CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 47, putative

Species:

Leishmania mexicana

UniProt:

E9ANK5_LEIMU

TriTrypDb:

LmxM.11.0600

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.524
CLV_C14_Caspase3-7	155	159	PF00656	0.756
CLV_C14_Caspase3-7	176	180	PF00656	0.784
CLV_C14_Caspase3-7	183	187	PF00656	0.641
CLV_C14_Caspase3-7	79	83	PF00656	0.517
CLV_NRD_NRD_1	261	263	PF00675	0.380
CLV_NRD_NRD_1	28	30	PF00675	0.518
CLV_NRD_NRD_1	378	380	PF00675	0.605
CLV_NRD_NRD_1	388	390	PF00675	0.637
CLV_NRD_NRD_1	451	453	PF00675	0.710
CLV_NRD_NRD_1	473	475	PF00675	0.735
CLV_NRD_NRD_1	493	495	PF00675	0.653
CLV_NRD_NRD_1	577	579	PF00675	0.768
CLV_NRD_NRD_1	581	583	PF00675	0.769
CLV_NRD_NRD_1	77	79	PF00675	0.821
CLV_PCSK_KEX2_1	261	263	PF00082	0.570
CLV_PCSK_KEX2_1	28	30	PF00082	0.613
CLV_PCSK_KEX2_1	378	380	PF00082	0.605
CLV_PCSK_KEX2_1	388	390	PF00082	0.637
CLV_PCSK_KEX2_1	451	453	PF00082	0.710
CLV_PCSK_KEX2_1	473	475	PF00082	0.738
CLV_PCSK_KEX2_1	492	494	PF00082	0.661
CLV_PCSK_KEX2_1	577	579	PF00082	0.774
CLV_PCSK_KEX2_1	581	583	PF00082	0.777
CLV_PCSK_KEX2_1	77	79	PF00082	0.706
CLV_PCSK_PC7_1	488	494	PF00082	0.751
CLV_PCSK_PC7_1	577	583	PF00082	0.553
CLV_PCSK_SKI1_1	290	294	PF00082	0.612
CLV_PCSK_SKI1_1	37	41	PF00082	0.591
DEG_SCF_TRCP1_1	584	589	PF00400	0.815
DEG_SPOP_SBC_1	12	16	PF00917	0.392
DEG_SPOP_SBC_1	334	338	PF00917	0.697
DEG_SPOP_SBC_1	508	512	PF00917	0.755
DOC_ANK_TNKS_1	4	11	PF00023	0.483
DOC_ANK_TNKS_1	77	84	PF00023	0.738
DOC_CKS1_1	274	279	PF01111	0.665
DOC_CKS1_1	283	288	PF01111	0.548
DOC_PIKK_1	183	191	PF02985	0.594
DOC_PP1_RVXF_1	233	239	PF00149	0.593
DOC_USP7_MATH_1	136	140	PF00917	0.702
DOC_USP7_MATH_1	204	208	PF00917	0.693
DOC_USP7_MATH_1	284	288	PF00917	0.625
DOC_USP7_MATH_1	396	400	PF00917	0.597
DOC_USP7_MATH_1	430	434	PF00917	0.797
DOC_USP7_MATH_1	507	511	PF00917	0.825
DOC_USP7_UBL2_3	153	157	PF12436	0.749
DOC_WW_Pin1_4	148	153	PF00397	0.688
DOC_WW_Pin1_4	264	269	PF00397	0.626
DOC_WW_Pin1_4	273	278	PF00397	0.629
DOC_WW_Pin1_4	282	287	PF00397	0.581
DOC_WW_Pin1_4	335	340	PF00397	0.638
DOC_WW_Pin1_4	421	426	PF00397	0.741
DOC_WW_Pin1_4	494	499	PF00397	0.842
DOC_WW_Pin1_4	509	514	PF00397	0.792
LIG_14-3-3_CanoR_1	270	275	PF00244	0.430
LIG_14-3-3_CanoR_1	358	363	PF00244	0.530
LIG_APCC_ABBAyCdc20_2	379	385	PF00400	0.639
LIG_BRCT_BRCA1_1	125	129	PF00533	0.706
LIG_BRCT_BRCA1_1	15	19	PF00533	0.367
LIG_BRCT_BRCA1_1	350	354	PF00533	0.350
LIG_BRCT_BRCA1_1	432	436	PF00533	0.734
LIG_BRCT_BRCA1_1	496	500	PF00533	0.761
LIG_eIF4E_1	588	594	PF01652	0.789
LIG_FHA_1	180	186	PF00498	0.631
LIG_FHA_1	200	206	PF00498	0.520
LIG_FHA_1	22	28	PF00498	0.542
LIG_FHA_1	270	276	PF00498	0.734
LIG_FHA_1	322	328	PF00498	0.690
LIG_FHA_2	174	180	PF00498	0.700
LIG_FHA_2	283	289	PF00498	0.685
LIG_FHA_2	359	365	PF00498	0.508
LIG_Integrin_RGD_1	582	584	PF01839	0.547
LIG_LIR_Apic_2	407	412	PF02991	0.779
LIG_LIR_Gen_1	329	339	PF02991	0.759
LIG_LIR_Gen_1	48	57	PF02991	0.476
LIG_LIR_Nem_3	278	283	PF02991	0.517
LIG_LIR_Nem_3	316	320	PF02991	0.622
LIG_LIR_Nem_3	329	334	PF02991	0.535
LIG_LIR_Nem_3	351	357	PF02991	0.524
LIG_LIR_Nem_3	433	439	PF02991	0.812
LIG_LIR_Nem_3	48	52	PF02991	0.476
LIG_Pex14_2	129	133	PF04695	0.688
LIG_PTB_Apo_2	369	376	PF02174	0.714
LIG_PTB_Apo_2	478	485	PF02174	0.746
LIG_PTB_Phospho_1	369	375	PF10480	0.711
LIG_PTB_Phospho_1	478	484	PF10480	0.745
LIG_SH2_CRK	219	223	PF00017	0.801
LIG_SH2_CRK	265	269	PF00017	0.604
LIG_SH2_CRK	331	335	PF00017	0.761
LIG_SH2_CRK	422	426	PF00017	0.721
LIG_SH2_GRB2like	469	472	PF00017	0.805
LIG_SH2_GRB2like	479	482	PF00017	0.678
LIG_SH2_NCK_1	219	223	PF00017	0.670
LIG_SH2_NCK_1	331	335	PF00017	0.761
LIG_SH2_NCK_1	495	499	PF00017	0.738
LIG_SH2_NCK_1	544	548	PF00017	0.544
LIG_SH2_PTP2	49	52	PF00017	0.446
LIG_SH2_STAP1	331	335	PF00017	0.761
LIG_SH2_STAT3	563	566	PF00017	0.844
LIG_SH2_STAT5	375	378	PF00017	0.725
LIG_SH2_STAT5	49	52	PF00017	0.446
LIG_SH3_3	206	212	PF00018	0.808
LIG_SH3_3	245	251	PF00018	0.547
LIG_SH3_3	271	277	PF00018	0.567
LIG_SH3_3	322	328	PF00018	0.630
LIG_SUMO_SIM_par_1	323	330	PF11976	0.711
LIG_SUMO_SIM_par_1	89	94	PF11976	0.712
LIG_TYR_ITIM	47	52	PF00017	0.481
LIG_WRC_WIRS_1	191	196	PF05994	0.594
MOD_CDC14_SPxK_1	267	270	PF00782	0.624
MOD_CDK_SPK_2	148	153	PF00069	0.829
MOD_CDK_SPxK_1	264	270	PF00069	0.629
MOD_CK1_1	137	143	PF00069	0.697
MOD_CK1_1	14	20	PF00069	0.613
MOD_CK1_1	273	279	PF00069	0.436
MOD_CK1_1	391	397	PF00069	0.751
MOD_CK1_1	400	406	PF00069	0.690
MOD_CK1_1	424	430	PF00069	0.718
MOD_CK1_1	434	440	PF00069	0.691
MOD_CK1_1	561	567	PF00069	0.745
MOD_CK2_1	111	117	PF00069	0.547
MOD_CK2_1	240	246	PF00069	0.657
MOD_CK2_1	282	288	PF00069	0.689
MOD_CK2_1	469	475	PF00069	0.822
MOD_CK2_1	542	548	PF00069	0.822
MOD_CK2_1	58	64	PF00069	0.588
MOD_Cter_Amidation	579	582	PF01082	0.581
MOD_GlcNHglycan	113	116	PF01048	0.735
MOD_GlcNHglycan	140	143	PF01048	0.697
MOD_GlcNHglycan	154	157	PF01048	0.817
MOD_GlcNHglycan	16	19	PF01048	0.556
MOD_GlcNHglycan	242	245	PF01048	0.554
MOD_GlcNHglycan	385	388	PF01048	0.574
MOD_GlcNHglycan	390	393	PF01048	0.632
MOD_GlcNHglycan	402	405	PF01048	0.747
MOD_GlcNHglycan	406	409	PF01048	0.776
MOD_GlcNHglycan	426	429	PF01048	0.553
MOD_GlcNHglycan	475	479	PF01048	0.793
MOD_GlcNHglycan	584	587	PF01048	0.728
MOD_GlcNHglycan	60	63	PF01048	0.605
MOD_GlcNHglycan	73	76	PF01048	0.725
MOD_GlcNHglycan	84	88	PF01048	0.729
MOD_GSK3_1	120	127	PF00069	0.521
MOD_GSK3_1	134	141	PF00069	0.695
MOD_GSK3_1	148	155	PF00069	0.711
MOD_GSK3_1	173	180	PF00069	0.812
MOD_GSK3_1	269	276	PF00069	0.716
MOD_GSK3_1	344	351	PF00069	0.710
MOD_GSK3_1	396	403	PF00069	0.755
MOD_GSK3_1	430	437	PF00069	0.735
MOD_GSK3_1	494	501	PF00069	0.788
MOD_GSK3_1	582	589	PF00069	0.783
MOD_GSK3_1	60	67	PF00069	0.654
MOD_N-GLC_1	172	177	PF02516	0.603
MOD_N-GLC_1	400	405	PF02516	0.719
MOD_N-GLC_1	480	485	PF02516	0.748
MOD_NEK2_1	129	134	PF00069	0.670
MOD_NEK2_1	254	259	PF00069	0.550
MOD_NEK2_1	320	325	PF00069	0.563
MOD_NEK2_1	333	338	PF00069	0.672
MOD_NEK2_1	383	388	PF00069	0.641
MOD_NEK2_2	124	129	PF00069	0.783
MOD_OFUCOSY	53	59	PF10250	0.623
MOD_PIKK_1	101	107	PF00454	0.639
MOD_PIKK_1	290	296	PF00454	0.730
MOD_PIKK_1	561	567	PF00454	0.829
MOD_PK_1	270	276	PF00069	0.432
MOD_PKA_1	388	394	PF00069	0.683
MOD_PKA_2	137	143	PF00069	0.506
MOD_PKA_2	269	275	PF00069	0.422
MOD_PKA_2	388	394	PF00069	0.683
MOD_PKA_2	542	548	PF00069	0.683
MOD_PKA_2	64	70	PF00069	0.773
MOD_Plk_1	172	178	PF00069	0.532
MOD_Plk_1	320	326	PF00069	0.571
MOD_Plk_1	480	486	PF00069	0.749
MOD_Plk_2-3	179	185	PF00069	0.784
MOD_Plk_4	124	130	PF00069	0.681
MOD_Plk_4	270	276	PF00069	0.432
MOD_Plk_4	321	327	PF00069	0.681
MOD_Plk_4	344	350	PF00069	0.680
MOD_Plk_4	358	364	PF00069	0.470
MOD_ProDKin_1	148	154	PF00069	0.689
MOD_ProDKin_1	264	270	PF00069	0.629
MOD_ProDKin_1	273	279	PF00069	0.630
MOD_ProDKin_1	282	288	PF00069	0.580
MOD_ProDKin_1	335	341	PF00069	0.639
MOD_ProDKin_1	421	427	PF00069	0.740
MOD_ProDKin_1	494	500	PF00069	0.841
MOD_ProDKin_1	509	515	PF00069	0.791
MOD_SUMO_rev_2	32	39	PF00179	0.501
TRG_ENDOCYTIC_2	219	222	PF00928	0.802
TRG_ENDOCYTIC_2	317	320	PF00928	0.622
TRG_ENDOCYTIC_2	331	334	PF00928	0.528
TRG_ENDOCYTIC_2	49	52	PF00928	0.468
TRG_ER_diArg_1	215	218	PF00400	0.706
TRG_ER_diArg_1	27	29	PF00400	0.518
TRG_ER_diArg_1	492	494	PF00400	0.729
TRG_NES_CRM1_1	35	48	PF08389	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T4	Leptomonas seymouri	47%	99%
A0A3Q8I8Z7	Leishmania donovani	86%	99%
A4H6I6	Leishmania braziliensis	69%	100%
A4HUX1	Leishmania infantum	87%	99%
Q4QH20	Leishmania major	86%	100%