08389 0.392
TRG_Pf-PMV_PEXEL_1 311 315 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 567 571 PF00026 0.405
TRG_Pf-PMV_PEXEL_1 742 746 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2K3 Leptomonas seymouri 65% 97%
A0A3S5H6J7 Leishmania donovani 94% 100%
A1DHK2 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 23% 92%
A4H6N8 Leishmania braziliensis 80% 99%
F4ICD9 Arabidopsis thaliana 26% 100%
Q3UPL0 Mus musculus 24% 95%
Q4QGW6 Leishmania major 92% 99%
Q4X0M4 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 92%
Q5F3X8 Gallus gallus 24% 95%
Q7SYD5 Danio rerio 23% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS