START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANN2_LEIMU

TriTrypDb:

LmxM.11.0880

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANN2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	22
GO:0008289	lipid binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.432
DOC_CKS1_1	24	29	PF01111	0.543
DOC_CKS1_1	32	37	PF01111	0.482
DOC_CYCLIN_RxL_1	135	148	PF00134	0.180
DOC_MAPK_gen_1	74	83	PF00069	0.494
DOC_PP1_RVXF_1	275	281	PF00149	0.432
DOC_USP7_MATH_1	89	93	PF00917	0.562
DOC_WW_Pin1_4	111	116	PF00397	0.532
DOC_WW_Pin1_4	154	159	PF00397	0.363
DOC_WW_Pin1_4	20	25	PF00397	0.612
DOC_WW_Pin1_4	293	298	PF00397	0.483
DOC_WW_Pin1_4	31	36	PF00397	0.429
LIG_14-3-3_CanoR_1	140	145	PF00244	0.426
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_CtBP_PxDLS_1	250	254	PF00389	0.276
LIG_deltaCOP1_diTrp_1	292	300	PF00928	0.444
LIG_FHA_1	215	221	PF00498	0.308
LIG_FHA_1	24	30	PF00498	0.545
LIG_FHA_1	252	258	PF00498	0.331
LIG_FHA_2	112	118	PF00498	0.342
LIG_FHA_2	23	29	PF00498	0.583
LIG_FHA_2	239	245	PF00498	0.300
LIG_FHA_2	61	67	PF00498	0.342
LIG_LIR_Gen_1	116	127	PF02991	0.297
LIG_LIR_Gen_1	179	189	PF02991	0.341
LIG_LIR_Nem_3	116	122	PF02991	0.297
LIG_LIR_Nem_3	129	134	PF02991	0.396
LIG_LIR_Nem_3	137	142	PF02991	0.360
LIG_LIR_Nem_3	179	184	PF02991	0.345
LIG_LIR_Nem_3	56	61	PF02991	0.343
LIG_LYPXL_SIV_4	208	216	PF13949	0.276
LIG_NRBOX	117	123	PF00104	0.458
LIG_Pex14_2	127	131	PF04695	0.348
LIG_Pex14_2	276	280	PF04695	0.491
LIG_PTB_Apo_2	161	168	PF02174	0.343
LIG_SH2_CRK	119	123	PF00017	0.343
LIG_SH2_CRK	32	36	PF00017	0.444
LIG_SH2_CRK	50	54	PF00017	0.395
LIG_SH2_NCK_1	75	79	PF00017	0.548
LIG_SH2_STAP1	289	293	PF00017	0.597
LIG_SH2_STAT3	239	242	PF00017	0.326
LIG_SH2_STAT5	181	184	PF00017	0.397
LIG_SH2_STAT5	209	212	PF00017	0.367
LIG_SH2_STAT5	219	222	PF00017	0.313
LIG_SH2_STAT5	239	242	PF00017	0.296
LIG_SH2_STAT5	256	259	PF00017	0.302
LIG_SH2_STAT5	289	292	PF00017	0.488
LIG_SH2_STAT5	59	62	PF00017	0.498
LIG_SH3_3	21	27	PF00018	0.637
LIG_SUMO_SIM_par_1	140	145	PF11976	0.405
LIG_SUMO_SIM_par_1	249	254	PF11976	0.276
LIG_WRC_WIRS_1	58	63	PF05994	0.447
LIG_WW_1	194	197	PF00397	0.276
MOD_CK1_1	145	151	PF00069	0.402
MOD_CK1_1	20	26	PF00069	0.618
MOD_CK1_1	214	220	PF00069	0.349
MOD_CK1_1	39	45	PF00069	0.497
MOD_CK2_1	111	117	PF00069	0.458
MOD_CK2_1	22	28	PF00069	0.582
MOD_GlcNHglycan	109	112	PF01048	0.390
MOD_GlcNHglycan	144	147	PF01048	0.402
MOD_GlcNHglycan	190	193	PF01048	0.403
MOD_GlcNHglycan	228	231	PF01048	0.490
MOD_GlcNHglycan	38	41	PF01048	0.451
MOD_GSK3_1	107	114	PF00069	0.396
MOD_GSK3_1	13	20	PF00069	0.697
MOD_GSK3_1	184	191	PF00069	0.390
MOD_GSK3_1	319	326	PF00069	0.398
MOD_GSK3_1	4	11	PF00069	0.719
MOD_GSK3_1	53	60	PF00069	0.443
MOD_N-GLC_1	184	189	PF02516	0.335
MOD_N-GLC_1	310	315	PF02516	0.428
MOD_N-GLC_1	89	94	PF02516	0.265
MOD_NEK2_1	142	147	PF00069	0.478
MOD_NEK2_1	184	189	PF00069	0.330
MOD_NEK2_2	89	94	PF00069	0.265
MOD_PIKK_1	238	244	PF00454	0.339
MOD_PIKK_1	39	45	PF00454	0.343
MOD_PKA_1	319	325	PF00069	0.571
MOD_Plk_1	184	190	PF00069	0.281
MOD_Plk_1	310	316	PF00069	0.439
MOD_Plk_1	89	95	PF00069	0.336
MOD_Plk_2-3	302	308	PF00069	0.611
MOD_Plk_4	235	241	PF00069	0.318
MOD_ProDKin_1	111	117	PF00069	0.443
MOD_ProDKin_1	154	160	PF00069	0.363
MOD_ProDKin_1	20	26	PF00069	0.601
MOD_ProDKin_1	293	299	PF00069	0.478
MOD_ProDKin_1	31	37	PF00069	0.434
MOD_SUMO_for_1	309	312	PF00179	0.517
MOD_SUMO_rev_2	2	8	PF00179	0.473
MOD_SUMO_rev_2	80	89	PF00179	0.502
TRG_DiLeu_BaEn_1	117	122	PF01217	0.318
TRG_ENDOCYTIC_2	119	122	PF00928	0.343
TRG_ENDOCYTIC_2	181	184	PF00928	0.394
TRG_ER_FFAT_2	28	37	PF00635	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	35%	89%
A0A0N1I4D8	Leptomonas seymouri	74%	97%
A0A0S4INS4	Bodo saltans	40%	100%
A0A0S4KH88	Bodo saltans	34%	83%
A0A1X0NV84	Trypanosomatidae	51%	100%
A0A1X0P910	Trypanosomatidae	35%	87%
A0A3Q8IBA5	Leishmania donovani	89%	100%
A0A3Q8IJ21	Leishmania donovani	36%	90%
A0A3R7KCX0	Trypanosoma rangeli	37%	90%
A0A422MZR8	Trypanosoma rangeli	47%	100%
A4H6L4	Leishmania braziliensis	78%	100%
A4HHT0	Leishmania braziliensis	36%	90%
A4HUZ7	Leishmania infantum	89%	79%
A4I4Z0	Leishmania infantum	36%	90%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	89%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AED5	Leishmania major	33%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QGZ1	Leishmania major	91%	100%
Q9JMD3	Mus musculus	33%	100%
Q9Y365	Homo sapiens	34%	100%
V5BC62	Trypanosoma cruzi	38%	90%
V5DT41	Trypanosoma cruzi	50%	100%