SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANN7_LEIMU

TriTrypDb:

LmxM.11.0930

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANN7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.456
CLV_NRD_NRD_1	20	22	PF00675	0.574
CLV_NRD_NRD_1	341	343	PF00675	0.688
CLV_NRD_NRD_1	357	359	PF00675	0.595
CLV_NRD_NRD_1	49	51	PF00675	0.588
CLV_NRD_NRD_1	83	85	PF00675	0.585
CLV_PCSK_FUR_1	117	121	PF00082	0.314
CLV_PCSK_FUR_1	338	342	PF00082	0.776
CLV_PCSK_KEX2_1	119	121	PF00082	0.384
CLV_PCSK_KEX2_1	175	177	PF00082	0.725
CLV_PCSK_KEX2_1	279	281	PF00082	0.522
CLV_PCSK_KEX2_1	308	310	PF00082	0.661
CLV_PCSK_KEX2_1	340	342	PF00082	0.617
CLV_PCSK_KEX2_1	357	359	PF00082	0.673
CLV_PCSK_KEX2_1	49	51	PF00082	0.599
CLV_PCSK_KEX2_1	83	85	PF00082	0.585
CLV_PCSK_KEX2_1	87	89	PF00082	0.521
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.725
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.522
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.661
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.498
CLV_PCSK_PC7_1	83	89	PF00082	0.513
CLV_PCSK_SKI1_1	119	123	PF00082	0.446
CLV_PCSK_SKI1_1	159	163	PF00082	0.641
CLV_PCSK_SKI1_1	172	176	PF00082	0.705
CLV_PCSK_SKI1_1	308	312	PF00082	0.664
CLV_Separin_Metazoa	64	68	PF03568	0.453
DOC_CKS1_1	319	324	PF01111	0.499
DOC_CYCLIN_yClb5_NLxxxL_5	22	30	PF00134	0.611
DOC_MAPK_gen_1	21	28	PF00069	0.609
DOC_MAPK_MEF2A_6	21	30	PF00069	0.609
DOC_MAPK_NFAT4_5	21	29	PF00069	0.572
DOC_PP2B_LxvP_1	248	251	PF13499	0.424
DOC_USP7_MATH_1	20	24	PF00917	0.564
DOC_USP7_MATH_1	298	302	PF00917	0.686
DOC_USP7_MATH_1	327	331	PF00917	0.692
DOC_USP7_UBL2_3	132	136	PF12436	0.594
DOC_USP7_UBL2_3	184	188	PF12436	0.687
DOC_USP7_UBL2_3	311	315	PF12436	0.670
DOC_WW_Pin1_4	233	238	PF00397	0.692
DOC_WW_Pin1_4	318	323	PF00397	0.736
DOC_WW_Pin1_4	333	338	PF00397	0.603
DOC_WW_Pin1_4	345	350	PF00397	0.511
DOC_WW_Pin1_4	66	71	PF00397	0.490
LIG_14-3-3_CanoR_1	340	349	PF00244	0.504
LIG_Actin_WH2_2	105	121	PF00022	0.361
LIG_FHA_1	234	240	PF00498	0.624
LIG_FHA_1	25	31	PF00498	0.512
LIG_FHA_1	55	61	PF00498	0.595
LIG_LIR_Gen_1	154	161	PF02991	0.643
LIG_LIR_Gen_1	254	265	PF02991	0.607
LIG_LIR_Gen_1	61	70	PF02991	0.579
LIG_LIR_Nem_3	154	160	PF02991	0.588
LIG_LIR_Nem_3	164	170	PF02991	0.523
LIG_LIR_Nem_3	254	260	PF02991	0.530
LIG_LIR_Nem_3	61	65	PF02991	0.521
LIG_LIR_Nem_3	69	75	PF02991	0.502
LIG_NRP_CendR_1	374	377	PF00754	0.632
LIG_SH2_PTP2	257	260	PF00017	0.597
LIG_SH2_STAT5	257	260	PF00017	0.532
LIG_SH2_STAT5	265	268	PF00017	0.481
LIG_SH3_1	150	156	PF00018	0.609
LIG_SH3_3	150	156	PF00018	0.706
LIG_SH3_3	177	183	PF00018	0.563
LIG_SH3_3	222	228	PF00018	0.630
LIG_SH3_3	255	261	PF00018	0.551
LIG_SH3_3	282	288	PF00018	0.527
LIG_SH3_4	311	318	PF00018	0.672
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.612
LIG_TRAF2_1	121	124	PF00917	0.539
LIG_TRAF2_1	144	147	PF00917	0.653
LIG_TRAF2_1	217	220	PF00917	0.475
LIG_TRAF2_1	261	264	PF00917	0.495
MOD_CDK_SPK_2	333	338	PF00069	0.719
MOD_CDK_SPK_2	345	350	PF00069	0.498
MOD_CDK_SPK_2	66	71	PF00069	0.475
MOD_CDK_SPxxK_3	333	340	PF00069	0.604
MOD_CDK_SPxxK_3	345	352	PF00069	0.500
MOD_CK1_1	336	342	PF00069	0.620
MOD_CK1_1	34	40	PF00069	0.516
MOD_CK1_1	348	354	PF00069	0.657
MOD_CK1_1	370	376	PF00069	0.679
MOD_CK2_1	184	190	PF00069	0.609
MOD_CK2_1	214	220	PF00069	0.512
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.603
MOD_GlcNHglycan	163	167	PF01048	0.488
MOD_GlcNHglycan	216	219	PF01048	0.491
MOD_GlcNHglycan	268	271	PF01048	0.527
MOD_GlcNHglycan	280	283	PF01048	0.462
MOD_GlcNHglycan	33	36	PF01048	0.526
MOD_GlcNHglycan	51	54	PF01048	0.578
MOD_GlcNHglycan	57	60	PF01048	0.566
MOD_GlcNHglycan	75	78	PF01048	0.459
MOD_GSK3_1	186	193	PF00069	0.702
MOD_GSK3_1	195	202	PF00069	0.644
MOD_GSK3_1	20	27	PF00069	0.633
MOD_GSK3_1	30	37	PF00069	0.466
MOD_GSK3_1	327	334	PF00069	0.796
MOD_GSK3_1	336	343	PF00069	0.729
MOD_GSK3_1	49	56	PF00069	0.541
MOD_N-GLC_1	24	29	PF02516	0.625
MOD_N-GLC_1	31	36	PF02516	0.582
MOD_NEK2_1	232	237	PF00069	0.602
MOD_NEK2_1	30	35	PF00069	0.469
MOD_NEK2_1	65	70	PF00069	0.462
MOD_PIKK_1	87	93	PF00454	0.397
MOD_PK_1	272	278	PF00069	0.603
MOD_PKA_1	278	284	PF00069	0.530
MOD_PKA_1	340	346	PF00069	0.741
MOD_PKA_1	49	55	PF00069	0.556
MOD_PKA_1	87	93	PF00069	0.519
MOD_PKA_2	20	26	PF00069	0.559
MOD_PKA_2	340	346	PF00069	0.741
MOD_PKA_2	370	376	PF00069	0.637
MOD_PKA_2	49	55	PF00069	0.613
MOD_PKA_2	87	93	PF00069	0.433
MOD_PKB_1	318	326	PF00069	0.573
MOD_PKB_1	338	346	PF00069	0.633
MOD_Plk_1	162	168	PF00069	0.554
MOD_Plk_1	24	30	PF00069	0.619
MOD_Plk_1	263	269	PF00069	0.488
MOD_Plk_4	253	259	PF00069	0.632
MOD_Plk_4	272	278	PF00069	0.364
MOD_ProDKin_1	233	239	PF00069	0.690
MOD_ProDKin_1	318	324	PF00069	0.736
MOD_ProDKin_1	333	339	PF00069	0.602
MOD_ProDKin_1	345	351	PF00069	0.511
MOD_ProDKin_1	66	72	PF00069	0.494
MOD_SUMO_for_1	161	164	PF00179	0.638
MOD_SUMO_for_1	183	186	PF00179	0.676
MOD_SUMO_rev_2	171	177	PF00179	0.704
MOD_SUMO_rev_2	178	185	PF00179	0.704
TRG_DiLeu_BaEn_1	220	225	PF01217	0.488
TRG_DiLeu_BaEn_2	146	152	PF01217	0.624
TRG_DiLeu_BaEn_4	123	129	PF01217	0.377
TRG_ENDOCYTIC_2	257	260	PF00928	0.618
TRG_ER_diArg_1	117	120	PF00400	0.380
TRG_ER_diArg_1	139	142	PF00400	0.466
TRG_ER_diArg_1	317	320	PF00400	0.719
TRG_ER_diArg_1	337	340	PF00400	0.669
TRG_ER_diArg_1	82	84	PF00400	0.581
TRG_NLS_MonoExtC_3	307	312	PF00514	0.661
TRG_NLS_MonoExtN_4	306	312	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D2	Leptomonas seymouri	53%	84%
A0A1X0NWL9	Trypanosomatidae	32%	80%
A0A3R7LWS6	Trypanosoma rangeli	34%	81%
A0A3S7WRS1	Leishmania donovani	92%	100%
A4H6L9	Leishmania braziliensis	84%	100%
A4HV02	Leishmania infantum	93%	100%
Q4QGY6	Leishmania major	92%	100%
V5DT45	Trypanosoma cruzi	35%	81%