LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family, putative
Species:
Leishmania mexicana
UniProt:
E9ANM8_LEIMU
TriTrypDb:
LmxM.11.0840
Length:
415

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9ANM8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANM8

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044255 cellular lipid metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016298 lipase activity 4 3
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0034338 short-chain carboxylesterase activity 5 3
GO:0047372 acylglycerol lipase activity 5 3
GO:0052689 carboxylic ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 262 264 PF00082 0.530
CLV_PCSK_KEX2_1 412 414 PF00082 0.551
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.498
CLV_PCSK_PC1ET2_1 412 414 PF00082 0.551
CLV_PCSK_SKI1_1 121 125 PF00082 0.315
CLV_PCSK_SKI1_1 255 259 PF00082 0.499
CLV_PCSK_SKI1_1 276 280 PF00082 0.517
CLV_PCSK_SKI1_1 391 395 PF00082 0.491
DEG_APCC_DBOX_1 240 248 PF00400 0.398
DEG_APCC_DBOX_1 357 365 PF00400 0.326
DEG_APCC_DBOX_1 390 398 PF00400 0.277
DEG_SCF_FBW7_2 175 182 PF00400 0.490
DOC_CYCLIN_RxL_1 273 283 PF00134 0.358
DOC_CYCLIN_RxL_1 346 355 PF00134 0.256
DOC_CYCLIN_yCln2_LP_2 23 29 PF00134 0.587
DOC_MAPK_DCC_7 188 196 PF00069 0.562
DOC_MAPK_FxFP_2 305 308 PF00069 0.207
DOC_MAPK_gen_1 356 364 PF00069 0.325
DOC_MAPK_gen_1 96 104 PF00069 0.504
DOC_MAPK_MEF2A_6 188 196 PF00069 0.482
DOC_MAPK_MEF2A_6 358 366 PF00069 0.295
DOC_MAPK_MEF2A_6 96 104 PF00069 0.503
DOC_PP2B_LxvP_1 240 243 PF13499 0.219
DOC_PP2B_LxvP_1 60 63 PF13499 0.503
DOC_PP2B_PxIxI_1 191 197 PF00149 0.408
DOC_PP4_FxxP_1 305 308 PF00568 0.311
DOC_PP4_FxxP_1 54 57 PF00568 0.575
DOC_USP7_MATH_1 180 184 PF00917 0.636
DOC_WW_Pin1_4 138 143 PF00397 0.480
DOC_WW_Pin1_4 175 180 PF00397 0.688
DOC_WW_Pin1_4 214 219 PF00397 0.414
DOC_WW_Pin1_4 226 231 PF00397 0.272
DOC_WW_Pin1_4 281 286 PF00397 0.292
DOC_WW_Pin1_4 325 330 PF00397 0.340
DOC_WW_Pin1_4 382 387 PF00397 0.316
DOC_WW_Pin1_4 4 9 PF00397 0.554
LIG_14-3-3_CanoR_1 15 23 PF00244 0.604
LIG_14-3-3_CanoR_1 289 294 PF00244 0.339
LIG_Actin_WH2_1 145 160 PF00022 0.409
LIG_BRCT_BRCA1_1 149 153 PF00533 0.553
LIG_BRCT_BRCA1_2 149 155 PF00533 0.407
LIG_Clathr_ClatBox_1 361 365 PF01394 0.360
LIG_Clathr_ClatBox_2 377 382 PF01394 0.260
LIG_CSL_BTD_1 80 83 PF09270 0.542
LIG_CtBP_PxDLS_1 57 61 PF00389 0.414
LIG_FHA_1 128 134 PF00498 0.523
LIG_FHA_1 152 158 PF00498 0.431
LIG_FHA_1 176 182 PF00498 0.614
LIG_FHA_1 204 210 PF00498 0.300
LIG_FHA_1 326 332 PF00498 0.250
LIG_FHA_2 139 145 PF00498 0.553
LIG_FHA_2 290 296 PF00498 0.287
LIG_FHA_2 383 389 PF00498 0.383
LIG_FHA_2 405 411 PF00498 0.287
LIG_FHA_2 74 80 PF00498 0.480
LIG_LIR_Apic_2 79 83 PF02991 0.543
LIG_LIR_Gen_1 219 228 PF02991 0.353
LIG_LIR_Gen_1 295 303 PF02991 0.319
LIG_LIR_Gen_1 348 354 PF02991 0.278
LIG_LIR_Nem_3 219 224 PF02991 0.360
LIG_LIR_Nem_3 251 257 PF02991 0.225
LIG_LIR_Nem_3 295 299 PF02991 0.326
LIG_LIR_Nem_3 348 353 PF02991 0.335
LIG_Pex14_2 149 153 PF04695 0.517
LIG_SH2_CRK 225 229 PF00017 0.250
LIG_SH2_CRK 249 253 PF00017 0.366
LIG_SH2_CRK 254 258 PF00017 0.318
LIG_SH2_CRK 38 42 PF00017 0.534
LIG_SH2_NCK_1 225 229 PF00017 0.346
LIG_SH2_NCK_1 249 253 PF00017 0.300
LIG_SH2_NCK_1 314 318 PF00017 0.246
LIG_SH2_STAP1 249 253 PF00017 0.320
LIG_SH2_STAT5 115 118 PF00017 0.482
LIG_SH2_STAT5 208 211 PF00017 0.282
LIG_SH2_STAT5 225 228 PF00017 0.264
LIG_SH2_STAT5 363 366 PF00017 0.305
LIG_SH3_3 337 343 PF00018 0.296
LIG_SH3_3 361 367 PF00018 0.294
LIG_SH3_3 99 105 PF00018 0.484
LIG_TRAF2_1 292 295 PF00917 0.219
LIG_TYR_ITIM 247 252 PF00017 0.267
LIG_UBA3_1 103 112 PF00899 0.386
LIG_UBA3_1 148 155 PF00899 0.422
MOD_CDK_SPK_2 4 9 PF00069 0.428
MOD_CDK_SPxxK_3 138 145 PF00069 0.347
MOD_CK1_1 380 386 PF00069 0.486
MOD_CK1_1 4 10 PF00069 0.507
MOD_CK1_1 403 409 PF00069 0.605
MOD_CK2_1 107 113 PF00069 0.436
MOD_CK2_1 138 144 PF00069 0.445
MOD_CK2_1 289 295 PF00069 0.252
MOD_CK2_1 382 388 PF00069 0.449
MOD_CK2_1 404 410 PF00069 0.452
MOD_CMANNOS 379 382 PF00535 0.386
MOD_GlcNHglycan 149 152 PF01048 0.350
MOD_GlcNHglycan 218 221 PF01048 0.425
MOD_GlcNHglycan 3 6 PF01048 0.541
MOD_GlcNHglycan 402 405 PF01048 0.525
MOD_GSK3_1 147 154 PF00069 0.338
MOD_GSK3_1 203 210 PF00069 0.316
MOD_GSK3_1 400 407 PF00069 0.482
MOD_N-GLC_1 231 236 PF02516 0.357
MOD_N-GLC_2 319 321 PF02516 0.203
MOD_NEK2_1 1 6 PF00069 0.573
MOD_NEK2_1 107 112 PF00069 0.368
MOD_NEK2_1 203 208 PF00069 0.277
MOD_NEK2_1 248 253 PF00069 0.431
MOD_NEK2_1 323 328 PF00069 0.346
MOD_PIKK_1 380 386 PF00454 0.450
MOD_PKA_2 31 37 PF00069 0.574
MOD_Plk_4 223 229 PF00069 0.385
MOD_Plk_4 248 254 PF00069 0.392
MOD_Plk_4 393 399 PF00069 0.408
MOD_Plk_4 46 52 PF00069 0.348
MOD_ProDKin_1 138 144 PF00069 0.350
MOD_ProDKin_1 175 181 PF00069 0.638
MOD_ProDKin_1 214 220 PF00069 0.527
MOD_ProDKin_1 226 232 PF00069 0.335
MOD_ProDKin_1 281 287 PF00069 0.352
MOD_ProDKin_1 325 331 PF00069 0.427
MOD_ProDKin_1 382 388 PF00069 0.388
MOD_ProDKin_1 4 10 PF00069 0.440
TRG_DiLeu_BaEn_2 294 300 PF01217 0.192
TRG_DiLeu_BaEn_2 387 393 PF01217 0.384
TRG_DiLeu_BaLyEn_6 170 175 PF01217 0.455
TRG_ENDOCYTIC_2 225 228 PF00928 0.436
TRG_ENDOCYTIC_2 249 252 PF00928 0.409
TRG_ENDOCYTIC_2 254 257 PF00928 0.400
TRG_ENDOCYTIC_2 363 366 PF00928 0.324
TRG_ER_diArg_1 35 38 PF00400 0.330
TRG_ER_diArg_1 95 98 PF00400 0.448
TRG_NES_CRM1_1 269 283 PF08389 0.274
TRG_Pf-PMV_PEXEL_1 158 162 PF00026 0.438

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 29% 91%
A0A0N1HZ60 Leptomonas seymouri 34% 90%
A0A0N1I523 Leptomonas seymouri 28% 94%
A0A0N1I5Q2 Leptomonas seymouri 63% 82%
A0A0N1I7U8 Leptomonas seymouri 32% 97%
A0A0S4JMS7 Bodo saltans 34% 96%
A0A0S4JTS9 Bodo saltans 32% 97%
A0A1X0NEW5 Trypanosomatidae 34% 100%
A0A1X0NSK7 Trypanosomatidae 34% 100%
A0A1X0NUZ6 Trypanosomatidae 32% 100%
A0A3S5H6J1 Leishmania donovani 35% 88%
A0A3S7X2V6 Leishmania donovani 33% 98%
A0A422NB49 Trypanosoma rangeli 33% 100%
A0A422NQC5 Trypanosoma rangeli 41% 95%
A4H6L0 Leishmania braziliensis 77% 100%
A4HHU6 Leishmania braziliensis 31% 100%
A4HUZ4 Leishmania infantum 35% 88%
A4I4Z6 Leishmania infantum 34% 98%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 97%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 88%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 98%
P38295 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 92%
Q02891 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 91%
Q03649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 92%
Q0VC00 Bos taurus 25% 100%
Q24093 Drosophila melanogaster 26% 100%
Q3T0A0 Bos taurus 27% 100%
Q40863 Picea glauca 27% 91%
Q4Q7V8 Leishmania major 33% 100%
Q4QGZ4 Leishmania major 34% 100%
Q4QGZ5 Leishmania major 79% 100%
Q54H38 Dictyostelium discoideum 25% 100%
Q5RK23 Rattus norvegicus 26% 100%
Q8WU67 Homo sapiens 26% 100%
Q91ZH7 Mus musculus 27% 100%
Q96SE0 Homo sapiens 26% 100%
Q9QZC8 Mus musculus 25% 100%
V5AZF4 Trypanosoma cruzi 37% 100%
V5BBC2 Trypanosoma cruzi 42% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS