WPP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANN3_LEIMU

TriTrypDb:

LmxM.11.0890

Length:

1007

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9ANN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.703
CLV_C14_Caspase3-7	484	488	PF00656	0.606
CLV_C14_Caspase3-7	504	508	PF00656	0.515
CLV_C14_Caspase3-7	562	566	PF00656	0.355
CLV_C14_Caspase3-7	621	625	PF00656	0.493
CLV_C14_Caspase3-7	924	928	PF00656	0.642
CLV_NRD_NRD_1	628	630	PF00675	0.605
CLV_NRD_NRD_1	656	658	PF00675	0.331
CLV_NRD_NRD_1	882	884	PF00675	0.429
CLV_PCSK_KEX2_1	627	629	PF00082	0.661
CLV_PCSK_KEX2_1	632	634	PF00082	0.610
CLV_PCSK_KEX2_1	656	658	PF00082	0.331
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.642
CLV_PCSK_PC7_1	628	634	PF00082	0.650
CLV_PCSK_SKI1_1	146	150	PF00082	0.617
CLV_PCSK_SKI1_1	153	157	PF00082	0.570
CLV_PCSK_SKI1_1	391	395	PF00082	0.395
CLV_PCSK_SKI1_1	537	541	PF00082	0.447
CLV_PCSK_SKI1_1	578	582	PF00082	0.410
CLV_PCSK_SKI1_1	628	632	PF00082	0.548
CLV_PCSK_SKI1_1	636	640	PF00082	0.412
CLV_PCSK_SKI1_1	827	831	PF00082	0.594
CLV_PCSK_SKI1_1	993	997	PF00082	0.469
DEG_APCC_DBOX_1	145	153	PF00400	0.612
DEG_APCC_DBOX_1	635	643	PF00400	0.395
DEG_APCC_DBOX_1	992	1000	PF00400	0.482
DEG_SCF_TRCP1_1	487	493	PF00400	0.595
DEG_SPOP_SBC_1	973	977	PF00917	0.446
DOC_CDC14_PxL_1	845	853	PF14671	0.558
DOC_CKS1_1	17	22	PF01111	0.753
DOC_CKS1_1	8	13	PF01111	0.787
DOC_CYCLIN_RxL_1	319	327	PF00134	0.404
DOC_CYCLIN_RxL_1	445	457	PF00134	0.472
DOC_CYCLIN_RxL_1	526	536	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	742	745	PF00134	0.517
DOC_MAPK_gen_1	153	163	PF00069	0.616
DOC_MAPK_gen_1	445	455	PF00069	0.399
DOC_MAPK_gen_1	526	535	PF00069	0.447
DOC_MAPK_gen_1	991	998	PF00069	0.523
DOC_MAPK_MEF2A_6	908	915	PF00069	0.569
DOC_MAPK_MEF2A_6	991	1000	PF00069	0.530
DOC_MAPK_NFAT4_5	991	999	PF00069	0.527
DOC_PP1_RVXF_1	278	285	PF00149	0.573
DOC_PP1_RVXF_1	724	730	PF00149	0.492
DOC_PP2B_LxvP_1	466	469	PF13499	0.709
DOC_PP2B_LxvP_1	742	745	PF13499	0.517
DOC_PP4_FxxP_1	430	433	PF00568	0.607
DOC_USP7_MATH_1	1003	1007	PF00917	0.625
DOC_USP7_MATH_1	207	211	PF00917	0.653
DOC_USP7_MATH_1	232	236	PF00917	0.678
DOC_USP7_MATH_1	367	371	PF00917	0.522
DOC_USP7_MATH_1	380	384	PF00917	0.529
DOC_USP7_MATH_1	75	79	PF00917	0.694
DOC_USP7_MATH_1	795	799	PF00917	0.308
DOC_USP7_MATH_1	920	924	PF00917	0.602
DOC_USP7_MATH_1	973	977	PF00917	0.670
DOC_USP7_UBL2_3	391	395	PF12436	0.395
DOC_WW_Pin1_4	16	21	PF00397	0.672
DOC_WW_Pin1_4	205	210	PF00397	0.540
DOC_WW_Pin1_4	353	358	PF00397	0.510
DOC_WW_Pin1_4	519	524	PF00397	0.489
DOC_WW_Pin1_4	63	68	PF00397	0.727
DOC_WW_Pin1_4	7	12	PF00397	0.731
DOC_WW_Pin1_4	827	832	PF00397	0.666
DOC_WW_Pin1_4	887	892	PF00397	0.602
LIG_14-3-3_CanoR_1	500	506	PF00244	0.451
LIG_14-3-3_CanoR_1	633	642	PF00244	0.555
LIG_14-3-3_CanoR_1	644	652	PF00244	0.421
LIG_14-3-3_CanoR_1	762	766	PF00244	0.536
LIG_BRCT_BRCA1_1	238	242	PF00533	0.701
LIG_BRCT_BRCA1_1	869	873	PF00533	0.464
LIG_Clathr_ClatBox_1	959	963	PF01394	0.517
LIG_deltaCOP1_diTrp_1	510	518	PF00928	0.430
LIG_FHA_1	190	196	PF00498	0.558
LIG_FHA_1	392	398	PF00498	0.394
LIG_FHA_1	413	419	PF00498	0.706
LIG_FHA_1	600	606	PF00498	0.385
LIG_FHA_1	8	14	PF00498	0.519
LIG_FHA_1	888	894	PF00498	0.604
LIG_FHA_1	908	914	PF00498	0.237
LIG_FHA_2	247	253	PF00498	0.667
LIG_FHA_2	554	560	PF00498	0.480
LIG_FHA_2	782	788	PF00498	0.341
LIG_FHA_2	92	98	PF00498	0.659
LIG_Integrin_RGD_1	346	348	PF01839	0.685
LIG_IRF3_LxIS_1	783	789	PF10401	0.415
LIG_IRF3_LxIS_1	851	857	PF10401	0.543
LIG_LIR_Apic_2	15	20	PF02991	0.780
LIG_LIR_Apic_2	427	433	PF02991	0.614
LIG_LIR_Apic_2	663	667	PF02991	0.513
LIG_LIR_Gen_1	325	336	PF02991	0.474
LIG_LIR_Gen_1	370	381	PF02991	0.502
LIG_LIR_Gen_1	510	520	PF02991	0.419
LIG_LIR_Gen_1	668	677	PF02991	0.496
LIG_LIR_Gen_1	787	797	PF02991	0.447
LIG_LIR_Gen_1	941	949	PF02991	0.531
LIG_LIR_Nem_3	215	221	PF02991	0.571
LIG_LIR_Nem_3	288	293	PF02991	0.520
LIG_LIR_Nem_3	325	331	PF02991	0.474
LIG_LIR_Nem_3	370	376	PF02991	0.495
LIG_LIR_Nem_3	432	437	PF02991	0.508
LIG_LIR_Nem_3	510	515	PF02991	0.446
LIG_LIR_Nem_3	668	672	PF02991	0.538
LIG_LIR_Nem_3	787	793	PF02991	0.447
LIG_LIR_Nem_3	941	945	PF02991	0.541
LIG_MLH1_MIPbox_1	869	873	PF16413	0.464
LIG_MYND_3	848	852	PF01753	0.482
LIG_NRBOX	708	714	PF00104	0.489
LIG_NRBOX	771	777	PF00104	0.559
LIG_NRBOX	897	903	PF00104	0.589
LIG_PCNA_yPIPBox_3	597	606	PF02747	0.555
LIG_Pex14_1	214	218	PF04695	0.580
LIG_SH2_CRK	328	332	PF00017	0.480
LIG_SH2_CRK	527	531	PF00017	0.335
LIG_SH2_CRK	570	574	PF00017	0.447
LIG_SH2_CRK	790	794	PF00017	0.392
LIG_SH2_GRB2like	373	376	PF00017	0.495
LIG_SH2_NCK_1	328	332	PF00017	0.402
LIG_SH2_NCK_1	790	794	PF00017	0.383
LIG_SH2_PTP2	17	20	PF00017	0.735
LIG_SH2_STAP1	272	276	PF00017	0.510
LIG_SH2_STAP1	285	289	PF00017	0.342
LIG_SH2_STAT3	525	528	PF00017	0.557
LIG_SH2_STAT3	714	717	PF00017	0.646
LIG_SH2_STAT5	17	20	PF00017	0.812
LIG_SH2_STAT5	296	299	PF00017	0.529
LIG_SH2_STAT5	373	376	PF00017	0.482
LIG_SH2_STAT5	579	582	PF00017	0.419
LIG_SH2_STAT5	664	667	PF00017	0.403
LIG_SH2_STAT5	904	907	PF00017	0.517
LIG_SH3_1	888	894	PF00018	0.604
LIG_SH3_3	10	16	PF00018	0.636
LIG_SH3_3	133	139	PF00018	0.532
LIG_SH3_3	154	160	PF00018	0.576
LIG_SH3_3	197	203	PF00018	0.563
LIG_SH3_3	2	8	PF00018	0.726
LIG_SH3_3	331	337	PF00018	0.525
LIG_SH3_3	415	421	PF00018	0.638
LIG_SH3_3	422	428	PF00018	0.627
LIG_SH3_3	746	752	PF00018	0.528
LIG_SH3_3	888	894	PF00018	0.604
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.382
LIG_SUMO_SIM_par_1	322	327	PF11976	0.408
LIG_SUMO_SIM_par_1	559	565	PF11976	0.335
LIG_SUMO_SIM_par_1	852	857	PF11976	0.500
LIG_TRAF2_1	340	343	PF00917	0.499
LIG_TRAF2_1	470	473	PF00917	0.723
LIG_TRAF2_1	482	485	PF00917	0.760
LIG_TRAF2_1	682	685	PF00917	0.394
LIG_TRAF2_1	705	708	PF00917	0.551
LIG_TRAF2_1	832	835	PF00917	0.605
LIG_TYR_ITIM	326	331	PF00017	0.480
LIG_TYR_ITIM	371	376	PF00017	0.495
LIG_TYR_ITIM	568	573	PF00017	0.447
LIG_TYR_ITIM	788	793	PF00017	0.408
LIG_UBA3_1	995	1001	PF00899	0.618
MOD_CDC14_SPxK_1	356	359	PF00782	0.480
MOD_CDK_SPK_2	887	892	PF00069	0.519
MOD_CDK_SPxK_1	353	359	PF00069	0.499
MOD_CDK_SPxxK_3	16	23	PF00069	0.763
MOD_CDK_SPxxK_3	519	526	PF00069	0.501
MOD_CK1_1	208	214	PF00069	0.617
MOD_CK1_1	236	242	PF00069	0.701
MOD_CK1_1	553	559	PF00069	0.480
MOD_CK1_1	761	767	PF00069	0.473
MOD_CK1_1	907	913	PF00069	0.549
MOD_CK1_1	977	983	PF00069	0.667
MOD_CK2_1	246	252	PF00069	0.676
MOD_CK2_1	553	559	PF00069	0.480
MOD_CK2_1	644	650	PF00069	0.560
MOD_CK2_1	805	811	PF00069	0.401
MOD_CK2_1	955	961	PF00069	0.568
MOD_GlcNHglycan	113	116	PF01048	0.497
MOD_GlcNHglycan	146	149	PF01048	0.667
MOD_GlcNHglycan	235	238	PF01048	0.735
MOD_GlcNHglycan	403	407	PF01048	0.498
MOD_GlcNHglycan	487	490	PF01048	0.742
MOD_GlcNHglycan	590	593	PF01048	0.631
MOD_GlcNHglycan	597	600	PF01048	0.346
MOD_GlcNHglycan	620	623	PF01048	0.666
MOD_GlcNHglycan	636	639	PF01048	0.334
MOD_GlcNHglycan	646	649	PF01048	0.426
MOD_GlcNHglycan	793	796	PF01048	0.419
MOD_GlcNHglycan	869	872	PF01048	0.509
MOD_GlcNHglycan	955	958	PF01048	0.475
MOD_GlcNHglycan	983	986	PF01048	0.649
MOD_GSK3_1	12	19	PF00069	0.743
MOD_GSK3_1	232	239	PF00069	0.659
MOD_GSK3_1	550	557	PF00069	0.553
MOD_GSK3_1	595	602	PF00069	0.564
MOD_GSK3_1	791	798	PF00069	0.305
MOD_GSK3_1	867	874	PF00069	0.550
MOD_GSK3_1	973	980	PF00069	0.652
MOD_LATS_1	626	632	PF00433	0.456
MOD_N-GLC_1	367	372	PF02516	0.397
MOD_N-GLC_1	554	559	PF02516	0.335
MOD_N-GLC_1	732	737	PF02516	0.516
MOD_N-GLC_1	791	796	PF02516	0.413
MOD_N-GLC_1	812	817	PF02516	0.420
MOD_N-GLC_1	933	938	PF02516	0.546
MOD_NEK2_1	131	136	PF00069	0.503
MOD_NEK2_1	324	329	PF00069	0.480
MOD_NEK2_1	37	42	PF00069	0.644
MOD_NEK2_1	501	506	PF00069	0.456
MOD_NEK2_1	533	538	PF00069	0.363
MOD_NEK2_1	581	586	PF00069	0.459
MOD_NEK2_1	660	665	PF00069	0.469
MOD_NEK2_1	673	678	PF00069	0.321
MOD_NEK2_1	701	706	PF00069	0.460
MOD_NEK2_1	758	763	PF00069	0.439
MOD_NEK2_1	786	791	PF00069	0.410
MOD_NEK2_1	812	817	PF00069	0.326
MOD_NEK2_1	854	859	PF00069	0.554
MOD_NEK2_1	873	878	PF00069	0.417
MOD_NEK2_1	914	919	PF00069	0.479
MOD_NEK2_2	285	290	PF00069	0.472
MOD_NEK2_2	367	372	PF00069	0.417
MOD_PIKK_1	246	252	PF00454	0.786
MOD_PIKK_1	73	79	PF00454	0.775
MOD_PKA_1	628	634	PF00069	0.579
MOD_PKA_2	628	634	PF00069	0.617
MOD_PKA_2	761	767	PF00069	0.538
MOD_PKA_2	907	913	PF00069	0.543
MOD_Plk_1	285	291	PF00069	0.473
MOD_Plk_1	324	330	PF00069	0.480
MOD_Plk_1	367	373	PF00069	0.396
MOD_Plk_1	554	560	PF00069	0.335
MOD_Plk_1	786	792	PF00069	0.420
MOD_Plk_1	933	939	PF00069	0.637
MOD_Plk_1	977	983	PF00069	0.692
MOD_Plk_4	285	291	PF00069	0.473
MOD_Plk_4	599	605	PF00069	0.402
MOD_Plk_4	660	666	PF00069	0.512
MOD_Plk_4	668	674	PF00069	0.498
MOD_Plk_4	795	801	PF00069	0.517
MOD_Plk_4	897	903	PF00069	0.589
MOD_Plk_4	914	920	PF00069	0.322
MOD_Plk_4	941	947	PF00069	0.448
MOD_Plk_4	955	961	PF00069	0.416
MOD_ProDKin_1	16	22	PF00069	0.665
MOD_ProDKin_1	205	211	PF00069	0.544
MOD_ProDKin_1	353	359	PF00069	0.507
MOD_ProDKin_1	519	525	PF00069	0.491
MOD_ProDKin_1	63	69	PF00069	0.729
MOD_ProDKin_1	7	13	PF00069	0.733
MOD_ProDKin_1	827	833	PF00069	0.659
MOD_ProDKin_1	887	893	PF00069	0.598
TRG_DiLeu_BaEn_1	708	713	PF01217	0.565
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.504
TRG_DiLeu_BaLyEn_6	990	995	PF01217	0.471
TRG_ENDOCYTIC_2	218	221	PF00928	0.560
TRG_ENDOCYTIC_2	31	34	PF00928	0.577
TRG_ENDOCYTIC_2	328	331	PF00928	0.480
TRG_ENDOCYTIC_2	373	376	PF00928	0.495
TRG_ENDOCYTIC_2	434	437	PF00928	0.482
TRG_ENDOCYTIC_2	527	530	PF00928	0.398
TRG_ENDOCYTIC_2	570	573	PF00928	0.447
TRG_ENDOCYTIC_2	790	793	PF00928	0.392
TRG_ER_diArg_1	627	629	PF00400	0.661
TRG_ER_diArg_1	655	657	PF00400	0.337
TRG_NES_CRM1_1	260	273	PF08389	0.505
TRG_NES_CRM1_1	847	860	PF08389	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE6	Leptomonas seymouri	53%	96%
A0A1X0NWD9	Trypanosomatidae	33%	100%
A0A3S7WRP9	Leishmania donovani	92%	100%
A0A422MZT7	Trypanosoma rangeli	33%	100%
A4H6L5	Leishmania braziliensis	82%	100%
A4HUZ8	Leishmania infantum	92%	100%
D0A7F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QGZ0	Leishmania major	91%	100%
V5C1B4	Trypanosoma cruzi	32%	100%