HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9ANP2_LEIMU

TriTrypDb:

LmxM.11.0980

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0000118	histone deacetylase complex	3	1
GO:0000812	Swr1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0097346	INO80-type complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

E9ANP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANP2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0031491	nucleosome binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.710
CLV_C14_Caspase3-7	229	233	PF00656	0.644
CLV_NRD_NRD_1	163	165	PF00675	0.742
CLV_NRD_NRD_1	171	173	PF00675	0.701
CLV_NRD_NRD_1	206	208	PF00675	0.818
CLV_NRD_NRD_1	216	218	PF00675	0.665
CLV_NRD_NRD_1	236	238	PF00675	0.739
CLV_NRD_NRD_1	299	301	PF00675	0.713
CLV_NRD_NRD_1	347	349	PF00675	0.701
CLV_NRD_NRD_1	401	403	PF00675	0.695
CLV_NRD_NRD_1	404	406	PF00675	0.710
CLV_NRD_NRD_1	86	88	PF00675	0.800
CLV_PCSK_FUR_1	402	406	PF00082	0.718
CLV_PCSK_KEX2_1	163	165	PF00082	0.742
CLV_PCSK_KEX2_1	171	173	PF00082	0.701
CLV_PCSK_KEX2_1	206	208	PF00082	0.716
CLV_PCSK_KEX2_1	218	220	PF00082	0.719
CLV_PCSK_KEX2_1	34	36	PF00082	0.604
CLV_PCSK_KEX2_1	347	349	PF00082	0.701
CLV_PCSK_KEX2_1	403	405	PF00082	0.723
CLV_PCSK_KEX2_1	82	84	PF00082	0.720
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.780
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.706
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.803
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.698
CLV_PCSK_SKI1_1	270	274	PF00082	0.559
CLV_PCSK_SKI1_1	352	356	PF00082	0.802
CLV_PCSK_SKI1_1	460	464	PF00082	0.313
CLV_PCSK_SKI1_1	477	481	PF00082	0.436
DEG_APCC_KENBOX_2	408	412	PF00400	0.638
DEG_Nend_UBRbox_3	1	3	PF02207	0.585
DEG_SPOP_SBC_1	293	297	PF00917	0.702
DOC_ANK_TNKS_1	206	213	PF00023	0.692
DOC_CYCLIN_RxL_1	473	482	PF00134	0.530
DOC_MAPK_gen_1	257	264	PF00069	0.657
DOC_PP1_RVXF_1	475	482	PF00149	0.548
DOC_PP4_FxxP_1	392	395	PF00568	0.577
DOC_PP4_FxxP_1	427	430	PF00568	0.786
DOC_PP4_FxxP_1	52	55	PF00568	0.715
DOC_USP7_MATH_1	141	145	PF00917	0.689
DOC_USP7_MATH_1	177	181	PF00917	0.560
DOC_USP7_MATH_1	250	254	PF00917	0.621
DOC_USP7_MATH_1	366	370	PF00917	0.828
DOC_USP7_MATH_1	41	45	PF00917	0.693
DOC_USP7_MATH_1	55	59	PF00917	0.579
DOC_USP7_MATH_1	69	73	PF00917	0.608
DOC_WW_Pin1_4	205	210	PF00397	0.699
DOC_WW_Pin1_4	282	287	PF00397	0.656
DOC_WW_Pin1_4	371	376	PF00397	0.725
LIG_14-3-3_CanoR_1	19	27	PF00244	0.713
LIG_14-3-3_CanoR_1	300	307	PF00244	0.738
LIG_14-3-3_CanoR_1	352	360	PF00244	0.743
LIG_14-3-3_CanoR_1	367	371	PF00244	0.641
LIG_14-3-3_CanoR_1	458	467	PF00244	0.569
LIG_14-3-3_CanoR_1	91	98	PF00244	0.754
LIG_Actin_WH2_2	464	482	PF00022	0.611
LIG_FHA_1	104	110	PF00498	0.570
LIG_FHA_1	318	324	PF00498	0.684
LIG_FHA_1	380	386	PF00498	0.588
LIG_FHA_1	474	480	PF00498	0.524
LIG_FHA_2	269	275	PF00498	0.574
LIG_FHA_2	353	359	PF00498	0.798
LIG_FHA_2	374	380	PF00498	0.714
LIG_GBD_Chelix_1	254	262	PF00786	0.539
LIG_LIR_Apic_2	426	430	PF02991	0.783
LIG_LIR_Apic_2	49	55	PF02991	0.711
LIG_LIR_Gen_1	23	33	PF02991	0.597
LIG_LIR_Gen_1	249	258	PF02991	0.403
LIG_LIR_Gen_1	336	345	PF02991	0.660
LIG_LIR_Gen_1	461	472	PF02991	0.619
LIG_LIR_Nem_3	23	29	PF02991	0.601
LIG_LIR_Nem_3	249	254	PF02991	0.420
LIG_LIR_Nem_3	336	340	PF02991	0.653
LIG_LIR_Nem_3	453	457	PF02991	0.518
LIG_LIR_Nem_3	461	467	PF02991	0.486
LIG_PDZ_Class_2	478	483	PF00595	0.572
LIG_SH2_CRK	251	255	PF00017	0.402
LIG_SH2_CRK	454	458	PF00017	0.546
LIG_SH2_SRC	116	119	PF00017	0.538
LIG_SH2_SRC	313	316	PF00017	0.711
LIG_SH2_STAP1	251	255	PF00017	0.402
LIG_SH2_STAT5	116	119	PF00017	0.538
LIG_SH2_STAT5	313	316	PF00017	0.788
LIG_SH3_3	280	286	PF00018	0.657
LIG_SUMO_SIM_par_1	197	204	PF11976	0.822
LIG_TRAF2_1	355	358	PF00917	0.801
LIG_TRFH_1	331	335	PF08558	0.649
LIG_WRC_WIRS_1	304	309	PF05994	0.504
MOD_CDK_SPxxK_3	282	289	PF00069	0.765
MOD_CK1_1	131	137	PF00069	0.576
MOD_CK1_1	181	187	PF00069	0.830
MOD_CK1_1	189	195	PF00069	0.741
MOD_CK1_1	285	291	PF00069	0.716
MOD_CK1_1	299	305	PF00069	0.612
MOD_CK1_1	373	379	PF00069	0.673
MOD_CK1_1	72	78	PF00069	0.809
MOD_CK2_1	141	147	PF00069	0.571
MOD_CK2_1	177	183	PF00069	0.747
MOD_CK2_1	268	274	PF00069	0.667
MOD_CK2_1	352	358	PF00069	0.801
MOD_CK2_1	373	379	PF00069	0.728
MOD_GlcNHglycan	137	142	PF01048	0.676
MOD_GlcNHglycan	143	146	PF01048	0.685
MOD_GlcNHglycan	180	183	PF01048	0.747
MOD_GlcNHglycan	192	195	PF01048	0.692
MOD_GlcNHglycan	412	415	PF01048	0.666
MOD_GlcNHglycan	416	419	PF01048	0.633
MOD_GlcNHglycan	65	68	PF01048	0.805
MOD_GlcNHglycan	71	74	PF01048	0.713
MOD_GlcNHglycan	77	80	PF01048	0.602
MOD_GlcNHglycan	9	12	PF01048	0.673
MOD_GSK3_1	128	135	PF00069	0.643
MOD_GSK3_1	137	144	PF00069	0.684
MOD_GSK3_1	177	184	PF00069	0.762
MOD_GSK3_1	185	192	PF00069	0.748
MOD_GSK3_1	194	201	PF00069	0.826
MOD_GSK3_1	292	299	PF00069	0.695
MOD_GSK3_1	313	320	PF00069	0.517
MOD_GSK3_1	329	336	PF00069	0.626
MOD_GSK3_1	366	373	PF00069	0.763
MOD_GSK3_1	375	382	PF00069	0.684
MOD_GSK3_1	410	417	PF00069	0.686
MOD_GSK3_1	63	70	PF00069	0.799
MOD_N-GLC_1	410	415	PF02516	0.739
MOD_NEK2_1	105	110	PF00069	0.559
MOD_NEK2_1	190	195	PF00069	0.704
MOD_NEK2_1	370	375	PF00069	0.711
MOD_NEK2_1	62	67	PF00069	0.770
MOD_NEK2_2	116	121	PF00069	0.541
MOD_NEK2_2	381	386	PF00069	0.605
MOD_PKA_1	87	93	PF00069	0.789
MOD_PKA_2	18	24	PF00069	0.720
MOD_PKA_2	227	233	PF00069	0.811
MOD_PKA_2	299	305	PF00069	0.713
MOD_PKA_2	366	372	PF00069	0.780
MOD_PKA_2	90	96	PF00069	0.674
MOD_Plk_1	268	274	PF00069	0.667
MOD_Plk_1	29	35	PF00069	0.552
MOD_Plk_1	42	48	PF00069	0.669
MOD_Plk_2-3	429	435	PF00069	0.686
MOD_Plk_4	181	187	PF00069	0.576
MOD_Plk_4	250	256	PF00069	0.696
MOD_Plk_4	366	372	PF00069	0.537
MOD_Plk_4	55	61	PF00069	0.724
MOD_ProDKin_1	205	211	PF00069	0.701
MOD_ProDKin_1	282	288	PF00069	0.658
MOD_ProDKin_1	371	377	PF00069	0.722
MOD_SUMO_for_1	258	261	PF00179	0.656
MOD_SUMO_rev_2	143	152	PF00179	0.796
MOD_SUMO_rev_2	232	239	PF00179	0.727
MOD_SUMO_rev_2	308	314	PF00179	0.733
TRG_DiLeu_BaEn_2	21	27	PF01217	0.633
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.665
TRG_ENDOCYTIC_2	251	254	PF00928	0.410
TRG_ENDOCYTIC_2	337	340	PF00928	0.709
TRG_ENDOCYTIC_2	454	457	PF00928	0.546
TRG_ER_diArg_1	205	207	PF00400	0.825
TRG_ER_diArg_1	217	220	PF00400	0.626
TRG_ER_diArg_1	402	405	PF00400	0.717
TRG_ER_diArg_1	457	460	PF00400	0.541
TRG_NLS_Bipartite_1	206	222	PF00514	0.822
TRG_NLS_MonoCore_2	217	222	PF00514	0.827
TRG_NLS_MonoCore_2	401	406	PF00514	0.800
TRG_NLS_MonoExtC_3	216	221	PF00514	0.827
TRG_NLS_MonoExtC_3	402	407	PF00514	0.806
TRG_NLS_MonoExtN_4	217	222	PF00514	0.823
TRG_NLS_MonoExtN_4	402	407	PF00514	0.806

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI9	Leptomonas seymouri	38%	91%
A0A3Q8I947	Leishmania donovani	88%	100%
A4H6M4	Leishmania braziliensis	76%	100%
A4HV07	Leishmania infantum	88%	100%
Q4QGY1	Leishmania major	87%	100%