Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANK6_LEIMU

TriTrypDb:

LmxM.11.0610

Length:

1076

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099080	supramolecular complex	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK6

Function

Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.647
CLV_MEL_PAP_1	835	841	PF00089	0.622
CLV_MEL_PAP_1	889	895	PF00089	0.578
CLV_NRD_NRD_1	45	47	PF00675	0.780
CLV_NRD_NRD_1	723	725	PF00675	0.808
CLV_NRD_NRD_1	792	794	PF00675	0.709
CLV_NRD_NRD_1	88	90	PF00675	0.511
CLV_NRD_NRD_1	915	917	PF00675	0.630
CLV_PCSK_KEX2_1	45	47	PF00082	0.721
CLV_PCSK_KEX2_1	792	794	PF00082	0.709
CLV_PCSK_KEX2_1	88	90	PF00082	0.511
CLV_PCSK_KEX2_1	915	917	PF00082	0.630
DEG_Nend_UBRbox_2	1	3	PF02207	0.656
DEG_SCF_FBW7_1	47	53	PF00400	0.823
DEG_SCF_FBW7_2	200	206	PF00400	0.770
DEG_SPOP_SBC_1	19	23	PF00917	0.663
DEG_SPOP_SBC_1	328	332	PF00917	0.563
DEG_SPOP_SBC_1	337	341	PF00917	0.554
DEG_SPOP_SBC_1	465	469	PF00917	0.811
DEG_SPOP_SBC_1	674	678	PF00917	0.713
DOC_CDC14_PxL_1	818	826	PF14671	0.599
DOC_CKS1_1	200	205	PF01111	0.771
DOC_CKS1_1	374	379	PF01111	0.730
DOC_CKS1_1	397	402	PF01111	0.570
DOC_CKS1_1	47	52	PF01111	0.820
DOC_CYCLIN_yClb1_LxF_4	734	740	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.606
DOC_PP4_FxxP_1	1065	1068	PF00568	0.816
DOC_PP4_FxxP_1	374	377	PF00568	0.648
DOC_USP7_MATH_1	1000	1004	PF00917	0.524
DOC_USP7_MATH_1	194	198	PF00917	0.546
DOC_USP7_MATH_1	328	332	PF00917	0.627
DOC_USP7_MATH_1	337	341	PF00917	0.686
DOC_USP7_MATH_1	470	474	PF00917	0.786
DOC_USP7_MATH_1	500	504	PF00917	0.746
DOC_USP7_MATH_1	542	546	PF00917	0.805
DOC_USP7_MATH_1	549	553	PF00917	0.764
DOC_USP7_MATH_1	562	566	PF00917	0.539
DOC_USP7_MATH_1	597	601	PF00917	0.650
DOC_USP7_MATH_1	668	672	PF00917	0.809
DOC_USP7_MATH_1	674	678	PF00917	0.703
DOC_USP7_MATH_1	761	765	PF00917	0.819
DOC_USP7_MATH_1	804	808	PF00917	0.726
DOC_USP7_MATH_1	983	987	PF00917	0.706
DOC_WW_Pin1_4	1030	1035	PF00397	0.590
DOC_WW_Pin1_4	1064	1069	PF00397	0.523
DOC_WW_Pin1_4	196	201	PF00397	0.718
DOC_WW_Pin1_4	373	378	PF00397	0.734
DOC_WW_Pin1_4	396	401	PF00397	0.708
DOC_WW_Pin1_4	46	51	PF00397	0.674
DOC_WW_Pin1_4	466	471	PF00397	0.772
DOC_WW_Pin1_4	483	488	PF00397	0.563
DOC_WW_Pin1_4	547	552	PF00397	0.797
DOC_WW_Pin1_4	554	559	PF00397	0.684
DOC_WW_Pin1_4	608	613	PF00397	0.680
DOC_WW_Pin1_4	617	622	PF00397	0.646
DOC_WW_Pin1_4	634	639	PF00397	0.675
DOC_WW_Pin1_4	675	680	PF00397	0.715
DOC_WW_Pin1_4	695	700	PF00397	0.714
DOC_WW_Pin1_4	716	721	PF00397	0.515
LIG_14-3-3_CanoR_1	154	159	PF00244	0.542
LIG_14-3-3_CanoR_1	193	199	PF00244	0.761
LIG_14-3-3_CanoR_1	270	275	PF00244	0.754
LIG_14-3-3_CanoR_1	276	285	PF00244	0.679
LIG_14-3-3_CanoR_1	300	304	PF00244	0.580
LIG_14-3-3_CanoR_1	675	679	PF00244	0.607
LIG_14-3-3_CanoR_1	757	766	PF00244	0.630
LIG_14-3-3_CanoR_1	792	796	PF00244	0.812
LIG_14-3-3_CanoR_1	922	932	PF00244	0.647
LIG_APCC_ABBA_1	739	744	PF00400	0.585
LIG_BRCT_BRCA1_1	1066	1070	PF00533	0.527
LIG_BRCT_BRCA1_1	181	185	PF00533	0.738
LIG_BRCT_BRCA1_1	370	374	PF00533	0.674
LIG_BRCT_BRCA1_1	40	44	PF00533	0.845
LIG_BRCT_BRCA1_1	54	58	PF00533	0.561
LIG_BRCT_BRCA1_1	6	10	PF00533	0.609
LIG_BRCT_BRCA1_1	647	651	PF00533	0.762
LIG_BRCT_BRCA1_1	76	80	PF00533	0.590
LIG_BRCT_BRCA1_1	93	97	PF00533	0.782
LIG_CtBP_PxDLS_1	259	263	PF00389	0.565
LIG_DLG_GKlike_1	270	277	PF00625	0.766
LIG_FHA_1	1053	1059	PF00498	0.534
LIG_FHA_1	211	217	PF00498	0.749
LIG_FHA_1	374	380	PF00498	0.728
LIG_FHA_1	51	57	PF00498	0.749
LIG_FHA_1	596	602	PF00498	0.539
LIG_FHA_1	701	707	PF00498	0.658
LIG_FHA_1	749	755	PF00498	0.814
LIG_FHA_1	813	819	PF00498	0.617
LIG_FHA_1	864	870	PF00498	0.608
LIG_FHA_1	872	878	PF00498	0.336
LIG_FHA_1	9	15	PF00498	0.665
LIG_FHA_1	924	930	PF00498	0.652
LIG_FHA_2	328	334	PF00498	0.785
LIG_FHA_2	716	722	PF00498	0.803
LIG_FHA_2	860	866	PF00498	0.644
LIG_GBD_Chelix_1	934	942	PF00786	0.536
LIG_Integrin_RGD_1	812	814	PF01839	0.759
LIG_LIR_Apic_2	1062	1068	PF02991	0.808
LIG_LIR_Apic_2	371	377	PF02991	0.659
LIG_LIR_Gen_1	210	220	PF02991	0.822
LIG_LIR_Gen_1	320	328	PF02991	0.568
LIG_LIR_Gen_1	622	633	PF02991	0.819
LIG_LIR_Gen_1	77	85	PF02991	0.539
LIG_LIR_Gen_1	902	910	PF02991	0.592
LIG_LIR_Nem_3	210	215	PF02991	0.830
LIG_LIR_Nem_3	320	325	PF02991	0.861
LIG_LIR_Nem_3	41	47	PF02991	0.848
LIG_LIR_Nem_3	579	584	PF02991	0.732
LIG_LIR_Nem_3	622	628	PF02991	0.820
LIG_LIR_Nem_3	77	83	PF02991	0.543
LIG_Pex14_1	878	882	PF04695	0.575
LIG_Pex14_2	827	831	PF04695	0.585
LIG_SH2_CRK	212	216	PF00017	0.827
LIG_SH2_PTP2	625	628	PF00017	0.709
LIG_SH2_SRC	230	233	PF00017	0.624
LIG_SH2_SRC	539	542	PF00017	0.544
LIG_SH2_STAP1	212	216	PF00017	0.827
LIG_SH2_STAP1	230	234	PF00017	0.490
LIG_SH2_STAP1	519	523	PF00017	0.831
LIG_SH2_STAT3	519	522	PF00017	0.832
LIG_SH2_STAT5	107	110	PF00017	0.817
LIG_SH2_STAT5	212	215	PF00017	0.830
LIG_SH2_STAT5	444	447	PF00017	0.544
LIG_SH2_STAT5	466	469	PF00017	0.837
LIG_SH2_STAT5	574	577	PF00017	0.808
LIG_SH2_STAT5	625	628	PF00017	0.826
LIG_SH2_STAT5	904	907	PF00017	0.580
LIG_SH2_STAT5	910	913	PF00017	0.448
LIG_SH3_3	120	126	PF00018	0.518
LIG_SH3_3	197	203	PF00018	0.697
LIG_SH3_3	212	218	PF00018	0.586
LIG_SH3_3	311	317	PF00018	0.752
LIG_SH3_3	374	380	PF00018	0.825
LIG_SH3_3	394	400	PF00018	0.588
LIG_SH3_3	54	60	PF00018	0.746
LIG_SH3_3	545	551	PF00018	0.798
LIG_SH3_3	572	578	PF00018	0.809
LIG_SH3_3	610	616	PF00018	0.588
LIG_SH3_3	635	641	PF00018	0.796
LIG_SH3_3	683	689	PF00018	0.536
LIG_SH3_3	710	716	PF00018	0.803
LIG_SH3_3	735	741	PF00018	0.528
LIG_SH3_3	819	825	PF00018	0.607
LIG_SH3_3	927	933	PF00018	0.616
LIG_SUMO_SIM_par_1	932	937	PF11976	0.587
LIG_TRAF2_1	147	150	PF00917	0.630
LIG_TRAF2_1	204	207	PF00917	0.842
LIG_TRAF2_1	416	419	PF00917	0.556
LIG_TYR_ITSM	208	215	PF00017	0.755
LIG_WRC_WIRS_1	319	324	PF05994	0.858
LIG_WRC_WIRS_1	857	862	PF05994	0.553
LIG_WW_3	642	646	PF00397	0.548
MOD_CDC14_SPxK_1	557	560	PF00782	0.560
MOD_CDC14_SPxK_1	637	640	PF00782	0.691
MOD_CDK_SPxK_1	554	560	PF00069	0.572
MOD_CDK_SPxK_1	634	640	PF00069	0.760
MOD_CDK_SPxxK_3	695	702	PF00069	0.752
MOD_CK1_1	1052	1058	PF00069	0.708
MOD_CK1_1	121	127	PF00069	0.748
MOD_CK1_1	157	163	PF00069	0.765
MOD_CK1_1	184	190	PF00069	0.699
MOD_CK1_1	192	198	PF00069	0.695
MOD_CK1_1	199	205	PF00069	0.765
MOD_CK1_1	269	275	PF00069	0.584
MOD_CK1_1	289	295	PF00069	0.533
MOD_CK1_1	299	305	PF00069	0.520
MOD_CK1_1	324	330	PF00069	0.762
MOD_CK1_1	339	345	PF00069	0.628
MOD_CK1_1	359	365	PF00069	0.602
MOD_CK1_1	423	429	PF00069	0.596
MOD_CK1_1	473	479	PF00069	0.585
MOD_CK1_1	524	530	PF00069	0.540
MOD_CK1_1	550	556	PF00069	0.692
MOD_CK1_1	596	602	PF00069	0.823
MOD_CK1_1	619	625	PF00069	0.641
MOD_CK1_1	698	704	PF00069	0.772
MOD_CK1_1	762	768	PF00069	0.658
MOD_CK1_1	773	779	PF00069	0.635
MOD_CK1_1	791	797	PF00069	0.704
MOD_CK1_1	807	813	PF00069	0.450
MOD_CK1_1	859	865	PF00069	0.536
MOD_CK1_1	91	97	PF00069	0.740
MOD_CK1_1	98	104	PF00069	0.735
MOD_CK2_1	306	312	PF00069	0.576
MOD_CK2_1	328	334	PF00069	0.691
MOD_CK2_1	413	419	PF00069	0.559
MOD_CK2_1	611	617	PF00069	0.819
MOD_CK2_1	64	70	PF00069	0.535
MOD_CK2_1	779	785	PF00069	0.815
MOD_CK2_1	859	865	PF00069	0.645
MOD_GlcNHglycan	1051	1054	PF01048	0.769
MOD_GlcNHglycan	120	123	PF01048	0.687
MOD_GlcNHglycan	142	145	PF01048	0.761
MOD_GlcNHglycan	181	184	PF01048	0.636
MOD_GlcNHglycan	186	189	PF01048	0.630
MOD_GlcNHglycan	224	227	PF01048	0.571
MOD_GlcNHglycan	279	282	PF01048	0.783
MOD_GlcNHglycan	293	296	PF01048	0.581
MOD_GlcNHglycan	341	344	PF01048	0.678
MOD_GlcNHglycan	361	364	PF01048	0.794
MOD_GlcNHglycan	370	373	PF01048	0.739
MOD_GlcNHglycan	449	452	PF01048	0.796
MOD_GlcNHglycan	460	463	PF01048	0.624
MOD_GlcNHglycan	483	486	PF01048	0.823
MOD_GlcNHglycan	488	491	PF01048	0.714
MOD_GlcNHglycan	523	526	PF01048	0.565
MOD_GlcNHglycan	534	537	PF01048	0.702
MOD_GlcNHglycan	544	547	PF01048	0.792
MOD_GlcNHglycan	562	565	PF01048	0.534
MOD_GlcNHglycan	595	598	PF01048	0.681
MOD_GlcNHglycan	601	604	PF01048	0.656
MOD_GlcNHglycan	613	616	PF01048	0.664
MOD_GlcNHglycan	647	650	PF01048	0.764
MOD_GlcNHglycan	668	671	PF01048	0.630
MOD_GlcNHglycan	70	73	PF01048	0.668
MOD_GlcNHglycan	744	747	PF01048	0.579
MOD_GlcNHglycan	759	762	PF01048	0.690
MOD_GlcNHglycan	770	773	PF01048	0.649
MOD_GlcNHglycan	80	83	PF01048	0.723
MOD_GSK3_1	1000	1007	PF00069	0.766
MOD_GSK3_1	1049	1056	PF00069	0.793
MOD_GSK3_1	1064	1071	PF00069	0.540
MOD_GSK3_1	135	142	PF00069	0.652
MOD_GSK3_1	15	22	PF00069	0.664
MOD_GSK3_1	150	157	PF00069	0.803
MOD_GSK3_1	184	191	PF00069	0.803
MOD_GSK3_1	192	199	PF00069	0.686
MOD_GSK3_1	207	214	PF00069	0.583
MOD_GSK3_1	266	273	PF00069	0.700
MOD_GSK3_1	317	324	PF00069	0.763
MOD_GSK3_1	4	11	PF00069	0.743
MOD_GSK3_1	404	411	PF00069	0.833
MOD_GSK3_1	429	436	PF00069	0.737
MOD_GSK3_1	443	450	PF00069	0.646
MOD_GSK3_1	456	463	PF00069	0.594
MOD_GSK3_1	46	53	PF00069	0.734
MOD_GSK3_1	466	473	PF00069	0.688
MOD_GSK3_1	479	486	PF00069	0.609
MOD_GSK3_1	500	507	PF00069	0.799
MOD_GSK3_1	524	531	PF00069	0.810
MOD_GSK3_1	549	556	PF00069	0.687
MOD_GSK3_1	593	600	PF00069	0.747
MOD_GSK3_1	602	609	PF00069	0.705
MOD_GSK3_1	616	623	PF00069	0.721
MOD_GSK3_1	64	71	PF00069	0.767
MOD_GSK3_1	675	682	PF00069	0.747
MOD_GSK3_1	691	698	PF00069	0.556
MOD_GSK3_1	700	707	PF00069	0.672
MOD_GSK3_1	74	81	PF00069	0.548
MOD_GSK3_1	755	762	PF00069	0.731
MOD_GSK3_1	766	773	PF00069	0.583
MOD_GSK3_1	859	866	PF00069	0.589
MOD_GSK3_1	91	98	PF00069	0.796
MOD_LATS_1	284	290	PF00433	0.754
MOD_N-GLC_1	139	144	PF02516	0.839
MOD_N-GLC_1	356	361	PF02516	0.649
MOD_N-GLC_1	423	428	PF02516	0.573
MOD_N-GLC_1	474	479	PF02516	0.766
MOD_N-GLC_1	504	509	PF02516	0.821
MOD_N-GLC_1	593	598	PF02516	0.738
MOD_N-GLC_1	634	639	PF02516	0.838
MOD_N-GLC_1	742	747	PF02516	0.544
MOD_N-GLC_1	762	767	PF02516	0.566
MOD_N-GLC_1	98	103	PF02516	0.624
MOD_N-GLC_1	983	988	PF02516	0.728
MOD_NEK2_1	10	15	PF00069	0.727
MOD_NEK2_1	1005	1010	PF00069	0.749
MOD_NEK2_1	1051	1056	PF00069	0.629
MOD_NEK2_1	139	144	PF00069	0.839
MOD_NEK2_1	186	191	PF00069	0.817
MOD_NEK2_1	268	273	PF00069	0.713
MOD_NEK2_1	277	282	PF00069	0.681
MOD_NEK2_1	460	465	PF00069	0.679
MOD_NEK2_1	521	526	PF00069	0.534
MOD_NEK2_1	573	578	PF00069	0.527
MOD_NEK2_1	68	73	PF00069	0.770
MOD_NEK2_1	766	771	PF00069	0.789
MOD_NEK2_1	788	793	PF00069	0.808
MOD_NEK2_2	1000	1005	PF00069	0.679
MOD_NEK2_2	181	186	PF00069	0.817
MOD_NEK2_2	668	673	PF00069	0.837
MOD_NEK2_2	910	915	PF00069	0.521
MOD_PIKK_1	1053	1059	PF00454	0.534
MOD_PIKK_1	378	384	PF00454	0.687
MOD_PIKK_1	38	44	PF00454	0.771
MOD_PIKK_1	423	429	PF00454	0.715
MOD_PIKK_1	434	440	PF00454	0.742
MOD_PIKK_1	509	515	PF00454	0.748
MOD_PIKK_1	550	556	PF00454	0.559
MOD_PIKK_1	650	656	PF00454	0.823
MOD_PIKK_1	74	80	PF00454	0.582
MOD_PIKK_1	797	803	PF00454	0.685
MOD_PIKK_1	91	97	PF00454	0.796
MOD_PKA_1	88	94	PF00069	0.526
MOD_PKA_2	192	198	PF00069	0.831
MOD_PKA_2	269	275	PF00069	0.748
MOD_PKA_2	299	305	PF00069	0.623
MOD_PKA_2	674	680	PF00069	0.708
MOD_PKA_2	791	797	PF00069	0.810
MOD_PKA_2	88	94	PF00069	0.526
MOD_PKB_1	757	765	PF00069	0.531
MOD_Plk_1	148	154	PF00069	0.608
MOD_Plk_1	762	768	PF00069	0.759
MOD_Plk_1	804	810	PF00069	0.548
MOD_Plk_1	864	870	PF00069	0.452
MOD_Plk_1	983	989	PF00069	0.728
MOD_Plk_4	10	16	PF00069	0.783
MOD_Plk_4	1000	1006	PF00069	0.797
MOD_Plk_4	108	114	PF00069	0.580
MOD_Plk_4	181	187	PF00069	0.818
MOD_Plk_4	211	217	PF00069	0.827
MOD_Plk_4	306	312	PF00069	0.533
MOD_Plk_4	451	457	PF00069	0.824
MOD_Plk_4	864	870	PF00069	0.608
MOD_Plk_4	88	94	PF00069	0.652
MOD_ProDKin_1	1030	1036	PF00069	0.592
MOD_ProDKin_1	1064	1070	PF00069	0.525
MOD_ProDKin_1	196	202	PF00069	0.719
MOD_ProDKin_1	373	379	PF00069	0.735
MOD_ProDKin_1	396	402	PF00069	0.705
MOD_ProDKin_1	46	52	PF00069	0.674
MOD_ProDKin_1	466	472	PF00069	0.774
MOD_ProDKin_1	483	489	PF00069	0.562
MOD_ProDKin_1	547	553	PF00069	0.799
MOD_ProDKin_1	554	560	PF00069	0.685
MOD_ProDKin_1	608	614	PF00069	0.679
MOD_ProDKin_1	617	623	PF00069	0.645
MOD_ProDKin_1	634	640	PF00069	0.680
MOD_ProDKin_1	675	681	PF00069	0.713
MOD_ProDKin_1	695	701	PF00069	0.713
MOD_ProDKin_1	716	722	PF00069	0.512
MOD_SUMO_rev_2	111	121	PF00179	0.734
MOD_SUMO_rev_2	351	359	PF00179	0.568
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.828
TRG_DiLeu_BaLyEn_6	568	573	PF01217	0.734
TRG_ENDOCYTIC_2	212	215	PF00928	0.830
TRG_ENDOCYTIC_2	625	628	PF00928	0.826
TRG_ENDOCYTIC_2	904	907	PF00928	0.580
TRG_ER_diArg_1	170	173	PF00400	0.668
TRG_ER_diArg_1	44	46	PF00400	0.773
TRG_ER_diArg_1	756	759	PF00400	0.535
TRG_ER_diArg_1	88	90	PF00400	0.511
TRG_ER_diArg_1	884	887	PF00400	0.556
TRG_ER_diArg_1	914	916	PF00400	0.517
TRG_ER_diArg_1	969	972	PF00400	0.798
TRG_ER_FFAT_2	182	191	PF00635	0.741
TRG_NES_CRM1_1	879	891	PF08389	0.563
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	887	891	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	915	919	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	944	949	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6I8	Leishmania donovani	83%	100%
E9AGA2	Leishmania infantum	84%	100%
E9AI42	Leishmania braziliensis	63%	100%
Q4QH19	Leishmania major	81%	100%