Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANQ2_LEIMU

TriTrypDb:

LmxM.11.1090

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ANQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.457
CLV_C14_Caspase3-7	184	188	PF00656	0.424
CLV_C14_Caspase3-7	327	331	PF00656	0.378
CLV_NRD_NRD_1	223	225	PF00675	0.669
CLV_NRD_NRD_1	235	237	PF00675	0.603
CLV_NRD_NRD_1	325	327	PF00675	0.632
CLV_PCSK_FUR_1	233	237	PF00082	0.583
CLV_PCSK_KEX2_1	223	225	PF00082	0.688
CLV_PCSK_KEX2_1	235	237	PF00082	0.615
CLV_PCSK_KEX2_1	324	326	PF00082	0.635
CLV_PCSK_KEX2_1	443	445	PF00082	0.708
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.708
CLV_PCSK_SKI1_1	236	240	PF00082	0.684
DOC_CKS1_1	66	71	PF01111	0.492
DOC_MAPK_MEF2A_6	401	409	PF00069	0.514
DOC_PP2B_LxvP_1	180	183	PF13499	0.470
DOC_PP4_FxxP_1	239	242	PF00568	0.498
DOC_PP4_FxxP_1	448	451	PF00568	0.403
DOC_USP7_MATH_1	146	150	PF00917	0.514
DOC_USP7_MATH_1	214	218	PF00917	0.563
DOC_USP7_MATH_1	242	246	PF00917	0.488
DOC_USP7_MATH_1	34	38	PF00917	0.504
DOC_USP7_UBL2_3	335	339	PF12436	0.435
DOC_WW_Pin1_4	57	62	PF00397	0.482
DOC_WW_Pin1_4	65	70	PF00397	0.488
DOC_WW_Pin1_4	74	79	PF00397	0.512
LIG_14-3-3_CanoR_1	241	247	PF00244	0.422
LIG_14-3-3_CanoR_1	433	438	PF00244	0.320
LIG_Actin_WH2_2	419	435	PF00022	0.359
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_BIR_III_4	187	191	PF00653	0.485
LIG_BRCT_BRCA1_1	262	266	PF00533	0.529
LIG_BRCT_BRCA1_1	396	400	PF00533	0.578
LIG_FHA_1	25	31	PF00498	0.493
LIG_FHA_1	445	451	PF00498	0.415
LIG_FHA_2	325	331	PF00498	0.378
LIG_LIR_Apic_2	228	234	PF02991	0.307
LIG_LIR_Apic_2	445	451	PF02991	0.387
LIG_LIR_Gen_1	245	253	PF02991	0.214
LIG_LIR_Gen_1	370	378	PF02991	0.338
LIG_LIR_Gen_1	434	441	PF02991	0.387
LIG_LIR_LC3C_4	283	286	PF02991	0.219
LIG_LIR_Nem_3	245	249	PF02991	0.236
LIG_LIR_Nem_3	263	269	PF02991	0.511
LIG_LIR_Nem_3	370	375	PF02991	0.350
LIG_LIR_Nem_3	434	440	PF02991	0.371
LIG_MLH1_MIPbox_1	396	400	PF16413	0.578
LIG_PCNA_yPIPBox_3	277	285	PF02747	0.627
LIG_Pex14_1	262	266	PF04695	0.529
LIG_Pex14_2	303	307	PF04695	0.284
LIG_SH2_CRK	231	235	PF00017	0.301
LIG_SH2_CRK	246	250	PF00017	0.268
LIG_SH2_CRK	253	257	PF00017	0.352
LIG_SH2_CRK	87	91	PF00017	0.443
LIG_SH2_GRB2like	313	316	PF00017	0.290
LIG_SH2_PTP2	269	272	PF00017	0.529
LIG_SH2_SRC	246	249	PF00017	0.314
LIG_SH2_SRC	437	440	PF00017	0.407
LIG_SH2_STAT5	231	234	PF00017	0.321
LIG_SH2_STAT5	253	256	PF00017	0.393
LIG_SH2_STAT5	269	272	PF00017	0.401
LIG_SH2_STAT5	273	276	PF00017	0.564
LIG_SH2_STAT5	299	302	PF00017	0.389
LIG_SH2_STAT5	360	363	PF00017	0.314
LIG_SH2_STAT5	399	402	PF00017	0.544
LIG_SH2_STAT5	427	430	PF00017	0.425
LIG_SH3_2	457	462	PF14604	0.357
LIG_SH3_3	176	182	PF00018	0.504
LIG_SH3_3	454	460	PF00018	0.417
LIG_SH3_3	66	72	PF00018	0.547
LIG_SH3_3	75	81	PF00018	0.465
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.421
LIG_SUMO_SIM_par_1	101	107	PF11976	0.450
LIG_SUMO_SIM_par_1	192	197	PF11976	0.456
LIG_SUMO_SIM_par_1	6	11	PF11976	0.430
LIG_TRAF2_1	451	454	PF00917	0.396
LIG_TYR_ITSM	433	440	PF00017	0.407
LIG_WRC_WIRS_1	372	377	PF05994	0.413
MOD_CDK_SPK_2	57	62	PF00069	0.473
MOD_CDK_SPK_2	68	73	PF00069	0.458
MOD_CK1_1	11	17	PF00069	0.477
MOD_CK1_1	24	30	PF00069	0.446
MOD_CK1_1	370	376	PF00069	0.447
MOD_CK2_1	206	212	PF00069	0.474
MOD_Cter_Amidation	441	444	PF01082	0.573
MOD_GlcNHglycan	1	4	PF01048	0.714
MOD_GlcNHglycan	10	13	PF01048	0.691
MOD_GlcNHglycan	152	157	PF01048	0.740
MOD_GlcNHglycan	166	170	PF01048	0.681
MOD_GlcNHglycan	315	318	PF01048	0.578
MOD_GlcNHglycan	367	370	PF01048	0.529
MOD_GlcNHglycan	396	399	PF01048	0.378
MOD_GlcNHglycan	90	93	PF01048	0.693
MOD_GSK3_1	225	232	PF00069	0.503
MOD_GSK3_1	324	331	PF00069	0.435
MOD_GSK3_1	367	374	PF00069	0.354
MOD_N-GLC_1	120	125	PF02516	0.635
MOD_N-GLC_1	74	79	PF02516	0.649
MOD_N-GLC_2	338	340	PF02516	0.635
MOD_N-GLC_2	352	354	PF02516	0.470
MOD_NEK2_1	165	170	PF00069	0.571
MOD_NEK2_1	260	265	PF00069	0.529
MOD_NEK2_1	303	308	PF00069	0.500
MOD_NEK2_1	432	437	PF00069	0.381
MOD_NEK2_1	56	61	PF00069	0.524
MOD_PIKK_1	271	277	PF00454	0.605
MOD_PKA_1	324	330	PF00069	0.435
MOD_PKA_2	113	119	PF00069	0.444
MOD_PKA_2	229	235	PF00069	0.521
MOD_PKA_2	324	330	PF00069	0.435
MOD_PKA_2	432	438	PF00069	0.285
MOD_Plk_1	120	126	PF00069	0.434
MOD_Plk_1	444	450	PF00069	0.407
MOD_Plk_4	120	126	PF00069	0.405
MOD_Plk_4	261	267	PF00069	0.529
MOD_Plk_4	286	292	PF00069	0.427
MOD_Plk_4	367	373	PF00069	0.432
MOD_Plk_4	377	383	PF00069	0.395
MOD_Plk_4	99	105	PF00069	0.480
MOD_ProDKin_1	57	63	PF00069	0.482
MOD_ProDKin_1	65	71	PF00069	0.489
MOD_ProDKin_1	74	80	PF00069	0.512
TRG_DiLeu_BaEn_1	101	106	PF01217	0.420
TRG_ENDOCYTIC_2	246	249	PF00928	0.279
TRG_ENDOCYTIC_2	253	256	PF00928	0.386
TRG_ENDOCYTIC_2	269	272	PF00928	0.401
TRG_ENDOCYTIC_2	299	302	PF00928	0.529
TRG_ENDOCYTIC_2	360	363	PF00928	0.435
TRG_ENDOCYTIC_2	427	430	PF00928	0.435
TRG_ENDOCYTIC_2	437	440	PF00928	0.317
TRG_ENDOCYTIC_2	87	90	PF00928	0.445
TRG_ER_diArg_1	223	225	PF00400	0.485
TRG_ER_diArg_1	233	236	PF00400	0.453
TRG_ER_diArg_1	324	326	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6J6	Leishmania donovani	91%	100%
A0A3S7WRS6	Leishmania donovani	46%	91%
A4H6N2	Leishmania braziliensis	49%	90%
A4H6N3	Leishmania braziliensis	63%	100%
A4HV16	Leishmania infantum	46%	91%
A4HV17	Leishmania infantum	86%	100%
E9ANQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	75%
Q4QGX2	Leishmania major	46%	100%