Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANN9_LEIMU

TriTrypDb:

LmxM.11.0950

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.553
CLV_C14_Caspase3-7	57	61	PF00656	0.549
CLV_NRD_NRD_1	192	194	PF00675	0.502
CLV_NRD_NRD_1	205	207	PF00675	0.566
CLV_NRD_NRD_1	214	216	PF00675	0.544
CLV_NRD_NRD_1	39	41	PF00675	0.545
CLV_NRD_NRD_1	79	81	PF00675	0.428
CLV_PCSK_KEX2_1	205	207	PF00082	0.580
CLV_PCSK_KEX2_1	214	216	PF00082	0.544
CLV_PCSK_KEX2_1	310	312	PF00082	0.670
CLV_PCSK_KEX2_1	39	41	PF00082	0.545
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.715
CLV_PCSK_SKI1_1	215	219	PF00082	0.532
CLV_PCSK_SKI1_1	46	50	PF00082	0.675
DEG_SPOP_SBC_1	18	22	PF00917	0.546
DEG_SPOP_SBC_1	3	7	PF00917	0.625
DEG_SPOP_SBC_1	91	95	PF00917	0.546
DOC_MAPK_gen_1	193	203	PF00069	0.530
DOC_MAPK_gen_1	211	221	PF00069	0.625
DOC_MAPK_HePTP_8	191	203	PF00069	0.434
DOC_MAPK_MEF2A_6	194	203	PF00069	0.443
DOC_MAPK_MEF2A_6	214	223	PF00069	0.547
DOC_USP7_MATH_1	127	131	PF00917	0.524
DOC_USP7_MATH_1	19	23	PF00917	0.617
DOC_USP7_MATH_1	236	240	PF00917	0.686
DOC_USP7_MATH_1	3	7	PF00917	0.616
DOC_WW_Pin1_4	103	108	PF00397	0.610
DOC_WW_Pin1_4	183	188	PF00397	0.380
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_CAP-Gly_1	408	414	PF01302	0.585
LIG_deltaCOP1_diTrp_1	109	113	PF00928	0.525
LIG_EH_1	74	78	PF12763	0.488
LIG_FHA_1	153	159	PF00498	0.595
LIG_FHA_1	349	355	PF00498	0.506
LIG_FHA_1	378	384	PF00498	0.695
LIG_FHA_2	112	118	PF00498	0.607
LIG_LIR_Gen_1	109	117	PF02991	0.528
LIG_LIR_Gen_1	273	283	PF02991	0.609
LIG_LIR_Nem_3	109	113	PF02991	0.525
LIG_LIR_Nem_3	273	279	PF02991	0.615
LIG_PDZ_Class_3	409	414	PF00595	0.672
LIG_Pex14_2	48	52	PF04695	0.545
LIG_SH2_CRK	276	280	PF00017	0.612
LIG_SH2_NCK_1	276	280	PF00017	0.676
LIG_SH2_SRC	300	303	PF00017	0.513
LIG_SH2_STAT5	300	303	PF00017	0.640
LIG_SH2_STAT5	47	50	PF00017	0.546
LIG_SH3_1	206	212	PF00018	0.539
LIG_SH3_2	209	214	PF14604	0.529
LIG_SH3_3	101	107	PF00018	0.713
LIG_SH3_3	166	172	PF00018	0.477
LIG_SH3_3	204	210	PF00018	0.552
LIG_SH3_3	216	222	PF00018	0.517
LIG_SH3_3	70	76	PF00018	0.669
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.609
LIG_SUMO_SIM_par_1	176	182	PF11976	0.516
LIG_SUMO_SIM_par_1	245	250	PF11976	0.542
LIG_WW_3	208	212	PF00397	0.531
LIG_WW_3	41	45	PF00397	0.542
MOD_CDK_SPxxK_3	183	190	PF00069	0.382
MOD_CK1_1	122	128	PF00069	0.532
MOD_CK1_1	14	20	PF00069	0.598
MOD_CK1_1	2	8	PF00069	0.586
MOD_CK1_1	281	287	PF00069	0.574
MOD_CK2_1	103	109	PF00069	0.557
MOD_CK2_1	122	128	PF00069	0.584
MOD_CK2_1	18	24	PF00069	0.548
MOD_CK2_1	226	232	PF00069	0.592
MOD_CK2_1	60	66	PF00069	0.537
MOD_GlcNHglycan	1	4	PF01048	0.576
MOD_GlcNHglycan	121	125	PF01048	0.625
MOD_GlcNHglycan	128	132	PF01048	0.645
MOD_GlcNHglycan	181	184	PF01048	0.513
MOD_GlcNHglycan	272	275	PF01048	0.718
MOD_GlcNHglycan	280	283	PF01048	0.487
MOD_GlcNHglycan	302	305	PF01048	0.709
MOD_GlcNHglycan	330	333	PF01048	0.624
MOD_GlcNHglycan	337	341	PF01048	0.648
MOD_GlcNHglycan	346	349	PF01048	0.691
MOD_GSK3_1	13	20	PF00069	0.586
MOD_GSK3_1	179	186	PF00069	0.416
MOD_GSK3_1	270	277	PF00069	0.674
MOD_GSK3_1	300	307	PF00069	0.581
MOD_GSK3_1	344	351	PF00069	0.760
MOD_GSK3_1	56	63	PF00069	0.557
MOD_NEK2_1	119	124	PF00069	0.522
MOD_NEK2_1	162	167	PF00069	0.437
MOD_NEK2_1	247	252	PF00069	0.644
MOD_NEK2_1	328	333	PF00069	0.606
MOD_NEK2_1	336	341	PF00069	0.611
MOD_PKA_2	11	17	PF00069	0.766
MOD_PKA_2	189	195	PF00069	0.482
MOD_PKA_2	304	310	PF00069	0.520
MOD_Plk_1	127	133	PF00069	0.603
MOD_Plk_1	173	179	PF00069	0.438
MOD_Plk_1	247	253	PF00069	0.643
MOD_Plk_2-3	60	66	PF00069	0.544
MOD_Plk_4	281	287	PF00069	0.660
MOD_ProDKin_1	103	109	PF00069	0.609
MOD_ProDKin_1	183	189	PF00069	0.378
MOD_SUMO_for_1	102	105	PF00179	0.611
MOD_SUMO_for_1	132	135	PF00179	0.608
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.598
TRG_ENDOCYTIC_2	276	279	PF00928	0.668
TRG_ENDOCYTIC_2	79	82	PF00928	0.518
TRG_ER_diArg_1	199	202	PF00400	0.559
TRG_ER_diArg_1	205	207	PF00400	0.592
TRG_ER_diArg_1	213	215	PF00400	0.567
TRG_ER_diArg_1	39	41	PF00400	0.551
TRG_ER_diArg_1	43	46	PF00400	0.525
TRG_NLS_MonoExtC_3	309	315	PF00514	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I1	Leptomonas seymouri	48%	79%
A0A3Q8IHH5	Leishmania donovani	87%	100%
A4H6M1	Leishmania braziliensis	73%	100%
A4HV04	Leishmania infantum	88%	100%
Q4QGY4	Leishmania major	91%	100%