EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANM5_LEIMU

TriTrypDb:

LmxM.11.0810

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.638
CLV_C14_Caspase3-7	629	633	PF00656	0.511
CLV_C14_Caspase3-7	701	705	PF00656	0.503
CLV_C14_Caspase3-7	89	93	PF00656	0.498
CLV_NRD_NRD_1	116	118	PF00675	0.472
CLV_NRD_NRD_1	12	14	PF00675	0.445
CLV_NRD_NRD_1	171	173	PF00675	0.431
CLV_NRD_NRD_1	22	24	PF00675	0.383
CLV_NRD_NRD_1	389	391	PF00675	0.501
CLV_NRD_NRD_1	420	422	PF00675	0.497
CLV_NRD_NRD_1	455	457	PF00675	0.485
CLV_NRD_NRD_1	540	542	PF00675	0.474
CLV_NRD_NRD_1	752	754	PF00675	0.472
CLV_NRD_NRD_1	776	778	PF00675	0.447
CLV_NRD_NRD_1	858	860	PF00675	0.537
CLV_NRD_NRD_1	902	904	PF00675	0.410
CLV_NRD_NRD_1	916	918	PF00675	0.544
CLV_PCSK_KEX2_1	116	118	PF00082	0.498
CLV_PCSK_KEX2_1	171	173	PF00082	0.431
CLV_PCSK_KEX2_1	21	23	PF00082	0.444
CLV_PCSK_KEX2_1	540	542	PF00082	0.513
CLV_PCSK_KEX2_1	776	778	PF00082	0.573
CLV_PCSK_KEX2_1	858	860	PF00082	0.535
CLV_PCSK_KEX2_1	902	904	PF00082	0.427
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.537
CLV_PCSK_SKI1_1	136	140	PF00082	0.571
CLV_PCSK_SKI1_1	22	26	PF00082	0.543
CLV_PCSK_SKI1_1	27	31	PF00082	0.505
CLV_PCSK_SKI1_1	347	351	PF00082	0.509
CLV_PCSK_SKI1_1	600	604	PF00082	0.523
CLV_PCSK_SKI1_1	714	718	PF00082	0.383
CLV_PCSK_SKI1_1	843	847	PF00082	0.532
CLV_PCSK_SKI1_1	897	901	PF00082	0.551
CLV_PCSK_SKI1_1	903	907	PF00082	0.490
DEG_APCC_DBOX_1	346	354	PF00400	0.507
DEG_APCC_DBOX_1	406	414	PF00400	0.432
DEG_SCF_FBW7_2	123	129	PF00400	0.510
DEG_SPOP_SBC_1	175	179	PF00917	0.411
DEG_SPOP_SBC_1	496	500	PF00917	0.598
DEG_SPOP_SBC_1	505	509	PF00917	0.516
DEG_SPOP_SBC_1	510	514	PF00917	0.474
DOC_CKS1_1	120	125	PF01111	0.379
DOC_CKS1_1	671	676	PF01111	0.481
DOC_CYCLIN_RxL_1	169	179	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	656	662	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	933	939	PF00134	0.383
DOC_MAPK_DCC_7	669	677	PF00069	0.385
DOC_MAPK_gen_1	390	396	PF00069	0.390
DOC_MAPK_gen_1	561	568	PF00069	0.461
DOC_MAPK_gen_1	645	652	PF00069	0.527
DOC_MAPK_MEF2A_6	561	568	PF00069	0.439
DOC_MAPK_RevD_3	444	457	PF00069	0.419
DOC_PP1_RVXF_1	712	719	PF00149	0.460
DOC_PP2B_LxvP_1	150	153	PF13499	0.499
DOC_PP2B_LxvP_1	656	659	PF13499	0.428
DOC_PP2B_LxvP_1	933	936	PF13499	0.372
DOC_PP4_FxxP_1	255	258	PF00568	0.589
DOC_PP4_MxPP_1	445	448	PF00568	0.464
DOC_USP7_MATH_1	109	113	PF00917	0.544
DOC_USP7_MATH_1	224	228	PF00917	0.608
DOC_USP7_MATH_1	363	367	PF00917	0.518
DOC_USP7_MATH_1	520	524	PF00917	0.640
DOC_USP7_MATH_1	553	557	PF00917	0.463
DOC_USP7_MATH_1	582	586	PF00917	0.470
DOC_USP7_MATH_1	739	743	PF00917	0.615
DOC_USP7_MATH_1	823	827	PF00917	0.588
DOC_USP7_MATH_1	853	857	PF00917	0.664
DOC_USP7_MATH_1	86	90	PF00917	0.689
DOC_USP7_MATH_1	863	867	PF00917	0.662
DOC_WW_Pin1_4	116	121	PF00397	0.680
DOC_WW_Pin1_4	122	127	PF00397	0.618
DOC_WW_Pin1_4	130	135	PF00397	0.579
DOC_WW_Pin1_4	335	340	PF00397	0.402
DOC_WW_Pin1_4	408	413	PF00397	0.512
DOC_WW_Pin1_4	463	468	PF00397	0.515
DOC_WW_Pin1_4	55	60	PF00397	0.585
DOC_WW_Pin1_4	670	675	PF00397	0.479
DOC_WW_Pin1_4	704	709	PF00397	0.624
DOC_WW_Pin1_4	793	798	PF00397	0.546
LIG_14-3-3_CanoR_1	116	120	PF00244	0.601
LIG_14-3-3_CanoR_1	164	168	PF00244	0.613
LIG_14-3-3_CanoR_1	259	266	PF00244	0.503
LIG_14-3-3_CanoR_1	40	46	PF00244	0.363
LIG_14-3-3_CanoR_1	437	447	PF00244	0.467
LIG_14-3-3_CanoR_1	456	461	PF00244	0.483
LIG_14-3-3_CanoR_1	497	505	PF00244	0.631
LIG_14-3-3_CanoR_1	714	719	PF00244	0.379
LIG_14-3-3_CanoR_1	777	785	PF00244	0.464
LIG_14-3-3_CanoR_1	801	807	PF00244	0.534
LIG_14-3-3_CanoR_1	902	910	PF00244	0.414
LIG_Actin_WH2_2	598	615	PF00022	0.454
LIG_BIR_III_2	550	554	PF00653	0.444
LIG_BIR_III_4	87	91	PF00653	0.525
LIG_BRCT_BRCA1_1	544	548	PF00533	0.456
LIG_BRCT_BRCA1_1	65	69	PF00533	0.449
LIG_BRCT_BRCA1_1	780	784	PF00533	0.423
LIG_FHA_1	149	155	PF00498	0.589
LIG_FHA_1	160	166	PF00498	0.597
LIG_FHA_1	241	247	PF00498	0.696
LIG_FHA_1	290	296	PF00498	0.385
LIG_FHA_1	439	445	PF00498	0.411
LIG_FHA_1	497	503	PF00498	0.749
LIG_FHA_1	596	602	PF00498	0.431
LIG_FHA_1	708	714	PF00498	0.563
LIG_FHA_1	902	908	PF00498	0.474
LIG_FHA_1	92	98	PF00498	0.415
LIG_FHA_2	123	129	PF00498	0.552
LIG_FHA_2	359	365	PF00498	0.560
LIG_FHA_2	382	388	PF00498	0.603
LIG_FHA_2	601	607	PF00498	0.578
LIG_FHA_2	627	633	PF00498	0.572
LIG_FHA_2	687	693	PF00498	0.514
LIG_FXI_DFP_1	30	34	PF00024	0.356
LIG_FXI_DFP_1	414	418	PF00024	0.396
LIG_FXI_DFP_1	661	665	PF00024	0.382
LIG_LIR_Apic_2	253	258	PF02991	0.554
LIG_LIR_Gen_1	28	36	PF02991	0.399
LIG_LIR_Gen_1	286	295	PF02991	0.409
LIG_LIR_Gen_1	416	425	PF02991	0.511
LIG_LIR_Gen_1	6	15	PF02991	0.288
LIG_LIR_Gen_1	95	105	PF02991	0.383
LIG_LIR_Nem_3	28	33	PF02991	0.374
LIG_LIR_Nem_3	281	287	PF02991	0.431
LIG_LIR_Nem_3	345	349	PF02991	0.404
LIG_LIR_Nem_3	416	420	PF02991	0.476
LIG_LIR_Nem_3	470	476	PF02991	0.368
LIG_LIR_Nem_3	6	11	PF02991	0.297
LIG_LIR_Nem_3	832	838	PF02991	0.347
LIG_LIR_Nem_3	95	101	PF02991	0.381
LIG_MAD2	63	71	PF02301	0.515
LIG_MLH1_MIPbox_1	544	548	PF16413	0.456
LIG_MLH1_MIPbox_1	780	784	PF16413	0.427
LIG_PCNA_PIPBox_1	679	688	PF02747	0.517
LIG_Pex14_2	25	29	PF04695	0.409
LIG_Pex14_2	660	664	PF04695	0.386
LIG_RPA_C_Fungi	11	23	PF08784	0.456
LIG_SH2_CRK	458	462	PF00017	0.520
LIG_SH2_GRB2like	98	101	PF00017	0.493
LIG_SH2_NCK_1	280	284	PF00017	0.475
LIG_SH2_NCK_1	458	462	PF00017	0.538
LIG_SH2_NCK_1	731	735	PF00017	0.515
LIG_SH2_SRC	280	283	PF00017	0.501
LIG_SH2_STAP1	280	284	PF00017	0.475
LIG_SH2_STAP1	98	102	PF00017	0.507
LIG_SH2_STAT5	326	329	PF00017	0.552
LIG_SH2_STAT5	382	385	PF00017	0.618
LIG_SH2_STAT5	458	461	PF00017	0.413
LIG_SH2_STAT5	474	477	PF00017	0.290
LIG_SH2_STAT5	715	718	PF00017	0.388
LIG_SH2_STAT5	920	923	PF00017	0.409
LIG_SH2_STAT5	958	961	PF00017	0.362
LIG_SH3_1	117	123	PF00018	0.419
LIG_SH3_3	117	123	PF00018	0.419
LIG_SH3_3	336	342	PF00018	0.677
LIG_SH3_3	457	463	PF00018	0.545
LIG_SH3_3	668	674	PF00018	0.508
LIG_SH3_3	933	939	PF00018	0.558
LIG_SUMO_SIM_par_1	966	974	PF11976	0.594
LIG_TRAF2_1	126	129	PF00917	0.548
LIG_TRAF2_1	261	264	PF00917	0.414
LIG_TRFH_1	312	316	PF08558	0.455
LIG_WRC_WIRS_1	26	31	PF05994	0.424
LIG_WRC_WIRS_1	5	10	PF05994	0.442
LIG_WRC_WIRS_1	715	720	PF05994	0.489
MOD_CDC14_SPxK_1	133	136	PF00782	0.315
MOD_CDK_SPxK_1	130	136	PF00069	0.317
MOD_CDK_SPxK_1	793	799	PF00069	0.549
MOD_CDK_SPxxK_3	408	415	PF00069	0.512
MOD_CK1_1	111	117	PF00069	0.428
MOD_CK1_1	118	124	PF00069	0.551
MOD_CK1_1	220	226	PF00069	0.547
MOD_CK1_1	245	251	PF00069	0.616
MOD_CK1_1	3	9	PF00069	0.510
MOD_CK1_1	466	472	PF00069	0.460
MOD_CK1_1	483	489	PF00069	0.513
MOD_CK1_1	490	496	PF00069	0.645
MOD_CK1_1	506	512	PF00069	0.698
MOD_CK1_1	595	601	PF00069	0.312
MOD_CK1_1	698	704	PF00069	0.511
MOD_CK1_1	707	713	PF00069	0.540
MOD_CK1_1	742	748	PF00069	0.711
MOD_CK1_1	866	872	PF00069	0.612
MOD_CK1_1	91	97	PF00069	0.570
MOD_CK2_1	122	128	PF00069	0.476
MOD_CK2_1	176	182	PF00069	0.569
MOD_CK2_1	258	264	PF00069	0.528
MOD_CK2_1	55	61	PF00069	0.424
MOD_CK2_1	600	606	PF00069	0.440
MOD_CK2_1	686	692	PF00069	0.405
MOD_Cter_Amidation	19	22	PF01082	0.475
MOD_GlcNHglycan	111	114	PF01048	0.579
MOD_GlcNHglycan	226	229	PF01048	0.690
MOD_GlcNHglycan	260	263	PF01048	0.469
MOD_GlcNHglycan	327	330	PF01048	0.588
MOD_GlcNHglycan	339	342	PF01048	0.631
MOD_GlcNHglycan	364	368	PF01048	0.621
MOD_GlcNHglycan	485	488	PF01048	0.622
MOD_GlcNHglycan	489	492	PF01048	0.657
MOD_GlcNHglycan	508	511	PF01048	0.666
MOD_GlcNHglycan	544	547	PF01048	0.442
MOD_GlcNHglycan	555	558	PF01048	0.400
MOD_GlcNHglycan	584	587	PF01048	0.532
MOD_GlcNHglycan	700	703	PF01048	0.521
MOD_GlcNHglycan	737	740	PF01048	0.629
MOD_GlcNHglycan	747	751	PF01048	0.569
MOD_GlcNHglycan	825	828	PF01048	0.499
MOD_GlcNHglycan	865	868	PF01048	0.639
MOD_GlcNHglycan	87	91	PF01048	0.688
MOD_GSK3_1	111	118	PF00069	0.650
MOD_GSK3_1	130	137	PF00069	0.296
MOD_GSK3_1	159	166	PF00069	0.461
MOD_GSK3_1	174	181	PF00069	0.449
MOD_GSK3_1	220	227	PF00069	0.468
MOD_GSK3_1	236	243	PF00069	0.605
MOD_GSK3_1	289	296	PF00069	0.392
MOD_GSK3_1	3	10	PF00069	0.341
MOD_GSK3_1	325	332	PF00069	0.482
MOD_GSK3_1	363	370	PF00069	0.573
MOD_GSK3_1	378	385	PF00069	0.577
MOD_GSK3_1	426	433	PF00069	0.415
MOD_GSK3_1	483	490	PF00069	0.435
MOD_GSK3_1	505	512	PF00069	0.696
MOD_GSK3_1	525	532	PF00069	0.263
MOD_GSK3_1	582	589	PF00069	0.488
MOD_GSK3_1	688	695	PF00069	0.410
MOD_GSK3_1	735	742	PF00069	0.623
MOD_GSK3_1	862	869	PF00069	0.501
MOD_N-GLC_1	335	340	PF02516	0.424
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	176	181	PF00069	0.570
MOD_NEK2_1	25	30	PF00069	0.430
MOD_NEK2_1	372	377	PF00069	0.489
MOD_NEK2_1	402	407	PF00069	0.424
MOD_NEK2_1	542	547	PF00069	0.411
MOD_NEK2_1	587	592	PF00069	0.545
MOD_NEK2_1	612	617	PF00069	0.510
MOD_NEK2_1	65	70	PF00069	0.521
MOD_NEK2_1	748	753	PF00069	0.623
MOD_NEK2_1	838	843	PF00069	0.413
MOD_NEK2_2	888	893	PF00069	0.452
MOD_PIKK_1	236	242	PF00454	0.441
MOD_PIKK_1	353	359	PF00454	0.569
MOD_PIKK_1	394	400	PF00454	0.436
MOD_PIKK_1	438	444	PF00454	0.501
MOD_PIKK_1	480	486	PF00454	0.567
MOD_PIKK_1	595	601	PF00454	0.432
MOD_PIKK_1	686	692	PF00454	0.536
MOD_PIKK_1	853	859	PF00454	0.504
MOD_PIKK_1	876	882	PF00454	0.525
MOD_PK_1	242	248	PF00069	0.558
MOD_PKA_1	456	462	PF00069	0.487
MOD_PKA_2	115	121	PF00069	0.532
MOD_PKA_2	159	165	PF00069	0.640
MOD_PKA_2	258	264	PF00069	0.559
MOD_PKA_2	39	45	PF00069	0.365
MOD_PKA_2	496	502	PF00069	0.712
MOD_PKA_2	592	598	PF00069	0.398
MOD_PKA_2	612	618	PF00069	0.435
MOD_PKA_2	901	907	PF00069	0.402
MOD_Plk_1	218	224	PF00069	0.640
MOD_Plk_1	329	335	PF00069	0.579
MOD_Plk_1	725	731	PF00069	0.568
MOD_Plk_1	966	972	PF00069	0.479
MOD_Plk_4	245	251	PF00069	0.703
MOD_Plk_4	25	31	PF00069	0.410
MOD_Plk_4	299	305	PF00069	0.589
MOD_Plk_4	378	384	PF00069	0.554
MOD_Plk_4	525	531	PF00069	0.530
MOD_Plk_4	695	701	PF00069	0.504
MOD_Plk_4	7	13	PF00069	0.426
MOD_Plk_4	714	720	PF00069	0.317
MOD_Plk_4	966	972	PF00069	0.479
MOD_ProDKin_1	116	122	PF00069	0.669
MOD_ProDKin_1	130	136	PF00069	0.574
MOD_ProDKin_1	335	341	PF00069	0.392
MOD_ProDKin_1	408	414	PF00069	0.508
MOD_ProDKin_1	463	469	PF00069	0.513
MOD_ProDKin_1	55	61	PF00069	0.579
MOD_ProDKin_1	670	676	PF00069	0.479
MOD_ProDKin_1	704	710	PF00069	0.621
MOD_ProDKin_1	793	799	PF00069	0.549
TRG_DiLeu_BaEn_1	183	188	PF01217	0.323
TRG_DiLeu_BaEn_1	449	454	PF01217	0.396
TRG_DiLeu_BaEn_1	941	946	PF01217	0.493
TRG_DiLeu_BaEn_2	344	350	PF01217	0.419
TRG_ENDOCYTIC_2	287	290	PF00928	0.424
TRG_ENDOCYTIC_2	346	349	PF00928	0.355
TRG_ENDOCYTIC_2	473	476	PF00928	0.371
TRG_ENDOCYTIC_2	715	718	PF00928	0.366
TRG_ENDOCYTIC_2	835	838	PF00928	0.342
TRG_ENDOCYTIC_2	958	961	PF00928	0.347
TRG_ENDOCYTIC_2	98	101	PF00928	0.366
TRG_ER_diArg_1	115	117	PF00400	0.617
TRG_ER_diArg_1	170	172	PF00400	0.413
TRG_ER_diArg_1	22	24	PF00400	0.432
TRG_ER_diArg_1	276	279	PF00400	0.396
TRG_ER_diArg_1	432	435	PF00400	0.456
TRG_ER_diArg_1	540	542	PF00400	0.516
TRG_ER_diArg_1	776	778	PF00400	0.502
TRG_ER_diArg_1	858	860	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ9	Leptomonas seymouri	59%	100%
A0A0S4JMU3	Bodo saltans	32%	100%
A0A1X0NV98	Trypanosomatidae	38%	98%
A0A3Q8I908	Leishmania donovani	92%	100%
A0A3R7KQI0	Trypanosoma rangeli	37%	100%
A4H6K5	Leishmania braziliensis	82%	100%
A4HUZ0	Leishmania infantum	93%	100%
D0A7F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QGZ8	Leishmania major	93%	100%
V5DT33	Trypanosoma cruzi	39%	100%