LeishMANIAdb
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DUF1772 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1772 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ANM4_LEIMU
TriTrypDb:
LmxM.11.0800
Length:
147

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANM4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANM4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 51 53 PF00675 0.577
CLV_PCSK_KEX2_1 21 23 PF00082 0.480
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.489
DOC_CYCLIN_RxL_1 5 16 PF00134 0.372
DOC_MAPK_FxFP_2 118 121 PF00069 0.498
DOC_PP4_FxxP_1 118 121 PF00568 0.462
DOC_PP4_FxxP_1 134 137 PF00568 0.525
DOC_USP7_MATH_1 67 71 PF00917 0.571
DOC_USP7_MATH_1 86 90 PF00917 0.446
LIG_14-3-3_CanoR_1 22 30 PF00244 0.480
LIG_14-3-3_CanoR_1 52 61 PF00244 0.484
LIG_14-3-3_CanoR_1 68 74 PF00244 0.469
LIG_14-3-3_CanoR_1 95 100 PF00244 0.444
LIG_FHA_1 7 13 PF00498 0.609
LIG_LIR_Apic_2 116 121 PF02991 0.460
LIG_LIR_Apic_2 75 81 PF02991 0.434
LIG_LIR_Gen_1 89 97 PF02991 0.471
LIG_LIR_Nem_3 16 20 PF02991 0.453
LIG_LIR_Nem_3 89 94 PF02991 0.434
LIG_Pex14_2 134 138 PF04695 0.388
LIG_SH2_CRK 54 58 PF00017 0.341
LIG_SH2_NCK_1 54 58 PF00017 0.574
LIG_SH2_PTP2 91 94 PF00017 0.480
LIG_SH2_STAP1 54 58 PF00017 0.459
LIG_SH2_STAT5 19 22 PF00017 0.545
LIG_SH2_STAT5 47 50 PF00017 0.523
LIG_SH2_STAT5 54 57 PF00017 0.481
LIG_SH2_STAT5 91 94 PF00017 0.622
LIG_SH3_3 39 45 PF00018 0.500
MOD_CK2_1 136 142 PF00069 0.568
MOD_CK2_1 68 74 PF00069 0.626
MOD_GlcNHglycan 129 132 PF01048 0.452
MOD_GlcNHglycan 36 39 PF01048 0.571
MOD_GlcNHglycan 65 68 PF01048 0.539
MOD_GlcNHglycan 95 98 PF01048 0.425
MOD_GSK3_1 138 145 PF00069 0.450
MOD_GSK3_1 63 70 PF00069 0.499
MOD_NEK2_2 86 91 PF00069 0.481
MOD_PIKK_1 1 7 PF00454 0.532
MOD_PKA_1 52 58 PF00069 0.577
MOD_PKA_2 67 73 PF00069 0.620
MOD_PKB_1 50 58 PF00069 0.575
MOD_Plk_4 86 92 PF00069 0.469
MOD_SUMO_rev_2 139 145 PF00179 0.575
TRG_ENDOCYTIC_2 54 57 PF00928 0.433
TRG_ENDOCYTIC_2 91 94 PF00928 0.526

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P635 Leptomonas seymouri 72% 98%
A0A0S4JUP0 Bodo saltans 31% 100%
A0A1X0NV26 Trypanosomatidae 47% 100%
A0A3S7WRP0 Leishmania donovani 90% 100%
A0A422NQB2 Trypanosoma rangeli 49% 97%
A4H6K4 Leishmania braziliensis 80% 100%
A4HUY9 Leishmania infantum 90% 100%
D0A7G0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
Q4QGZ9 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS