Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANK6_LEIMU

TriTrypDb:

LmxM.11.0610

Length:

1076

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

E9ANK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK6

Function

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Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.647
CLV_MEL_PAP_1	835	841	PF00089	0.622
CLV_MEL_PAP_1	889	895	PF00089	0.578
CLV_NRD_NRD_1	45	47	PF00675	0.780
CLV_NRD_NRD_1	723	725	PF00675	0.808
CLV_NRD_NRD_1	792	794	PF00675	0.709
CLV_NRD_NRD_1	88	90	PF00675	0.511
CLV_NRD_NRD_1	915	917	PF00675	0.630
CLV_PCSK_KEX2_1	45	47	PF00082	0.721
CLV_PCSK_KEX2_1	792	794	PF00082	0.709

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6I8	Leishmania donovani	83%	100%
E9AGA2	Leishmania infantum	84%	100%
E9AI42	Leishmania braziliensis	63%	100%
Q4QH19	Leishmania major	81%	100%

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