LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania mexicana
UniProt:
E9ANL2_LEIMU
TriTrypDb:
LmxM.11.0670
Length:
573

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 96
NetGPI no yes: 0, no: 96
Cellular components
Term Name Level Count
GO:0016020 membrane 2 91
GO:0110165 cellular anatomical entity 1 91

Expansion

Sequence features

E9ANL2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANL2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 43
GO:0022857 transmembrane transporter activity 2 43

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 557 561 PF00656 0.535
CLV_NRD_NRD_1 116 118 PF00675 0.357
CLV_NRD_NRD_1 375 377 PF00675 0.384
CLV_NRD_NRD_1 514 516 PF00675 0.339
CLV_NRD_NRD_1 522 524 PF00675 0.358
CLV_PCSK_KEX2_1 116 118 PF00082 0.373
CLV_PCSK_KEX2_1 375 377 PF00082 0.368
CLV_PCSK_KEX2_1 521 523 PF00082 0.347
CLV_PCSK_PC1ET2_1 375 377 PF00082 0.392
CLV_PCSK_SKI1_1 234 238 PF00082 0.600
CLV_PCSK_SKI1_1 408 412 PF00082 0.523
CLV_PCSK_SKI1_1 515 519 PF00082 0.350
DEG_MDM2_SWIB_1 448 456 PF02201 0.439
DEG_Nend_Nbox_1 1 3 PF02207 0.358
DOC_CKS1_1 144 149 PF01111 0.190
DOC_CYCLIN_yClb5_NLxxxL_5 492 501 PF00134 0.215
DOC_CYCLIN_yCln2_LP_2 144 150 PF00134 0.190
DOC_MAPK_gen_1 116 123 PF00069 0.531
DOC_MAPK_gen_1 375 384 PF00069 0.566
DOC_MAPK_gen_1 470 480 PF00069 0.402
DOC_MAPK_MEF2A_6 208 217 PF00069 0.489
DOC_MAPK_MEF2A_6 377 386 PF00069 0.559
DOC_MAPK_MEF2A_6 482 491 PF00069 0.312
DOC_PP2B_LxvP_1 403 406 PF13499 0.421
DOC_PP4_FxxP_1 388 391 PF00568 0.418
DOC_PP4_FxxP_1 41 44 PF00568 0.326
DOC_SPAK_OSR1_1 86 90 PF12202 0.320
DOC_USP7_MATH_1 224 228 PF00917 0.345
DOC_USP7_MATH_1 4 8 PF00917 0.275
DOC_USP7_MATH_1 406 410 PF00917 0.406
DOC_USP7_MATH_1 415 419 PF00917 0.339
DOC_USP7_MATH_1 530 534 PF00917 0.679
DOC_USP7_UBL2_3 438 442 PF12436 0.535
DOC_WW_Pin1_4 143 148 PF00397 0.336
DOC_WW_Pin1_4 328 333 PF00397 0.400
DOC_WW_Pin1_4 337 342 PF00397 0.415
LIG_14-3-3_CanoR_1 183 190 PF00244 0.557
LIG_14-3-3_CanoR_1 26 34 PF00244 0.333
LIG_14-3-3_CanoR_1 363 369 PF00244 0.304
LIG_14-3-3_CanoR_1 381 387 PF00244 0.412
LIG_BRCT_BRCA1_1 330 334 PF00533 0.369
LIG_BRCT_BRCA1_1 6 10 PF00533 0.305
LIG_BRCT_BRCA1_1 97 101 PF00533 0.415
LIG_FHA_1 130 136 PF00498 0.213
LIG_FHA_1 224 230 PF00498 0.340
LIG_FHA_1 274 280 PF00498 0.702
LIG_FHA_1 296 302 PF00498 0.529
LIG_FHA_1 304 310 PF00498 0.498
LIG_FHA_1 338 344 PF00498 0.399
LIG_FHA_1 390 396 PF00498 0.341
LIG_FHA_1 426 432 PF00498 0.310
LIG_FHA_1 496 502 PF00498 0.399
LIG_FHA_2 285 291 PF00498 0.588
LIG_FHA_2 45 51 PF00498 0.469
LIG_FHA_2 73 79 PF00498 0.172
LIG_GBD_Chelix_1 120 128 PF00786 0.430
LIG_GBD_Chelix_1 215 223 PF00786 0.313
LIG_GBD_Chelix_1 453 461 PF00786 0.386
LIG_IRF3_LxIS_1 504 509 PF10401 0.534
LIG_LIR_Apic_2 288 294 PF02991 0.567
LIG_LIR_Apic_2 385 391 PF02991 0.398
LIG_LIR_Apic_2 50 54 PF02991 0.468
LIG_LIR_Gen_1 253 264 PF02991 0.360
LIG_LIR_Gen_1 308 317 PF02991 0.338
LIG_LIR_Gen_1 323 332 PF02991 0.374
LIG_LIR_Gen_1 47 57 PF02991 0.421
LIG_LIR_Gen_1 502 513 PF02991 0.376
LIG_LIR_Gen_1 7 17 PF02991 0.294
LIG_LIR_Gen_1 75 84 PF02991 0.232
LIG_LIR_Nem_3 308 313 PF02991 0.310
LIG_LIR_Nem_3 315 320 PF02991 0.321
LIG_LIR_Nem_3 323 327 PF02991 0.333
LIG_LIR_Nem_3 331 337 PF02991 0.303
LIG_LIR_Nem_3 367 372 PF02991 0.577
LIG_LIR_Nem_3 47 52 PF02991 0.374
LIG_LIR_Nem_3 502 508 PF02991 0.324
LIG_LIR_Nem_3 509 513 PF02991 0.494
LIG_LIR_Nem_3 7 13 PF02991 0.282
LIG_LIR_Nem_3 75 79 PF02991 0.262
LIG_NRBOX 457 463 PF00104 0.306
LIG_NRBOX 496 502 PF00104 0.476
LIG_NRBOX 66 72 PF00104 0.281
LIG_PAM2_1 142 154 PF00658 0.190
LIG_Pex14_2 324 328 PF04695 0.380
LIG_Pex14_2 448 452 PF04695 0.393
LIG_SH2_CRK 45 49 PF00017 0.327
LIG_SH2_PTP2 291 294 PF00017 0.543
LIG_SH2_SRC 179 182 PF00017 0.656
LIG_SH2_SRC 505 508 PF00017 0.489
LIG_SH2_STAP1 8 12 PF00017 0.298
LIG_SH2_STAT3 199 202 PF00017 0.531
LIG_SH2_STAT5 150 153 PF00017 0.320
LIG_SH2_STAT5 199 202 PF00017 0.551
LIG_SH2_STAT5 210 213 PF00017 0.310
LIG_SH2_STAT5 222 225 PF00017 0.311
LIG_SH2_STAT5 291 294 PF00017 0.548
LIG_SH2_STAT5 372 375 PF00017 0.588
LIG_SH2_STAT5 40 43 PF00017 0.306
LIG_SH2_STAT5 505 508 PF00017 0.343
LIG_SH2_STAT5 51 54 PF00017 0.493
LIG_SH2_STAT5 550 553 PF00017 0.664
LIG_SH2_STAT5 58 61 PF00017 0.332
LIG_SH3_2 536 541 PF14604 0.755
LIG_SH3_3 218 224 PF00018 0.320
LIG_SH3_3 258 264 PF00018 0.370
LIG_SH3_3 482 488 PF00018 0.320
LIG_SH3_3 533 539 PF00018 0.658
LIG_SUMO_SIM_anti_2 212 217 PF11976 0.391
LIG_SUMO_SIM_anti_2 392 398 PF11976 0.326
LIG_SUMO_SIM_anti_2 426 431 PF11976 0.347
LIG_SUMO_SIM_par_1 156 161 PF11976 0.369
LIG_SUMO_SIM_par_1 392 398 PF11976 0.336
LIG_SUMO_SIM_par_1 428 434 PF11976 0.294
LIG_SUMO_SIM_par_1 92 98 PF11976 0.340
LIG_TRFH_1 40 44 PF08558 0.370
LIG_TYR_ITIM 43 48 PF00017 0.344
LIG_UBA3_1 333 342 PF00899 0.495
MOD_CDK_SPK_2 337 342 PF00069 0.300
MOD_CK1_1 137 143 PF00069 0.392
MOD_CK1_1 182 188 PF00069 0.542
MOD_CK1_1 303 309 PF00069 0.396
MOD_CK1_1 335 341 PF00069 0.427
MOD_CK1_1 511 517 PF00069 0.466
MOD_CK1_1 554 560 PF00069 0.663
MOD_CK1_1 95 101 PF00069 0.370
MOD_CK2_1 364 370 PF00069 0.400
MOD_GlcNHglycan 13 16 PF01048 0.326
MOD_GlcNHglycan 226 229 PF01048 0.341
MOD_GlcNHglycan 281 284 PF01048 0.566
MOD_GlcNHglycan 334 337 PF01048 0.375
MOD_GlcNHglycan 358 361 PF01048 0.284
MOD_GlcNHglycan 533 536 PF01048 0.491
MOD_GSK3_1 108 115 PF00069 0.347
MOD_GSK3_1 170 177 PF00069 0.403
MOD_GSK3_1 22 29 PF00069 0.333
MOD_GSK3_1 267 274 PF00069 0.423
MOD_GSK3_1 296 303 PF00069 0.436
MOD_GSK3_1 328 335 PF00069 0.424
MOD_GSK3_1 495 502 PF00069 0.393
MOD_GSK3_1 554 561 PF00069 0.593
MOD_N-GLC_1 328 333 PF02516 0.444
MOD_N-GLC_1 495 500 PF02516 0.297
MOD_NEK2_1 123 128 PF00069 0.397
MOD_NEK2_1 13 18 PF00069 0.330
MOD_NEK2_1 209 214 PF00069 0.358
MOD_NEK2_1 300 305 PF00069 0.384
MOD_NEK2_1 343 348 PF00069 0.406
MOD_NEK2_1 364 369 PF00069 0.400
MOD_NEK2_1 423 428 PF00069 0.345
MOD_NEK2_1 495 500 PF00069 0.342
MOD_NEK2_1 506 511 PF00069 0.339
MOD_NEK2_1 72 77 PF00069 0.304
MOD_NEK2_2 44 49 PF00069 0.245
MOD_PIKK_1 198 204 PF00454 0.492
MOD_PIKK_1 235 241 PF00454 0.463
MOD_PIKK_1 370 376 PF00454 0.454
MOD_PIKK_1 95 101 PF00454 0.431
MOD_PKA_2 182 188 PF00069 0.406
MOD_PKA_2 267 273 PF00069 0.450
MOD_PKA_2 511 517 PF00069 0.372
MOD_Plk_1 343 349 PF00069 0.418
MOD_Plk_1 495 501 PF00069 0.320
MOD_Plk_2-3 284 290 PF00069 0.609
MOD_Plk_4 102 108 PF00069 0.322
MOD_Plk_4 123 129 PF00069 0.368
MOD_Plk_4 296 302 PF00069 0.404
MOD_Plk_4 305 311 PF00069 0.328
MOD_Plk_4 349 355 PF00069 0.307
MOD_Plk_4 364 370 PF00069 0.366
MOD_Plk_4 390 396 PF00069 0.346
MOD_Plk_4 425 431 PF00069 0.328
MOD_Plk_4 44 50 PF00069 0.383
MOD_Plk_4 554 560 PF00069 0.616
MOD_Plk_4 80 86 PF00069 0.332
MOD_ProDKin_1 143 149 PF00069 0.412
MOD_ProDKin_1 328 334 PF00069 0.501
MOD_ProDKin_1 337 343 PF00069 0.518
MOD_SUMO_rev_2 181 191 PF00179 0.458
TRG_DiLeu_BaLyEn_6 457 462 PF01217 0.328
TRG_DiLeu_BaLyEn_6 485 490 PF01217 0.381
TRG_ENDOCYTIC_2 150 153 PF00928 0.287
TRG_ENDOCYTIC_2 210 213 PF00928 0.370
TRG_ENDOCYTIC_2 222 225 PF00928 0.319
TRG_ENDOCYTIC_2 40 43 PF00928 0.315
TRG_ENDOCYTIC_2 45 48 PF00928 0.328
TRG_ENDOCYTIC_2 49 52 PF00928 0.347
TRG_ENDOCYTIC_2 505 508 PF00928 0.388
TRG_ENDOCYTIC_2 510 513 PF00928 0.391
TRG_ER_diArg_1 521 523 PF00400 0.443
TRG_Pf-PMV_PEXEL_1 460 465 PF00026 0.389
TRG_Pf-PMV_PEXEL_1 516 520 PF00026 0.460
TRG_Pf-PMV_PEXEL_1 522 526 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 569 573 PF00026 0.432

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 39% 90%
A0A0N1HT40 Leptomonas seymouri 73% 100%
A0A0N1HZC2 Leptomonas seymouri 27% 91%
A0A0N1IKC5 Leptomonas seymouri 46% 94%
A0A0N1PB63 Leptomonas seymouri 25% 87%
A0A0S4JR45 Bodo saltans 32% 100%
A0A1X0NKK0 Trypanosomatidae 31% 94%
A0A1X0NL32 Trypanosomatidae 34% 92%
A0A1X0NM09 Trypanosomatidae 31% 94%
A0A1X0NRW5 Trypanosomatidae 40% 82%
A0A1X0NV13 Trypanosomatidae 48% 88%
A0A1X0NV19 Trypanosomatidae 48% 96%
A0A1X0NV27 Trypanosomatidae 48% 96%
A0A1X0NVH8 Trypanosomatidae 46% 87%
A0A1X0NVM7 Trypanosomatidae 54% 89%
A0A1X0NWQ1 Trypanosomatidae 44% 89%
A0A1X0NZE6 Trypanosomatidae 34% 96%
A0A1X0NZU5 Trypanosomatidae 33% 98%
A0A1X0NZW1 Trypanosomatidae 29% 95%
A0A1X0P0M7 Trypanosomatidae 33% 97%
A0A3Q8I7Y9 Leishmania donovani 96% 100%
A0A3Q8IF95 Leishmania donovani 28% 100%
A0A3Q8ISY9 Leishmania donovani 38% 90%
A0A3R7JPZ0 Trypanosoma rangeli 26% 100%
A0A3R7JSQ9 Trypanosoma rangeli 29% 100%
A0A3R7KKN8 Trypanosoma rangeli 30% 96%
A0A3R7MAQ7 Trypanosoma rangeli 36% 81%
A0A3R7N415 Trypanosoma rangeli 30% 95%
A0A3R7N921 Trypanosoma rangeli 29% 100%
A0A3R7R443 Trypanosoma rangeli 30% 96%
A0A3R7R6N6 Trypanosoma rangeli 27% 100%
A0A3S7WRJ4 Leishmania donovani 46% 89%
A0A3S7WRJ5 Leishmania donovani 42% 82%
A0A3S7WRL4 Leishmania donovani 93% 92%
A0A3S7WSR4 Leishmania donovani 45% 94%
A0A3S7WWU1 Leishmania donovani 25% 86%
A0A3S7XB11 Leishmania donovani 29% 94%
A0A422MSE4 Trypanosoma rangeli 48% 100%
A0A422MSP6 Trypanosoma rangeli 34% 100%
A0A422MST9 Trypanosoma rangeli 28% 95%
A0A422MU68 Trypanosoma rangeli 27% 100%
A4H6J0 Leishmania braziliensis 46% 100%
A4H6J3 Leishmania braziliensis 83% 100%
A4HC19 Leishmania braziliensis 26% 100%
A4HJW3 Leishmania braziliensis 39% 100%
A4HPE2 Leishmania braziliensis 28% 100%
A4HUX5 Leishmania infantum 46% 89%
A4HUX6 Leishmania infantum 42% 82%
A4HUX7 Leishmania infantum 93% 92%
A4HUX8 Leishmania infantum 92% 98%
A4HZF5 Leishmania infantum 28% 100%
A4HZJ4 Leishmania infantum 25% 86%
A4I7C5 Leishmania infantum 39% 90%
A4ICI3 Leishmania infantum 29% 94%
C9ZL97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 96%
C9ZL98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 98%
C9ZL99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 96%
C9ZLA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 98%
C9ZLA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 96%
C9ZTR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 96%
C9ZTR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 95%
C9ZTR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZTR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 96%
C9ZTR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 98%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 96%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 97%
D0A7H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0AAQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 84%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AGK5 Leishmania infantum 45% 94%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 95%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 97%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 93%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 87%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 90%
Q4Q1E4 Leishmania major 29% 100%
Q4Q5T8 Leishmania major 38% 100%
Q4QC27 Leishmania major 26% 100%
Q4QC28 Leishmania major 30% 100%
Q4QFY5 Leishmania major 44% 100%
Q4QH10 Leishmania major 92% 100%
Q4QH11 Leishmania major 93% 100%
Q4QH12 Leishmania major 93% 100%
Q4QH13 Leishmania major 93% 100%
Q4QH14 Leishmania major 41% 100%
Q4QH15 Leishmania major 46% 100%
V5B647 Trypanosoma cruzi 47% 91%
V5B983 Trypanosoma cruzi 33% 98%
V5BBB1 Trypanosoma cruzi 45% 97%
V5BFV8 Trypanosoma cruzi 30% 86%
V5BQY6 Trypanosoma cruzi 38% 81%
V5BVP0 Trypanosoma cruzi 46% 97%
V5DT25 Trypanosoma cruzi 57% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS