Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein Associated with Differentiation, putative

Species:

Leishmania mexicana

UniProt:

E9ANL0_LEIMU

TriTrypDb:

LmxM.11.0650

Length:

641

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 121
NetGPI	no	yes: 0, no: 121

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	114
GO:0110165	cellular anatomical entity	1	114
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9ANL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANL0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	54
GO:0022857	transmembrane transporter activity	2	54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.241
CLV_NRD_NRD_1	244	246	PF00675	0.268
CLV_NRD_NRD_1	308	310	PF00675	0.434
CLV_NRD_NRD_1	323	325	PF00675	0.561
CLV_NRD_NRD_1	457	459	PF00675	0.358
CLV_NRD_NRD_1	597	599	PF00675	0.344
CLV_PCSK_KEX2_1	228	230	PF00082	0.235
CLV_PCSK_KEX2_1	244	246	PF00082	0.270
CLV_PCSK_KEX2_1	308	310	PF00082	0.453
CLV_PCSK_KEX2_1	323	325	PF00082	0.554
CLV_PCSK_KEX2_1	457	459	PF00082	0.342
CLV_PCSK_KEX2_1	559	561	PF00082	0.559
CLV_PCSK_KEX2_1	597	599	PF00082	0.340
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.345
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.559
CLV_PCSK_PC7_1	304	310	PF00082	0.424
CLV_PCSK_PC7_1	593	599	PF00082	0.393
CLV_PCSK_SKI1_1	229	233	PF00082	0.331
CLV_PCSK_SKI1_1	245	249	PF00082	0.262
CLV_PCSK_SKI1_1	27	31	PF00082	0.243
CLV_PCSK_SKI1_1	515	519	PF00082	0.271
CLV_PCSK_SKI1_1	597	601	PF00082	0.360
DEG_APCC_DBOX_1	26	34	PF00400	0.459
DOC_CYCLIN_yClb1_LxF_4	275	280	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.246
DOC_MAPK_gen_1	244	252	PF00069	0.444
DOC_MAPK_gen_1	457	466	PF00069	0.522
DOC_MAPK_JIP1_4	274	280	PF00069	0.162
DOC_MAPK_MEF2A_6	245	254	PF00069	0.468
DOC_MAPK_MEF2A_6	459	468	PF00069	0.523
DOC_MAPK_MEF2A_6	564	573	PF00069	0.316
DOC_PP1_RVXF_1	275	281	PF00149	0.267
DOC_PP2B_LxvP_1	485	488	PF13499	0.416
DOC_PP2B_LxvP_1	49	52	PF13499	0.365
DOC_PP2B_LxvP_1	492	495	PF13499	0.298
DOC_PP4_FxxP_1	78	81	PF00568	0.312
DOC_USP7_MATH_1	261	265	PF00917	0.356
DOC_USP7_MATH_1	344	348	PF00917	0.734
DOC_USP7_MATH_1	355	359	PF00917	0.737
DOC_USP7_MATH_1	425	429	PF00917	0.395
DOC_USP7_UBL2_3	520	524	PF12436	0.493
DOC_USP7_UBL2_3	555	559	PF12436	0.386
DOC_WW_Pin1_4	1	6	PF00397	0.617
LIG_14-3-3_CanoR_1	445	451	PF00244	0.298
LIG_14-3-3_CanoR_1	57	65	PF00244	0.342
LIG_14-3-3_CanoR_1	591	596	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_deltaCOP1_diTrp_1	391	397	PF00928	0.503
LIG_FHA_1	119	125	PF00498	0.304
LIG_FHA_1	136	142	PF00498	0.366
LIG_FHA_1	199	205	PF00498	0.368
LIG_FHA_1	232	238	PF00498	0.438
LIG_FHA_1	261	267	PF00498	0.327
LIG_FHA_1	282	288	PF00498	0.377
LIG_FHA_1	387	393	PF00498	0.494
LIG_FHA_1	412	418	PF00498	0.324
LIG_FHA_1	428	434	PF00498	0.270
LIG_FHA_1	46	52	PF00498	0.310
LIG_FHA_1	465	471	PF00498	0.463
LIG_FHA_1	472	478	PF00498	0.316
LIG_FHA_1	582	588	PF00498	0.399
LIG_FHA_1	68	74	PF00498	0.331
LIG_FHA_2	368	374	PF00498	0.516
LIG_FHA_2	611	617	PF00498	0.629
LIG_FHA_2	82	88	PF00498	0.467
LIG_LIR_Apic_2	371	377	PF02991	0.499
LIG_LIR_Apic_2	87	91	PF02991	0.471
LIG_LIR_Gen_1	129	137	PF02991	0.348
LIG_LIR_Gen_1	185	195	PF02991	0.285
LIG_LIR_Gen_1	288	299	PF02991	0.345
LIG_LIR_Gen_1	406	415	PF02991	0.370
LIG_LIR_Gen_1	84	94	PF02991	0.398
LIG_LIR_Nem_3	129	133	PF02991	0.312
LIG_LIR_Nem_3	163	167	PF02991	0.331
LIG_LIR_Nem_3	174	179	PF02991	0.317
LIG_LIR_Nem_3	185	190	PF02991	0.257
LIG_LIR_Nem_3	288	294	PF02991	0.284
LIG_LIR_Nem_3	35	39	PF02991	0.350
LIG_LIR_Nem_3	406	410	PF02991	0.323
LIG_LIR_Nem_3	449	453	PF02991	0.517
LIG_LIR_Nem_3	547	551	PF02991	0.337
LIG_LIR_Nem_3	84	89	PF02991	0.348
LIG_NRBOX	428	434	PF00104	0.215
LIG_Pex14_2	175	179	PF04695	0.314
LIG_Pex14_2	190	194	PF04695	0.359
LIG_Pex14_2	43	47	PF04695	0.346
LIG_Pex14_2	78	82	PF04695	0.405
LIG_PTB_Apo_2	409	416	PF02174	0.331
LIG_SH2_CRK	291	295	PF00017	0.466
LIG_SH2_CRK	86	90	PF00017	0.460
LIG_SH2_GRB2like	269	272	PF00017	0.349
LIG_SH2_PTP2	374	377	PF00017	0.495
LIG_SH2_SRC	216	219	PF00017	0.574
LIG_SH2_SRC	496	499	PF00017	0.340
LIG_SH2_STAP1	45	49	PF00017	0.334
LIG_SH2_STAP1	549	553	PF00017	0.290
LIG_SH2_STAT3	236	239	PF00017	0.457
LIG_SH2_STAT3	549	552	PF00017	0.344
LIG_SH2_STAT5	149	152	PF00017	0.477
LIG_SH2_STAT5	187	190	PF00017	0.321
LIG_SH2_STAT5	236	239	PF00017	0.468
LIG_SH2_STAT5	259	262	PF00017	0.293
LIG_SH2_STAT5	269	272	PF00017	0.277
LIG_SH2_STAT5	374	377	PF00017	0.504
LIG_SH2_STAT5	450	453	PF00017	0.502
LIG_SH2_STAT5	496	499	PF00017	0.315
LIG_SH2_STAT5	549	552	PF00017	0.311
LIG_SH2_STAT5	88	91	PF00017	0.476
LIG_SH3_3	293	299	PF00018	0.352
LIG_SH3_3	361	367	PF00018	0.609
LIG_SH3_3	564	570	PF00018	0.319
LIG_Sin3_3	47	54	PF02671	0.178
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.343
LIG_SUMO_SIM_anti_2	284	291	PF11976	0.297
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.213
LIG_SUMO_SIM_anti_2	626	632	PF11976	0.739
LIG_SUMO_SIM_par_1	29	35	PF11976	0.428
LIG_SUMO_SIM_par_1	474	480	PF11976	0.311
LIG_SUMO_SIM_par_1	92	98	PF11976	0.332
LIG_TRAF2_1	222	225	PF00917	0.404
LIG_TYR_ITIM	267	272	PF00017	0.283
LIG_TYR_ITIM	289	294	PF00017	0.333
LIG_WRC_WIRS_1	127	132	PF05994	0.378
LIG_WRC_WIRS_1	172	177	PF05994	0.370
LIG_WRC_WIRS_1	33	38	PF05994	0.425
LIG_WRC_WIRS_1	592	597	PF05994	0.558
MOD_CDC14_SPxK_1	4	7	PF00782	0.538
MOD_CDK_SPxK_1	1	7	PF00069	0.550
MOD_CK1_1	129	135	PF00069	0.390
MOD_CK1_1	219	225	PF00069	0.533
MOD_CK1_1	35	41	PF00069	0.305
MOD_CK1_1	67	73	PF00069	0.320
MOD_CK1_1	98	104	PF00069	0.339
MOD_CK2_1	219	225	PF00069	0.442
MOD_CK2_1	446	452	PF00069	0.356
MOD_CK2_1	610	616	PF00069	0.570
MOD_CMANNOS	393	396	PF00535	0.351
MOD_GlcNHglycan	168	171	PF01048	0.324
MOD_GlcNHglycan	263	266	PF01048	0.334
MOD_GlcNHglycan	440	443	PF01048	0.315
MOD_GlcNHglycan	530	533	PF01048	0.287
MOD_GlcNHglycan	579	582	PF01048	0.364
MOD_GSK3_1	129	136	PF00069	0.386
MOD_GSK3_1	145	152	PF00069	0.498
MOD_GSK3_1	281	288	PF00069	0.374
MOD_GSK3_1	308	315	PF00069	0.610
MOD_GSK3_1	35	42	PF00069	0.327
MOD_GSK3_1	427	434	PF00069	0.286
MOD_GSK3_1	473	480	PF00069	0.328
MOD_GSK3_1	530	537	PF00069	0.326
MOD_GSK3_1	577	584	PF00069	0.370
MOD_LATS_1	589	595	PF00433	0.601
MOD_N-GLC_1	198	203	PF02516	0.358
MOD_N-GLC_1	312	317	PF02516	0.521
MOD_N-GLC_1	411	416	PF02516	0.564
MOD_N-GLC_1	58	63	PF02516	0.510
MOD_N-GLC_2	386	388	PF02516	0.215
MOD_NEK2_1	160	165	PF00069	0.390
MOD_NEK2_1	197	202	PF00069	0.288
MOD_NEK2_1	32	37	PF00069	0.302
MOD_NEK2_1	395	400	PF00069	0.263
MOD_NEK2_1	420	425	PF00069	0.327
MOD_NEK2_1	446	451	PF00069	0.357
MOD_NEK2_1	483	488	PF00069	0.321
MOD_NEK2_1	528	533	PF00069	0.293
MOD_NEK2_1	534	539	PF00069	0.297
MOD_NEK2_1	577	582	PF00069	0.314
MOD_NEK2_2	81	86	PF00069	0.481
MOD_PIKK_1	182	188	PF00454	0.344
MOD_PIKK_1	231	237	PF00454	0.513
MOD_PIKK_1	452	458	PF00454	0.508
MOD_PIKK_1	506	512	PF00454	0.365
MOD_PIKK_1	58	64	PF00454	0.250
MOD_PKA_1	308	314	PF00069	0.591
MOD_PKA_2	153	159	PF00069	0.438
MOD_PKA_2	308	314	PF00069	0.590
MOD_PKA_2	322	328	PF00069	0.785
MOD_PKA_2	631	637	PF00069	0.757
MOD_PKB_1	591	599	PF00069	0.414
MOD_Plk_1	344	350	PF00069	0.734
MOD_Plk_1	411	417	PF00069	0.331
MOD_Plk_4	142	148	PF00069	0.277
MOD_Plk_4	153	159	PF00069	0.484
MOD_Plk_4	171	177	PF00069	0.372
MOD_Plk_4	282	288	PF00069	0.352
MOD_Plk_4	379	385	PF00069	0.525
MOD_Plk_4	398	404	PF00069	0.351
MOD_Plk_4	411	417	PF00069	0.314
MOD_Plk_4	431	437	PF00069	0.334
MOD_Plk_4	446	452	PF00069	0.280
MOD_Plk_4	473	479	PF00069	0.317
MOD_Plk_4	534	540	PF00069	0.302
MOD_Plk_4	81	87	PF00069	0.368
MOD_Plk_4	95	101	PF00069	0.296
MOD_ProDKin_1	1	7	PF00069	0.616
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.317
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.314
TRG_ENDOCYTIC_2	187	190	PF00928	0.293
TRG_ENDOCYTIC_2	269	272	PF00928	0.261
TRG_ENDOCYTIC_2	291	294	PF00928	0.305
TRG_ENDOCYTIC_2	450	453	PF00928	0.448
TRG_ENDOCYTIC_2	592	595	PF00928	0.520
TRG_ENDOCYTIC_2	86	89	PF00928	0.483
TRG_ER_diArg_1	228	230	PF00400	0.479
TRG_ER_diArg_1	243	245	PF00400	0.463
TRG_ER_diArg_1	597	599	PF00400	0.555
TRG_ER_diArg_1	603	606	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	40%	100%
A0A0N1HT40	Leptomonas seymouri	46%	100%
A0A0N1HZC2	Leptomonas seymouri	29%	100%
A0A0N1IKC5	Leptomonas seymouri	56%	100%
A0A0N1PB63	Leptomonas seymouri	28%	97%
A0A0N1PD04	Leptomonas seymouri	23%	100%
A0A0N1PFR4	Leptomonas seymouri	27%	97%
A0A0S4JR45	Bodo saltans	29%	100%
A0A1X0NKK0	Trypanosomatidae	30%	100%
A0A1X0NM09	Trypanosomatidae	30%	100%
A0A1X0NRW5	Trypanosomatidae	39%	92%
A0A1X0NV13	Trypanosomatidae	50%	99%
A0A1X0NV19	Trypanosomatidae	51%	100%
A0A1X0NV27	Trypanosomatidae	52%	100%
A0A1X0NVH8	Trypanosomatidae	43%	97%
A0A1X0NVM7	Trypanosomatidae	48%	99%
A0A1X0NWQ1	Trypanosomatidae	48%	100%
A0A1X0NZE6	Trypanosomatidae	32%	100%
A0A1X0NZU2	Trypanosomatidae	30%	99%
A0A1X0NZU5	Trypanosomatidae	34%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	31%	100%
A0A381MMW5	Leishmania infantum	30%	98%
A0A3Q8I7Y9	Leishmania donovani	47%	100%
A0A3Q8IEC4	Leishmania donovani	30%	99%
A0A3Q8IF95	Leishmania donovani	28%	100%
A0A3Q8IIT5	Leishmania donovani	25%	95%
A0A3Q8ISY9	Leishmania donovani	40%	100%
A0A3R7JSQ9	Trypanosoma rangeli	28%	100%
A0A3R7KKN8	Trypanosoma rangeli	29%	100%
A0A3R7MAQ7	Trypanosoma rangeli	36%	91%
A0A3R7N3S6	Trypanosoma rangeli	22%	99%
A0A3R7N415	Trypanosoma rangeli	27%	100%
A0A3R7N921	Trypanosoma rangeli	30%	100%
A0A3R7R443	Trypanosoma rangeli	28%	100%
A0A3S7WRJ4	Leishmania donovani	93%	100%
A0A3S7WRJ5	Leishmania donovani	52%	92%
A0A3S7WRL4	Leishmania donovani	46%	100%
A0A3S7WRS3	Leishmania donovani	24%	100%
A0A3S7WSR4	Leishmania donovani	55%	100%
A0A3S7WWU1	Leishmania donovani	26%	97%
A0A3S7X2G0	Leishmania donovani	30%	98%
A0A3S7X2K5	Leishmania donovani	29%	100%
A0A3S7XB11	Leishmania donovani	30%	100%
A0A422MSE4	Trypanosoma rangeli	48%	100%
A0A422MSP6	Trypanosoma rangeli	33%	100%
A0A422MST9	Trypanosoma rangeli	26%	100%
A0A422MU68	Trypanosoma rangeli	28%	100%
A4H6J0	Leishmania braziliensis	82%	100%
A4H6J1	Leishmania braziliensis	56%	100%
A4H6J3	Leishmania braziliensis	47%	95%
A4H6Q5	Leishmania braziliensis	25%	100%
A4HC19	Leishmania braziliensis	29%	100%
A4HHG2	Leishmania braziliensis	24%	100%
A4HHG3	Leishmania braziliensis	30%	100%
A4HHG4	Leishmania braziliensis	31%	100%
A4HJW3	Leishmania braziliensis	40%	100%
A4HPE2	Leishmania braziliensis	30%	100%
A4HUX5	Leishmania infantum	93%	100%
A4HUX6	Leishmania infantum	53%	92%
A4HUX7	Leishmania infantum	46%	100%
A4HUX8	Leishmania infantum	46%	100%
A4HV40	Leishmania infantum	24%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	26%	97%
A4I4L2	Leishmania infantum	25%	95%
A4I7C5	Leishmania infantum	40%	100%
A4ICI3	Leishmania infantum	30%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9AE01	Leishmania major	30%	100%
E9AE09	Leishmania major	25%	100%
E9AE10	Leishmania major	25%	100%
E9AE11	Leishmania major	30%	100%
E9AGK5	Leishmania infantum	55%	100%
E9AHJ0	Leishmania infantum	30%	99%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	98%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	98%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4Q1E4	Leishmania major	30%	100%
Q4Q5T8	Leishmania major	39%	100%
Q4QC27	Leishmania major	27%	100%
Q4QC28	Leishmania major	28%	96%
Q4QFY5	Leishmania major	55%	97%
Q4QGU8	Leishmania major	24%	100%
Q4QH10	Leishmania major	47%	96%
Q4QH11	Leishmania major	47%	93%
Q4QH12	Leishmania major	47%	93%
Q4QH13	Leishmania major	47%	93%
Q4QH14	Leishmania major	50%	100%
Q4QH15	Leishmania major	92%	100%
V5B647	Trypanosoma cruzi	47%	100%
V5B983	Trypanosoma cruzi	31%	100%
V5BBB1	Trypanosoma cruzi	43%	100%
V5BFV8	Trypanosoma cruzi	30%	96%
V5BQY6	Trypanosoma cruzi	37%	91%
V5BVP0	Trypanosoma cruzi	50%	100%
V5DT25	Trypanosoma cruzi	50%	100%