Inositol-1,4,5-trisphosphate (IP3) 5-phosphatase,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9ANP5_LEIMU

TriTrypDb:

LmxM.11.1010

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANP5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019751	polyol metabolic process	4	1
GO:0019932	second-messenger-mediated signaling	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0048016	inositol phosphate-mediated signaling	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0046030	inositol trisphosphate phosphatase activity	7	7
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	8	6
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	8	6
GO:0052743	inositol tetrakisphosphate phosphatase activity	7	6
GO:0052745	inositol phosphate phosphatase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.610
CLV_C14_Caspase3-7	96	100	PF00656	0.670
CLV_NRD_NRD_1	262	264	PF00675	0.752
CLV_NRD_NRD_1	366	368	PF00675	0.487
CLV_NRD_NRD_1	409	411	PF00675	0.500
CLV_PCSK_KEX2_1	262	264	PF00082	0.831
CLV_PCSK_KEX2_1	409	411	PF00082	0.500
CLV_PCSK_KEX2_1	463	465	PF00082	0.637
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.637
CLV_PCSK_PC7_1	459	465	PF00082	0.643
CLV_PCSK_SKI1_1	368	372	PF00082	0.531
CLV_PCSK_SKI1_1	396	400	PF00082	0.505
CLV_PCSK_SKI1_1	412	416	PF00082	0.479
CLV_PCSK_SKI1_1	616	620	PF00082	0.423
DEG_APCC_DBOX_1	187	195	PF00400	0.644
DEG_SCF_FBW7_2	64	70	PF00400	0.565
DEG_SPOP_SBC_1	140	144	PF00917	0.476
DEG_SPOP_SBC_1	154	158	PF00917	0.510
DEG_SPOP_SBC_1	243	247	PF00917	0.608
DEG_SPOP_SBC_1	582	586	PF00917	0.515
DOC_AGCK_PIF_3	684	687	PF00069	0.649
DOC_CKS1_1	64	69	PF01111	0.565
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.550
DOC_MAPK_gen_1	365	375	PF00069	0.568
DOC_MAPK_JIP1_4	33	39	PF00069	0.610
DOC_MAPK_MEF2A_6	188	196	PF00069	0.465
DOC_MAPK_MEF2A_6	29	38	PF00069	0.642
DOC_MAPK_MEF2A_6	367	375	PF00069	0.553
DOC_MAPK_NFAT4_5	368	376	PF00069	0.554
DOC_PP1_RVXF_1	614	620	PF00149	0.468
DOC_PP2B_LxvP_1	330	333	PF13499	0.491
DOC_PP2B_PxIxI_1	189	195	PF00149	0.455
DOC_PP4_FxxP_1	318	321	PF00568	0.508
DOC_PP4_FxxP_1	475	478	PF00568	0.546
DOC_PP4_FxxP_1	86	89	PF00568	0.729
DOC_SPAK_OSR1_1	20	24	PF12202	0.666
DOC_USP7_MATH_1	136	140	PF00917	0.659
DOC_USP7_MATH_1	155	159	PF00917	0.681
DOC_USP7_MATH_1	172	176	PF00917	0.557
DOC_USP7_MATH_1	243	247	PF00917	0.549
DOC_USP7_MATH_1	312	316	PF00917	0.463
DOC_USP7_MATH_1	363	367	PF00917	0.510
DOC_USP7_MATH_1	398	402	PF00917	0.613
DOC_USP7_MATH_1	419	423	PF00917	0.495
DOC_USP7_MATH_1	587	591	PF00917	0.629
DOC_USP7_MATH_1	641	645	PF00917	0.825
DOC_USP7_MATH_1	78	82	PF00917	0.745
DOC_USP7_MATH_1	9	13	PF00917	0.690
DOC_USP7_UBL2_3	205	209	PF12436	0.627
DOC_WW_Pin1_4	102	107	PF00397	0.605
DOC_WW_Pin1_4	159	164	PF00397	0.806
DOC_WW_Pin1_4	165	170	PF00397	0.769
DOC_WW_Pin1_4	2	7	PF00397	0.704
DOC_WW_Pin1_4	237	242	PF00397	0.491
DOC_WW_Pin1_4	267	272	PF00397	0.564
DOC_WW_Pin1_4	317	322	PF00397	0.504
DOC_WW_Pin1_4	399	404	PF00397	0.518
DOC_WW_Pin1_4	537	542	PF00397	0.697
DOC_WW_Pin1_4	583	588	PF00397	0.783
DOC_WW_Pin1_4	596	601	PF00397	0.578
DOC_WW_Pin1_4	63	68	PF00397	0.707
LIG_14-3-3_CanoR_1	109	119	PF00244	0.339
LIG_14-3-3_CanoR_1	125	129	PF00244	0.542
LIG_14-3-3_CanoR_1	181	186	PF00244	0.550
LIG_14-3-3_CanoR_1	20	24	PF00244	0.666
LIG_14-3-3_CanoR_1	220	224	PF00244	0.574
LIG_14-3-3_CanoR_1	251	258	PF00244	0.768
LIG_14-3-3_CanoR_1	262	267	PF00244	0.686
LIG_14-3-3_CanoR_1	631	636	PF00244	0.740
LIG_14-3-3_CanoR_1	661	670	PF00244	0.591
LIG_APCC_ABBA_1	387	392	PF00400	0.562
LIG_APCC_ABBA_1	431	436	PF00400	0.436
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	21	25	PF00533	0.598
LIG_BRCT_BRCA1_1	314	318	PF00533	0.468
LIG_BRCT_BRCA1_1	356	360	PF00533	0.498
LIG_BRCT_BRCA1_1	75	79	PF00533	0.700
LIG_deltaCOP1_diTrp_1	469	475	PF00928	0.527
LIG_FHA_1	111	117	PF00498	0.339
LIG_FHA_1	182	188	PF00498	0.668
LIG_FHA_1	219	225	PF00498	0.627
LIG_FHA_1	228	234	PF00498	0.407
LIG_FHA_1	297	303	PF00498	0.761
LIG_FHA_1	3	9	PF00498	0.754
LIG_FHA_1	38	44	PF00498	0.538
LIG_FHA_1	409	415	PF00498	0.394
LIG_FHA_1	566	572	PF00498	0.696
LIG_FHA_1	583	589	PF00498	0.507
LIG_FHA_2	262	268	PF00498	0.797
LIG_FHA_2	415	421	PF00498	0.369
LIG_FHA_2	478	484	PF00498	0.632
LIG_FHA_2	547	553	PF00498	0.754
LIG_FHA_2	57	63	PF00498	0.732
LIG_FHA_2	676	682	PF00498	0.569
LIG_GSK3_LRP6_1	163	168	PF00069	0.772
LIG_LIR_Apic_2	315	321	PF02991	0.489
LIG_LIR_Apic_2	473	478	PF02991	0.544
LIG_LIR_Apic_2	84	89	PF02991	0.721
LIG_LIR_Gen_1	307	318	PF02991	0.506
LIG_LIR_Gen_1	469	478	PF02991	0.538
LIG_LIR_Gen_1	517	523	PF02991	0.571
LIG_LIR_Gen_1	681	687	PF02991	0.569
LIG_LIR_Gen_1	76	86	PF02991	0.738
LIG_LIR_Gen_1	90	98	PF02991	0.700
LIG_LIR_Nem_3	307	313	PF02991	0.533
LIG_LIR_Nem_3	336	340	PF02991	0.491
LIG_LIR_Nem_3	469	475	PF02991	0.527
LIG_LIR_Nem_3	517	521	PF02991	0.662
LIG_LIR_Nem_3	665	670	PF02991	0.667
LIG_LIR_Nem_3	681	687	PF02991	0.456
LIG_LIR_Nem_3	90	94	PF02991	0.716
LIG_Pex14_2	21	25	PF04695	0.598
LIG_Pex14_2	211	215	PF04695	0.496
LIG_Pex14_2	471	475	PF04695	0.586
LIG_PTB_Apo_2	205	212	PF02174	0.550
LIG_Rb_LxCxE_1	461	483	PF01857	0.639
LIG_SH2_CRK	518	522	PF00017	0.626
LIG_SH2_NCK_1	518	522	PF00017	0.626
LIG_SH2_NCK_1	670	674	PF00017	0.587
LIG_SH2_PTP2	337	340	PF00017	0.513
LIG_SH2_PTP2	91	94	PF00017	0.667
LIG_SH2_SRC	337	340	PF00017	0.513
LIG_SH2_SRC	668	671	PF00017	0.622
LIG_SH2_SRC	91	94	PF00017	0.714
LIG_SH2_STAP1	183	187	PF00017	0.442
LIG_SH2_STAP1	518	522	PF00017	0.588
LIG_SH2_STAP1	668	672	PF00017	0.622
LIG_SH2_STAT5	183	186	PF00017	0.586
LIG_SH2_STAT5	214	217	PF00017	0.453
LIG_SH2_STAT5	309	312	PF00017	0.499
LIG_SH2_STAT5	337	340	PF00017	0.479
LIG_SH2_STAT5	406	409	PF00017	0.495
LIG_SH2_STAT5	91	94	PF00017	0.724
LIG_SH3_1	633	639	PF00018	0.753
LIG_SH3_3	158	164	PF00018	0.720
LIG_SH3_3	184	190	PF00018	0.641
LIG_SH3_3	279	285	PF00018	0.544
LIG_SH3_3	3	9	PF00018	0.754
LIG_SH3_3	338	344	PF00018	0.655
LIG_SH3_3	570	576	PF00018	0.627
LIG_SH3_3	58	64	PF00018	0.793
LIG_SH3_3	633	639	PF00018	0.706
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.420
LIG_SUMO_SIM_anti_2	35	40	PF11976	0.534
LIG_SUMO_SIM_anti_2	497	504	PF11976	0.611
LIG_SUMO_SIM_par_1	35	40	PF11976	0.534
LIG_SUMO_SIM_par_1	422	429	PF11976	0.576
LIG_TRAF2_1	480	483	PF00917	0.581
LIG_WW_2	6	9	PF00397	0.750
MOD_CDC14_SPxK_1	599	602	PF00782	0.664
MOD_CDK_SPK_2	317	322	PF00069	0.504
MOD_CDK_SPxK_1	596	602	PF00069	0.668
MOD_CDK_SPxxK_3	102	109	PF00069	0.592
MOD_CK1_1	127	133	PF00069	0.520
MOD_CK1_1	139	145	PF00069	0.475
MOD_CK1_1	156	162	PF00069	0.551
MOD_CK1_1	2	8	PF00069	0.645
MOD_CK1_1	293	299	PF00069	0.719
MOD_CK1_1	32	38	PF00069	0.567
MOD_CK1_1	328	334	PF00069	0.492
MOD_CK1_1	401	407	PF00069	0.521
MOD_CK1_1	643	649	PF00069	0.647
MOD_CK1_1	662	668	PF00069	0.584
MOD_CK1_1	81	87	PF00069	0.627
MOD_CK2_1	261	267	PF00069	0.772
MOD_CK2_1	414	420	PF00069	0.368
MOD_CK2_1	477	483	PF00069	0.563
MOD_CK2_1	500	506	PF00069	0.519
MOD_CK2_1	56	62	PF00069	0.784
MOD_Cter_Amidation	407	410	PF01082	0.571
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.696
MOD_GlcNHglycan	129	132	PF01048	0.608
MOD_GlcNHglycan	137	141	PF01048	0.561
MOD_GlcNHglycan	143	146	PF01048	0.690
MOD_GlcNHglycan	148	151	PF01048	0.680
MOD_GlcNHglycan	15	18	PF01048	0.483
MOD_GlcNHglycan	158	161	PF01048	0.562
MOD_GlcNHglycan	2	5	PF01048	0.815
MOD_GlcNHglycan	230	233	PF01048	0.676
MOD_GlcNHglycan	278	281	PF01048	0.733
MOD_GlcNHglycan	356	359	PF01048	0.507
MOD_GlcNHglycan	420	424	PF01048	0.486
MOD_GlcNHglycan	552	556	PF01048	0.581
MOD_GlcNHglycan	627	630	PF01048	0.573
MOD_GlcNHglycan	633	636	PF01048	0.709
MOD_GlcNHglycan	645	648	PF01048	0.752
MOD_GlcNHglycan	650	653	PF01048	0.669
MOD_GlcNHglycan	661	664	PF01048	0.579
MOD_GlcNHglycan	74	78	PF01048	0.764
MOD_GSK3_1	136	143	PF00069	0.676
MOD_GSK3_1	155	162	PF00069	0.692
MOD_GSK3_1	179	186	PF00069	0.686
MOD_GSK3_1	25	32	PF00069	0.472
MOD_GSK3_1	286	293	PF00069	0.749
MOD_GSK3_1	308	315	PF00069	0.554
MOD_GSK3_1	404	411	PF00069	0.407
MOD_GSK3_1	473	480	PF00069	0.603
MOD_GSK3_1	524	531	PF00069	0.704
MOD_GSK3_1	547	554	PF00069	0.784
MOD_GSK3_1	583	590	PF00069	0.702
MOD_GSK3_1	625	632	PF00069	0.582
MOD_GSK3_1	641	648	PF00069	0.645
MOD_GSK3_1	9	16	PF00069	0.720
MOD_N-GLC_1	276	281	PF02516	0.749
MOD_N-GLC_1	293	298	PF02516	0.786
MOD_N-GLC_2	383	385	PF02516	0.442
MOD_N-GLC_2	604	606	PF02516	0.709
MOD_NEK2_1	244	249	PF00069	0.836
MOD_NEK2_1	261	266	PF00069	0.550
MOD_NEK2_1	354	359	PF00069	0.482
MOD_NEK2_1	37	42	PF00069	0.596
MOD_NEK2_1	371	376	PF00069	0.453
MOD_NEK2_1	454	459	PF00069	0.629
MOD_NEK2_1	56	61	PF00069	0.543
MOD_NEK2_2	183	188	PF00069	0.437
MOD_PIKK_1	37	43	PF00454	0.523
MOD_PIKK_1	477	483	PF00454	0.652
MOD_PKA_1	262	268	PF00069	0.834
MOD_PKA_2	124	130	PF00069	0.539
MOD_PKA_2	19	25	PF00069	0.661
MOD_PKA_2	219	225	PF00069	0.576
MOD_PKA_2	261	267	PF00069	0.751
MOD_PKA_2	286	292	PF00069	0.730
MOD_PKA_2	408	414	PF00069	0.398
MOD_PKB_1	251	259	PF00069	0.755
MOD_Plk_1	419	425	PF00069	0.483
MOD_Plk_4	124	130	PF00069	0.539
MOD_Plk_4	219	225	PF00069	0.529
MOD_Plk_4	312	318	PF00069	0.481
MOD_Plk_4	32	38	PF00069	0.567
MOD_Plk_4	401	407	PF00069	0.504
MOD_Plk_4	81	87	PF00069	0.611
MOD_ProDKin_1	102	108	PF00069	0.598
MOD_ProDKin_1	159	165	PF00069	0.807
MOD_ProDKin_1	2	8	PF00069	0.703
MOD_ProDKin_1	237	243	PF00069	0.499
MOD_ProDKin_1	267	273	PF00069	0.565
MOD_ProDKin_1	317	323	PF00069	0.506
MOD_ProDKin_1	399	405	PF00069	0.521
MOD_ProDKin_1	537	543	PF00069	0.695
MOD_ProDKin_1	583	589	PF00069	0.782
MOD_ProDKin_1	596	602	PF00069	0.576
MOD_ProDKin_1	63	69	PF00069	0.704
MOD_SUMO_rev_2	26	35	PF00179	0.660
MOD_SUMO_rev_2	436	446	PF00179	0.445
MOD_SUMO_rev_2	448	454	PF00179	0.611
TRG_DiLeu_BaEn_1	491	496	PF01217	0.489
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.590
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.527
TRG_ENDOCYTIC_2	337	340	PF00928	0.513
TRG_ENDOCYTIC_2	518	521	PF00928	0.573
TRG_ENDOCYTIC_2	670	673	PF00928	0.581
TRG_ENDOCYTIC_2	91	94	PF00928	0.714
TRG_ER_diArg_1	261	263	PF00400	0.795
TRG_ER_diArg_1	409	412	PF00400	0.441
TRG_ER_diArg_1	484	487	PF00400	0.554
TRG_ER_diArg_1	523	526	PF00400	0.665
TRG_ER_diArg_1	571	574	PF00400	0.828
TRG_NLS_MonoExtN_4	460	467	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E4	Leptomonas seymouri	51%	100%
A0A3S5H6J4	Leishmania donovani	89%	100%
A4H6M7	Leishmania braziliensis	72%	100%
A4HV10	Leishmania infantum	88%	100%
Q4QGX8	Leishmania major	87%	99%