Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania mexicana

UniProt:

E9ANK7_LEIMU

TriTrypDb:

LmxM.11.0620

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ANK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004177	aminopeptidase activity	5	5
GO:0005488	binding	1	5
GO:0008233	peptidase activity	3	5
GO:0008235	metalloexopeptidase activity	5	5
GO:0008237	metallopeptidase activity	4	5
GO:0008238	exopeptidase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0030145	manganese ion binding	6	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0070006	metalloaminopeptidase activity	6	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	271	273	PF00675	0.416
CLV_PCSK_KEX2_1	271	273	PF00082	0.416
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.416
CLV_PCSK_SKI1_1	146	150	PF00082	0.440
CLV_PCSK_SKI1_1	91	95	PF00082	0.440
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.440
DOC_MAPK_gen_1	257	265	PF00069	0.440
DOC_MAPK_MEF2A_6	257	265	PF00069	0.440
DOC_PP4_FxxP_1	258	261	PF00568	0.523
DOC_USP7_MATH_1	180	184	PF00917	0.440
DOC_USP7_MATH_1	241	245	PF00917	0.407
DOC_WW_Pin1_4	223	228	PF00397	0.440
DOC_WW_Pin1_4	234	239	PF00397	0.308
LIG_BIR_II_1	1	5	PF00653	0.243
LIG_BIR_III_4	142	146	PF00653	0.440
LIG_BRCT_BRCA1_1	254	258	PF00533	0.440
LIG_CtBP_PxDLS_1	6	12	PF00389	0.352
LIG_FHA_1	107	113	PF00498	0.440
LIG_FHA_1	199	205	PF00498	0.243
LIG_FHA_2	139	145	PF00498	0.440
LIG_LIR_Apic_2	221	227	PF02991	0.440
LIG_LIR_Apic_2	255	261	PF02991	0.515
LIG_LIR_Apic_2	32	38	PF02991	0.440
LIG_LIR_Gen_1	98	108	PF02991	0.440
LIG_LIR_Nem_3	11	17	PF02991	0.527
LIG_LIR_Nem_3	208	214	PF02991	0.440
LIG_LIR_Nem_3	98	103	PF02991	0.440
LIG_LYPXL_yS_3	211	214	PF13949	0.440
LIG_Pex14_2	258	262	PF04695	0.527
LIG_SH2_CRK	14	18	PF00017	0.440
LIG_SH2_CRK	224	228	PF00017	0.440
LIG_SH2_CRK	35	39	PF00017	0.440
LIG_SH2_STAT5	189	192	PF00017	0.243
LIG_SH2_STAT5	215	218	PF00017	0.440
LIG_SH2_STAT5	248	251	PF00017	0.440
LIG_Sin3_3	86	93	PF02671	0.440
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.440
LIG_SUMO_SIM_anti_2	135	142	PF11976	0.320
LIG_TYR_ITIM	209	214	PF00017	0.440
MOD_CK1_1	132	138	PF00069	0.515
MOD_CK1_1	237	243	PF00069	0.440
MOD_CK2_1	138	144	PF00069	0.440
MOD_CK2_1	188	194	PF00069	0.440
MOD_GlcNHglycan	131	134	PF01048	0.527
MOD_GlcNHglycan	205	208	PF01048	0.418
MOD_GlcNHglycan	239	242	PF01048	0.492
MOD_GlcNHglycan	78	81	PF01048	0.440
MOD_GSK3_1	236	243	PF00069	0.506
MOD_GSK3_1	67	74	PF00069	0.453
MOD_N-GLC_1	104	109	PF02516	0.440
MOD_N-GLC_1	38	43	PF02516	0.243
MOD_NEK2_1	76	81	PF00069	0.449
MOD_Plk_1	104	110	PF00069	0.440
MOD_Plk_1	38	44	PF00069	0.243
MOD_ProDKin_1	223	229	PF00069	0.440
MOD_ProDKin_1	234	240	PF00069	0.308
MOD_SUMO_for_1	4	7	PF00179	0.375
TRG_ENDOCYTIC_2	14	17	PF00928	0.440
TRG_ENDOCYTIC_2	211	214	PF00928	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICD9	Leishmania donovani	91%	96%
A4HUX2	Leishmania infantum	91%	96%
Q4QH18	Leishmania major	91%	100%