Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANQ1_LEIMU

TriTrypDb:

LmxM.11.1080

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ANQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANQ1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016409	palmitoyltransferase activity	5	9
GO:0016417	S-acyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	9
GO:0019707	protein-cysteine S-acyltransferase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	486	490	PF00656	0.519
CLV_C14_Caspase3-7	55	59	PF00656	0.666
CLV_NRD_NRD_1	262	264	PF00675	0.474
CLV_NRD_NRD_1	316	318	PF00675	0.429
CLV_NRD_NRD_1	364	366	PF00675	0.480
CLV_NRD_NRD_1	394	396	PF00675	0.388
CLV_NRD_NRD_1	46	48	PF00675	0.482
CLV_NRD_NRD_1	484	486	PF00675	0.362
CLV_NRD_NRD_1	617	619	PF00675	0.388
CLV_NRD_NRD_1	69	71	PF00675	0.539
CLV_PCSK_KEX2_1	261	263	PF00082	0.473
CLV_PCSK_KEX2_1	315	317	PF00082	0.459
CLV_PCSK_KEX2_1	394	396	PF00082	0.397
CLV_PCSK_KEX2_1	45	47	PF00082	0.476
CLV_PCSK_KEX2_1	483	485	PF00082	0.364
CLV_PCSK_KEX2_1	601	603	PF00082	0.495
CLV_PCSK_KEX2_1	68	70	PF00082	0.537
CLV_PCSK_KEX2_1	74	76	PF00082	0.510
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.459
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.495
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.516
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.502
CLV_PCSK_PC7_1	70	76	PF00082	0.461
CLV_PCSK_SKI1_1	103	107	PF00082	0.470
CLV_PCSK_SKI1_1	212	216	PF00082	0.469
CLV_PCSK_SKI1_1	395	399	PF00082	0.433
CLV_PCSK_SKI1_1	520	524	PF00082	0.257
DEG_SCF_FBW7_1	11	17	PF00400	0.651
DEG_SCF_FBW7_1	21	27	PF00400	0.632
DEG_SPOP_SBC_1	28	32	PF00917	0.637
DOC_CKS1_1	11	16	PF01111	0.656
DOC_CKS1_1	21	26	PF01111	0.634
DOC_MAPK_gen_1	601	608	PF00069	0.595
DOC_MAPK_RevD_3	300	316	PF00069	0.618
DOC_PP1_RVXF_1	518	524	PF00149	0.411
DOC_PP1_RVXF_1	602	609	PF00149	0.601
DOC_PP4_FxxP_1	34	37	PF00568	0.639
DOC_PP4_FxxP_1	398	401	PF00568	0.639
DOC_USP7_MATH_1	164	168	PF00917	0.669
DOC_USP7_MATH_1	187	191	PF00917	0.703
DOC_USP7_MATH_1	373	377	PF00917	0.703
DOC_USP7_MATH_1	401	405	PF00917	0.623
DOC_USP7_MATH_1	86	90	PF00917	0.660
DOC_USP7_MATH_2	237	243	PF00917	0.684
DOC_USP7_UBL2_3	494	498	PF12436	0.578
DOC_USP7_UBL2_3	68	72	PF12436	0.652
DOC_WW_Pin1_4	123	128	PF00397	0.771
DOC_WW_Pin1_4	14	19	PF00397	0.642
DOC_WW_Pin1_4	142	147	PF00397	0.697
DOC_WW_Pin1_4	20	25	PF00397	0.630
DOC_WW_Pin1_4	202	207	PF00397	0.773
DOC_WW_Pin1_4	243	248	PF00397	0.730
DOC_WW_Pin1_4	5	10	PF00397	0.660
LIG_14-3-3_CanoR_1	119	127	PF00244	0.691
LIG_14-3-3_CanoR_1	19	24	PF00244	0.650
LIG_14-3-3_CanoR_1	291	299	PF00244	0.627
LIG_14-3-3_CanoR_1	340	345	PF00244	0.693
LIG_14-3-3_CanoR_1	389	393	PF00244	0.643
LIG_14-3-3_CanoR_1	400	406	PF00244	0.569
LIG_14-3-3_CanoR_1	520	526	PF00244	0.282
LIG_14-3-3_CanoR_1	53	63	PF00244	0.690
LIG_BRCT_BRCA1_1	241	245	PF00533	0.708
LIG_BRCT_BRCA1_1	421	425	PF00533	0.430
LIG_BRCT_BRCA1_1	555	559	PF00533	0.319
LIG_EH1_1	445	453	PF00400	0.215
LIG_eIF4E_1	458	464	PF01652	0.327
LIG_FHA_1	124	130	PF00498	0.665
LIG_FHA_1	158	164	PF00498	0.641
LIG_FHA_1	275	281	PF00498	0.688
LIG_FHA_1	28	34	PF00498	0.657
LIG_FHA_1	287	293	PF00498	0.647
LIG_FHA_1	457	463	PF00498	0.332
LIG_FHA_1	566	572	PF00498	0.303
LIG_FHA_2	214	220	PF00498	0.662
LIG_FHA_2	251	257	PF00498	0.641
LIG_FHA_2	484	490	PF00498	0.519
LIG_LIR_Apic_2	31	37	PF02991	0.641
LIG_LIR_Gen_1	376	385	PF02991	0.546
LIG_LIR_Gen_1	545	552	PF02991	0.239
LIG_LIR_Gen_1	585	590	PF02991	0.523
LIG_LIR_Gen_1	593	599	PF02991	0.498
LIG_LIR_Nem_3	205	210	PF02991	0.629
LIG_LIR_Nem_3	376	381	PF02991	0.613
LIG_LIR_Nem_3	422	428	PF02991	0.493
LIG_LIR_Nem_3	533	538	PF02991	0.298
LIG_LIR_Nem_3	545	551	PF02991	0.232
LIG_LIR_Nem_3	585	589	PF02991	0.514
LIG_LIR_Nem_3	593	598	PF02991	0.488
LIG_MLH1_MIPbox_1	555	559	PF16413	0.319
LIG_PCNA_yPIPBox_3	436	444	PF02747	0.379
LIG_Pex14_1	421	425	PF04695	0.430
LIG_SH2_CRK	165	169	PF00017	0.660
LIG_SH2_CRK	458	462	PF00017	0.366
LIG_SH2_GRB2like	378	381	PF00017	0.544
LIG_SH2_GRB2like	472	475	PF00017	0.488
LIG_SH2_NCK_1	165	169	PF00017	0.615
LIG_SH2_PTP2	378	381	PF00017	0.544
LIG_SH2_PTP2	428	431	PF00017	0.393
LIG_SH2_SRC	378	381	PF00017	0.544
LIG_SH2_SRC	595	598	PF00017	0.541
LIG_SH2_STAP1	165	169	PF00017	0.615
LIG_SH2_STAP1	458	462	PF00017	0.303
LIG_SH2_STAT5	165	168	PF00017	0.618
LIG_SH2_STAT5	220	223	PF00017	0.704
LIG_SH2_STAT5	378	381	PF00017	0.549
LIG_SH2_STAT5	428	431	PF00017	0.338
LIG_SH2_STAT5	432	435	PF00017	0.348
LIG_SH2_STAT5	458	461	PF00017	0.343
LIG_SH2_STAT5	543	546	PF00017	0.327
LIG_SH2_STAT5	558	561	PF00017	0.349
LIG_SH2_STAT5	586	589	PF00017	0.634
LIG_SH3_3	124	130	PF00018	0.736
LIG_SH3_3	141	147	PF00018	0.714
LIG_SH3_3	150	156	PF00018	0.702
LIG_SH3_3	177	183	PF00018	0.676
LIG_SH3_3	18	24	PF00018	0.639
LIG_SH3_3	218	224	PF00018	0.687
LIG_SH3_3	235	241	PF00018	0.656
LIG_SH3_3	252	258	PF00018	0.650
LIG_SH3_3	273	279	PF00018	0.674
LIG_SH3_3	299	305	PF00018	0.680
LIG_SH3_3	6	12	PF00018	0.660
LIG_SH3_3	603	609	PF00018	0.611
LIG_Sin3_3	447	454	PF02671	0.303
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.335
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.363
LIG_SUMO_SIM_anti_2	568	573	PF11976	0.303
LIG_SUMO_SIM_par_1	459	465	PF11976	0.363
LIG_TRAF2_1	237	240	PF00917	0.681
LIG_TYR_ITIM	163	168	PF00017	0.617
LIG_TYR_ITSM	591	598	PF00017	0.541
LIG_UBA3_1	214	222	PF00899	0.661
LIG_UBA3_1	461	467	PF00899	0.448
LIG_WRC_WIRS_1	463	468	PF05994	0.348
LIG_WRC_WIRS_1	522	527	PF05994	0.473
LIG_WW_3	145	149	PF00397	0.629
MOD_CDC14_SPxK_1	145	148	PF00782	0.624
MOD_CDK_SPK_2	14	19	PF00069	0.652
MOD_CDK_SPxK_1	142	148	PF00069	0.630
MOD_CK1_1	10	16	PF00069	0.651
MOD_CK1_1	137	143	PF00069	0.644
MOD_CK1_1	157	163	PF00069	0.630
MOD_CK1_1	190	196	PF00069	0.706
MOD_CK1_1	213	219	PF00069	0.705
MOD_CK1_1	243	249	PF00069	0.726
MOD_CK1_1	51	57	PF00069	0.665
MOD_CK1_1	524	530	PF00069	0.486
MOD_CK1_1	610	616	PF00069	0.657
MOD_CK1_1	96	102	PF00069	0.670
MOD_CK2_1	164	170	PF00069	0.678
MOD_CK2_1	205	211	PF00069	0.663
MOD_CK2_1	213	219	PF00069	0.670
MOD_CK2_1	246	252	PF00069	0.752
MOD_CK2_1	280	286	PF00069	0.696
MOD_CK2_1	79	85	PF00069	0.645
MOD_Cter_Amidation	363	366	PF01082	0.402
MOD_Cter_Amidation	43	46	PF01082	0.456
MOD_GlcNHglycan	121	124	PF01048	0.505
MOD_GlcNHglycan	207	210	PF01048	0.480
MOD_GlcNHglycan	248	251	PF01048	0.502
MOD_GlcNHglycan	3	6	PF01048	0.456
MOD_GlcNHglycan	328	331	PF01048	0.470
MOD_GlcNHglycan	369	372	PF01048	0.429
MOD_GlcNHglycan	474	477	PF01048	0.319
MOD_GlcNHglycan	526	529	PF01048	0.430
MOD_GlcNHglycan	555	558	PF01048	0.519
MOD_GlcNHglycan	609	612	PF01048	0.443
MOD_GlcNHglycan	81	84	PF01048	0.489
MOD_GSK3_1	1	8	PF00069	0.664
MOD_GSK3_1	10	17	PF00069	0.640
MOD_GSK3_1	119	126	PF00069	0.731
MOD_GSK3_1	129	136	PF00069	0.683
MOD_GSK3_1	20	27	PF00069	0.619
MOD_GSK3_1	239	246	PF00069	0.702
MOD_GSK3_1	340	347	PF00069	0.631
MOD_GSK3_1	384	391	PF00069	0.650
MOD_GSK3_1	48	55	PF00069	0.667
MOD_GSK3_1	483	490	PF00069	0.564
MOD_GSK3_1	75	82	PF00069	0.676
MOD_GSK3_1	92	99	PF00069	0.647
MOD_LATS_1	73	79	PF00433	0.655
MOD_N-GLC_1	379	384	PF02516	0.403
MOD_N-GLC_2	497	499	PF02516	0.364
MOD_N-GLC_2	511	513	PF02516	0.364
MOD_NEK2_1	210	215	PF00069	0.691
MOD_NEK2_1	326	331	PF00069	0.727
MOD_NEK2_1	339	344	PF00069	0.629
MOD_NEK2_1	419	424	PF00069	0.508
MOD_NEK2_1	457	462	PF00069	0.395
MOD_NEK2_1	521	526	PF00069	0.335
MOD_NEK2_1	582	587	PF00069	0.387
MOD_NEK2_1	617	622	PF00069	0.615
MOD_NEK2_2	373	378	PF00069	0.570
MOD_PIKK_1	139	145	PF00454	0.638
MOD_PIKK_1	256	262	PF00454	0.637
MOD_PIKK_1	388	394	PF00454	0.599
MOD_PIKK_1	430	436	PF00454	0.422
MOD_PKA_1	483	489	PF00069	0.564
MOD_PKA_1	74	80	PF00069	0.658
MOD_PKA_2	187	193	PF00069	0.688
MOD_PKA_2	197	203	PF00069	0.642
MOD_PKA_2	250	256	PF00069	0.640
MOD_PKA_2	339	345	PF00069	0.660
MOD_PKA_2	388	394	PF00069	0.667
MOD_PKA_2	48	54	PF00069	0.715
MOD_PKA_2	483	489	PF00069	0.564
MOD_PKA_2	553	559	PF00069	0.307
MOD_PKA_2	617	623	PF00069	0.556
MOD_PKA_2	74	80	PF00069	0.658
MOD_PKB_1	117	125	PF00069	0.695
MOD_PKB_1	338	346	PF00069	0.691
MOD_Plk_1	190	196	PF00069	0.704
MOD_Plk_1	210	216	PF00069	0.588
MOD_Plk_4	210	216	PF00069	0.639
MOD_Plk_4	229	235	PF00069	0.629
MOD_Plk_4	240	246	PF00069	0.710
MOD_Plk_4	29	35	PF00069	0.681
MOD_Plk_4	328	334	PF00069	0.640
MOD_Plk_4	373	379	PF00069	0.566
MOD_Plk_4	420	426	PF00069	0.430
MOD_Plk_4	457	463	PF00069	0.375
MOD_Plk_4	530	536	PF00069	0.361
MOD_Plk_4	539	545	PF00069	0.359
MOD_Plk_4	565	571	PF00069	0.303
MOD_Plk_4	582	588	PF00069	0.335
MOD_ProDKin_1	123	129	PF00069	0.771
MOD_ProDKin_1	14	20	PF00069	0.642
MOD_ProDKin_1	142	148	PF00069	0.700
MOD_ProDKin_1	202	208	PF00069	0.772
MOD_ProDKin_1	24	30	PF00069	0.637
MOD_ProDKin_1	243	249	PF00069	0.729
MOD_ProDKin_1	5	11	PF00069	0.661
MOD_SUMO_rev_2	110	115	PF00179	0.733
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.624
TRG_ENDOCYTIC_2	165	168	PF00928	0.662
TRG_ENDOCYTIC_2	378	381	PF00928	0.544
TRG_ENDOCYTIC_2	428	431	PF00928	0.412
TRG_ENDOCYTIC_2	458	461	PF00928	0.430
TRG_ENDOCYTIC_2	519	522	PF00928	0.564
TRG_ENDOCYTIC_2	586	589	PF00928	0.564
TRG_ENDOCYTIC_2	595	598	PF00928	0.449
TRG_ER_diArg_1	117	120	PF00400	0.695
TRG_ER_diArg_1	261	263	PF00400	0.744
TRG_ER_diArg_1	316	318	PF00400	0.629
TRG_ER_diArg_1	393	395	PF00400	0.613
TRG_ER_diArg_1	45	47	PF00400	0.674
TRG_ER_diArg_1	483	485	PF00400	0.519
TRG_ER_diArg_1	621	624	PF00400	0.641
TRG_NLS_Bipartite_1	601	622	PF00514	0.625
TRG_NLS_MonoExtC_3	617	622	PF00514	0.610
TRG_NLS_MonoExtC_3	67	72	PF00514	0.648
TRG_NLS_MonoExtN_4	616	622	PF00514	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRS6	Leishmania donovani	86%	100%
A4H6N2	Leishmania braziliensis	64%	100%
A4H6N3	Leishmania braziliensis	43%	100%
A4HV16	Leishmania infantum	86%	100%
A4HV17	Leishmania infantum	45%	100%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4QGX2	Leishmania major	82%	100%