PUF_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUF nine target 1

Species:

Leishmania mexicana

UniProt:

E9ANL7_LEIMU

TriTrypDb:

LmxM.11.0720

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	600	604	PF00656	0.654
CLV_C14_Caspase3-7	617	621	PF00656	0.632
CLV_C14_Caspase3-7	642	646	PF00656	0.499
CLV_NRD_NRD_1	298	300	PF00675	0.550
CLV_NRD_NRD_1	351	353	PF00675	0.618
CLV_NRD_NRD_1	358	360	PF00675	0.671
CLV_NRD_NRD_1	4	6	PF00675	0.425
CLV_NRD_NRD_1	515	517	PF00675	0.518
CLV_PCSK_KEX2_1	298	300	PF00082	0.686
CLV_PCSK_KEX2_1	351	353	PF00082	0.619
CLV_PCSK_KEX2_1	357	359	PF00082	0.674
CLV_PCSK_KEX2_1	4	6	PF00082	0.517
CLV_PCSK_KEX2_1	510	512	PF00082	0.612
CLV_PCSK_KEX2_1	514	516	PF00082	0.601
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.589
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.580
CLV_PCSK_PC7_1	511	517	PF00082	0.542
CLV_PCSK_SKI1_1	320	324	PF00082	0.413
CLV_PCSK_SKI1_1	35	39	PF00082	0.366
CLV_PCSK_SKI1_1	392	396	PF00082	0.619
CLV_PCSK_SKI1_1	510	514	PF00082	0.559
CLV_PCSK_SKI1_1	515	519	PF00082	0.566
DEG_APCC_DBOX_1	239	247	PF00400	0.527
DOC_CYCLIN_RxL_1	387	398	PF00134	0.616
DOC_CYCLIN_RxL_1	4	16	PF00134	0.422
DOC_MAPK_gen_1	181	188	PF00069	0.351
DOC_MAPK_gen_1	298	308	PF00069	0.537
DOC_MAPK_gen_1	32	42	PF00069	0.413
DOC_MAPK_gen_1	4	12	PF00069	0.378
DOC_PP1_RVXF_1	588	594	PF00149	0.612
DOC_PP2B_LxvP_1	610	613	PF13499	0.716
DOC_PP4_FxxP_1	182	185	PF00568	0.292
DOC_PP4_FxxP_1	258	261	PF00568	0.603
DOC_USP7_MATH_1	374	378	PF00917	0.646
DOC_USP7_MATH_1	379	383	PF00917	0.644
DOC_USP7_MATH_1	403	407	PF00917	0.759
DOC_USP7_MATH_1	435	439	PF00917	0.548
DOC_USP7_MATH_1	44	48	PF00917	0.372
DOC_USP7_MATH_1	534	538	PF00917	0.609
DOC_USP7_MATH_1	594	598	PF00917	0.492
DOC_USP7_MATH_1	621	625	PF00917	0.637
DOC_USP7_MATH_1	87	91	PF00917	0.347
DOC_USP7_UBL2_3	510	514	PF12436	0.578
DOC_USP7_UBL2_3	518	522	PF12436	0.588
DOC_USP7_UBL2_3	60	64	PF12436	0.452
DOC_WW_Pin1_4	281	286	PF00397	0.604
DOC_WW_Pin1_4	436	441	PF00397	0.719
DOC_WW_Pin1_4	530	535	PF00397	0.640
DOC_WW_Pin1_4	576	581	PF00397	0.711
DOC_WW_Pin1_4	630	635	PF00397	0.793
LIG_14-3-3_CanoR_1	109	113	PF00244	0.351
LIG_14-3-3_CanoR_1	231	235	PF00244	0.494
LIG_14-3-3_CanoR_1	277	285	PF00244	0.643
LIG_14-3-3_CanoR_1	35	43	PF00244	0.398
LIG_14-3-3_CanoR_1	583	593	PF00244	0.639
LIG_BRCT_BRCA1_1	379	383	PF00533	0.622
LIG_CtBP_PxDLS_1	447	451	PF00389	0.607
LIG_DLG_GKlike_1	636	643	PF00625	0.565
LIG_FHA_1	147	153	PF00498	0.298
LIG_FHA_1	208	214	PF00498	0.292
LIG_FHA_1	278	284	PF00498	0.499
LIG_FHA_1	328	334	PF00498	0.560
LIG_FHA_1	580	586	PF00498	0.546
LIG_FHA_2	162	168	PF00498	0.351
LIG_FHA_2	204	210	PF00498	0.378
LIG_FHA_2	422	428	PF00498	0.491
LIG_FHA_2	489	495	PF00498	0.471
LIG_FHA_2	598	604	PF00498	0.606
LIG_Integrin_RGD_1	202	204	PF01839	0.351
LIG_LIR_Apic_2	180	185	PF02991	0.292
LIG_LIR_Apic_2	233	238	PF02991	0.567
LIG_LIR_Apic_2	256	261	PF02991	0.599
LIG_LIR_Gen_1	101	110	PF02991	0.392
LIG_LIR_Gen_1	123	133	PF02991	0.360
LIG_LIR_Gen_1	167	176	PF02991	0.357
LIG_LIR_Gen_1	204	213	PF02991	0.292
LIG_LIR_Gen_1	494	502	PF02991	0.586
LIG_LIR_Gen_1	639	644	PF02991	0.563
LIG_LIR_Gen_1	75	81	PF02991	0.406
LIG_LIR_Nem_3	101	105	PF02991	0.355
LIG_LIR_Nem_3	123	129	PF02991	0.360
LIG_LIR_Nem_3	167	171	PF02991	0.357
LIG_LIR_Nem_3	204	208	PF02991	0.272
LIG_LIR_Nem_3	233	237	PF02991	0.600
LIG_LIR_Nem_3	639	643	PF02991	0.615
LIG_LIR_Nem_3	75	80	PF02991	0.392
LIG_LIR_Nem_3	90	94	PF02991	0.250
LIG_PCNA_yPIPBox_3	623	636	PF02747	0.610
LIG_PDZ_Class_1	648	653	PF00595	0.656
LIG_Pex14_2	131	135	PF04695	0.292
LIG_Pex14_2	80	84	PF04695	0.404
LIG_SH2_CRK	235	239	PF00017	0.570
LIG_SH2_CRK	640	644	PF00017	0.606
LIG_SH2_CRK	66	70	PF00017	0.472
LIG_SH2_NCK_1	229	233	PF00017	0.459
LIG_SH2_NCK_1	235	239	PF00017	0.510
LIG_SH2_PTP2	102	105	PF00017	0.412
LIG_SH2_STAP1	481	485	PF00017	0.461
LIG_SH2_STAT3	481	484	PF00017	0.529
LIG_SH2_STAT5	102	105	PF00017	0.353
LIG_SH2_STAT5	151	154	PF00017	0.292
LIG_SH2_STAT5	196	199	PF00017	0.292
LIG_SH2_STAT5	219	222	PF00017	0.377
LIG_SH2_STAT5	328	331	PF00017	0.399
LIG_SH2_STAT5	640	643	PF00017	0.617
LIG_SH2_STAT5	91	94	PF00017	0.309
LIG_SH3_3	498	504	PF00018	0.614
LIG_SH3_3	571	577	PF00018	0.593
LIG_SH3_3	631	637	PF00018	0.604
LIG_Sin3_3	126	133	PF02671	0.357
LIG_SUMO_SIM_par_1	286	291	PF11976	0.645
LIG_SUMO_SIM_par_1	321	327	PF11976	0.403
LIG_SxIP_EBH_1	466	476	PF03271	0.399
LIG_TRAF2_1	424	427	PF00917	0.535
LIG_TRAF2_1	457	460	PF00917	0.461
LIG_UBA3_1	322	326	PF00899	0.390
LIG_WRC_WIRS_1	77	82	PF05994	0.367
LIG_WW_3	1	5	PF00397	0.483
MOD_CDC14_SPxK_1	633	636	PF00782	0.589
MOD_CDK_SPK_2	530	535	PF00069	0.640
MOD_CDK_SPK_2	576	581	PF00069	0.608
MOD_CDK_SPxK_1	630	636	PF00069	0.589
MOD_CDK_SPxxK_3	576	583	PF00069	0.553
MOD_CK1_1	177	183	PF00069	0.328
MOD_CK1_1	327	333	PF00069	0.604
MOD_CK1_1	377	383	PF00069	0.618
MOD_CK1_1	449	455	PF00069	0.587
MOD_CK1_1	496	502	PF00069	0.539
MOD_CK1_1	579	585	PF00069	0.615
MOD_CK1_1	597	603	PF00069	0.604
MOD_CK1_1	604	610	PF00069	0.638
MOD_CK1_1	639	645	PF00069	0.662
MOD_CK2_1	421	427	PF00069	0.498
MOD_CK2_1	454	460	PF00069	0.518
MOD_CK2_1	488	494	PF00069	0.449
MOD_CMANNOS	23	26	PF00535	0.363
MOD_Cter_Amidation	355	358	PF01082	0.636
MOD_GlcNHglycan	176	179	PF01048	0.296
MOD_GlcNHglycan	272	275	PF01048	0.756
MOD_GlcNHglycan	290	293	PF01048	0.463
MOD_GlcNHglycan	370	373	PF01048	0.627
MOD_GlcNHglycan	406	409	PF01048	0.612
MOD_GlcNHglycan	456	459	PF01048	0.486
MOD_GlcNHglycan	494	498	PF01048	0.565
MOD_GlcNHglycan	522	525	PF01048	0.548
MOD_GlcNHglycan	562	565	PF01048	0.761
MOD_GlcNHglycan	610	613	PF01048	0.607
MOD_GlcNHglycan	650	653	PF01048	0.656
MOD_GSK3_1	170	177	PF00069	0.384
MOD_GSK3_1	203	210	PF00069	0.287
MOD_GSK3_1	277	284	PF00069	0.674
MOD_GSK3_1	308	315	PF00069	0.561
MOD_GSK3_1	374	381	PF00069	0.646
MOD_GSK3_1	44	51	PF00069	0.378
MOD_GSK3_1	446	453	PF00069	0.786
MOD_GSK3_1	476	483	PF00069	0.543
MOD_GSK3_1	520	527	PF00069	0.662
MOD_GSK3_1	530	537	PF00069	0.591
MOD_GSK3_1	579	586	PF00069	0.523
MOD_GSK3_1	593	600	PF00069	0.640
MOD_GSK3_1	602	609	PF00069	0.678
MOD_GSK3_1	639	646	PF00069	0.674
MOD_LATS_1	144	150	PF00433	0.351
MOD_N-GLC_1	174	179	PF02516	0.351
MOD_N-GLC_1	597	602	PF02516	0.638
MOD_NEK2_1	13	18	PF00069	0.422
MOD_NEK2_1	288	293	PF00069	0.632
MOD_NEK2_1	308	313	PF00069	0.401
MOD_NEK2_1	450	455	PF00069	0.568
MOD_NEK2_1	488	493	PF00069	0.432
MOD_NEK2_1	506	511	PF00069	0.607
MOD_NEK2_1	593	598	PF00069	0.696
MOD_NEK2_1	606	611	PF00069	0.641
MOD_NEK2_1	614	619	PF00069	0.510
MOD_NEK2_1	76	81	PF00069	0.359
MOD_PIKK_1	253	259	PF00454	0.531
MOD_PIKK_1	421	427	PF00454	0.593
MOD_PIKK_1	468	474	PF00454	0.299
MOD_PIKK_1	480	486	PF00454	0.453
MOD_PK_1	476	482	PF00069	0.527
MOD_PKA_2	108	114	PF00069	0.351
MOD_PKA_2	230	236	PF00069	0.505
MOD_PKA_2	294	300	PF00069	0.555
MOD_PKB_1	277	285	PF00069	0.485
MOD_PKB_1	357	365	PF00069	0.653
MOD_PKB_1	581	589	PF00069	0.541
MOD_Plk_1	174	180	PF00069	0.375
MOD_Plk_1	18	24	PF00069	0.483
MOD_Plk_1	203	209	PF00069	0.303
MOD_Plk_1	308	314	PF00069	0.565
MOD_Plk_1	426	432	PF00069	0.600
MOD_Plk_1	493	499	PF00069	0.560
MOD_Plk_1	602	608	PF00069	0.644
MOD_Plk_2-3	48	54	PF00069	0.432
MOD_Plk_4	230	236	PF00069	0.488
MOD_Plk_4	308	314	PF00069	0.550
MOD_Plk_4	324	330	PF00069	0.359
MOD_Plk_4	476	482	PF00069	0.527
MOD_Plk_4	76	82	PF00069	0.366
MOD_ProDKin_1	281	287	PF00069	0.603
MOD_ProDKin_1	436	442	PF00069	0.720
MOD_ProDKin_1	530	536	PF00069	0.637
MOD_ProDKin_1	576	582	PF00069	0.710
MOD_ProDKin_1	630	636	PF00069	0.795
MOD_SUMO_rev_2	315	322	PF00179	0.487
TRG_DiLeu_BaEn_4	426	432	PF01217	0.491
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.564
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.349
TRG_ENDOCYTIC_2	102	105	PF00928	0.353
TRG_ENDOCYTIC_2	168	171	PF00928	0.357
TRG_ENDOCYTIC_2	495	498	PF00928	0.509
TRG_ENDOCYTIC_2	640	643	PF00928	0.748
TRG_ENDOCYTIC_2	66	69	PF00928	0.409
TRG_ER_diArg_1	298	301	PF00400	0.710
TRG_ER_diArg_1	3	5	PF00400	0.459
TRG_ER_diArg_1	351	353	PF00400	0.631
TRG_ER_diArg_1	357	359	PF00400	0.670
TRG_ER_diArg_1	580	583	PF00400	0.720
TRG_NES_CRM1_1	460	472	PF08389	0.282
TRG_NLS_MonoExtC_3	513	518	PF00514	0.562
TRG_NLS_MonoExtN_4	511	518	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	583	588	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q1	Leptomonas seymouri	72%	100%
A0A3S5H6I9	Leishmania donovani	91%	100%
A4H6J7	Leishmania braziliensis	80%	98%
A4HUY2	Leishmania infantum	91%	100%
D0A7G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QH06	Leishmania major	90%	100%