Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANL6_LEIMU

TriTrypDb:

LmxM.11.0710

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.322
CLV_NRD_NRD_1	117	119	PF00675	0.669
CLV_NRD_NRD_1	194	196	PF00675	0.602
CLV_NRD_NRD_1	285	287	PF00675	0.418
CLV_NRD_NRD_1	349	351	PF00675	0.456
CLV_NRD_NRD_1	381	383	PF00675	0.450
CLV_NRD_NRD_1	417	419	PF00675	0.483
CLV_NRD_NRD_1	446	448	PF00675	0.568
CLV_PCSK_KEX2_1	116	118	PF00082	0.703
CLV_PCSK_KEX2_1	194	196	PF00082	0.602
CLV_PCSK_KEX2_1	285	287	PF00082	0.384
CLV_PCSK_KEX2_1	348	350	PF00082	0.447
CLV_PCSK_KEX2_1	381	383	PF00082	0.459
CLV_PCSK_KEX2_1	416	418	PF00082	0.437
CLV_PCSK_KEX2_1	446	448	PF00082	0.454
CLV_PCSK_PC7_1	442	448	PF00082	0.442
CLV_PCSK_SKI1_1	195	199	PF00082	0.595
CLV_PCSK_SKI1_1	290	294	PF00082	0.591
CLV_PCSK_SKI1_1	334	338	PF00082	0.474
CLV_PCSK_SKI1_1	382	386	PF00082	0.490
CLV_PCSK_SKI1_1	398	402	PF00082	0.368
DEG_APCC_DBOX_1	437	445	PF00400	0.512
DEG_APCC_DBOX_1	81	89	PF00400	0.540
DOC_CKS1_1	227	232	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.585
DOC_MAPK_gen_1	47	57	PF00069	0.552
DOC_MAPK_MEF2A_6	50	57	PF00069	0.555
DOC_MAPK_NFAT4_5	50	58	PF00069	0.556
DOC_PP2B_LxvP_1	218	221	PF13499	0.645
DOC_PP2B_LxvP_1	224	227	PF13499	0.607
DOC_USP7_MATH_1	159	163	PF00917	0.572
DOC_USP7_MATH_1	179	183	PF00917	0.787
DOC_USP7_MATH_1	411	415	PF00917	0.502
DOC_USP7_UBL2_3	424	428	PF12436	0.509
DOC_WW_Pin1_4	110	115	PF00397	0.659
DOC_WW_Pin1_4	166	171	PF00397	0.677
DOC_WW_Pin1_4	173	178	PF00397	0.657
DOC_WW_Pin1_4	196	201	PF00397	0.748
DOC_WW_Pin1_4	226	231	PF00397	0.622
LIG_14-3-3_CanoR_1	266	270	PF00244	0.500
LIG_14-3-3_CanoR_1	273	283	PF00244	0.501
LIG_14-3-3_CanoR_1	316	323	PF00244	0.522
LIG_14-3-3_CanoR_1	438	442	PF00244	0.466
LIG_Actin_WH2_2	319	336	PF00022	0.512
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	227	231	PF00533	0.552
LIG_FHA_1	243	249	PF00498	0.611
LIG_FHA_1	278	284	PF00498	0.514
LIG_FHA_1	52	58	PF00498	0.497
LIG_FHA_1	63	69	PF00498	0.590
LIG_GBD_Chelix_1	401	409	PF00786	0.456
LIG_LIR_Gen_1	26	36	PF02991	0.478
LIG_LIR_Nem_3	26	32	PF02991	0.481
LIG_LYPXL_yS_3	367	370	PF13949	0.536
LIG_MYND_1	196	200	PF01753	0.591
LIG_PTB_Apo_2	216	223	PF02174	0.574
LIG_PTB_Phospho_1	216	222	PF10480	0.570
LIG_SH2_STAP1	75	79	PF00017	0.556
LIG_SH2_STAT3	222	225	PF00017	0.606
LIG_SH2_STAT3	75	78	PF00017	0.440
LIG_SH2_STAT5	29	32	PF00017	0.482
LIG_SH2_STAT5	294	297	PF00017	0.453
LIG_SH2_STAT5	356	359	PF00017	0.501
LIG_SH3_3	224	230	PF00018	0.576
LIG_SUMO_SIM_anti_2	299	308	PF11976	0.444
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.461
LIG_SUMO_SIM_par_1	245	254	PF11976	0.562
LIG_TRAF2_1	336	339	PF00917	0.440
LIG_TRAF2_1	457	460	PF00917	0.537
LIG_TYR_ITIM	448	453	PF00017	0.568
MOD_CDK_SPxK_1	110	116	PF00069	0.477
MOD_CDK_SPxxK_3	110	117	PF00069	0.522
MOD_CK1_1	234	240	PF00069	0.675
MOD_CK1_1	51	57	PF00069	0.535
MOD_CK2_1	142	148	PF00069	0.618
MOD_GlcNHglycan	142	147	PF01048	0.559
MOD_GlcNHglycan	161	164	PF01048	0.497
MOD_GlcNHglycan	233	236	PF01048	0.766
MOD_GSK3_1	124	131	PF00069	0.672
MOD_GSK3_1	173	180	PF00069	0.656
MOD_GSK3_1	239	246	PF00069	0.570
MOD_NEK2_1	147	152	PF00069	0.696
MOD_NEK2_1	437	442	PF00069	0.547
MOD_NEK2_2	179	184	PF00069	0.587
MOD_PKA_2	265	271	PF00069	0.468
MOD_PKA_2	27	33	PF00069	0.490
MOD_PKA_2	275	281	PF00069	0.468
MOD_PKA_2	360	366	PF00069	0.540
MOD_PKA_2	437	443	PF00069	0.547
MOD_PKA_2	62	68	PF00069	0.552
MOD_PKB_1	98	106	PF00069	0.641
MOD_Plk_1	142	148	PF00069	0.685
MOD_Plk_1	305	311	PF00069	0.516
MOD_Plk_1	51	57	PF00069	0.535
MOD_Plk_1	69	75	PF00069	0.334
MOD_Plk_1	7	13	PF00069	0.433
MOD_Plk_2-3	455	461	PF00069	0.602
MOD_ProDKin_1	110	116	PF00069	0.662
MOD_ProDKin_1	166	172	PF00069	0.676
MOD_ProDKin_1	173	179	PF00069	0.659
MOD_ProDKin_1	196	202	PF00069	0.746
MOD_ProDKin_1	226	232	PF00069	0.620
MOD_SUMO_for_1	32	35	PF00179	0.516
MOD_SUMO_for_1	409	412	PF00179	0.480
MOD_SUMO_rev_2	289	295	PF00179	0.414
MOD_SUMO_rev_2	420	430	PF00179	0.620
TRG_DiLeu_BaEn_1	213	218	PF01217	0.548
TRG_DiLeu_BaEn_1	84	89	PF01217	0.307
TRG_DiLeu_BaEn_4	253	259	PF01217	0.427
TRG_DiLeu_BaEn_4	420	426	PF01217	0.435
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.438
TRG_ENDOCYTIC_2	29	32	PF00928	0.482
TRG_ENDOCYTIC_2	367	370	PF00928	0.558
TRG_ENDOCYTIC_2	450	453	PF00928	0.525
TRG_ER_diArg_1	116	118	PF00400	0.749
TRG_ER_diArg_1	194	196	PF00400	0.602
TRG_ER_diArg_1	348	350	PF00400	0.462
TRG_ER_diArg_1	416	418	PF00400	0.457
TRG_ER_diArg_1	446	448	PF00400	0.568
TRG_NES_CRM1_1	331	347	PF08389	0.466
TRG_NES_CRM1_1	426	439	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P310	Leptomonas seymouri	52%	85%
A0A0S4IYQ0	Bodo saltans	24%	100%
A0A1X0NVG8	Trypanosomatidae	31%	100%
A0A3Q8IB95	Leishmania donovani	91%	100%
A0A3R7L4W3	Trypanosoma rangeli	33%	100%
A4H6J6	Leishmania braziliensis	81%	100%
A4HUY1	Leishmania infantum	91%	85%
Q4QH07	Leishmania major	91%	100%
V5C199	Trypanosoma cruzi	34%	100%