DUF1421 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANM6_LEIMU

TriTrypDb:

LmxM.11.0820

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	99	101	PF00082	0.493
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.481
CLV_PCSK_SKI1_1	68	72	PF00082	0.554
CLV_PCSK_SKI1_1	92	96	PF00082	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.636
DEG_SIAH_1	176	184	PF03145	0.678
DOC_PP1_RVXF_1	66	73	PF00149	0.528
DOC_PP4_FxxP_1	72	75	PF00568	0.567
DOC_PP4_MxPP_1	201	204	PF00568	0.666
DOC_PP4_MxPP_1	288	291	PF00568	0.780
DOC_USP7_MATH_1	105	109	PF00917	0.497
DOC_USP7_MATH_1	169	173	PF00917	0.653
DOC_USP7_MATH_1	19	23	PF00917	0.527
DOC_USP7_MATH_1	331	335	PF00917	0.627
DOC_WW_Pin1_4	173	178	PF00397	0.619
DOC_WW_Pin1_4	179	184	PF00397	0.620
DOC_WW_Pin1_4	2	7	PF00397	0.634
LIG_14-3-3_CanoR_1	170	177	PF00244	0.614
LIG_14-3-3_CanoR_1	317	323	PF00244	0.673
LIG_14-3-3_CanoR_1	68	73	PF00244	0.551
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.603
LIG_FHA_1	129	135	PF00498	0.458
LIG_FHA_1	69	75	PF00498	0.616
LIG_FHA_1	80	86	PF00498	0.437
LIG_LIR_Apic_2	71	75	PF02991	0.554
LIG_PTB_Apo_2	32	39	PF02174	0.602
LIG_SH2_NCK_1	322	326	PF00017	0.587
LIG_SH2_STAP1	295	299	PF00017	0.613
LIG_SH2_STAP1	54	58	PF00017	0.540
LIG_SH2_STAT3	221	224	PF00017	0.670
LIG_SH3_1	284	290	PF00018	0.624
LIG_SH3_3	284	290	PF00018	0.617
LIG_SH3_3	5	11	PF00018	0.597
LIG_SUMO_SIM_par_1	57	64	PF11976	0.528
LIG_TRAF2_1	23	26	PF00917	0.686
MOD_CK1_1	318	324	PF00069	0.734
MOD_CK2_1	19	25	PF00069	0.711
MOD_CK2_1	58	64	PF00069	0.510
MOD_CK2_1	80	86	PF00069	0.514
MOD_GlcNHglycan	21	24	PF01048	0.687
MOD_GlcNHglycan	211	214	PF01048	0.684
MOD_GlcNHglycan	271	274	PF01048	0.691
MOD_GlcNHglycan	333	336	PF01048	0.693
MOD_GlcNHglycan	82	85	PF01048	0.527
MOD_GSK3_1	158	165	PF00069	0.627
MOD_GSK3_1	169	176	PF00069	0.591
MOD_N-GLC_1	68	73	PF02516	0.515
MOD_NEK2_1	143	148	PF00069	0.513
MOD_PIKK_1	143	149	PF00454	0.462
MOD_PIKK_1	158	164	PF00454	0.627
MOD_PIKK_1	169	175	PF00454	0.574
MOD_PIKK_1	315	321	PF00454	0.763
MOD_PKA_2	169	175	PF00069	0.616
MOD_Plk_1	116	122	PF00069	0.461
MOD_Plk_1	68	74	PF00069	0.514
MOD_Plk_4	58	64	PF00069	0.542
MOD_ProDKin_1	173	179	PF00069	0.620
MOD_ProDKin_1	181	187	PF00069	0.617
MOD_ProDKin_1	2	8	PF00069	0.631
TRG_DiLeu_BaEn_1	137	142	PF01217	0.516
TRG_DiLeu_BaEn_3	25	31	PF01217	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL54	Leptomonas seymouri	59%	71%
A0A3S7WRM1	Leishmania donovani	97%	100%
A4H6K6	Leishmania braziliensis	83%	100%
A4HUZ1	Leishmania infantum	97%	100%
Q4QGZ7	Leishmania major	96%	100%