PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Short C-terminal domain/PUB domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANN6_LEIMU

TriTrypDb:

LmxM.11.0920

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.753
CLV_C14_Caspase3-7	370	374	PF00656	0.614
CLV_C14_Caspase3-7	478	482	PF00656	0.575
CLV_NRD_NRD_1	19	21	PF00675	0.595
CLV_NRD_NRD_1	200	202	PF00675	0.398
CLV_NRD_NRD_1	287	289	PF00675	0.552
CLV_NRD_NRD_1	497	499	PF00675	0.633
CLV_NRD_NRD_1	529	531	PF00675	0.650
CLV_NRD_NRD_1	554	556	PF00675	0.648
CLV_NRD_NRD_1	558	560	PF00675	0.669
CLV_NRD_NRD_1	565	567	PF00675	0.707
CLV_NRD_NRD_1	9	11	PF00675	0.538
CLV_PCSK_FUR_1	495	499	PF00082	0.633
CLV_PCSK_FUR_1	527	531	PF00082	0.709
CLV_PCSK_KEX2_1	19	21	PF00082	0.595
CLV_PCSK_KEX2_1	200	202	PF00082	0.334
CLV_PCSK_KEX2_1	287	289	PF00082	0.604
CLV_PCSK_KEX2_1	497	499	PF00082	0.552
CLV_PCSK_KEX2_1	524	526	PF00082	0.538
CLV_PCSK_KEX2_1	529	531	PF00082	0.562
CLV_PCSK_KEX2_1	553	555	PF00082	0.650
CLV_PCSK_KEX2_1	558	560	PF00082	0.670
CLV_PCSK_KEX2_1	565	567	PF00082	0.711
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.587
CLV_PCSK_PC7_1	520	526	PF00082	0.694
CLV_PCSK_PC7_1	550	556	PF00082	0.748
CLV_PCSK_SKI1_1	13	17	PF00082	0.621
CLV_PCSK_SKI1_1	25	29	PF00082	0.747
CLV_PCSK_SKI1_1	59	63	PF00082	0.549
CLV_PCSK_SKI1_1	64	68	PF00082	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DEG_SCF_FBW7_1	156	162	PF00400	0.565
DEG_SCF_FBW7_1	476	483	PF00400	0.689
DEG_SPOP_SBC_1	163	167	PF00917	0.517
DEG_SPOP_SBC_1	29	33	PF00917	0.535
DEG_SPOP_SBC_1	311	315	PF00917	0.513
DEG_SPOP_SBC_1	456	460	PF00917	0.642
DEG_SPOP_SBC_1	567	571	PF00917	0.811
DEG_SPOP_SBC_1	572	576	PF00917	0.699
DEG_SPOP_SBC_1	618	622	PF00917	0.842
DOC_CKS1_1	156	161	PF01111	0.557
DOC_CKS1_1	95	100	PF01111	0.624
DOC_MAPK_MEF2A_6	296	304	PF00069	0.621
DOC_MAPK_MEF2A_6	422	429	PF00069	0.503
DOC_PP2B_LxvP_1	120	123	PF13499	0.814
DOC_PP4_FxxP_1	436	439	PF00568	0.676
DOC_USP7_MATH_1	103	107	PF00917	0.705
DOC_USP7_MATH_1	125	129	PF00917	0.738
DOC_USP7_MATH_1	138	142	PF00917	0.587
DOC_USP7_MATH_1	161	165	PF00917	0.728
DOC_USP7_MATH_1	217	221	PF00917	0.524
DOC_USP7_MATH_1	238	242	PF00917	0.738
DOC_USP7_MATH_1	29	33	PF00917	0.535
DOC_USP7_MATH_1	311	315	PF00917	0.513
DOC_USP7_MATH_1	343	347	PF00917	0.728
DOC_USP7_MATH_1	400	404	PF00917	0.614
DOC_USP7_MATH_1	449	453	PF00917	0.751
DOC_USP7_MATH_1	456	460	PF00917	0.676
DOC_USP7_MATH_1	480	484	PF00917	0.680
DOC_USP7_MATH_1	515	519	PF00917	0.598
DOC_USP7_MATH_1	567	571	PF00917	0.839
DOC_USP7_MATH_1	572	576	PF00917	0.671
DOC_USP7_MATH_1	580	584	PF00917	0.561
DOC_USP7_MATH_1	588	592	PF00917	0.531
DOC_USP7_MATH_1	618	622	PF00917	0.710
DOC_USP7_MATH_1	73	77	PF00917	0.621
DOC_USP7_MATH_1	80	84	PF00917	0.645
DOC_USP7_MATH_1	91	95	PF00917	0.741
DOC_WW_Pin1_4	105	110	PF00397	0.705
DOC_WW_Pin1_4	121	126	PF00397	0.689
DOC_WW_Pin1_4	127	132	PF00397	0.715
DOC_WW_Pin1_4	155	160	PF00397	0.578
DOC_WW_Pin1_4	236	241	PF00397	0.537
DOC_WW_Pin1_4	312	317	PF00397	0.742
DOC_WW_Pin1_4	350	355	PF00397	0.758
DOC_WW_Pin1_4	450	455	PF00397	0.680
DOC_WW_Pin1_4	457	462	PF00397	0.649
DOC_WW_Pin1_4	476	481	PF00397	0.478
DOC_WW_Pin1_4	568	573	PF00397	0.730
DOC_WW_Pin1_4	607	612	PF00397	0.667
DOC_WW_Pin1_4	94	99	PF00397	0.784
LIG_14-3-3_CanoR_1	13	22	PF00244	0.588
LIG_14-3-3_CanoR_1	140	145	PF00244	0.630
LIG_14-3-3_CanoR_1	566	572	PF00244	0.584
LIG_14-3-3_CanoR_1	64	73	PF00244	0.469
LIG_BIR_III_4	115	119	PF00653	0.758
LIG_BRCT_BRCA1_1	140	144	PF00533	0.691
LIG_CaM_IQ_9	490	506	PF13499	0.562
LIG_deltaCOP1_diTrp_1	145	151	PF00928	0.529
LIG_EVH1_2	169	173	PF00568	0.632
LIG_FHA_1	151	157	PF00498	0.661
LIG_FHA_1	409	415	PF00498	0.582
LIG_FHA_1	441	447	PF00498	0.794
LIG_FHA_1	469	475	PF00498	0.664
LIG_FHA_1	485	491	PF00498	0.335
LIG_FHA_2	110	116	PF00498	0.775
LIG_FHA_2	141	147	PF00498	0.561
LIG_FHA_2	365	371	PF00498	0.537
LIG_FHA_2	464	470	PF00498	0.747
LIG_FHA_2	49	55	PF00498	0.588
LIG_FHA_2	587	593	PF00498	0.796
LIG_GBD_Chelix_1	598	606	PF00786	0.546
LIG_LIR_Gen_1	373	382	PF02991	0.496
LIG_LIR_Nem_3	145	150	PF02991	0.535
LIG_LIR_Nem_3	196	202	PF02991	0.384
LIG_LIR_Nem_3	413	418	PF02991	0.492
LIG_NRBOX	182	188	PF00104	0.513
LIG_SH2_CRK	199	203	PF00017	0.411
LIG_SH2_CRK	415	419	PF00017	0.467
LIG_SH2_NCK_1	389	393	PF00017	0.622
LIG_SH2_SRC	389	392	PF00017	0.544
LIG_SH2_STAP1	389	393	PF00017	0.622
LIG_SH2_STAP1	470	474	PF00017	0.665
LIG_SH2_STAT3	289	292	PF00017	0.722
LIG_SH2_STAT3	470	473	PF00017	0.673
LIG_SH2_STAT5	111	114	PF00017	0.779
LIG_SH2_STAT5	2	5	PF00017	0.531
LIG_SH2_STAT5	280	283	PF00017	0.619
LIG_SH2_STAT5	361	364	PF00017	0.468
LIG_SH2_STAT5	366	369	PF00017	0.441
LIG_SH2_STAT5	470	473	PF00017	0.571
LIG_SH3_1	191	197	PF00018	0.319
LIG_SH3_3	119	125	PF00018	0.700
LIG_SH3_3	153	159	PF00018	0.506
LIG_SH3_3	191	197	PF00018	0.513
LIG_SH3_3	349	355	PF00018	0.687
LIG_SH3_3	443	449	PF00018	0.650
LIG_SH3_3	610	616	PF00018	0.590
LIG_SUMO_SIM_anti_2	600	606	PF11976	0.595
LIG_TRAF2_1	143	146	PF00917	0.524
LIG_TRAF2_1	51	54	PF00917	0.597
LIG_WRC_WIRS_1	63	68	PF05994	0.578
MOD_CDK_SPK_2	121	126	PF00069	0.520
MOD_CDK_SPxK_1	94	100	PF00069	0.662
MOD_CDK_SPxxK_3	457	464	PF00069	0.521
MOD_CK1_1	105	111	PF00069	0.711
MOD_CK1_1	164	170	PF00069	0.664
MOD_CK1_1	346	352	PF00069	0.778
MOD_CK1_1	4	10	PF00069	0.620
MOD_CK1_1	463	469	PF00069	0.504
MOD_CK1_1	570	576	PF00069	0.737
MOD_CK1_1	578	584	PF00069	0.706
MOD_CK1_1	65	71	PF00069	0.609
MOD_CK1_1	83	89	PF00069	0.781
MOD_CK1_1	94	100	PF00069	0.713
MOD_CK2_1	140	146	PF00069	0.509
MOD_CK2_1	212	218	PF00069	0.513
MOD_CK2_1	364	370	PF00069	0.526
MOD_CK2_1	48	54	PF00069	0.604
MOD_CK2_1	581	587	PF00069	0.709
MOD_CK2_1	83	89	PF00069	0.757
MOD_Cter_Amidation	606	609	PF01082	0.668
MOD_GlcNHglycan	104	108	PF01048	0.752
MOD_GlcNHglycan	127	130	PF01048	0.737
MOD_GlcNHglycan	166	169	PF01048	0.730
MOD_GlcNHglycan	218	222	PF01048	0.391
MOD_GlcNHglycan	240	243	PF01048	0.712
MOD_GlcNHglycan	345	348	PF01048	0.794
MOD_GlcNHglycan	535	538	PF01048	0.746
MOD_GlcNHglycan	577	580	PF01048	0.599
MOD_GlcNHglycan	75	78	PF01048	0.738
MOD_GlcNHglycan	83	86	PF01048	0.688
MOD_GSK3_1	105	112	PF00069	0.763
MOD_GSK3_1	121	128	PF00069	0.585
MOD_GSK3_1	136	143	PF00069	0.614
MOD_GSK3_1	155	162	PF00069	0.620
MOD_GSK3_1	236	243	PF00069	0.717
MOD_GSK3_1	346	353	PF00069	0.742
MOD_GSK3_1	400	407	PF00069	0.637
MOD_GSK3_1	456	463	PF00069	0.697
MOD_GSK3_1	476	483	PF00069	0.459
MOD_GSK3_1	566	573	PF00069	0.773
MOD_GSK3_1	574	581	PF00069	0.638
MOD_GSK3_1	607	614	PF00069	0.667
MOD_GSK3_1	62	69	PF00069	0.498
MOD_GSK3_1	81	88	PF00069	0.829
MOD_GSK3_1	90	97	PF00069	0.658
MOD_LATS_1	551	557	PF00433	0.797
MOD_LATS_1	564	570	PF00433	0.628
MOD_NEK2_1	1	6	PF00069	0.788
MOD_NEK2_1	150	155	PF00069	0.643
MOD_NEK2_1	28	33	PF00069	0.581
MOD_NEK2_1	294	299	PF00069	0.572
MOD_NEK2_1	375	380	PF00069	0.560
MOD_NEK2_1	404	409	PF00069	0.374
MOD_NEK2_1	455	460	PF00069	0.623
MOD_NEK2_1	66	71	PF00069	0.472
MOD_NEK2_2	515	520	PF00069	0.599
MOD_PIKK_1	13	19	PF00454	0.501
MOD_PIKK_1	4	10	PF00454	0.523
MOD_PIKK_1	440	446	PF00454	0.705
MOD_PIKK_1	48	54	PF00454	0.706
MOD_PIKK_1	544	550	PF00454	0.663
MOD_PKA_1	553	559	PF00069	0.809
MOD_PKA_2	202	208	PF00069	0.436
MOD_PKA_2	463	469	PF00069	0.612
MOD_PKA_2	553	559	PF00069	0.728
MOD_Plk_1	468	474	PF00069	0.682
MOD_Plk_1	515	521	PF00069	0.598
MOD_Plk_2-3	212	218	PF00069	0.513
MOD_Plk_2-3	364	370	PF00069	0.526
MOD_Plk_4	357	363	PF00069	0.632
MOD_Plk_4	404	410	PF00069	0.570
MOD_Plk_4	91	97	PF00069	0.644
MOD_ProDKin_1	105	111	PF00069	0.707
MOD_ProDKin_1	121	127	PF00069	0.690
MOD_ProDKin_1	155	161	PF00069	0.586
MOD_ProDKin_1	236	242	PF00069	0.538
MOD_ProDKin_1	312	318	PF00069	0.747
MOD_ProDKin_1	350	356	PF00069	0.751
MOD_ProDKin_1	450	456	PF00069	0.681
MOD_ProDKin_1	457	463	PF00069	0.643
MOD_ProDKin_1	476	482	PF00069	0.469
MOD_ProDKin_1	568	574	PF00069	0.730
MOD_ProDKin_1	607	613	PF00069	0.672
MOD_ProDKin_1	94	100	PF00069	0.786
MOD_SUMO_for_1	523	526	PF00179	0.589
MOD_SUMO_rev_2	141	150	PF00179	0.574
MOD_SUMO_rev_2	53	61	PF00179	0.683
TRG_DiLeu_BaEn_4	145	151	PF01217	0.507
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.513
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.527
TRG_ENDOCYTIC_2	199	202	PF00928	0.411
TRG_ENDOCYTIC_2	415	418	PF00928	0.481
TRG_ER_diArg_1	199	201	PF00400	0.398
TRG_ER_diArg_1	287	289	PF00400	0.600
TRG_ER_diArg_1	495	498	PF00400	0.626
TRG_ER_diArg_1	527	530	PF00400	0.654
TRG_ER_diArg_1	553	555	PF00400	0.650
TRG_NES_CRM1_1	292	305	PF08389	0.579
TRG_NLS_MonoExtC_3	9	14	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ9	Leptomonas seymouri	43%	100%
A0A3S7WRQ6	Leishmania donovani	88%	100%
A4H6L8	Leishmania braziliensis	72%	100%
A4HV01	Leishmania infantum	89%	100%
Q4QGY7	Leishmania major	88%	100%