Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANM3_LEIMU

TriTrypDb:

LmxM.11.0790

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.422
CLV_NRD_NRD_1	83	85	PF00675	0.657
CLV_PCSK_KEX2_1	148	150	PF00082	0.422
CLV_PCSK_KEX2_1	82	84	PF00082	0.553
CLV_PCSK_SKI1_1	148	152	PF00082	0.430
CLV_PCSK_SKI1_1	176	180	PF00082	0.331
CLV_PCSK_SKI1_1	192	196	PF00082	0.283
CLV_PCSK_SKI1_1	220	224	PF00082	0.448
CLV_PCSK_SKI1_1	52	56	PF00082	0.478
DEG_APCC_DBOX_1	179	187	PF00400	0.277
DEG_SCF_FBW7_1	166	172	PF00400	0.309
DEG_SPOP_SBC_1	221	225	PF00917	0.452
DOC_CKS1_1	10	15	PF01111	0.557
DOC_CKS1_1	166	171	PF01111	0.314
DOC_USP7_MATH_1	121	125	PF00917	0.439
DOC_USP7_MATH_1	14	18	PF00917	0.523
DOC_USP7_UBL2_3	109	113	PF12436	0.430
DOC_WW_Pin1_4	114	119	PF00397	0.262
DOC_WW_Pin1_4	165	170	PF00397	0.457
DOC_WW_Pin1_4	9	14	PF00397	0.563
LIG_APCC_ABBA_1	21	26	PF00400	0.568
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_FHA_1	70	76	PF00498	0.379
LIG_FHA_2	221	227	PF00498	0.503
LIG_FHA_2	71	77	PF00498	0.502
LIG_LIR_Nem_3	172	178	PF02991	0.410
LIG_LIR_Nem_3	200	206	PF02991	0.394
LIG_SH2_CRK	175	179	PF00017	0.309
LIG_SH2_SRC	244	247	PF00017	0.624
LIG_SH2_STAP1	71	75	PF00017	0.313
LIG_SH2_STAT5	122	125	PF00017	0.351
LIG_SH2_STAT5	218	221	PF00017	0.509
LIG_SH2_STAT5	244	247	PF00017	0.558
LIG_SH2_STAT5	62	65	PF00017	0.390
LIG_SH2_STAT5	71	74	PF00017	0.369
LIG_TRAF2_1	45	48	PF00917	0.462
LIG_TRFH_1	243	247	PF08558	0.531
LIG_TYR_ITIM	63	68	PF00017	0.333
MOD_CDK_SPxK_1	9	15	PF00069	0.563
MOD_CK1_1	124	130	PF00069	0.433
MOD_CK1_1	17	23	PF00069	0.446
MOD_CK1_1	70	76	PF00069	0.241
MOD_CK1_1	94	100	PF00069	0.638
MOD_CK2_1	220	226	PF00069	0.472
MOD_CK2_1	70	76	PF00069	0.494
MOD_CK2_1	97	103	PF00069	0.593
MOD_GlcNHglycan	1	4	PF01048	0.633
MOD_GlcNHglycan	137	140	PF01048	0.392
MOD_GlcNHglycan	89	92	PF01048	0.622
MOD_GlcNHglycan	93	96	PF01048	0.554
MOD_GSK3_1	121	128	PF00069	0.406
MOD_GSK3_1	165	172	PF00069	0.524
MOD_GSK3_1	87	94	PF00069	0.642
MOD_PIKK_1	125	131	PF00454	0.419
MOD_PIKK_1	14	20	PF00454	0.452
MOD_ProDKin_1	114	120	PF00069	0.263
MOD_ProDKin_1	165	171	PF00069	0.443
MOD_ProDKin_1	9	15	PF00069	0.563
MOD_SUMO_rev_2	22	29	PF00179	0.509
MOD_SUMO_rev_2	70	80	PF00179	0.462
TRG_DiLeu_BaEn_1	76	81	PF01217	0.431
TRG_DiLeu_BaEn_3	235	241	PF01217	0.429
TRG_ENDOCYTIC_2	175	178	PF00928	0.316
TRG_ENDOCYTIC_2	65	68	PF00928	0.347
TRG_ER_diArg_1	81	84	PF00400	0.590
TRG_ER_FFAT_2	67	77	PF00635	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKT7	Leptomonas seymouri	71%	100%
A0A0S4JTR3	Bodo saltans	50%	100%
A0A1X0NV10	Trypanosomatidae	51%	100%
A0A3S7WRK9	Leishmania donovani	91%	100%
A4H6K3	Leishmania braziliensis	83%	100%
A4HUY8	Leishmania infantum	91%	100%
D0A7G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QH00	Leishmania major	92%	100%
V5C1A3	Trypanosoma cruzi	50%	100%